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SLC38A1 SLC38A1 GNB1 GNB1 MAPK3 MAPK3 SLC38A2 SLC38A2 ADCY4 ADCY4 HOMER1 HOMER1 ADCY7 ADCY7 PPP3CC PPP3CC ENSUAMP00000032618 ENSUAMP00000032618 GLUL GLUL PRKACB PRKACB GRIK4 GRIK4 GRIN2B GRIN2B GNG3 GNG3 ENSUAMP00000034431 ENSUAMP00000034431 ENSUAMP00000034433 ENSUAMP00000034433 ENSUAMP00000034435 ENSUAMP00000034435 GRM6 GRM6 ENSUAMP00000034830 ENSUAMP00000034830 ENSUAMP00000035186 ENSUAMP00000035186 GNB3 GNB3 ADCY6 ADCY6 GNG12 GNG12 SLC17A8 SLC17A8 SLC1A6 SLC1A6 GNAI2 GNAI2 SLC38A3 SLC38A3 GNB2 GNB2 CACNA1D CACNA1D GNG7 GNG7 GRM3 GRM3 GNG13 GNG13 ENSUAMP00000015620 ENSUAMP00000015620 ENSUAMP00000015381 ENSUAMP00000015381 ENSUAMP00000014629 ENSUAMP00000014629 GRIA3 GRIA3 SLC17A6 SLC17A6 MAPK1 MAPK1 GNG2 GNG2 ENSUAMP00000013482 ENSUAMP00000013482 PLCB3 PLCB3 ENSUAMP00000019493 ENSUAMP00000019493 GNGT2 GNGT2 ENSUAMP00000020340 ENSUAMP00000020340 PRKCG PRKCG ENSUAMP00000020433 ENSUAMP00000020433 SLC1A7 SLC1A7 GNAQ GNAQ GNG8 GNG8 GRIN2A GRIN2A DLG4 DLG4 ENSUAMP00000021954 ENSUAMP00000021954 ENSUAMP00000022172 ENSUAMP00000022172 ENSUAMP00000022227 ENSUAMP00000022227 ENSUAMP00000023102 ENSUAMP00000023102 ENSUAMP00000023632 ENSUAMP00000023632 SHANK2 SHANK2 ENSUAMP00000025177 ENSUAMP00000025177 ENSUAMP00000025300 ENSUAMP00000025300 ENSUAMP00000025663 ENSUAMP00000025663 PLA2G4F PLA2G4F PLA2G4D PLA2G4D ENSUAMP00000026030 ENSUAMP00000026030 ENSUAMP00000026337 ENSUAMP00000026337 ENSUAMP00000026424 ENSUAMP00000026424 GRM2 GRM2 GRIN3A GRIN3A GRIK5 GRIK5 TRPC1 TRPC1 HOMER2 HOMER2 PLA2G4A PLA2G4A GRIK3 GRIK3 ENSUAMP00000011731 ENSUAMP00000011731 GRK3 GRK3 SLC1A1 SLC1A1 ENSUAMP00000010738 ENSUAMP00000010738 PLCB1 PLCB1 PRKCA PRKCA PPP3CB PPP3CB ENSUAMP00000010227 ENSUAMP00000010227 GNAO1 GNAO1 GNB4 GNB4 SLC17A7 SLC17A7 ADCY3 ADCY3 ADCY2 ADCY2 ENSUAMP00000008385 ENSUAMP00000008385 PPP3CA PPP3CA GNAI3 GNAI3 PRKCB PRKCB KCNJ3 KCNJ3 ENSUAMP00000007288 ENSUAMP00000007288 GNG4 GNG4 GRK2 GRK2 GRIN3B GRIN3B PLD2 PLD2 ADCY9 ADCY9 ITPR3 ITPR3 GNB5 GNB5 PLCB2 PLCB2 ENSUAMP00000003880 ENSUAMP00000003880 ENSUAMP00000003818 ENSUAMP00000003818 LGSN LGSN ENSUAMP00000002341 ENSUAMP00000002341 ENSUAMP00000001479 ENSUAMP00000001479 ENSUAMP00000001454 ENSUAMP00000001454 GRIA4 GRIA4 GNG11 GNG11 GNGT1 GNGT1 ENSUAMP00000000499 ENSUAMP00000000499 ENSUAMP00000000314 ENSUAMP00000000314 GRIA1 GRIA1 ENSUAMP00000027869 ENSUAMP00000027869 GRIN1 GRIN1 SLC1A2 SLC1A2 ADCY5 ADCY5 ADCY1 ADCY1 GLS2 GLS2 GNAS GNAS ENSUAMP00000028672 ENSUAMP00000028672 JMJD7 JMJD7 PLCB4 PLCB4 ENSUAMP00000028781 ENSUAMP00000028781 ENSUAMP00000029001 ENSUAMP00000029001 PLA2G4E PLA2G4E GRM4 GRM4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLC38A1Solute carrier family 38 member 1. (487 aa)
GNB1G protein subunit beta 1. (224 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
SLC38A2Solute carrier family 38 member 2. (510 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
HOMER1Homer scaffold protein 1. (191 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
PPP3CCSerine/threonine-protein phosphatase. (449 aa)
ENSUAMP00000032618Uncharacterized protein. (68 aa)
GLULGlutamine synthetase. (484 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (361 aa)
GRIK4Glutamate ionotropic receptor kainate type subunit 4. (903 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
ENSUAMP00000034431ANK_REP_REGION domain-containing protein. (93 aa)
ENSUAMP00000034433Uncharacterized protein. (103 aa)
ENSUAMP00000034435EF-hand_14 domain-containing protein. (259 aa)
GRM6Glutamate metabotropic receptor 6. (908 aa)
ENSUAMP00000034830Uncharacterized protein. (1872 aa)
ENSUAMP00000035186ANF_receptor domain-containing protein. (305 aa)
GNB3G protein subunit beta 3. (339 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
SLC17A8Solute carrier family 17 member 8. (585 aa)
SLC1A6Amino acid transporter. (564 aa)
GNAI2G protein subunit alpha i2. (436 aa)
SLC38A3Solute carrier family 38 member 3. (512 aa)
GNB2G protein subunit beta 2. (340 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2160 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GRM3Glutamate metabotropic receptor 3. (879 aa)
GNG13G protein subunit gamma 13. (67 aa)
ENSUAMP00000015620Uncharacterized protein. (577 aa)
ENSUAMP00000015381ANF_receptor domain-containing protein. (158 aa)
ENSUAMP00000014629Uncharacterized protein. (105 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (601 aa)
SLC17A6Solute carrier family 17 member 6. (582 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (105 aa)
ENSUAMP00000013482Uncharacterized protein. (91 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
