81 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CALML5	Calmodulin like 5. (156 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (479 aa)
	PRKCA	Protein kinase C alpha; Belongs to the protein kinase superfamily. (484 aa)
	PLCB1	Phosphoinositide phospholipase C. (658 aa)
	RPS6KA6	Non-specific serine/threonine protein kinase. (686 aa)
	RAP1B	RAP1B, member of RAS oncogene family. (184 aa)
	ENSUAMP00000010738	Uncharacterized protein. (181 aa)
	RPS6KA2	Ribosomal protein S6 kinase. (753 aa)
	ENSUAMP00000011731	Ion_trans domain-containing protein. (408 aa)
	PPP1R1A	Protein phosphatase 1 regulatory inhibitor subunit 1A. (171 aa)
	ENSUAMP00000013482	Uncharacterized protein. (91 aa)
	MAPK1	Mitogen-activated protein kinase. (364 aa)
	ERAS	ES cell expressed Ras. (219 aa)
	PPP1CC	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (326 aa)
	CALML6	Calmodulin like 6. (180 aa)
	RPS6KA1	Ribosomal protein S6 kinase. (836 aa)
	ENSUAMP00000015381	ANF_receptor domain-containing protein. (158 aa)
	ENSUAMP00000015620	Uncharacterized protein. (577 aa)
	ENSUAMP00000015993	Uncharacterized protein. (98 aa)
	RAP1A	RAP1A, member of RAS oncogene family. (184 aa)
	ENSUAMP00000019174	CaMKII_AD domain-containing protein. (267 aa)
	ENSUAMP00000019181	Protein kinase domain-containing protein. (206 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
	CALML4	Calmodulin like 4. (153 aa)
	CAMK2B	Calcium/calmodulin dependent protein kinase II beta. (589 aa)
	PRKCG	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (714 aa)
	ENSUAMP00000020485	Protein kinase domain-containing protein. (108 aa)
	KRAS	KRAS proto-oncogene, GTPase. (188 aa)
	GNAQ	G protein subunit alpha q. (352 aa)
	ENSUAMP00000021380	Uncharacterized protein. (424 aa)
	ENSUAMP00000021381	Protein kinase domain-containing protein. (363 aa)
	CALM3	Calmodulin 3; Belongs to the calmodulin family. (149 aa)
	GRIN2A	Glutamate ionotropic receptor NMDA type subunit 2A. (1427 aa)
	ENSUAMP00000021954	Uncharacterized protein. (209 aa)
	ENSUAMP00000023102	Uncharacterized protein. (1102 aa)
	ENSUAMP00000023165	Protein kinase domain-containing protein. (270 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (728 aa)
	ENSUAMP00000006694	SER_THR_PHOSPHATASE domain-containing protein. (148 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2656 aa)
	ATF4	Activating transcription factor 4. (351 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1166 aa)
	ENSUAMP00000003693	Uncharacterized protein. (166 aa)
	ENSUAMP00000003358	SER_THR_PHOSPHATASE domain-containing protein. (106 aa)
	ENSUAMP00000003355	Uncharacterized protein. (76 aa)
	ENSUAMP00000002341	Uncharacterized protein. (957 aa)
	ENSUAMP00000000176	Protein kinase domain-containing protein. (82 aa)
	ENSUAMP00000034830	Uncharacterized protein. (1872 aa)
	GRIN2B	Glutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (361 aa)
	ARSI	Arylsulfatase family member I. (573 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (449 aa)
	ENSUAMP00000032382	CaMKII_AD domain-containing protein. (189 aa)
	EP300	E1A binding protein p300. (2399 aa)
	ENSUAMP00000031719	Uncharacterized protein. (627 aa)
	MAPK3	Mitogen-activated protein kinase. (354 aa)
	ENSUAMP00000030787	Uncharacterized protein. (84 aa)
	ENSUAMP00000035622	Uncharacterized protein. (662 aa)
	ENSUAMP00000035608	Uncharacterized protein. (85 aa)
	ENSUAMP00000035186	ANF_receptor domain-containing protein. (305 aa)
	ENSUAMP00000036324	Uncharacterized protein. (189 aa)
	CALM2	Calmodulin 2; Belongs to the calmodulin family. (163 aa)
	CREBBP	CREB binding protein. (2333 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (564 aa)
	RPS6KA3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
