STRINGSTRING
ENSUAMP00000025368 ENSUAMP00000025368 ENSUAMP00000025425 ENSUAMP00000025425 ENSUAMP00000025429 ENSUAMP00000025429 TNFRSF11B TNFRSF11B ENSUAMP00000025548 ENSUAMP00000025548 ENSUAMP00000025567 ENSUAMP00000025567 ENSUAMP00000025599 ENSUAMP00000025599 ENSUAMP00000025782 ENSUAMP00000025782 TYK2 TYK2 ENSUAMP00000025996 ENSUAMP00000025996 FOSB FOSB TYROBP TYROBP BLNK BLNK FOSL1 FOSL1 RELA RELA MAP2K6 MAP2K6 SOCS1 SOCS1 BTK BTK FYN FYN MAP2K7 MAP2K7 MAPK9 MAPK9 CSF1 CSF1 TNFRSF1A TNFRSF1A MITF MITF TRAF6 TRAF6 CYLD CYLD RELB RELB NFKBIA NFKBIA SOCS3 SOCS3 MAP3K14 MAP3K14 IRF9 IRF9 MAPK3 MAPK3 MAP3K7 MAP3K7 SYK SYK CSF1R CSF1R MAPK14 MAPK14 MAPK13 MAPK13 ENSUAMP00000032511 ENSUAMP00000032511 PPP3CC PPP3CC IL1B IL1B IL1A IL1A PTK6 PTK6 SRMS SRMS ENSUAMP00000033199 ENSUAMP00000033199 FHL2 FHL2 STAT1 STAT1 FOSL2 FOSL2 ENSUAMP00000034569 ENSUAMP00000034569 STAT2 STAT2 NOX1 NOX1 ENSUAMP00000035331 ENSUAMP00000035331 SQSTM1 SQSTM1 TREM2 TREM2 TREML1 TREML1 CHUK CHUK LCP2 LCP2 ENSUAMP00000037480 ENSUAMP00000037480 AKT2 AKT2 ACP5 ACP5 IL1R1 IL1R1 GAB2 GAB2 TRAF2 TRAF2 PPARG PPARG TAB2 TAB2 TAB1 TAB1 ENSUAMP00000005057 ENSUAMP00000005057 NCF4 NCF4 NFKB2 NFKB2 OSCAR OSCAR ENSUAMP00000006374 ENSUAMP00000006374 TNFSF11 TNFSF11 ENSUAMP00000007314 ENSUAMP00000007314 PLCG2 PLCG2 PPP3CA PPP3CA JUN JUN TGFBR2 TGFBR2 PIK3CA PIK3CA MAPK8 MAPK8 PPP3CB PPP3CB NCF1 NCF1 PIK3R1 PIK3R1 ENSUAMP00000010596 ENSUAMP00000010596 ENSUAMP00000010602 ENSUAMP00000010602 AKT1 AKT1 NFATC1 NFATC1 JAK1 JAK1 ENSUAMP00000011509 ENSUAMP00000011509 ENSUAMP00000011552 ENSUAMP00000011552 ENSUAMP00000011661 ENSUAMP00000011661 AKT3 AKT3 ENSUAMP00000011858 ENSUAMP00000011858 TEC TEC TGFB1 TGFB1 GRB2 GRB2 ENSUAMP00000012729 ENSUAMP00000012729 CALCR CALCR CTSK CTSK ENSUAMP00000013482 ENSUAMP00000013482 MAPK1 MAPK1 IKBKG IKBKG ENSUAMP00000014737 ENSUAMP00000014737 TNF TNF ENSUAMP00000016192 ENSUAMP00000016192 ENSUAMP00000016793 ENSUAMP00000016793 TGFBR1 TGFBR1 MAPK12 MAPK12 MAPK11 MAPK11 ENSUAMP00000017435 ENSUAMP00000017435 ENSUAMP00000017691 ENSUAMP00000017691 ENSUAMP00000017692 ENSUAMP00000017692 NOXA1 NOXA1 SPI1 SPI1 IFNGR2 IFNGR2 ENSUAMP00000019021 ENSUAMP00000019021 PIK3CD PIK3CD ENSUAMP00000020485 ENSUAMP00000020485 IKBKB IKBKB TGFB2 TGFB2 NFKB1 NFKB1 ENSUAMP00000021954 ENSUAMP00000021954 ENSUAMP00000022131 ENSUAMP00000022131 NCF2 NCF2 IFNGR1 IFNGR1 MAPK10 MAPK10 ENSUAMP00000023165 ENSUAMP00000023165 CREB1 CREB1 ENSUAMP00000025159 ENSUAMP00000025159 ENSUAMP00000025215 ENSUAMP00000025215 RELCH RELCH ENSUAMP00000025370 ENSUAMP00000025370
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000025368TNFR-Cys domain-containing protein. (263 aa)
ENSUAMP00000025425Uncharacterized protein. (382 aa)
ENSUAMP00000025429Uncharacterized protein. (445 aa)
TNFRSF11BTumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (401 aa)
ENSUAMP00000025548Uncharacterized protein. (400 aa)
ENSUAMP00000025567Uncharacterized protein. (366 aa)
ENSUAMP00000025599Uncharacterized protein. (374 aa)
ENSUAMP00000025782Uncharacterized protein. (257 aa)
TYK2Tyrosine-protein kinase. (1202 aa)
ENSUAMP00000025996Uncharacterized protein. (432 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
TYROBPTYRO protein tyrosine kinase binding protein. (129 aa)
BLNKB cell linker. (483 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
RELARELA proto-oncogene, NF-kB subunit. (508 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
SOCS1Suppressor of cytokine signaling 1. (214 aa)
BTKTyrosine-protein kinase. (663 aa)
FYNTyrosine-protein kinase. (537 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
MAPK9Mitogen-activated protein kinase. (433 aa)
CSF1Colony stimulating factor 1. (518 aa)
TNFRSF1ATNF receptor superfamily member 1A. (502 aa)
MITFMelanocyte inducing transcription factor. (525 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (953 aa)
RELBRELB proto-oncogene, NF-kB subunit. (575 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (955 aa)
IRF9Interferon regulatory factor 9. (466 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
SYKSpleen associated tyrosine kinase. (638 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (967 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
ENSUAMP00000032511Protein kinase domain-containing protein. (132 aa)
PPP3CCSerine/threonine-protein phosphatase. (449 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (244 aa)
PTK6Tyrosine-protein kinase. (482 aa)
SRMSTyrosine-protein kinase. (492 aa)