ENSUAMP00000019493Uncharacterized protein. (519 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
ENSUAMP00000020340WH1 domain-containing protein. (244 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (714 aa)
ENSUAMP00000020433Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
SLC1A7Amino acid transporter. (595 aa)
GNAQG protein subunit alpha q. (352 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1427 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (724 aa)
ENSUAMP00000021954Uncharacterized protein. (209 aa)
ENSUAMP00000022172Uncharacterized protein. (157 aa)
ENSUAMP00000022227Uncharacterized protein. (64 aa)
ENSUAMP00000023102Uncharacterized protein. (1102 aa)
ENSUAMP00000023632Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
SHANK2SH3 and multiple ankyrin repeat domains 2. (1832 aa)
ENSUAMP00000025177Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
ENSUAMP00000025300Non-specific serine/threonine protein kinase. (254 aa)
ENSUAMP00000025663ANF_receptor domain-containing protein. (192 aa)
PLA2G4FPhospholipase A2. (837 aa)
PLA2G4DPhospholipase A2. (776 aa)
ENSUAMP00000026030Uncharacterized protein. (236 aa)
ENSUAMP00000026337Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
ENSUAMP00000026424Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
GRM2Glutamate metabotropic receptor 2. (872 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (1103 aa)
GRIK5Glutamate ionotropic receptor kainate type subunit 5. (969 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (794 aa)
HOMER2Homer scaffold protein 2. (341 aa)
PLA2G4APhospholipase A2. (756 aa)
GRIK3Glutamate ionotropic receptor kainate type subunit 3. (950 aa)
ENSUAMP00000011731Ion_trans domain-containing protein. (408 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (649 aa)
SLC1A1Amino acid transporter. (501 aa)
ENSUAMP00000010738Uncharacterized protein. (181 aa)
PLCB1Phosphoinositide phospholipase C. (658 aa)
PRKCAProtein kinase C alpha; Belongs to the protein kinase superfamily. (484 aa)
PPP3CBSerine/threonine-protein phosphatase. (479 aa)
ENSUAMP00000010227Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
GNAO1G protein subunit alpha o1. (354 aa)
GNB4G protein subunit beta 4. (331 aa)
SLC17A7Solute carrier family 17 member 7. (560 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (973 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
ENSUAMP00000008385WH1 domain-containing protein. (359 aa)
PPP3CASerine/threonine-protein phosphatase. (317 aa)
GNAI3G protein subunit alpha i3. (295 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (651 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (308 aa)
ENSUAMP00000007288Ca_chan_IQ domain-containing protein. (832 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (647 aa)
GRIN3BGlutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1001 aa)
PLD2Phospholipase. (1025 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1338 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2656 aa)
GNB5G protein subunit beta 5. (264 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1166 aa)
ENSUAMP00000003880Uncharacterized protein. (91 aa)
ENSUAMP00000003818Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
LGSNLengsin, lens protein with glutamine synthetase domain; Belongs to the glutamine synthetase family. (509 aa)
ENSUAMP00000002341Uncharacterized protein. (957 aa)
ENSUAMP00000001479Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (121 aa)
ENSUAMP00000001454Uncharacterized protein. (150 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (957 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
ENSUAMP00000000499Uncharacterized protein. (435 aa)
ENSUAMP00000000314Amino acid transporter. (115 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (906 aa)
ENSUAMP00000027869PBPe domain-containing protein; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (282 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (814 aa)
SLC1A2Amino acid transporter. (565 aa)
ADCY5Adenylate cyclase 5. (940 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
GLS2Glutaminase 2. (602 aa)
GNASGNAS complex locus. (994 aa)
ENSUAMP00000028672Phospholipase A2. (765 aa)
JMJD7Jumonji domain containing 7. (303 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1136 aa)
ENSUAMP00000028781G protein gamma domain-containing protein. (61 aa)
ENSUAMP00000029001ANF_receptor domain-containing protein. (195 aa)
PLA2G4EPhospholipase A2. (822 aa)
GRM4Glutamate metabotropic receptor 4. (947 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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