STRINGSTRING
ENSUAMP00000012266 ENSUAMP00000012266 PARD6A PARD6A AXIN1 AXIN1 FZD6 FZD6 NF2 NF2 PRKCI PRKCI NKD2 NKD2 SNAI2 SNAI2 DLG4 DLG4 DVL2 DVL2 APC2 APC2 BIRC3 BIRC3 BIRC2 BIRC2 SMAD4 SMAD4 ENSUAMP00000018321 ENSUAMP00000018321 WNT10A WNT10A TEAD3 TEAD3 WWTR1 WWTR1 ENSUAMP00000017478 ENSUAMP00000017478 ENSUAMP00000017340 ENSUAMP00000017340 CTNNB1 CTNNB1 TGFBR1 TGFBR1 TGFB3 TGFB3 ENSUAMP00000016387 ENSUAMP00000016387 AREG AREG ENSUAMP00000016187 ENSUAMP00000016187 LDAH LDAH DVL1 DVL1 ENSUAMP00000016017 ENSUAMP00000016017 WNT7B WNT7B TP73 TP73 CSNK1D CSNK1D YWHAG YWHAG FRMD6 FRMD6 PPP1CC PPP1CC LLGL1 LLGL1 MYO15A MYO15A PPP2R1A PPP2R1A TGFB1 TGFB1 WNT9A WNT9A WNT3A WNT3A GSK3B GSK3B ENSUAMP00000012044 ENSUAMP00000012044 PPP2R2D PPP2R2D FZD5 FZD5 CCN2 CCN2 MPP5 MPP5 FZD4 FZD4 TP53BP2 TP53BP2 DLG5 DLG5 SERPINE1 SERPINE1 AJUBA AJUBA ENSUAMP00000010389 ENSUAMP00000010389 GDF5 GDF5 WNT2 WNT2 ENSUAMP00000009120 ENSUAMP00000009120 TGFBR2 TGFBR2 ENSUAMP00000008994 ENSUAMP00000008994 TEAD2 TEAD2 WNT2B WNT2B TCF7 TCF7 ENSUAMP00000007208 ENSUAMP00000007208 LATS1 LATS1 ENSUAMP00000006884 ENSUAMP00000006884 DVL3 DVL3 ENSUAMP00000006694 ENSUAMP00000006694 ENSUAMP00000005526 ENSUAMP00000005526 LRRC1 LRRC1 WNT8B WNT8B ENSUAMP00000003358 ENSUAMP00000003358 ENSUAMP00000003355 ENSUAMP00000003355 ENSUAMP00000003260 ENSUAMP00000003260 ENSUAMP00000003060 ENSUAMP00000003060 LLGL2 LLGL2 WNT11 WNT11 ENSUAMP00000002344 ENSUAMP00000002344 ENSUAMP00000002339 ENSUAMP00000002339 LIMD1 LIMD1 FZD2 FZD2 ENSUAMP00000001583 ENSUAMP00000001583 sry sry LATS2 LATS2 WNT6 WNT6 ENSUAMP00000001492 ENSUAMP00000001492 ENSUAMP00000001392 ENSUAMP00000001392 AXIN2 AXIN2 PPP2R2C PPP2R2C ENSUAMP00000000756 ENSUAMP00000000756 GDF6 GDF6 APC APC RASSF1 RASSF1 BMPR2 BMPR2 CCND3 CCND3 TCF7L1 TCF7L1 FZD1 FZD1 ENSUAMP00000036253 ENSUAMP00000036253 BMPR1A BMPR1A MOB1B MOB1B WNT9B WNT9B WNT3 WNT3 ENSUAMP00000035901 ENSUAMP00000035901 ENSUAMP00000035777 ENSUAMP00000035777 WNT7A WNT7A WNT10B WNT10B WNT1 WNT1 ENSUAMP00000035378 ENSUAMP00000035378 ENSUAMP00000035027 ENSUAMP00000035027 ITGB2 ITGB2 CDH1 CDH1 ENSUAMP00000033929 ENSUAMP00000033929 ENSUAMP00000033613 ENSUAMP00000033613 ENSUAMP00000033009 ENSUAMP00000033009 FZD7 FZD7 BMPR1B BMPR1B SAV1 SAV1 ENSUAMP00000032535 ENSUAMP00000032535 ENSUAMP00000032533 ENSUAMP00000032533 AMOT AMOT CCND1 CCND1 NKD1 NKD1 FBXW11 FBXW11 ENSUAMP00000032150 ENSUAMP00000032150 YWHAZ YWHAZ DLG1 DLG1 MYC MYC BTRC BTRC ENSUAMP00000031057 ENSUAMP00000031057 ENSUAMP00000030750 ENSUAMP00000030750 ID1 ID1 ENSUAMP00000030367 ENSUAMP00000030367 FGF1 FGF1 BMP4 BMP4 FZD10 FZD10 PPP2CB PPP2CB BIRC5 BIRC5 PARD6B PARD6B SMAD7 SMAD7 TEAD4 TEAD4 ENSUAMP00000026981 ENSUAMP00000026981 ENSUAMP00000026963 ENSUAMP00000026963 PPP2R2A PPP2R2A SMAD2 SMAD2 SMAD3 SMAD3 WNT4 WNT4 TCF7L2 TCF7L2 PPP1CB PPP1CB ENSUAMP00000025705 ENSUAMP00000025705 ENSUAMP00000025477 ENSUAMP00000025477 ENSUAMP00000025109 ENSUAMP00000025109 WNT8A WNT8A DLG3 DLG3 YWHAH YWHAH ENSUAMP00000023751 ENSUAMP00000023751 SOX2 SOX2 PPP2CA PPP2CA WNT5A WNT5A ENSUAMP00000023048 ENSUAMP00000023048 CRB2 CRB2 YWHAB YWHAB ENSUAMP00000022339 ENSUAMP00000022339 ENSUAMP00000022336 ENSUAMP00000022336 FZD3 FZD3 WNT16 WNT16 BMP2 BMP2 ACTG1 ACTG1 PPP2R2B PPP2R2B FZD9 FZD9 FRMD1 FRMD1 TGFB2 TGFB2 MOB1A MOB1A RASSF6 RASSF6 ENSUAMP00000020432 ENSUAMP00000020432 AFP AFP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000012266CTNNB1_binding domain-containing protein. (162 aa)
PARD6APar-6 family cell polarity regulator alpha. (348 aa)
AXIN1Axin 1. (867 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (657 aa)
NF2Neurofibromin 2. (596 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (587 aa)
NKD2NKD inhibitor of WNT signaling pathway 2. (450 aa)
SNAI2Snail family transcriptional repressor 2. (230 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (724 aa)
DVL2Dishevelled segment polarity protein 2. (731 aa)
APC2APC regulator of WNT signaling pathway 2. (2266 aa)
