STRINGSTRING
CFL2 CFL2 ASAP2 ASAP2 VAV2 VAV2 PIK3CA PIK3CA PRKCD PRKCD CRKL CRKL PLCG2 PLCG2 PRKCB PRKCB PAK1 PAK1 ENSUAMP00000007032 ENSUAMP00000007032 RPS6KB2 RPS6KB2 ENSUAMP00000006326 ENSUAMP00000006326 ENSUAMP00000006194 ENSUAMP00000006194 PLD2 PLD2 ARPC5 ARPC5 GSN GSN ENSUAMP00000002680 ENSUAMP00000002680 GAB2 GAB2 ENSUAMP00000001254 ENSUAMP00000001254 WASF2 WASF2 ENSUAMP00000000169 ENSUAMP00000000169 AKT2 AKT2 INPP5D INPP5D INPPL1 INPPL1 PIP5K1A PIP5K1A ENSUAMP00000035681 ENSUAMP00000035681 ENSUAMP00000035568 ENSUAMP00000035568 ASAP1 ASAP1 ENSUAMP00000035555 ENSUAMP00000035555 LIMK1 LIMK1 ENSUAMP00000035331 ENSUAMP00000035331 ENSUAMP00000034569 ENSUAMP00000034569 ENSUAMP00000033631 ENSUAMP00000033631 ENSUAMP00000032677 ENSUAMP00000032677 SYK SYK ENSUAMP00000031604 ENSUAMP00000031604 MAPK3 MAPK3 VAV1 VAV1 ENSUAMP00000031486 ENSUAMP00000031486 RAC2 RAC2 ENSUAMP00000030787 ENSUAMP00000030787 RAF1 RAF1 PLPP1 PLPP1 PLA2G4E PLA2G4E SPHK1 SPHK1 BOLA1 BOLA1 ENSUAMP00000028987 ENSUAMP00000028987 JMJD7 JMJD7 ENSUAMP00000028672 ENSUAMP00000028672 WAS WAS ENSUAMP00000028558 ENSUAMP00000028558 ENSUAMP00000028152 ENSUAMP00000028152 WASF1 WASF1 CFL1 CFL1 CDC42 CDC42 ENSUAMP00000026127 ENSUAMP00000026127 ENSUAMP00000026123 ENSUAMP00000026123 VASP VASP PLA2G4D PLA2G4D PLA2G4F PLA2G4F ENSUAMP00000025619 ENSUAMP00000025619 ENSUAMP00000025300 ENSUAMP00000025300 ENSUAMP00000024111 ENSUAMP00000024111 CCDC125 CCDC125 RPS6KB1 RPS6KB1 ENSUAMP00000022227 ENSUAMP00000022227 ENSUAMP00000022131 ENSUAMP00000022131 PIP5K1C PIP5K1C IGHM IGHM PRKCG PRKCG DOCK5 DOCK5 PLPP2 PLPP2 ENSUAMP00000019945 ENSUAMP00000019945 PIK3CD PIK3CD ENSUAMP00000019309 ENSUAMP00000019309 LIMK2 LIMK2 ARPC5L ARPC5L MARCKSL1 MARCKSL1 ENSUAMP00000017692 ENSUAMP00000017692 ENSUAMP00000017435 ENSUAMP00000017435 ENSUAMP00000017307 ENSUAMP00000017307 CRK CRK ARF6 ARF6 ENSUAMP00000014737 ENSUAMP00000014737 ARPC4 ARPC4 ARPC3 ARPC3 MAPK1 MAPK1 SPHK2 SPHK2 PLA2G4A PLA2G4A BIN1 BIN1 AKT3 AKT3 SCIN SCIN AKT1 AKT1 PRKCA PRKCA PIK3R1 PIK3R1 ASAP3 ASAP3 ENSUAMP00000010475 ENSUAMP00000010475 NCF1 NCF1 PLCG1 PLCG1 ENSUAMP00000010104 ENSUAMP00000010104 ENSUAMP00000009775 ENSUAMP00000009775 ARPC1B ARPC1B ARPC1A ARPC1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (148 aa)
ASAP2ArfGAP with SH3 domain, ankyrin repeat and PH domain 2. (980 aa)
VAV2Vav guanine nucleotide exchange factor 2. (855 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1252 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (651 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
ENSUAMP00000007032Uncharacterized protein. (505 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
ENSUAMP00000006326Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (106 aa)
ENSUAMP00000006194ANK_REP_REGION domain-containing protein. (259 aa)
PLD2Phospholipase. (1025 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
GSNGelsolin. (742 aa)
ENSUAMP00000002680Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (57 aa)
GAB2GRB2 associated binding protein 2. (665 aa)
ENSUAMP00000001254Uncharacterized protein. (96 aa)
WASF2WASP family member 2. (461 aa)
ENSUAMP00000000169Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (278 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1197 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1261 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (549 aa)
ENSUAMP00000035681Protein kinase domain-containing protein. (217 aa)
ENSUAMP00000035568Uncharacterized protein. (99 aa)
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 1. (852 aa)
ENSUAMP00000035555WH2 domain-containing protein. (207 aa)
LIMK1LIM domain kinase 1. (580 aa)
ENSUAMP00000035331Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (506 aa)
ENSUAMP00000034569Uncharacterized protein. (250 aa)
