STRINGSTRING
CALML5 CALML5 ADCY3 ADCY3 GNB4 GNB4 GNAO1 GNAO1 ENSUAMP00000010227 ENSUAMP00000010227 PRKCA PRKCA PLCB1 PLCB1 ENSUAMP00000010738 ENSUAMP00000010738 ADCYAP1R1 ADCYAP1R1 ENSUAMP00000011731 ENSUAMP00000011731 ENSUAMP00000012276 ENSUAMP00000012276 CACNA1G CACNA1G GNG2 GNG2 MAPK1 MAPK1 CALML6 CALML6 GRIA3 GRIA3 ENSUAMP00000014629 ENSUAMP00000014629 KCNJ9 KCNJ9 ENSUAMP00000015381 ENSUAMP00000015381 ENSUAMP00000015620 ENSUAMP00000015620 PER2 PER2 GNG13 GNG13 CACNA1H CACNA1H ENSUAMP00000016322 ENSUAMP00000016322 GNG7 GNG7 ENSUAMP00000016793 ENSUAMP00000016793 MTNR1A MTNR1A RPS6KA5 RPS6KA5 RYR1 RYR1 CACNA1D CACNA1D KCNJ5 KCNJ5 ENSUAMP00000019174 ENSUAMP00000019174 ENSUAMP00000019181 ENSUAMP00000019181 PLCB3 PLCB3 CALML4 CALML4 CAMK2B CAMK2B GNGT2 GNGT2 PRKCG PRKCG ENSUAMP00000020433 ENSUAMP00000020433 ADCYAP1 ADCYAP1 GNAQ GNAQ CALM3 CALM3 GNG8 GNG8 GRIN2A GRIN2A ENSUAMP00000022172 ENSUAMP00000022172 ENSUAMP00000023632 ENSUAMP00000023632 CREB1 CREB1 ENSUAMP00000025177 ENSUAMP00000025177 ENSUAMP00000025300 ENSUAMP00000025300 ENSUAMP00000025311 ENSUAMP00000025311 ENSUAMP00000025726 ENSUAMP00000025726 ENSUAMP00000026030 ENSUAMP00000026030 ENSUAMP00000026337 ENSUAMP00000026337 ENSUAMP00000026424 ENSUAMP00000026424 GRIA1 GRIA1 GRIN1 GRIN1 ADCY5 ADCY5 ADCY1 ADCY1 GUCY1B1 GUCY1B1 GNAS GNAS PLCB4 PLCB4 ENSUAMP00000028781 ENSUAMP00000028781 ENSUAMP00000029679 ENSUAMP00000029679 GNB1 GNB1 MAPK3 MAPK3 ADCY4 ADCY4 ENSUAMP00000032382 ENSUAMP00000032382 ADCY7 ADCY7 ENSUAMP00000032618 ENSUAMP00000032618 ARSI ARSI PRKACB PRKACB PRKG2 PRKG2 GRIN2B GRIN2B GNG3 GNG3 NOS1 NOS1 FBXO21 FBXO21 ENSUAMP00000034830 ENSUAMP00000034830 GNB3 GNB3 CALM2 CALM2 ADCY6 ADCY6 GNG12 GNG12 C1orf226 C1orf226 ENSUAMP00000036508 ENSUAMP00000036508 GNAI2 GNAI2 ENSUAMP00000007690 ENSUAMP00000007690 ADCY2 ADCY2 GNAI3 GNAI3 PRKCB PRKCB GNB2 GNB2 ENSUAMP00000000176 ENSUAMP00000000176 GUCY1A1 GUCY1A1 GNGT1 GNGT1 GNG11 GNG11 GRIA4 GRIA4 ENSUAMP00000001454 ENSUAMP00000001454 ENSUAMP00000001479 ENSUAMP00000001479 ENSUAMP00000002251 ENSUAMP00000002251 RYR3 RYR3 ENSUAMP00000003460 ENSUAMP00000003460 ENSUAMP00000003818 ENSUAMP00000003818 ENSUAMP00000003880 ENSUAMP00000003880 PLCB2 PLCB2 CACNA1I CACNA1I GNB5 GNB5 ITPR3 ITPR3 ADCY9 ADCY9 PER1 PER1 RASD1 RASD1 GNG4 GNG4 ENSUAMP00000007288 ENSUAMP00000007288 KCNJ3 KCNJ3 ENSUAMP00000007617 ENSUAMP00000007617
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CALML5Calmodulin like 5. (156 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (973 aa)
GNB4G protein subunit beta 4. (331 aa)
GNAO1G protein subunit alpha o1. (354 aa)
ENSUAMP00000010227Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
PRKCAProtein kinase C alpha; Belongs to the protein kinase superfamily. (484 aa)
PLCB1Phosphoinositide phospholipase C. (658 aa)
ENSUAMP00000010738Uncharacterized protein. (181 aa)
ADCYAP1R1ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (440 aa)
ENSUAMP00000011731Ion_trans domain-containing protein. (408 aa)
ENSUAMP00000012276B30.2/SPRY domain-containing protein. (334 aa)
CACNA1GCalcium voltage-gated channel subunit alpha1 G. (2369 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (105 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
CALML6Calmodulin like 6. (180 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (601 aa)
ENSUAMP00000014629Uncharacterized protein. (105 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (392 aa)
ENSUAMP00000015381ANF_receptor domain-containing protein. (158 aa)
ENSUAMP00000015620Uncharacterized protein. (577 aa)
PER2Period circadian regulator 2. (1267 aa)
GNG13G protein subunit gamma 13. (67 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2205 aa)
ENSUAMP00000016322PID domain-containing protein. (269 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ENSUAMP00000016793BZIP domain-containing protein. (179 aa)
MTNR1AMelatonin receptor 1A; Belongs to the G-protein coupled receptor 1 family. (351 aa)
RPS6KA5Ribosomal protein S6 kinase. (798 aa)
