(88 nodes) Antigen processing and presentation network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NFYB	Nuclear transcription factor Y subunit beta. (216 aa)
	ENSUAMP00000035001	Uncharacterized protein. (321 aa)
	ENSUAMP00000005117	Ig-like domain-containing protein. (412 aa)
	ENSUAMP00000004899	Uncharacterized protein. (240 aa)
	ENSUAMP00000003525	Ig-like domain-containing protein; Belongs to the MHC class II family. (205 aa)
	ENSUAMP00000003263	Ig-like domain-containing protein. (160 aa)
	ENSUAMP00000003162	Ig-like domain-containing protein. (206 aa)
	ENSUAMP00000002874	Ig-like domain-containing protein. (122 aa)
	RFXAP	Regulatory factor X associated protein. (282 aa)
	CTSV	Cathepsin V; Belongs to the peptidase C1 family. (324 aa)
	ENSUAMP00000001757	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (151 aa)
	ENSUAMP00000001165	Uncharacterized protein. (96 aa)
	ENSUAMP00000000976	Ig-like domain-containing protein; Belongs to the MHC class I family. (481 aa)
	ENSUAMP00000000885	Uncharacterized protein. (67 aa)
	ENSUAMP00000000641	Uncharacterized protein. (139 aa)
	RFXANK	Regulatory factor X associated ankyrin containing protein. (260 aa)
	CD4	CD4 molecule. (469 aa)
	HLA-DOA	Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (283 aa)
	ENSUAMP00000035427	Ig-like domain-containing protein; Belongs to the MHC class II family. (241 aa)
	TAPBP	TAP binding protein. (448 aa)
	LGMN	Legumain. (433 aa)
	ENSUAMP00000036029	Ig-like domain-containing protein; Belongs to the MHC class I family. (359 aa)
	ENSUAMP00000036043	MHC_I-like_Ag-recog domain-containing protein. (150 aa)
	RFX5	Regulatory factor X5. (532 aa)
	ENSUAMP00000036336	Inhibitor_I29 domain-containing protein. (93 aa)
	ENSUAMP00000036430	Uncharacterized protein; Belongs to the peptidase C1 family. (372 aa)
	ENSUAMP00000036524	Uncharacterized protein. (347 aa)
	ENSUAMP00000036887	Ig-like domain-containing protein. (179 aa)
	ENSUAMP00000037283	Ig-like domain-containing protein. (145 aa)
	ENSUAMP00000005351	Uncharacterized protein. (94 aa)
	ENSUAMP00000005465	Ig-like domain-containing protein; Belongs to the MHC class I family. (431 aa)
	ENSUAMP00000006240	Ig-like domain-containing protein; Belongs to the MHC class I family. (359 aa)
	ENSUAMP00000006865	MHC_II_beta domain-containing protein. (274 aa)
	ENSUAMP00000006872	MHC_II_beta domain-containing protein. (218 aa)
	CIITA	Class II major histocompatibility complex transactivator. (1063 aa)
	CTSB	Cathepsin B; Belongs to the peptidase C1 family. (339 aa)
	ENSUAMP00000009584	Ig-like domain-containing protein; Belongs to the MHC class I family. (336 aa)
	KLRG1	Killer cell lectin like receptor G1. (191 aa)
	ENSUAMP00000011260	DUF1968 domain-containing protein. (153 aa)
	ENSUAMP00000011956	Uncharacterized protein. (119 aa)
	HLA-DMA	Major histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (261 aa)
	ENSUAMP00000012503	Ig-like domain-containing protein. (263 aa)
	CALR	Calreticulin. (417 aa)
	NFYC	Nuclear transcription factor Y subunit gamma. (335 aa)
	CTSS	Cathepsin S; Belongs to the peptidase C1 family. (313 aa)
	ENSUAMP00000014588	IGv domain-containing protein. (107 aa)
	ENSUAMP00000014590	Ig-like domain-containing protein. (148 aa)
	ENSUAMP00000014720	Ig-like domain-containing protein. (177 aa)
	TRBV16	T cell receptor beta variable 16 (gene/pseudogene). (127 aa)
	CANX	Calnexin. (589 aa)
	HSPA4	Heat shock protein family A (Hsp70) member 4. (833 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (230 aa)
	ENSUAMP00000015817	Ig-like domain-containing protein. (126 aa)
	ENSUAMP00000015819	Ig-like domain-containing protein. (141 aa)
	TRBV28	T cell receptor beta variable 28. (113 aa)
	ENSUAMP00000016042	Ig-like domain-containing protein. (387 aa)
	ENSUAMP00000016352	Ig-like domain-containing protein; Belongs to the MHC class I family. (358 aa)
	ENSUAMP00000016547	MHC_II_beta domain-containing protein. (275 aa)
	HLA-DOB	Major histocompatibility complex, class II, DO beta. (261 aa)
	PSME3	Proteasome activator subunit 3. (254 aa)
	IFI30	IFI30 lysosomal thiol reductase. (239 aa)
	ENSUAMP00000017400	Uncharacterized protein. (703 aa)
	TAP1	Transporter 1, ATP binding cassette subfamily B member. (750 aa)
	HSPA5	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
