STRINGSTRING
GEM GEM HTR2B HTR2B GNA11 GNA11 GUCY1A1 GUCY1A1 GNAI2 GNAI2 ENSUAMP00000036324 ENSUAMP00000036324 ENSUAMP00000036314 ENSUAMP00000036314 ENSUAMP00000036162 ENSUAMP00000036162 ADCY6 ADCY6 GJA1 GJA1 ENSUAMP00000035186 ENSUAMP00000035186 ENSUAMP00000034830 ENSUAMP00000034830 TUBB TUBB TUBA8 TUBA8 PRKG2 PRKG2 PRKACB PRKACB PDGFC PDGFC ENSUAMP00000032909 ENSUAMP00000032909 SOS1 SOS1 ENSUAMP00000032618 ENSUAMP00000032618 ADCY7 ADCY7 PDGFRB PDGFRB ADCY4 ADCY4 ENSUAMP00000031719 ENSUAMP00000031719 MAPK3 MAPK3 ENSUAMP00000030787 ENSUAMP00000030787 RAF1 RAF1 REM1 REM1 MAP2K1 MAP2K1 ENSUAMP00000030280 ENSUAMP00000030280 SRC SRC TUBB4A TUBB4A ENSUAMP00000029679 ENSUAMP00000029679 ENSUAMP00000029031 ENSUAMP00000029031 PLCB4 PLCB4 TUBB1 TUBB1 GNAS GNAS TUBB6 TUBB6 ENSUAMP00000028179 ENSUAMP00000028179 ENSUAMP00000028178 ENSUAMP00000028178 GUCY1B1 GUCY1B1 ADCY1 ADCY1 ADCY5 ADCY5 TUBB4B TUBB4B ENSUAMP00000026993 ENSUAMP00000026993 ENSUAMP00000026980 ENSUAMP00000026980 ENSUAMP00000026030 ENSUAMP00000026030 ENSUAMP00000025300 ENSUAMP00000025300 CDK1 CDK1 ENSUAMP00000023740 ENSUAMP00000023740 ENSUAMP00000023102 ENSUAMP00000023102 DRD2 DRD2 ENSUAMP00000022900 ENSUAMP00000022900 ENSUAMP00000022447 ENSUAMP00000022447 ENSUAMP00000022172 ENSUAMP00000022172 GNAQ GNAQ KRAS KRAS PRKCG PRKCG ENSUAMP00000019671 ENSUAMP00000019671 MC1R MC1R TUBB2A TUBB2A TJP1 TJP1 PLCB3 PLCB3 PDGFRA PDGFRA ENSUAMP00000018426 ENSUAMP00000018426 PDGFD PDGFD ENSUAMP00000015993 ENSUAMP00000015993 TUBB2B TUBB2B SOS2 SOS2 DRD1 DRD1 ENSUAMP00000014629 ENSUAMP00000014629 CSNK1D CSNK1D ENSUAMP00000014440 ENSUAMP00000014440 ERAS ERAS MAPK1 MAPK1 GRB2 GRB2 MAP3K2 MAP3K2 ENSUAMP00000011731 ENSUAMP00000011731 ENSUAMP00000011107 ENSUAMP00000011107 TUBA4A TUBA4A PLCB1 PLCB1 PRKCA PRKCA ENSUAMP00000010013 ENSUAMP00000010013 PDGFA PDGFA ADCY3 ADCY3 ENSUAMP00000008644 ENSUAMP00000008644 TUBAL3 TUBAL3 ADCY2 ADCY2 GNAI3 GNAI3 RRAD RRAD PRKCB PRKCB ENSUAMP00000007690 ENSUAMP00000007690 HTR2C HTR2C ADCY9 ADCY9 ENSUAMP00000005655 ENSUAMP00000005655 ENSUAMP00000005650 ENSUAMP00000005650 ITPR3 ITPR3 ENSUAMP00000005617 ENSUAMP00000005617 PDGFB PDGFB PLCB2 PLCB2 LPAR1 LPAR1 ENSUAMP00000004064 ENSUAMP00000004064 ENSUAMP00000003880 ENSUAMP00000003880 ENSUAMP00000003693 ENSUAMP00000003693 ENSUAMP00000002811 ENSUAMP00000002811 ENSUAMP00000002586 ENSUAMP00000002586 ENSUAMP00000002341 ENSUAMP00000002341 EGF EGF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
HTR2B5-hydroxytryptamine receptor 2B. (480 aa)
GNA11G protein subunit alpha 11. (353 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (681 aa)
GNAI2G protein subunit alpha i2. (436 aa)
ENSUAMP00000036324Uncharacterized protein. (189 aa)
ENSUAMP00000036314Protein kinase domain-containing protein. (321 aa)
ENSUAMP00000036162Protein kinase domain-containing protein. (462 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
GJA1Gap junction alpha-1 protein; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli a [...] (382 aa)
ENSUAMP00000035186ANF_receptor domain-containing protein. (305 aa)
ENSUAMP00000034830Uncharacterized protein. (1872 aa)
TUBBTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
TUBA8Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
PRKG2cGMP-dependent protein kinase. (711 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (361 aa)
PDGFCPlatelet derived growth factor C. (218 aa)
ENSUAMP00000032909Uncharacterized protein. (592 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1232 aa)
ENSUAMP00000032618Uncharacterized protein. (68 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1100 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ENSUAMP00000031719Uncharacterized protein. (627 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
ENSUAMP00000030787Uncharacterized protein. (84 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (564 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (313 aa)
MAP2K1Protein kinase domain-containing protein. (216 aa)
ENSUAMP00000030280Protein kinase domain-containing protein. (206 aa)
SRCTyrosine-protein kinase. (557 aa)
TUBB4ATubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
ENSUAMP00000029679Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (673 aa)
ENSUAMP00000029031Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1136 aa)