RYR1Ryanodine receptor 1. (3775 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2160 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
ENSUAMP00000019174CaMKII_AD domain-containing protein. (267 aa)
ENSUAMP00000019181Protein kinase domain-containing protein. (206 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
CALML4Calmodulin like 4. (153 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (589 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (714 aa)
ENSUAMP00000020433Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (176 aa)
GNAQG protein subunit alpha q. (352 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (149 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1427 aa)
ENSUAMP00000022172Uncharacterized protein. (157 aa)
ENSUAMP00000023632Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
ENSUAMP00000025177Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
ENSUAMP00000025300Non-specific serine/threonine protein kinase. (254 aa)
ENSUAMP00000025311Uncharacterized protein. (295 aa)
ENSUAMP00000025726annotation not available (113 aa)
ENSUAMP00000026030Uncharacterized protein. (236 aa)
ENSUAMP00000026337Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
ENSUAMP00000026424Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (906 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (814 aa)
ADCY5Adenylate cyclase 5. (940 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (540 aa)
GNASGNAS complex locus. (994 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1136 aa)
ENSUAMP00000028781G protein gamma domain-containing protein. (61 aa)
ENSUAMP00000029679Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (673 aa)
GNB1G protein subunit beta 1. (224 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ENSUAMP00000032382CaMKII_AD domain-containing protein. (189 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
ENSUAMP00000032618Uncharacterized protein. (68 aa)
ARSIArylsulfatase family member I. (573 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (361 aa)
PRKG2cGMP-dependent protein kinase. (711 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1095 aa)
FBXO21F-box protein 21. (456 aa)
ENSUAMP00000034830Uncharacterized protein. (1872 aa)
GNB3G protein subunit beta 3. (339 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (163 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
C1orf226Chromosome 1 open reading frame 226. (257 aa)
ENSUAMP00000036508Guanylate cyclase domain-containing protein. (363 aa)
GNAI2G protein subunit alpha i2. (436 aa)
ENSUAMP00000007690Uncharacterized protein. (259 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
GNAI3G protein subunit alpha i3. (295 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (651 aa)
GNB2G protein subunit beta 2. (340 aa)
ENSUAMP00000000176Protein kinase domain-containing protein. (82 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (681 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (957 aa)
ENSUAMP00000001454Uncharacterized protein. (150 aa)
ENSUAMP00000001479Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (121 aa)
ENSUAMP00000002251Uncharacterized protein. (450 aa)
RYR3Ryanodine receptor 3. (4856 aa)
ENSUAMP00000003460Uncharacterized protein. (281 aa)
ENSUAMP00000003818Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ENSUAMP00000003880Uncharacterized protein. (91 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1166 aa)
CACNA1ICalcium voltage-gated channel subunit alpha1 I. (2118 aa)
GNB5G protein subunit beta 5. (264 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2656 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1338 aa)
PER1Period circadian regulator 1. (1293 aa)
RASD1Ras related dexamethasone induced 1. (186 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
ENSUAMP00000007288Ca_chan_IQ domain-containing protein. (832 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (308 aa)
ENSUAMP00000007617Protein kinase domain-containing protein. (271 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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