(60 nodes) Hedgehog signaling pathway network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CSNK1G1	Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily. (499 aa)
	KIF7	Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1311 aa)
	CUL1	Cullin 1; Belongs to the cullin family. (742 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (419 aa)
	LRP4	LDL receptor related protein 4. (1852 aa)
	EVC2	EvC ciliary complex subunit 2. (992 aa)
	ENSUAMP00000027843	Uncharacterized protein. (119 aa)
	ENSUAMP00000027842	Uncharacterized protein. (99 aa)
	ENSUAMP00000027679	Uncharacterized protein. (51 aa)
	TSPAN33	Tetraspanin. (350 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
	EVC	EvC ciliary complex subunit 1. (976 aa)
	CSNK1A1	Casein kinase 1 alpha 1; Belongs to the protein kinase superfamily. (365 aa)
	ARR3	Arrestin 3. (380 aa)
	GLI1	GLI family zinc finger 1. (1105 aa)
	SMURF2	E3 ubiquitin-protein ligase. (736 aa)
	KIF27	Kinesin family member 27; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1401 aa)
	DHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
	LMBR1L	Limb development membrane protein 1 like. (317 aa)
	ATRN	Attractin. (1419 aa)
	CSNK1G2	Casein kinase 1 gamma 2; Belongs to the protein kinase superfamily. (489 aa)
	CSNK1G3	Casein kinase 1 gamma 3; Belongs to the protein kinase superfamily. (435 aa)
	MGRN1	Mahogunin ring finger 1. (539 aa)
	PTCH2	Patched 2. (1207 aa)
	ENSUAMP00000023083	Uncharacterized protein. (485 aa)
	ARRB1	Arrestin beta 1. (380 aa)
	SPOP	Speckle type BTB/POZ protein. (374 aa)
	ENSUAMP00000024123	Uncharacterized protein. (522 aa)
	LRP2	LDL receptor related protein 2. (4684 aa)
	ENSUAMP00000005526	Uncharacterized protein. (704 aa)
	ENSUAMP00000005615	Uncharacterized protein. (177 aa)
	ARRB2	Arrestin beta 2. (405 aa)
	GRK2	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (647 aa)
	ENSUAMP00000006884	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
	PTCH1	Patched 1. (1453 aa)
	ENSUAMP00000009120	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (436 aa)
	HHIP	Hedgehog interacting protein. (508 aa)
	GPR161	G protein-coupled receptor 161. (413 aa)
	ENSUAMP00000010093	SUFU_C domain-containing protein. (81 aa)
	ATRNL1	Attractin like 1. (1188 aa)
	MOSMO	Modulator of smoothened. (94 aa)
	ENSUAMP00000011222	Uncharacterized protein. (686 aa)
	ENSUAMP00000011226	Ig-like domain-containing protein. (152 aa)
	GRK3	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (649 aa)
	BCL2	BCL2 apoptosis regulator. (205 aa)
	GSK3B	Glycogen synthase kinase 3 beta. (335 aa)
	CDON	Cell adhesion associated, oncogene regulated. (1021 aa)
	MEGF8	Multiple EGF like domains 8. (2820 aa)
	CSNK1D	Casein kinase 1 delta; Belongs to the protein kinase superfamily. (428 aa)
	CUL3	Cullin 3; Belongs to the cullin family. (766 aa)
	KIF3A	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (684 aa)
	LMBR1	Limb development membrane protein 1; Belongs to the LIMR family. (490 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (361 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (294 aa)
	GLI3	GLI family zinc finger 3. (1413 aa)
	FBXW11	F-box and WD repeat domain containing 11. (543 aa)
	BTRC	Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
	ENSUAMP00000030381	Uncharacterized protein. (67 aa)
	SPOPL	Speckle type BTB/POZ protein like. (392 aa)
	ENSUAMP00000030304	HH_signal domain-containing protein. (146 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARR3	ENSUAMP00000005526	ENSUAMP00000024882	ENSUAMP00000005526	Arrestin 3.	Uncharacterized protein.	0.813
ARR3	ENSUAMP00000027842	ENSUAMP00000024882	ENSUAMP00000027842	Arrestin 3.	Uncharacterized protein.	0.554
ARR3	ENSUAMP00000027843	ENSUAMP00000024882	ENSUAMP00000027843	Arrestin 3.	Uncharacterized protein.	0.554
ARR3	GLI1	ENSUAMP00000024882	ENSUAMP00000024684	Arrestin 3.	GLI family zinc finger 1.	0.818
ARR3	GLI3	ENSUAMP00000024882	ENSUAMP00000032392	Arrestin 3.	GLI family zinc finger 3.	0.554
ARR3	GPR161	ENSUAMP00000024882	ENSUAMP00000009615	Arrestin 3.	G protein-coupled receptor 161.	0.839
ARR3	GRK2	ENSUAMP00000024882	ENSUAMP00000006716	Arrestin 3.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.892
ARR3	GRK3	ENSUAMP00000024882	ENSUAMP00000011411	Arrestin 3.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.866
ARR3	KIF3A	ENSUAMP00000024882	ENSUAMP00000034148	Arrestin 3.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.877
ARR3	SMO	ENSUAMP00000024882	ENSUAMP00000027495	Arrestin 3.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.869
ARRB1	ENSUAMP00000005526	ENSUAMP00000023607	ENSUAMP00000005526	Arrestin beta 1.	Uncharacterized protein.	0.839
ARRB1	ENSUAMP00000027842	ENSUAMP00000023607	ENSUAMP00000027842	Arrestin beta 1.	Uncharacterized protein.	0.688
ARRB1	ENSUAMP00000027843	ENSUAMP00000023607	ENSUAMP00000027843	Arrestin beta 1.	Uncharacterized protein.	0.688
ARRB1	GLI1	ENSUAMP00000023607	ENSUAMP00000024684	Arrestin beta 1.	GLI family zinc finger 1.	0.843
ARRB1	GLI3	ENSUAMP00000023607	ENSUAMP00000032392	Arrestin beta 1.	GLI family zinc finger 3.	0.688
ARRB1	GPR161	ENSUAMP00000023607	ENSUAMP00000009615	Arrestin beta 1.	G protein-coupled receptor 161.	0.862
ARRB1	GRK2	ENSUAMP00000023607	ENSUAMP00000006716	Arrestin beta 1.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.904
ARRB1	GRK3	ENSUAMP00000023607	ENSUAMP00000011411	Arrestin beta 1.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.884
ARRB1	KIF3A	ENSUAMP00000023607	ENSUAMP00000034148	Arrestin beta 1.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.894
ARRB1	SMO	ENSUAMP00000023607	ENSUAMP00000027495	Arrestin beta 1.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.887