STRINGSTRING
ENSUAMP00000029031 ENSUAMP00000029031 IKBKE IKBKE BPIFC BPIFC LBP LBP ENSUAMP00000030153 ENSUAMP00000030153 ENSUAMP00000030280 ENSUAMP00000030280 MAP2K1 MAP2K1 TRAF6 TRAF6 NFKBIA NFKBIA IL6 IL6 TLR4 TLR4 CXCL10 CXCL10 ENSUAMP00000032598 ENSUAMP00000032598 AKT2 AKT2 ENSUAMP00000037480 ENSUAMP00000037480 CHUK CHUK ENSUAMP00000035925 ENSUAMP00000035925 ENSUAMP00000035331 ENSUAMP00000035331 TLR8 TLR8 TLR7 TLR7 IRAK4 IRAK4 STAT1 STAT1 TRAF3 TRAF3 MAP2K4 MAP2K4 IL1B IL1B TAB2 TAB2 ENSUAMP00000001501 ENSUAMP00000001501 CXCL11 CXCL11 ENSUAMP00000032511 ENSUAMP00000032511 MAPK13 MAPK13 MAPK14 MAPK14 MAP3K7 MAP3K7 ENSUAMP00000003212 ENSUAMP00000003212 TAB1 TAB1 ENSUAMP00000005552 ENSUAMP00000005552 CCL5 CCL5 MYD88 MYD88 ENSUAMP00000006118 ENSUAMP00000006118 TIRAP TIRAP ENSUAMP00000006398 ENSUAMP00000006398 ENSUAMP00000006641 ENSUAMP00000006641 ENSUAMP00000006735 ENSUAMP00000006735 CASP8 CASP8 ENSUAMP00000008826 ENSUAMP00000008826 JUN JUN PIK3CA PIK3CA MAPK8 MAPK8 ENSUAMP00000009537 ENSUAMP00000009537 PIK3R1 PIK3R1 AKT1 AKT1 ENSUAMP00000011161 ENSUAMP00000011161 IL12A IL12A ENSUAMP00000011530 ENSUAMP00000011530 ENSUAMP00000011531 ENSUAMP00000011531 AKT3 AKT3 TMED3 TMED3 ENSUAMP00000012032 ENSUAMP00000012032 ENSUAMP00000012035 ENSUAMP00000012035 ENSUAMP00000012037 ENSUAMP00000012037 CD80 CD80 CTSK CTSK MAPK1 MAPK1 IKBKG IKBKG IL12B IL12B TOLLIP TOLLIP CD40 CD40 TNF TNF ENSUAMP00000016793 ENSUAMP00000016793 MAPK12 MAPK12 MAPK11 MAPK11 ENSUAMP00000017435 ENSUAMP00000017435 ENSUAMP00000017692 ENSUAMP00000017692 TBK1 TBK1 TICAM1 TICAM1 ENSUAMP00000019021 ENSUAMP00000019021 ENSUAMP00000019310 ENSUAMP00000019310 TLR6 TLR6 TLR1 TLR1 ENSUAMP00000019351 ENSUAMP00000019351 PIK3CD PIK3CD TLR3 TLR3 RIPK1 RIPK1 MAP2K3 MAP2K3 CXCL8 CXCL8 IKBKB IKBKB IRF6 IRF6 NFKB1 NFKB1 ENSUAMP00000022131 ENSUAMP00000022131 MAPK3 MAPK3 TLR2 TLR2 MAPK10 MAPK10 IRAK1 IRAK1 ENSUAMP00000025608 ENSUAMP00000025608 ENSUAMP00000025678 ENSUAMP00000025678 TMED7 TMED7 ENSUAMP00000026449 ENSUAMP00000026449 RELA RELA MAP2K6 MAP2K6 ENSUAMP00000026919 ENSUAMP00000026919 IRF5 IRF5 FADD FADD MAP2K7 MAP2K7 TLR5 TLR5 IRF7 IRF7 MAPK9 MAPK9 SPP1 SPP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000029031Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (693 aa)
BPIFCBPI fold containing family C. (507 aa)
LBPLipopolysaccharide binding protein. (406 aa)
ENSUAMP00000030153BPI2 domain-containing protein. (268 aa)
ENSUAMP00000030280Protein kinase domain-containing protein. (206 aa)
MAP2K1Protein kinase domain-containing protein. (216 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
IL6Interleukin 6. (212 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
CXCL10C-X-C motif chemokine. (98 aa)
ENSUAMP00000032598SCY domain-containing protein. (64 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSUAMP00000037480Uncharacterized protein. (520 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
ENSUAMP00000035925Ig-like domain-containing protein. (236 aa)
ENSUAMP00000035331Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (506 aa)
TLR8Toll like receptor 8; Belongs to the Toll-like receptor family. (1039 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1059 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (477 aa)
STAT1Signal transducer and activator of transcription. (824 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (416 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (683 aa)
ENSUAMP00000001501Uncharacterized protein. (470 aa)
CXCL11C-X-C motif chemokine. (96 aa)
ENSUAMP00000032511Protein kinase domain-containing protein. (132 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
