STRINGSTRING
APC APC AKT2 AKT2 ENSUAMP00000037566 ENSUAMP00000037566 PCGF2 PCGF2 PCGF6 PCGF6 BMPR2 BMPR2 FGFR4 FGFR4 ENSUAMP00000036515 ENSUAMP00000036515 FZD1 FZD1 ENSUAMP00000036324 ENSUAMP00000036324 LHX1 LHX1 BMPR1A BMPR1A HESX1 HESX1 WNT9B WNT9B WNT3 WNT3 WNT7A WNT7A WNT10B WNT10B WNT1 WNT1 ENSUAMP00000035331 ENSUAMP00000035331 SETDB1 SETDB1 ENSUAMP00000035029 ENSUAMP00000035029 RIF1 RIF1 HOXD1 HOXD1 FZD7 FZD7 BMPR1B BMPR1B ISL2 ISL2 MAPK13 MAPK13 MAPK14 MAPK14 NFIL3 NFIL3 ENSUAMP00000031719 ENSUAMP00000031719 MYC MYC SMAD9 SMAD9 MAPK3 MAPK3 ONECUT1 ONECUT1 ENSUAMP00000030787 ENSUAMP00000030787 RAF1 RAF1 ID1 ID1 ID3 ID3 MAP2K1 MAP2K1 ENSUAMP00000030280 ENSUAMP00000030280 ZIC3 ZIC3 IL6ST IL6ST DLX5 DLX5 ENSUAMP00000029322 ENSUAMP00000029322 SMARCAD1 SMARCAD1 ENSUAMP00000029031 ENSUAMP00000029031 PRRX1 PRRX1 BMP4 BMP4 ENSUAMP00000028265 ENSUAMP00000028265 ENSUAMP00000028179 ENSUAMP00000028179 ENSUAMP00000028178 ENSUAMP00000028178 PCGF1 PCGF1 FZD10 FZD10 ENSUAMP00000026993 ENSUAMP00000026993 SMAD2 SMAD2 SMAD3 SMAD3 WNT4 WNT4 JARID2 JARID2 FGFR1 FGFR1 WNT8A WNT8A HAND1 HAND1 INHBE INHBE INHBC INHBC LIFR LIFR ESRRB ESRRB JAK3 JAK3 SOX2 SOX2 ESRRG ESRRG WNT5A WNT5A ACVR1C ACVR1C FGFR2 FGFR2 ENSUAMP00000022339 ENSUAMP00000022339 ENSUAMP00000022336 ENSUAMP00000022336 SMAD5 SMAD5 ENSUAMP00000022131 ENSUAMP00000022131 FZD3 FZD3 WNT16 WNT16 MYF5 MYF5 ENSUAMP00000021661 ENSUAMP00000021661 IGF1 IGF1 FZD9 FZD9 KLF4 KLF4 KRAS KRAS PCGF3 PCGF3 ZIC1 ZIC1 AXIN1 AXIN1 OTX1 OTX1 FZD6 FZD6 DUSP9 DUSP9 PIK3CD PIK3CD SKIL SKIL DVL2 DVL2 TCF3 TCF3 APC2 APC2 SMAD4 SMAD4 WNT10A WNT10A HOXA1 HOXA1 ENSUAMP00000017830 ENSUAMP00000017830 ENSUAMP00000017692 ENSUAMP00000017692 ACVR1B ACVR1B ENSUAMP00000017435 ENSUAMP00000017435 ENSUAMP00000017364 ENSUAMP00000017364 MAPK11 MAPK11 CTNNB1 CTNNB1 ENSUAMP00000017162 ENSUAMP00000017162 NEUROG1 NEUROG1 MAPK12 MAPK12 ENSUAMP00000016349 ENSUAMP00000016349 DVL1 DVL1 ENSUAMP00000015993 ENSUAMP00000015993 WNT7B WNT7B ENSUAMP00000015591 ENSUAMP00000015591 ACVR2A ACVR2A IGF1R IGF1R ENSUAMP00000014216 ENSUAMP00000014216 ERAS ERAS MAPK1 MAPK1 GRB2 GRB2 WNT9A WNT9A WNT3A WNT3A GSK3B GSK3B AKT3 AKT3 FZD5 FZD5 JAK1 JAK1 KAT6A KAT6A FZD4 FZD4 HOXB1 HOXB1 FGFR3 FGFR3 AKT1 AKT1 PIK3R1 PIK3R1 NODAL NODAL WNT2 WNT2 PIK3CA PIK3CA STAT3 STAT3 JAK2 JAK2 LIF LIF WNT2B WNT2B TCF7 TCF7 INHBA INHBA ACVR2B ACVR2B DVL3 DVL3 ENSUAMP00000006610 ENSUAMP00000006610 ENSUAMP00000006598 ENSUAMP00000006598 ISL1 ISL1 ACVR1 ACVR1 ENSUAMP00000003693 ENSUAMP00000003693 WNT8B WNT8B PCGF5 PCGF5 ENSUAMP00000002924 ENSUAMP00000002924 ID2 ID2 WNT11 WNT11 FZD2 FZD2 ENSUAMP00000001661 ENSUAMP00000001661 ENSUAMP00000001583 ENSUAMP00000001583 sry sry WNT6 WNT6 ENSUAMP00000001392 ENSUAMP00000001392 TBX2 TBX2 AXIN2 AXIN2 MEIS1 MEIS1 ENSUAMP00000000756 ENSUAMP00000000756 ENSUAMP00000000600 ENSUAMP00000000600 ENSUAMP00000000397 ENSUAMP00000000397 LHX5 LHX5 ENSUAMP00000000316 ENSUAMP00000000316 ENSUAMP00000000201 ENSUAMP00000000201 MEIS2 MEIS2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APCAPC regulator of WNT signaling pathway. (2832 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSUAMP00000037566TGF_BETA_2 domain-containing protein. (293 aa)
PCGF2Polycomb group ring finger 2. (344 aa)
PCGF6Polycomb group ring finger 6. (322 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (857 aa)
FGFR4Fibroblast growth factor receptor. (836 aa)
ENSUAMP00000036515Uncharacterized protein. (78 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (534 aa)