ENSUAMP00000033631DHR-1 domain-containing protein; Belongs to the DOCK family. (759 aa)
ENSUAMP00000032677DHR-2 domain-containing protein; Belongs to the DOCK family. (412 aa)
SYKSpleen associated tyrosine kinase. (638 aa)
ENSUAMP00000031604Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1428 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
VAV1Vav guanine nucleotide exchange factor 1. (774 aa)
ENSUAMP00000031486Calponin-homology (CH) domain-containing protein. (86 aa)
RAC2Rac family small GTPase 2. (192 aa)
ENSUAMP00000030787Uncharacterized protein. (84 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (564 aa)
PLPP1Phospholipid phosphatase 1. (286 aa)
PLA2G4EPhospholipase A2. (822 aa)
SPHK1Sphingosine kinase 1. (387 aa)
BOLA1BolA family member 1; Belongs to the BolA/IbaG family. (137 aa)
ENSUAMP00000028987Uncharacterized protein. (448 aa)
JMJD7Jumonji domain containing 7. (303 aa)
ENSUAMP00000028672Phospholipase A2. (765 aa)
WASWASP actin nucleation promoting factor. (503 aa)
ENSUAMP00000028558Uncharacterized protein. (222 aa)
ENSUAMP00000028152SH3 domain-containing protein. (120 aa)
WASF1WASP family member 1. (530 aa)
CFL1Cofilin 1; Belongs to the actin-binding proteins ADF family. (166 aa)
CDC42Cell division cycle 42. (191 aa)
ENSUAMP00000026127Uncharacterized protein. (86 aa)
ENSUAMP00000026123Uncharacterized protein. (823 aa)
VASPVasodilator stimulated phosphoprotein. (359 aa)
PLA2G4DPhospholipase A2. (776 aa)
PLA2G4FPhospholipase A2. (837 aa)
ENSUAMP00000025619ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (153 aa)
ENSUAMP00000025300Non-specific serine/threonine protein kinase. (254 aa)
ENSUAMP00000024111PIPK domain-containing protein. (248 aa)
CCDC125Coiled-coil domain containing 125. (513 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (524 aa)
ENSUAMP00000022227Uncharacterized protein. (64 aa)
ENSUAMP00000022131Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (636 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (624 aa)
IGHMImmunoglobulin heavy constant mu. (480 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (714 aa)
DOCK5Dedicator of cytokinesis 5; Belongs to the DOCK family. (1750 aa)
PLPP2Phospholipid phosphatase 2. (288 aa)
ENSUAMP00000019945Uncharacterized protein. (237 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
ENSUAMP00000019309Calponin-homology (CH) domain-containing protein. (82 aa)
LIMK2LIM domain kinase 2. (617 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (148 aa)
MARCKSL1MARCKS like 1. (199 aa)
ENSUAMP00000017692Uncharacterized protein. (704 aa)
ENSUAMP00000017435Uncharacterized protein. (459 aa)
ENSUAMP00000017307SH3 domain-containing protein. (240 aa)
CRKCRK proto-oncogene, adaptor protein. (204 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
ENSUAMP00000014737Uncharacterized protein. (242 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (170 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
SPHK2Sphingosine kinase 2. (662 aa)
PLA2G4APhospholipase A2. (756 aa)
BIN1Bridging integrator 1. (686 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SCINScinderin. (699 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
PRKCAProtein kinase C alpha; Belongs to the protein kinase superfamily. (484 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (676 aa)
ASAP3ArfGAP with SH3 domain, ankyrin repeat and PH domain 3. (864 aa)
ENSUAMP00000010475IGv domain-containing protein. (144 aa)
NCF1Neutrophil cytosolic factor 1. (396 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1256 aa)
ENSUAMP00000010104acidPPc domain-containing protein. (312 aa)
ENSUAMP00000009775C2 domain-containing protein. (151 aa)
ARPC1BActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (372 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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