STRINGSTRING
CASP7 CASP7 AKT2 AKT2 CHUK CHUK CREB3 CREB3 ENSUAMP00000035331 ENSUAMP00000035331 CREB3L1 CREB3L1 ENSUAMP00000034960 ENSUAMP00000034960 JAG1 JAG1 TRAF3 TRAF3 CEACAM16 CEACAM16 TNFRSF1B TNFRSF1B MAP2K4 MAP2K4 IL1B IL1B ENSUAMP00000032843 ENSUAMP00000032843 CXCL10 CXCL10 ENSUAMP00000032511 ENSUAMP00000032511 MAPK13 MAPK13 MAPK14 MAPK14 RIPK3 RIPK3 MAP3K7 MAP3K7 CREB3L4 CREB3L4 MAPK3 MAPK3 IL6 IL6 MAP3K14 MAP3K14 SOCS3 SOCS3 VEGFD VEGFD NFKBIA NFKBIA EDN1 EDN1 RPS6KA4 RPS6KA4 MMP14 MMP14 TNFRSF1A TNFRSF1A CSF1 CSF1 MAPK9 MAPK9 MMP9 MMP9 DAB2IP DAB2IP CCL20 CCL20 MAP2K7 MAP2K7 FADD FADD TAB3 TAB3 TNFAIP3 TNFAIP3 CEBPB CEBPB MAP2K6 MAP2K6 RELA RELA ITCH ITCH CREB5 CREB5 ENSUAMP00000026301 ENSUAMP00000026301 IL15 IL15 ENSUAMP00000025215 ENSUAMP00000025215 ENSUAMP00000025159 ENSUAMP00000025159 CREB3L3 CREB3L3 CREB1 CREB1 BCL3 BCL3 ENSUAMP00000023119 ENSUAMP00000023119 MAPK10 MAPK10 ENSUAMP00000022203 ENSUAMP00000022203 MMP3 MMP3 ENSUAMP00000022131 ENSUAMP00000022131 CX3CL1 CX3CL1 NFKB1 NFKB1 ATF6B ATF6B CASP3 CASP3 IKBKB IKBKB MAP2K3 MAP2K3 TRADD TRADD IRF1 IRF1 RIPK1 RIPK1 PIK3CD PIK3CD PTGS2 PTGS2 BIRC3 BIRC3 BIRC2 BIRC2 DNM1L DNM1L ENSUAMP00000018082 ENSUAMP00000018082 ENSUAMP00000017692 ENSUAMP00000017692 RPS6KA5 RPS6KA5 ENSUAMP00000017435 ENSUAMP00000017435 MAPK11 MAPK11 ENSUAMP00000017215 ENSUAMP00000017215 ENSUAMP00000017185 ENSUAMP00000017185 ENSUAMP00000017182 ENSUAMP00000017182 ENSUAMP00000017060 ENSUAMP00000017060 ENSUAMP00000017057 ENSUAMP00000017057 MAPK12 MAPK12 ENSUAMP00000016793 ENSUAMP00000016793 LTA LTA TNF TNF ENSUAMP00000015612 ENSUAMP00000015612 VEGFC VEGFC IKBKG IKBKG MAPK1 MAPK1 ENSUAMP00000013506 ENSUAMP00000013506 CCL2 CCL2 PGAM5 PGAM5 AKT3 AKT3 ENSUAMP00000011161 ENSUAMP00000011161 AKT1 AKT1 ENSUAMP00000010535 ENSUAMP00000010535 PIK3R1 PIK3R1 ATF2 ATF2 ENSUAMP00000009537 ENSUAMP00000009537 MAPK8 MAPK8 PIK3CA PIK3CA JUN JUN MMP12 MMP12 CSF2 CSF2 ENSUAMP00000008343 ENSUAMP00000008343 CASP8 CASP8 CASP10 CASP10 ENSUAMP00000007992 ENSUAMP00000007992 ENSUAMP00000007969 ENSUAMP00000007969 LIF LIF MAP3K5 MAP3K5 ENSUAMP00000006128 ENSUAMP00000006128 CCL5 CCL5 VCAM1 VCAM1 TAB1 TAB1 ATF4 ATF4 ENSUAMP00000004598 ENSUAMP00000004598 BAG4 BAG4 IRGC IRGC ENSUAMP00000003435 ENSUAMP00000003435 ENSUAMP00000003236 ENSUAMP00000003236 ENSUAMP00000002835 ENSUAMP00000002835 ENSUAMP00000002712 ENSUAMP00000002712 TAB2 TAB2 TRAF2 TRAF2 TRAF1 TRAF1 ENSUAMP00000001437 ENSUAMP00000001437 IL18R1 IL18R1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CASP7Caspase 7; Belongs to the peptidase C14A family. (301 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
CREB3cAMP responsive element binding protein 3. (352 aa)
ENSUAMP00000035331Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (506 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
ENSUAMP00000034960C2H2-type domain-containing protein. (123 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1226 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
CEACAM16Carcinoembryonic antigen related cell adhesion molecule 16. (429 aa)
TNFRSF1BTNF receptor superfamily member 1B. (460 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (416 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
ENSUAMP00000032843Uncharacterized protein. (186 aa)
CXCL10C-X-C motif chemokine. (98 aa)
ENSUAMP00000032511Protein kinase domain-containing protein. (132 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
RIPK3Receptor interacting serine/threonine kinase 3; Belongs to the protein kinase superfamily. (451 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (247 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
IL6Interleukin 6. (212 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (955 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (329 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
EDN1Endothelin 1. (202 aa)
RPS6KA4Ribosomal protein S6 kinase. (772 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
TNFRSF1ATNF receptor superfamily member 1A. (502 aa)
CSF1Colony stimulating factor 1. (518 aa)
MAPK9Mitogen-activated protein kinase. (433 aa)
MMP9Matrix metallopeptidase 9. (704 aa)
DAB2IPDAB2 interacting protein. (1100 aa)
CCL20C-C motif chemokine. (96 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (220 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (717 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
CEBPBCCAAT/enhancer-binding protein. (346 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
RELARELA proto-oncogene, NF-kB subunit. (508 aa)