ENSUAMP00000036324Uncharacterized protein. (189 aa)
LHX1LIM homeobox 1. (406 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
HESX1HESX homeobox 1. (185 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
ENSUAMP00000035331Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (506 aa)
SETDB1SET domain bifurcated histone lysine methyltransferase 1. (1299 aa)
ENSUAMP00000035029POU domain protein. (360 aa)
RIF1Replication timing regulatory factor 1. (2251 aa)
HOXD1Homeobox D1. (326 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
ISL2ISL LIM homeobox 2. (359 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
NFIL3Nuclear factor, interleukin 3 regulated. (462 aa)
ENSUAMP00000031719Uncharacterized protein. (627 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
SMAD9Mothers against decapentaplegic homolog. (469 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
ONECUT1One cut domain family member. (465 aa)
ENSUAMP00000030787Uncharacterized protein. (84 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (564 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
MAP2K1Protein kinase domain-containing protein. (216 aa)
ENSUAMP00000030280Protein kinase domain-containing protein. (206 aa)
ZIC3Uncharacterized protein. (466 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
DLX5Distal-less homeobox 5. (289 aa)
ENSUAMP00000029322Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
SMARCAD1Uncharacterized protein. (1028 aa)
ENSUAMP00000029031Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
PRRX1Paired related homeobox 1. (245 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
ENSUAMP00000028265RING-type domain-containing protein. (357 aa)
ENSUAMP00000028179CSD domain-containing protein. (89 aa)
ENSUAMP00000028178Uncharacterized protein. (311 aa)
PCGF1Polycomb group ring finger 1. (263 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (595 aa)
ENSUAMP00000026993Uncharacterized protein. (118 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (343 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1160 aa)
FGFR1Fibroblast growth factor receptor. (848 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (344 aa)
HAND1Heart and neural crest derivatives expressed 1. (218 aa)
INHBEInhibin subunit beta E. (351 aa)
INHBCInhibin subunit beta C. (352 aa)
LIFRLIF receptor subunit alpha. (824 aa)
ESRRBEstrogen related receptor beta. (454 aa)
JAK3Tyrosine-protein kinase. (1015 aa)
SOX2SRY-box transcription factor 2. (321 aa)
ESRRGEstrogen related receptor gamma. (435 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (494 aa)
FGFR2Fibroblast growth factor receptor 2. (661 aa)
ENSUAMP00000022339Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (107 aa)
ENSUAMP00000022336Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (163 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
ENSUAMP00000022131Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (636 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
ENSUAMP00000021661Uncharacterized protein. (164 aa)
IGF1Insulin like growth factor 1. (171 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (561 aa)
KLF4Kruppel like factor 4. (487 aa)
KRASKRAS proto-oncogene, GTPase. (188 aa)
PCGF3Polycomb group ring finger 3. (267 aa)
ZIC1Zic family member 1. (447 aa)
AXIN1Axin 1. (867 aa)
OTX1Orthodenticle homeobox 1. (355 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (657 aa)
DUSP9Dual specificity phosphatase 9. (245 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