BIRC3Baculoviral IAP repeat containing 3. (603 aa)
BIRC2Baculoviral IAP repeat containing 2. (619 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ENSUAMP00000018321Uncharacterized protein. (509 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
TEAD3Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (434 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
ENSUAMP00000017478Guanylate kinase-like domain-containing protein. (307 aa)
ENSUAMP00000017340Uncharacterized protein. (131 aa)
CTNNB1Catenin beta 1. (781 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ENSUAMP00000016387Uncharacterized protein. (118 aa)
AREGAmphiregulin. (257 aa)
ENSUAMP00000016187Uncharacterized protein. (81 aa)
LDAHLipid droplet associated hydrolase. (324 aa)
DVL1Dishevelled segment polarity protein 1. (700 aa)
ENSUAMP00000016017PDZ domain-containing protein. (394 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (634 aa)
CSNK1DCasein kinase 1 delta; Belongs to the protein kinase superfamily. (428 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
FRMD6FERM domain containing 6. (591 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (326 aa)
LLGL1LLGL scribble cell polarity complex component 1. (1134 aa)
MYO15AMyosin XVA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (3421 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
GSK3BGlycogen synthase kinase 3 beta. (335 aa)
ENSUAMP00000012044TGF_BETA_2 domain-containing protein. (154 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (449 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (727 aa)
CCN2Cellular communication network factor 2. (349 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
TP53BP2Tumor protein p53 binding protein 2. (1157 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1866 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
AJUBAAjuba LIM protein. (548 aa)
ENSUAMP00000010389Uncharacterized protein. (363 aa)
GDF5Growth differentiation factor 5. (499 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
ENSUAMP00000009120Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (436 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
ENSUAMP0000000899414_3_3 domain-containing protein; Belongs to the 14-3-3 family. (100 aa)
TEAD2TEA domain transcription factor 2. (447 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (299 aa)
TCF7Transcription factor 7. (443 aa)
ENSUAMP00000007208Uncharacterized protein. (81 aa)
LATS1Uncharacterized protein. (1012 aa)
ENSUAMP00000006884Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
DVL3Dishevelled segment polarity protein 3. (716 aa)
ENSUAMP00000006694SER_THR_PHOSPHATASE domain-containing protein. (148 aa)
ENSUAMP00000005526Uncharacterized protein. (704 aa)
LRRC1Leucine rich repeat containing 1. (435 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (332 aa)
ENSUAMP00000003358SER_THR_PHOSPHATASE domain-containing protein. (106 aa)
ENSUAMP00000003355Uncharacterized protein. (76 aa)
ENSUAMP00000003260Uncharacterized protein. (261 aa)
ENSUAMP00000003060Uncharacterized protein. (1520 aa)
LLGL2LLGL scribble cell polarity complex component 2. (1022 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
ENSUAMP00000002344Uncharacterized protein. (257 aa)
ENSUAMP00000002339Uncharacterized protein. (108 aa)
LIMD1LIM domains containing 1. (672 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (563 aa)
ENSUAMP00000001583annotation not available (221 aa)
srySex-determining region Y protein; Transcriptional regulator that controls a genetic switch in male development; Belongs to the SRY family. (221 aa)
LATS2Non-specific serine/threonine protein kinase. (1084 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
ENSUAMP00000001492Uncharacterized protein. (66 aa)
ENSUAMP00000001392Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (545 aa)
AXIN2Axin 2. (843 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (425 aa)
