STRINGSTRING
RRAD RRAD PLCG2 PLCG2 CASP8 CASP8 PPP3CA PPP3CA NFATC4 NFATC4 KSR1 KSR1 ENSUAMP00000008469 ENSUAMP00000008469 CALML5 CALML5 RHOB RHOB ENSUAMP00000008748 ENSUAMP00000008748 RRAS RRAS PRKCD PRKCD JUN JUN PIK3CA PIK3CA MAPK8 MAPK8 MRAS MRAS PPP3CB PPP3CB PTPN11 PTPN11 PYCARD PYCARD CLEC4G CLEC4G PIK3R1 PIK3R1 AKT1 AKT1 CBLB CBLB CLEC7A CLEC7A ENSUAMP00000011223 ENSUAMP00000011223 NFATC1 NFATC1 IL12A IL12A AKT3 AKT3 ENSUAMP00000011731 ENSUAMP00000011731 CARD9 CARD9 NLRP3 NLRP3 ENSUAMP00000012405 ENSUAMP00000012405 ENSUAMP00000012729 ENSUAMP00000012729 ENSUAMP00000030264 ENSUAMP00000030264 CYLD CYLD CLEC1A CLEC1A CLEC9A CLEC9A CLEC1B CLEC1B RELB RELB NFKBIA NFKBIA REM1 REM1 MAP3K14 MAP3K14 RAF1 RAF1 ENSUAMP00000030787 ENSUAMP00000030787 IL6 IL6 IRF9 IRF9 MAPK3 MAPK3 ENSUAMP00000031719 ENSUAMP00000031719 SYK SYK MAPK14 MAPK14 MAPK13 MAPK13 ENSUAMP00000032511 ENSUAMP00000032511 ARHGEF12 ARHGEF12 PPP3CC PPP3CC EGR3 EGR3 IL1B IL1B ENSUAMP00000033199 ENSUAMP00000033199 FCER1G FCER1G CEACAM16 CEACAM16 STAT1 STAT1 ENSUAMP00000034830 ENSUAMP00000034830 STAT2 STAT2 IL23A IL23A ENSUAMP00000035331 ENSUAMP00000035331 CALM2 CALM2 ENSUAMP00000036324 ENSUAMP00000036324 CHUK CHUK AKT2 AKT2 PAK1 PAK1 MAPKAPK2 MAPKAPK2 IL10 IL10 CLEC4E CLEC4E CLEC4D CLEC4D EGR2 EGR2 ENSUAMP00000002341 ENSUAMP00000002341 ENSUAMP00000003693 ENSUAMP00000003693 NFKB2 NFKB2 ITPR3 ITPR3 ENSUAMP00000005976 ENSUAMP00000005976 ENSUAMP00000012767 ENSUAMP00000012767 ENSUAMP00000013266 ENSUAMP00000013266 ENSUAMP00000013482 ENSUAMP00000013482 MAPK1 MAPK1 ERAS ERAS CALML6 CALML6 IKBKG IKBKG IL12B IL12B TNF TNF ENSUAMP00000015993 ENSUAMP00000015993 EFCAB13 EFCAB13 MAPK12 MAPK12 MAPK11 MAPK11 ENSUAMP00000017692 ENSUAMP00000017692 PTGS2 PTGS2 PIK3CD PIK3CD CALML4 CALML4 IRF1 IRF1 NFATC3 NFATC3 IKBKB IKBKB KRAS KRAS GEM GEM NFKB1 NFKB1 CALM3 CALM3 CCL22 CCL22 ENSUAMP00000021954 ENSUAMP00000021954 ENSUAMP00000022131 ENSUAMP00000022131 MAPK10 MAPK10 ENSUAMP00000022818 ENSUAMP00000022818 ENSUAMP00000023102 ENSUAMP00000023102 BCL3 BCL3 TMEM52B TMEM52B MDM2 MDM2 ENSUAMP00000017435 ENSUAMP00000017435 BCL10 BCL10 ENSUAMP00000025311 ENSUAMP00000025311 RRAS2 RRAS2 ENSUAMP00000025726 ENSUAMP00000025726 RELA RELA ENSUAMP00000026993 ENSUAMP00000026993 LSP1 LSP1 ENSUAMP00000027429 ENSUAMP00000027429 ENSUAMP00000027431 ENSUAMP00000027431 ENSUAMP00000027770 ENSUAMP00000027770 ENSUAMP00000028178 ENSUAMP00000028178 ENSUAMP00000028179 ENSUAMP00000028179 EFCAB3 EFCAB3 MAPK9 MAPK9 IL2 IL2 CLEC4A CLEC4A IKBKE IKBKE ENSUAMP00000030120 ENSUAMP00000030120 ENSUAMP00000030146 ENSUAMP00000030146 SRC SRC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RRADRRAD, Ras related glycolysis inhibitor and calcium channel regulator. (373 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1252 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (395 aa)
PPP3CASerine/threonine-protein phosphatase. (317 aa)
NFATC4Nuclear factor of activated T cells 4. (911 aa)
KSR1Kinase suppressor of ras 1. (872 aa)
ENSUAMP00000008469IGv domain-containing protein. (287 aa)
CALML5Calmodulin like 5. (156 aa)
RHOBRas homolog family member B. (172 aa)
ENSUAMP00000008748Uncharacterized protein. (510 aa)
RRASRAS related. (218 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAPK8Mitogen-activated protein kinase. (456 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
PPP3CBSerine/threonine-protein phosphatase. (479 aa)
PTPN11Protein tyrosine phosphatase non-receptor type 11. (552 aa)
PYCARDPYD and CARD domain containing. (194 aa)
CLEC4GC-type lectin domain family 4 member G. (254 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (676 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
CBLBCbl proto-oncogene B. (717 aa)
CLEC7AC-type lectin domain containing 7A. (237 aa)
ENSUAMP00000011223Uncharacterized protein. (224 aa)
NFATC1Nuclear factor of activated T cells 1. (931 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ENSUAMP00000011731Ion_trans domain-containing protein. (408 aa)
CARD9Caspase recruitment domain family member 9. (566 aa)
NLRP3NLR family pyrin domain containing 3. (922 aa)
ENSUAMP00000012405Uncharacterized protein. (110 aa)
ENSUAMP00000012729RHD domain-containing protein. (481 aa)
ENSUAMP00000030264Uncharacterized protein. (473 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (953 aa)
CLEC1AC-type lectin domain family 1 member A. (270 aa)
CLEC9AC-type lectin domain containing 9A. (226 aa)
CLEC1BC-type lectin domain family 1 member B. (231 aa)