	MAP2K1	Protein kinase domain-containing protein. (216 aa)
	ENSUAMP00000030280	Protein kinase domain-containing protein. (206 aa)
	ENSUAMP00000029031	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1136 aa)
	ENSUAMP00000028179	CSD domain-containing protein. (89 aa)
	ENSUAMP00000028178	Uncharacterized protein. (311 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
	GRIN1	Glutamate ionotropic receptor NMDA type subunit 1. (814 aa)
	GRIA1	Glutamate ionotropic receptor AMPA type subunit 1. (906 aa)
	ENSUAMP00000026993	Uncharacterized protein. (118 aa)
	PPP1CB	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
	ENSUAMP00000025726	annotation not available (113 aa)
	ENSUAMP00000025311	Uncharacterized protein. (295 aa)
	ENSUAMP00000025300	Non-specific serine/threonine protein kinase. (254 aa)
	ENSUAMP00000007617	Protein kinase domain-containing protein. (271 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (651 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (317 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	CALM2	ENSUAMP00000028025	ENSUAMP00000035625	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 2; Belongs to the calmodulin family.	0.848
ADCY1	CALM3	ENSUAMP00000028025	ENSUAMP00000021541	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 3; Belongs to the calmodulin family.	0.848
ADCY1	CALML4	ENSUAMP00000028025	ENSUAMP00000019475	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 4.	0.930
ADCY1	CALML5	ENSUAMP00000028025	ENSUAMP00000008609	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 5.	0.956
ADCY1	CALML6	ENSUAMP00000028025	ENSUAMP00000013788	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 6.	0.957
ADCY1	CAMK2B	ENSUAMP00000028025	ENSUAMP00000019832	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase II beta.	0.851
ADCY1	ENSUAMP00000000176	ENSUAMP00000028025	ENSUAMP00000000176	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase domain-containing protein.	0.875
ADCY1	ENSUAMP00000007617	ENSUAMP00000028025	ENSUAMP00000007617	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase domain-containing protein.	0.875
ADCY1	ENSUAMP00000019174	ENSUAMP00000028025	ENSUAMP00000019174	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	CaMKII_AD domain-containing protein.	0.843
ADCY1	ENSUAMP00000019181	ENSUAMP00000028025	ENSUAMP00000019181	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase domain-containing protein.	0.843
ADCY1	ENSUAMP00000020485	ENSUAMP00000028025	ENSUAMP00000020485	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase domain-containing protein.	0.874
ADCY1	ENSUAMP00000023165	ENSUAMP00000028025	ENSUAMP00000023165	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase domain-containing protein.	0.874
ADCY1	ENSUAMP00000025300	ENSUAMP00000028025	ENSUAMP00000025300	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase.	0.875
ADCY1	ENSUAMP00000025311	ENSUAMP00000028025	ENSUAMP00000025311	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.844
ADCY1	ENSUAMP00000025726	ENSUAMP00000028025	ENSUAMP00000025726	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	annotation not available	0.848
ADCY1	ENSUAMP00000035608	ENSUAMP00000028025	ENSUAMP00000035608	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.891
ADCY1	ENSUAMP00000035622	ENSUAMP00000028025	ENSUAMP00000035622	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.891
ADCY1	PRKACB	ENSUAMP00000028025	ENSUAMP00000033341	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.947
ADCY1	PRKCA	ENSUAMP00000028025	ENSUAMP00000010550	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C alpha; Belongs to the protein kinase superfamily.	0.875
ADCY1	PRKCB	ENSUAMP00000028025	ENSUAMP00000007701	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.925