	HLA-DRA	Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
	PDIA3	Protein disulfide-isomerase. (460 aa)
	ENSUAMP00000020061	Ig-like domain-containing protein; Belongs to the MHC class I family. (332 aa)
	ENSUAMP00000020826	Ig-like domain-containing protein. (196 aa)
	HSP90AB1	Heat shock protein 90 alpha family class B member 1. (728 aa)
	ENSUAMP00000021540	Uncharacterized protein. (311 aa)
	ENSUAMP00000022734	Uncharacterized protein; Belongs to the peptidase C1 family. (323 aa)
	ENSUAMP00000023350	Uncharacterized protein. (152 aa)
	ENSUAMP00000023351	Uncharacterized protein. (151 aa)
	ENSUAMP00000023352	Uncharacterized protein. (251 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa)
	HSP90AA1	Heat shock protein 90 alpha family class A member 1. (733 aa)
	ENSUAMP00000023925	Ig-like domain-containing protein. (180 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	ENSUAMP00000024850	Ig-like domain-containing protein. (269 aa)
	ENSUAMP00000024857	Ig-like domain-containing protein. (284 aa)
	HSPA2	Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (611 aa)
	HSPA8	Uncharacterized protein; Belongs to the heat shock protein 70 family. (646 aa)
	ENSUAMP00000029280	DUF1968 domain-containing protein. (198 aa)
	PSME1	Proteasome activator subunit 1. (249 aa)
	PSME2	Proteasome activator subunit 2. (239 aa)
	ENSUAMP00000031983	Uncharacterized protein; Belongs to the heat shock protein 70 family. (653 aa)
	CD74	CD74 molecule. (279 aa)
	ENSUAMP00000033175	Uncharacterized protein. (91 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B2M	CALR	ENSUAMP00000023655	ENSUAMP00000012645	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Calreticulin.	0.926
B2M	CANX	ENSUAMP00000023655	ENSUAMP00000015468	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Calnexin.	0.468
B2M	CD4	ENSUAMP00000023655	ENSUAMP00000035363	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	CD4 molecule.	0.698
B2M	CD74	ENSUAMP00000023655	ENSUAMP00000032952	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	CD74 molecule.	0.542
B2M	ENSUAMP00000000885	ENSUAMP00000023655	ENSUAMP00000000885	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Uncharacterized protein.	0.717
B2M	ENSUAMP00000000976	ENSUAMP00000023655	ENSUAMP00000000976	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.955
B2M	ENSUAMP00000003525	ENSUAMP00000023655	ENSUAMP00000003525	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein; Belongs to the MHC class II family.	0.610
B2M	ENSUAMP00000005117	ENSUAMP00000023655	ENSUAMP00000005117	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein.	0.667
B2M	ENSUAMP00000005465	ENSUAMP00000023655	ENSUAMP00000005465	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.955
B2M	ENSUAMP00000006240	ENSUAMP00000023655	ENSUAMP00000006240	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.955
B2M	ENSUAMP00000006865	ENSUAMP00000023655	ENSUAMP00000006865	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	MHC_II_beta domain-containing protein.	0.465
B2M	ENSUAMP00000006872	ENSUAMP00000023655	ENSUAMP00000006872	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	MHC_II_beta domain-containing protein.	0.465
B2M	ENSUAMP00000009584	ENSUAMP00000023655	ENSUAMP00000009584	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.955
B2M	ENSUAMP00000011260	ENSUAMP00000023655	ENSUAMP00000011260	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	DUF1968 domain-containing protein.	0.863
B2M	ENSUAMP00000012503	ENSUAMP00000023655	ENSUAMP00000012503	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein.	0.615
B2M	ENSUAMP00000014588	ENSUAMP00000023655	ENSUAMP00000014588	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	IGv domain-containing protein.	0.445
B2M	ENSUAMP00000014590	ENSUAMP00000023655	ENSUAMP00000014590	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein.	0.525
B2M	ENSUAMP00000014720	ENSUAMP00000023655	ENSUAMP00000014720	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein.	0.462
B2M	ENSUAMP00000015817	ENSUAMP00000023655	ENSUAMP00000015817	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein.	0.445
B2M	ENSUAMP00000015819	ENSUAMP00000023655	ENSUAMP00000015819	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein.	0.445