(72 nodes) RIG-I-like receptor signaling pathway network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSUAMP00000003094	Uncharacterized protein. (162 aa)
	ENSUAMP00000003212	Uncharacterized protein. (165 aa)
	TRIM47	Tripartite motif containing 47. (642 aa)
	TRIM65	Tripartite motif containing 65. (521 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (508 aa)
	ENSUAMP00000025608	IRF-3 domain-containing protein. (295 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	PIN1	Peptidyl-prolyl cis-trans isomerase. (163 aa)
	AZI2	5-azacytidine induced 2. (393 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
	MAPK10	Mitogen-activated protein kinase. (422 aa)
	TKFC	Triokinase and FMN cyclase. (578 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (972 aa)
	IFIH1	Interferon induced with helicase C domain 1. (1017 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (703 aa)
	CXCL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
	TRADD	TNFRSF1A associated via death domain. (314 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (550 aa)
	ENSUAMP00000019351	Uncharacterized protein. (165 aa)
	ENSUAMP00000019310	Uncharacterized protein. (182 aa)
	TBK1	TANK binding kinase 1. (709 aa)
	NLRX1	NLR family member X1. (975 aa)
	IFNE	Interferon epsilon. (204 aa)
	MAPK11	Mitogen-activated protein kinase. (357 aa)
	MAPK12	Mitogen-activated protein kinase 12. (373 aa)
	DDX3X	DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (675 aa)
	ENSUAMP00000016276	Uncharacterized protein; Belongs to the DEAD box helicase family. (661 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (230 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (442 aa)
	NFKBIB	NFKB inhibitor beta. (354 aa)
	ENSUAMP00000013636	Uncharacterized protein. (265 aa)
	ENSUAMP00000013008	Uncharacterized protein. (603 aa)
	ENSUAMP00000011531	Uncharacterized protein. (172 aa)
	ENSUAMP00000011530	Uncharacterized protein. (197 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
	ENSUAMP00000010841	Uncharacterized protein. (303 aa)
	RNF125	Ring finger protein 125. (232 aa)
	MAPK8	Mitogen-activated protein kinase. (456 aa)
	ENSUAMP00000008826	IRF tryptophan pentad repeat domain-containing protein. (421 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	ENSUAMP00000006118	Uncharacterized protein. (165 aa)
	ENSUAMP00000006641	Uncharacterized protein. (184 aa)
	ENSUAMP00000006735	Uncharacterized protein. (185 aa)
	CASP10	Caspase 10; Belongs to the peptidase C14A family. (481 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (395 aa)
	COIL	Coilin. (578 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
	CYLD	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (953 aa)
	NFKBIA	NFKB inhibitor alpha. (314 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
	DHX58	DExH-box helicase 58. (674 aa)
	IFNK	Interferon kappa. (190 aa)
	TANK	TRAF family member associated NFKB activator. (426 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
	ISG15	ISG15 ubiquitin like modifier. (157 aa)
	MAVS	Mitochondrial antiviral signaling protein. (523 aa)
	STING1	Transmembrane protein 173. (392 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
	CXCL10	C-X-C motif chemokine. (98 aa)
	ENSUAMP00000032511	Protein kinase domain-containing protein. (132 aa)
	MAPK13	Mitogen-activated protein kinase. (366 aa)
	IRF7	Interferon regulatory factor 7. (470 aa)
	MAPK9	Mitogen-activated protein kinase. (433 aa)
	IKBKE	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (693 aa)
	MAP3K1	Mitogen-activated protein kinase kinase kinase 1. (1508 aa)
	DDX58	DExD/H-box helicase 58. (928 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (220 aa)
	SIKE1	Suppressor of IKBKE 1. (207 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
	FGFR1OP2	FGFR1 oncogene partner 2. (253 aa)
	ENSUAMP00000002291	B30.2/SPRY domain-containing protein. (210 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG12	ATG5	ENSUAMP00000022894	ENSUAMP00000024668	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG12	CASP8	ENSUAMP00000022894	ENSUAMP00000007996	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Caspase 8; Belongs to the peptidase C14A family.	0.405
ATG12	DDX58	ENSUAMP00000022894	ENSUAMP00000026887	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	DExD/H-box helicase 58.	0.969
ATG12	DHX58	ENSUAMP00000022894	ENSUAMP00000032004	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	DExH-box helicase 58.	0.490
ATG12	FADD	ENSUAMP00000022894	ENSUAMP00000027565	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.509
ATG12	IFIH1	ENSUAMP00000022894	ENSUAMP00000020969	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Interferon induced with helicase C domain 1.	0.643
ATG12	MAVS	ENSUAMP00000022894	ENSUAMP00000035479	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Mitochondrial antiviral signaling protein.	0.979
ATG12	NLRX1	ENSUAMP00000022894	ENSUAMP00000018290	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	NLR family member X1.	0.553
ATG5	ATG12	ENSUAMP00000024668	ENSUAMP00000022894	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.999
ATG5	CASP10	ENSUAMP00000024668	ENSUAMP00000007994	Autophagy protein 5; Involved in autophagic vesicle formation.	Caspase 10; Belongs to the peptidase C14A family.	0.485
ATG5	CASP8	ENSUAMP00000024668	ENSUAMP00000007996	Autophagy protein 5; Involved in autophagic vesicle formation.	Caspase 8; Belongs to the peptidase C14A family.	0.623
ATG5	DDX58	ENSUAMP00000024668	ENSUAMP00000026887	Autophagy protein 5; Involved in autophagic vesicle formation.	DExD/H-box helicase 58.	0.969
ATG5	DHX58	ENSUAMP00000024668	ENSUAMP00000032004	Autophagy protein 5; Involved in autophagic vesicle formation.	DExH-box helicase 58.	0.488
ATG5	FADD	ENSUAMP00000024668	ENSUAMP00000027565	Autophagy protein 5; Involved in autophagic vesicle formation.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.874
ATG5	IFIH1	ENSUAMP00000024668	ENSUAMP00000020969	Autophagy protein 5; Involved in autophagic vesicle formation.	Interferon induced with helicase C domain 1.	0.633
ATG5	MAVS	ENSUAMP00000024668	ENSUAMP00000035479	Autophagy protein 5; Involved in autophagic vesicle formation.	Mitochondrial antiviral signaling protein.	0.974
ATG5	NLRX1	ENSUAMP00000024668	ENSUAMP00000018290	Autophagy protein 5; Involved in autophagic vesicle formation.	NLR family member X1.	0.558
ATG5	RIPK1	ENSUAMP00000024668	ENSUAMP00000019468	Autophagy protein 5; Involved in autophagic vesicle formation.	Receptor interacting serine/threonine kinase 1.	0.446
ATG5	TBK1	ENSUAMP00000024668	ENSUAMP00000018386	Autophagy protein 5; Involved in autophagic vesicle formation.	TANK binding kinase 1.	0.414
ATG5	TNF	ENSUAMP00000024668	ENSUAMP00000015695	Autophagy protein 5; Involved in autophagic vesicle formation.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.446