SKILSKI like proto-oncogene. (684 aa)
DVL2Dishevelled segment polarity protein 2. (731 aa)
TCF3Transcription factor 3. (640 aa)
APC2APC regulator of WNT signaling pathway 2. (2266 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
HOXA1Homeobox A1. (332 aa)
ENSUAMP00000017830Uncharacterized protein. (157 aa)
ENSUAMP00000017692Uncharacterized protein. (704 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
ENSUAMP00000017435Uncharacterized protein. (459 aa)
ENSUAMP00000017364Uncharacterized protein. (53 aa)
MAPK11Mitogen-activated protein kinase. (357 aa)
CTNNB1Catenin beta 1. (781 aa)
ENSUAMP00000017162Uncharacterized protein. (137 aa)
NEUROG1Neurogenin 1. (251 aa)
MAPK12Mitogen-activated protein kinase 12. (373 aa)
ENSUAMP00000016349Uncharacterized protein. (121 aa)
DVL1Dishevelled segment polarity protein 1. (700 aa)
ENSUAMP00000015993Uncharacterized protein. (98 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
ENSUAMP00000015591Uncharacterized protein. (184 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
IGF1RTyrosine-protein kinase receptor. (1288 aa)
ENSUAMP00000014216Homeobox domain-containing protein. (315 aa)
ERASES cell expressed Ras. (219 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
GRB2Growth factor receptor bound protein 2. (203 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
GSK3BGlycogen synthase kinase 3 beta. (335 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (727 aa)
JAK1Tyrosine-protein kinase. (1152 aa)
KAT6AHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2004 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
HOXB1Homeobox B1. (301 aa)
FGFR3Fibroblast growth factor receptor. (691 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (676 aa)
NODALNodal growth differentiation factor. (348 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (299 aa)
TCF7Transcription factor 7. (443 aa)
INHBAInhibin subunit beta A. (424 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (527 aa)
DVL3Dishevelled segment polarity protein 3. (716 aa)
ENSUAMP00000006610CUT domain-containing protein. (259 aa)
ENSUAMP00000006598Homeobox domain-containing protein. (209 aa)
ISL1ISL LIM homeobox 1. (349 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ENSUAMP00000003693Uncharacterized protein. (166 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (332 aa)
PCGF5Polycomb group ring finger 5. (190 aa)
ENSUAMP00000002924Uncharacterized protein. (335 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (563 aa)
ENSUAMP00000001661TGF_BETA_2 domain-containing protein. (194 aa)
ENSUAMP00000001583annotation not available (221 aa)
srySex-determining region Y protein; Transcriptional regulator that controls a genetic switch in male development; Belongs to the SRY family. (221 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
ENSUAMP00000001392Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (545 aa)
TBX2T-box transcription factor 2. (697 aa)
AXIN2Axin 2. (843 aa)
MEIS1Meis homeobox 1. (288 aa)
ENSUAMP00000000756MH1 domain-containing protein. (170 aa)
ENSUAMP00000000600Uncharacterized protein. (130 aa)
ENSUAMP00000000397Paired domain-containing protein. (216 aa)
LHX5LIM homeobox 5. (402 aa)
ENSUAMP00000000316Homeobox domain-containing protein. (280 aa)
ENSUAMP00000000201Uncharacterized protein. (199 aa)
MEIS2Meis homeobox 2. (394 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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