RELBRELB proto-oncogene, NF-kB subunit. (575 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (313 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (955 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (564 aa)
ENSUAMP00000030787Uncharacterized protein. (84 aa)
IL6Interleukin 6. (212 aa)
IRF9Interferon regulatory factor 9. (466 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
ENSUAMP00000031719Uncharacterized protein. (627 aa)
SYKSpleen associated tyrosine kinase. (638 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
ENSUAMP00000032511Protein kinase domain-containing protein. (132 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1439 aa)
PPP3CCSerine/threonine-protein phosphatase. (449 aa)
EGR3Early growth response 3. (387 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
ENSUAMP00000033199RHD domain-containing protein. (458 aa)
FCER1GFc fragment of IgE receptor Ig. (80 aa)
CEACAM16Carcinoembryonic antigen related cell adhesion molecule 16. (429 aa)
STAT1Signal transducer and activator of transcription. (824 aa)
ENSUAMP00000034830Uncharacterized protein. (1872 aa)
STAT2Signal transducer and activator of transcription. (848 aa)
IL23AInterleukin 23 subunit alpha. (190 aa)
ENSUAMP00000035331Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (506 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (163 aa)
ENSUAMP00000036324Uncharacterized protein. (189 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (387 aa)
IL10Interleukin 10. (178 aa)
CLEC4EC-type lectin domain family 4 member E. (154 aa)
CLEC4DC-type lectin domain family 4 member D. (211 aa)
EGR2Early growth response 2. (471 aa)
ENSUAMP00000002341Uncharacterized protein. (957 aa)
ENSUAMP00000003693Uncharacterized protein. (166 aa)
NFKB2Nuclear factor kappa B subunit 2. (581 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2656 aa)
ENSUAMP00000005976Uncharacterized protein. (94 aa)
ENSUAMP00000012767C-C motif chemokine. (101 aa)
ENSUAMP00000013266Uncharacterized protein. (429 aa)
ENSUAMP00000013482Uncharacterized protein. (91 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
ERASES cell expressed Ras. (219 aa)
CALML6Calmodulin like 6. (180 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (442 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (230 aa)
ENSUAMP00000015993Uncharacterized protein. (98 aa)
EFCAB13EF-hand calcium binding domain 13. (939 aa)
MAPK12Mitogen-activated protein kinase 12. (373 aa)
MAPK11Mitogen-activated protein kinase. (357 aa)
ENSUAMP00000017692Uncharacterized protein. (704 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
CALML4Calmodulin like 4. (153 aa)
IRF1Interferon regulatory factor. (322 aa)
NFATC3Nuclear factor of activated T cells 3. (1079 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (703 aa)
KRASKRAS proto-oncogene, GTPase. (188 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
NFKB1Nuclear factor kappa B subunit 1. (972 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (149 aa)
CCL22C-C motif chemokine. (93 aa)
ENSUAMP00000021954Uncharacterized protein. (209 aa)
ENSUAMP00000022131Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (636 aa)
MAPK10Mitogen-activated protein kinase. (422 aa)
ENSUAMP00000022818Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
ENSUAMP00000023102Uncharacterized protein. (1102 aa)
BCL3BCL3 transcription coactivator. (424 aa)
TMEM52BTransmembrane protein 52B. (181 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (495 aa)
ENSUAMP00000017435Uncharacterized protein. (459 aa)
BCL10BCL10 immune signaling adaptor. (234 aa)
ENSUAMP00000025311Uncharacterized protein. (295 aa)
RRAS2RAS related 2. (204 aa)
ENSUAMP00000025726annotation not available (113 aa)
RELARELA proto-oncogene, NF-kB subunit. (508 aa)
ENSUAMP00000026993Uncharacterized protein. (118 aa)
LSP1Lymphocyte specific protein 1. (361 aa)
ENSUAMP00000027429Uncharacterized protein. (165 aa)
ENSUAMP00000027431Uncharacterized protein. (74 aa)
ENSUAMP00000027770C-type lectin domain-containing protein. (246 aa)
ENSUAMP00000028178Uncharacterized protein. (311 aa)
ENSUAMP00000028179CSD domain-containing protein. (89 aa)
EFCAB3EF-hand calcium binding domain 3. (436 aa)
MAPK9Mitogen-activated protein kinase. (433 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
CLEC4AC-type lectin domain family 4 member A. (250 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (693 aa)
ENSUAMP00000030120Ig-like domain-containing protein. (321 aa)
ENSUAMP00000030146Uncharacterized protein. (668 aa)
SRCTyrosine-protein kinase. (557 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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