ENSUAMP00000000756MH1 domain-containing protein. (170 aa)
GDF6Growth differentiation factor 6. (289 aa)
APCAPC regulator of WNT signaling pathway. (2832 aa)
RASSF1Ras association domain family member 1. (272 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (857 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
TCF7L1Transcription factor 7 like 1. (597 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (534 aa)
ENSUAMP00000036253Protein kinase domain-containing protein. (66 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
MOB1BMOB kinase activator 1B. (174 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
ENSUAMP00000035901Uncharacterized protein. (79 aa)
ENSUAMP00000035777HMG box domain-containing protein. (191 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
ENSUAMP00000035378Uncharacterized protein. (1036 aa)
ENSUAMP00000035027Uncharacterized protein. (146 aa)
ITGB2Integrin beta. (815 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (881 aa)
ENSUAMP00000033929PB1 domain-containing protein. (137 aa)
ENSUAMP00000033613Uncharacterized protein. (72 aa)
ENSUAMP00000033009Uncharacterized protein. (1337 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
ENSUAMP00000032535Uncharacterized protein. (145 aa)
ENSUAMP00000032533Uncharacterized protein. (127 aa)
AMOTAngiomotin. (1058 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (294 aa)
NKD1NKD inhibitor of WNT signaling pathway 1. (447 aa)
FBXW11F-box and WD repeat domain containing 11. (543 aa)
ENSUAMP00000032150PB1 domain-containing protein. (125 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (245 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (806 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
ENSUAMP00000031057Uncharacterized protein. (169 aa)
ENSUAMP00000030750Uncharacterized protein. (160 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
ENSUAMP00000030367Uncharacterized protein. (201 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (595 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
BIRC5Baculoviral IAP repeat containing 5. (142 aa)
PARD6BPar-6 family cell polarity regulator beta. (370 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
TEAD4TEA domain transcription factor 4. (353 aa)
ENSUAMP00000026981Uncharacterized protein. (580 aa)
ENSUAMP00000026963Protein kinase domain-containing protein. (93 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (458 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (343 aa)
TCF7L2Transcription factor 7 like 2. (524 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
ENSUAMP00000025705Uncharacterized protein. (84 aa)
ENSUAMP00000025477Uncharacterized protein. (185 aa)
ENSUAMP00000025109Uncharacterized protein. (168 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (344 aa)
DLG3Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (830 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
ENSUAMP00000023751Uncharacterized protein. (407 aa)
SOX2SRY-box transcription factor 2. (321 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ENSUAMP00000023048PB1 domain-containing protein. (123 aa)
CRB2Crumbs cell polarity complex component 2. (1280 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (244 aa)
ENSUAMP00000022339Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (107 aa)
ENSUAMP00000022336Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (163 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
ACTG1Actin gamma 1. (375 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (443 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (561 aa)
FRMD1FERM domain containing 1. (570 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (439 aa)
MOB1AMOB kinase activator 1A. (223 aa)
RASSF6Ras association domain family member 6. (337 aa)
ENSUAMP00000020432Uncharacterized protein. (604 aa)
AFPAlpha fetoprotein. (614 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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