ITCHE3 ubiquitin-protein ligase. (740 aa)
CREB5cAMP responsive element binding protein 5. (327 aa)
ENSUAMP00000026301Ig-like domain-containing protein. (331 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (161 aa)
ENSUAMP00000025215BZIP domain-containing protein. (347 aa)
ENSUAMP00000025159BZIP domain-containing protein. (314 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (457 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
BCL3BCL3 transcription coactivator. (424 aa)
ENSUAMP00000023119Uncharacterized protein. (607 aa)
MAPK10Mitogen-activated protein kinase. (422 aa)
ENSUAMP00000022203C-X-C motif chemokine. (141 aa)
MMP3ZnMc domain-containing protein. (477 aa)
ENSUAMP00000022131Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (636 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (392 aa)
NFKB1Nuclear factor kappa B subunit 1. (972 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (266 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (703 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
TRADDTNFRSF1A associated via death domain. (314 aa)
IRF1Interferon regulatory factor. (322 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (550 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
BIRC3Baculoviral IAP repeat containing 3. (603 aa)
BIRC2Baculoviral IAP repeat containing 2. (619 aa)
DNM1LDynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (736 aa)
ENSUAMP00000018082Uncharacterized protein. (249 aa)
ENSUAMP00000017692Uncharacterized protein. (704 aa)
RPS6KA5Ribosomal protein S6 kinase. (798 aa)
ENSUAMP00000017435Uncharacterized protein. (459 aa)
MAPK11Mitogen-activated protein kinase. (357 aa)
ENSUAMP00000017215IRG-type G domain-containing protein. (427 aa)
ENSUAMP00000017185IRG-type G domain-containing protein. (409 aa)
ENSUAMP00000017182IRG-type G domain-containing protein. (410 aa)
ENSUAMP00000017060C-X-C motif chemokine. (107 aa)
ENSUAMP00000017057C-X-C motif chemokine. (107 aa)
MAPK12Mitogen-activated protein kinase 12. (373 aa)
ENSUAMP00000016793BZIP domain-containing protein. (179 aa)
LTALymphotoxin alpha; Belongs to the tumor necrosis factor family. (204 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (230 aa)
ENSUAMP00000015612IRG-type G domain-containing protein. (429 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (391 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (442 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
ENSUAMP00000013506IRG-type G domain-containing protein. (431 aa)
CCL2C-C motif chemokine. (101 aa)
PGAM5PGAM family member 5, mitochondrial serine/threonine protein phosphatase. (289 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ENSUAMP00000011161Mitogen-activated protein kinase kinase kinase 8. (139 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
ENSUAMP00000010535Uncharacterized protein. (406 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (676 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ENSUAMP00000009537Mitogen-activated protein kinase kinase kinase 8. (174 aa)
MAPK8Mitogen-activated protein kinase. (456 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
MMP12Matrix metallopeptidase 12. (495 aa)
CSF2Colony stimulating factor 2. (155 aa)
ENSUAMP00000008343Uncharacterized protein. (163 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (395 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (481 aa)
ENSUAMP00000007992Uncharacterized protein. (219 aa)
ENSUAMP00000007969Uncharacterized protein. (166 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1212 aa)
ENSUAMP00000006128annotation not available (106 aa)
CCL5C-C motif chemokine. (116 aa)
VCAM1Vascular cell adhesion molecule 1. (702 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
ATF4Activating transcription factor 4. (351 aa)
ENSUAMP00000004598Uncharacterized protein. (299 aa)
BAG4BCL2 associated athanogene 4. (457 aa)
IRGCImmunity related GTPase cinema. (464 aa)
ENSUAMP00000003435IRG-type G domain-containing protein. (482 aa)
ENSUAMP00000003236C-X-C motif chemokine. (106 aa)
ENSUAMP00000002835ICAM_N domain-containing protein. (149 aa)
ENSUAMP00000002712Uncharacterized protein. (561 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (683 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
TRAF1TNF receptor-associated factor. (415 aa)
ENSUAMP00000001437Uncharacterized protein. (607 aa)
IL18R1Interleukin 18 receptor 1. (541 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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