ENSUAMP00000003212Uncharacterized protein. (165 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
ENSUAMP00000005552SCY domain-containing protein. (93 aa)
CCL5C-C motif chemokine. (116 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
ENSUAMP00000006118Uncharacterized protein. (165 aa)
TIRAPTIR domain containing adaptor protein. (224 aa)
ENSUAMP00000006398annotation not available (356 aa)
ENSUAMP00000006641Uncharacterized protein. (184 aa)
ENSUAMP00000006735Uncharacterized protein. (185 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (395 aa)
ENSUAMP00000008826IRF tryptophan pentad repeat domain-containing protein. (421 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAPK8Mitogen-activated protein kinase. (456 aa)
ENSUAMP00000009537Mitogen-activated protein kinase kinase kinase 8. (174 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (676 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
ENSUAMP00000011161Mitogen-activated protein kinase kinase kinase 8. (139 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
ENSUAMP00000011530Uncharacterized protein. (197 aa)
ENSUAMP00000011531Uncharacterized protein. (172 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
TMED3Transmembrane p24 trafficking protein 3. (215 aa)
ENSUAMP00000012032C-C motif chemokine. (93 aa)
ENSUAMP00000012035C-C motif chemokine. (93 aa)
ENSUAMP00000012037C-C motif chemokine. (92 aa)
CD80CD80 molecule. (283 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (330 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (442 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
TOLLIPToll interacting protein. (347 aa)
CD40CD40 molecule. (265 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (230 aa)
ENSUAMP00000016793BZIP domain-containing protein. (179 aa)
MAPK12Mitogen-activated protein kinase 12. (373 aa)
MAPK11Mitogen-activated protein kinase. (357 aa)
ENSUAMP00000017435Uncharacterized protein. (459 aa)
ENSUAMP00000017692Uncharacterized protein. (704 aa)
TBK1TANK binding kinase 1. (709 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (751 aa)
ENSUAMP00000019021Interfer-bind domain-containing protein. (307 aa)
ENSUAMP00000019310Uncharacterized protein. (182 aa)
TLR6Toll like receptor 6; Belongs to the Toll-like receptor family. (778 aa)
TLR1Toll like receptor 1; Belongs to the Toll-like receptor family. (802 aa)
ENSUAMP00000019351Uncharacterized protein. (165 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (550 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (703 aa)
IRF6Interferon regulatory factor 6. (462 aa)
NFKB1Nuclear factor kappa B subunit 1. (972 aa)
ENSUAMP00000022131Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (636 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (787 aa)
MAPK10Mitogen-activated protein kinase. (422 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (664 aa)
ENSUAMP00000025608IRF-3 domain-containing protein. (295 aa)
ENSUAMP00000025678Uncharacterized protein. (163 aa)
TMED7GOLD domain-containing protein. (224 aa)
ENSUAMP00000026449Uncharacterized protein. (121 aa)
RELARELA proto-oncogene, NF-kB subunit. (508 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
ENSUAMP00000026919TIR domain-containing protein. (1033 aa)
IRF5Interferon regulatory factor 5. (503 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (220 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
TLR5Toll like receptor 5; Belongs to the Toll-like receptor family. (883 aa)
IRF7Interferon regulatory factor 7. (470 aa)
MAPK9Mitogen-activated protein kinase. (433 aa)
SPP1Secreted phosphoprotein 1. (298 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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