ENSUAMP00000033199RHD domain-containing protein. (458 aa)
FHL2Four and a half LIM domains 2. (279 aa)
STAT1Signal transducer and activator of transcription. (824 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (325 aa)
ENSUAMP00000034569Uncharacterized protein. (250 aa)
STAT2Signal transducer and activator of transcription. (848 aa)
NOX1NADPH oxidase 1. (594 aa)
ENSUAMP00000035331Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (506 aa)
SQSTM1Sequestosome 1. (491 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
TREML1Triggering receptor expressed on myeloid cells like 1. (311 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
LCP2Lymphocyte cytosolic protein 2. (511 aa)
ENSUAMP00000037480Uncharacterized protein. (520 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (335 aa)
IL1R1Interleukin 1 receptor type 1. (584 aa)
GAB2GRB2 associated binding protein 2. (665 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (683 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
ENSUAMP00000005057Uncharacterized protein. (445 aa)
NCF4Neutrophil cytosolic factor 4. (338 aa)
NFKB2Nuclear factor kappa B subunit 2. (581 aa)
OSCAROsteoclast associated Ig-like receptor. (251 aa)
ENSUAMP00000006374Uncharacterized protein. (178 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (242 aa)
ENSUAMP00000007314Ig-like domain-containing protein. (624 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1252 aa)
PPP3CASerine/threonine-protein phosphatase. (317 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAPK8Mitogen-activated protein kinase. (456 aa)
PPP3CBSerine/threonine-protein phosphatase. (479 aa)
NCF1Neutrophil cytosolic factor 1. (396 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (676 aa)
ENSUAMP00000010596Ig-like domain-containing protein. (149 aa)
ENSUAMP00000010602Uncharacterized protein. (715 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
NFATC1Nuclear factor of activated T cells 1. (931 aa)
JAK1Tyrosine-protein kinase. (1152 aa)
ENSUAMP00000011509Ig-like domain-containing protein. (352 aa)
ENSUAMP00000011552Ig-like domain-containing protein. (505 aa)
ENSUAMP00000011661Uncharacterized protein. (629 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ENSUAMP00000011858Ig-like domain-containing protein. (518 aa)
TECTyrosine-protein kinase. (631 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
GRB2Growth factor receptor bound protein 2. (203 aa)
ENSUAMP00000012729RHD domain-containing protein. (481 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (530 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (330 aa)
ENSUAMP00000013482Uncharacterized protein. (91 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (442 aa)
ENSUAMP00000014737Uncharacterized protein. (242 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (230 aa)
ENSUAMP00000016192Integrin beta; Belongs to the integrin beta chain family. (786 aa)
ENSUAMP00000016793BZIP domain-containing protein. (179 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
MAPK12Mitogen-activated protein kinase 12. (373 aa)
MAPK11Mitogen-activated protein kinase. (357 aa)
ENSUAMP00000017435Uncharacterized protein. (459 aa)
ENSUAMP00000017691ETS domain-containing protein. (264 aa)
ENSUAMP00000017692Uncharacterized protein. (704 aa)
NOXA1NADPH oxidase activator 1. (467 aa)
SPI1Spi-1 proto-oncogene. (257 aa)
IFNGR2Interferon gamma receptor 2. (343 aa)
ENSUAMP00000019021Interfer-bind domain-containing protein. (307 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
ENSUAMP00000020485Protein kinase domain-containing protein. (108 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (703 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (439 aa)
NFKB1Nuclear factor kappa B subunit 1. (972 aa)
ENSUAMP00000021954Uncharacterized protein. (209 aa)
ENSUAMP00000022131Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (636 aa)
NCF2Neutrophil cytosolic factor 2. (517 aa)
IFNGR1Interferon gamma receptor 1. (505 aa)
MAPK10Mitogen-activated protein kinase. (422 aa)
ENSUAMP00000023165Protein kinase domain-containing protein. (270 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
ENSUAMP00000025159BZIP domain-containing protein. (314 aa)
ENSUAMP00000025215BZIP domain-containing protein. (347 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (777 aa)
ENSUAMP00000025370Uncharacterized protein. (358 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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