TUBB1Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (457 aa)
GNASGNAS complex locus. (994 aa)
TUBB6Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (432 aa)
ENSUAMP00000028179CSD domain-containing protein. (89 aa)
ENSUAMP00000028178Uncharacterized protein. (311 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (540 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
ADCY5Adenylate cyclase 5. (940 aa)
TUBB4BTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
ENSUAMP00000026993Uncharacterized protein. (118 aa)
ENSUAMP00000026980Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (299 aa)
ENSUAMP00000026030Uncharacterized protein. (236 aa)
ENSUAMP00000025300Non-specific serine/threonine protein kinase. (254 aa)
CDK1Cyclin dependent kinase 1. (305 aa)
ENSUAMP00000023740annotation not available (321 aa)
ENSUAMP00000023102Uncharacterized protein. (1102 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
ENSUAMP00000022900Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
ENSUAMP00000022447G_PROTEIN_RECEP_F1_2 domain-containing protein. (221 aa)
ENSUAMP00000022172Uncharacterized protein. (157 aa)
GNAQG protein subunit alpha q. (352 aa)
KRASKRAS proto-oncogene, GTPase. (188 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (714 aa)
ENSUAMP00000019671Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
MC1RMelanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (317 aa)
TUBB2ATubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (373 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1744 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
ENSUAMP00000018426Tubulin_C domain-containing protein; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (250 aa)
PDGFDPlatelet derived growth factor D. (368 aa)
ENSUAMP00000015993Uncharacterized protein. (98 aa)
TUBB2BTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1306 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
ENSUAMP00000014629Uncharacterized protein. (105 aa)
CSNK1DCasein kinase 1 delta; Belongs to the protein kinase superfamily. (428 aa)
ENSUAMP00000014440Protein kinase domain-containing protein. (251 aa)
ERASES cell expressed Ras. (219 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
GRB2Growth factor receptor bound protein 2. (203 aa)
MAP3K2Mitogen-activated protein kinase kinase kinase 2. (620 aa)
ENSUAMP00000011731Ion_trans domain-containing protein. (408 aa)
ENSUAMP00000011107Uncharacterized protein; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (420 aa)
TUBA4ATubulin alpha 4a; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (708 aa)
PLCB1Phosphoinositide phospholipase C. (658 aa)
PRKCAProtein kinase C alpha; Belongs to the protein kinase superfamily. (484 aa)
ENSUAMP00000010013Uncharacterized protein. (73 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (248 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (973 aa)
ENSUAMP00000008644Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (477 aa)
TUBAL3Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (461 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
GNAI3G protein subunit alpha i3. (295 aa)
RRADRRAD, Ras related glycolysis inhibitor and calcium channel regulator. (373 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (651 aa)
ENSUAMP00000007690Uncharacterized protein. (259 aa)
HTR2C5-hydroxytryptamine receptor 2C. (305 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1338 aa)
ENSUAMP00000005655Tubulin domain-containing protein. (85 aa)
ENSUAMP00000005650Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (434 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2656 aa)
ENSUAMP00000005617Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (485 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1166 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (271 aa)
ENSUAMP00000004064G_PROTEIN_RECEP_F1_2 domain-containing protein. (138 aa)
ENSUAMP00000003880Uncharacterized protein. (91 aa)
ENSUAMP00000003693Uncharacterized protein. (166 aa)
ENSUAMP00000002811Tubulin domain-containing protein. (97 aa)
ENSUAMP00000002586Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (321 aa)
ENSUAMP00000002341Uncharacterized protein. (957 aa)
EGFEpidermal growth factor. (979 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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