(126 nodes) Inflammatory mediator regulation of TRP channels network (Ursus americanus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PLA2G4F	Phospholipase A2. (837 aa)
	PPP1CB	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
	ENSUAMP00000025726	annotation not available (113 aa)
	BDKRB2	Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (392 aa)
	BDKRB1	Bradykinin receptor B1. (353 aa)
	ENSUAMP00000025311	Uncharacterized protein. (295 aa)
	ENSUAMP00000025300	Non-specific serine/threonine protein kinase. (254 aa)
	ENSUAMP00000023102	Uncharacterized protein. (1102 aa)
	MAPK10	Mitogen-activated protein kinase. (422 aa)
	ENSUAMP00000022447	G_PROTEIN_RECEP_F1_2 domain-containing protein. (221 aa)
	ENSUAMP00000022131	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (636 aa)
	CALM3	Calmodulin 3; Belongs to the calmodulin family. (149 aa)
	IGF1	Insulin like growth factor 1. (171 aa)
	GNAQ	G protein subunit alpha q. (352 aa)
	MAP2K3	Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
	TRPV2	Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (801 aa)
	PRKCG	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (714 aa)
	TRPA1	Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1068 aa)
	ENSUAMP00000019938	Uncharacterized protein. (193 aa)
	CAMK2B	Calcium/calmodulin dependent protein kinase II beta. (589 aa)
	CALML4	Calmodulin like 4. (153 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
	ENSUAMP00000019181	Protein kinase domain-containing protein. (206 aa)
	ENSUAMP00000019174	CaMKII_AD domain-containing protein. (267 aa)
	ENSUAMP00000019124	Uncharacterized protein. (241 aa)
	ENSUAMP00000019082	Uncharacterized protein; Belongs to the cytochrome P450 family. (411 aa)
	PTGER2	Prostaglandin E receptor 2; Belongs to the G-protein coupled receptor 1 family. (347 aa)
	ENSUAMP00000017692	Uncharacterized protein. (704 aa)
	ENSUAMP00000017435	Uncharacterized protein. (459 aa)
	NTRK1	Tyrosine-protein kinase receptor. (787 aa)
	MAPK11	Mitogen-activated protein kinase. (357 aa)
	ENSUAMP00000017095	Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (164 aa)
	MAPK12	Mitogen-activated protein kinase 12. (373 aa)
	ENSUAMP00000014578	Uncharacterized protein. (217 aa)
	CYP2J2	Cytochrome P450 family 2 subfamily J member 2; Belongs to the cytochrome P450 family. (469 aa)
	CALML6	Calmodulin like 6. (180 aa)
	PPP1CC	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (326 aa)
	PLA2G4A	Phospholipase A2. (756 aa)
	ENSUAMP00000012113	Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (199 aa)
	ENSUAMP00000011731	Ion_trans domain-containing protein. (408 aa)
	PLCB1	Phosphoinositide phospholipase C. (658 aa)
	PRKCA	Protein kinase C alpha; Belongs to the protein kinase superfamily. (484 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (676 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1256 aa)
	PTGER4	Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (489 aa)
	ENSUAMP00000009775	C2 domain-containing protein. (151 aa)
	MAPK8	Mitogen-activated protein kinase. (456 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	PRKCD	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (973 aa)
	CALML5	Calmodulin like 5. (156 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
	ENSUAMP00000008298	AGC-kinase C-terminal domain-containing protein. (89 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1252 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (651 aa)
	ENSUAMP00000007617	Protein kinase domain-containing protein. (271 aa)
	ENSUAMP00000007378	Protein kinase domain-containing protein. (111 aa)
	ENSUAMP00000007135	Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (254 aa)
	HTR2C	5-hydroxytryptamine receptor 2C. (305 aa)
	P2RY2	Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family. (377 aa)
	ENSUAMP00000006694	SER_THR_PHOSPHATASE domain-containing protein. (148 aa)
	ENSUAMP00000006194	ANK_REP_REGION domain-containing protein. (259 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1338 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2656 aa)
	F2RL1	F2R like trypsin receptor 1. (397 aa)
	PRKCQ	Protein kinase C theta. (526 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1166 aa)
	ENSUAMP00000004579	Abhydrolase_3 domain-containing protein. (224 aa)
	ENSUAMP00000004064	G_PROTEIN_RECEP_F1_2 domain-containing protein. (138 aa)
	ENSUAMP00000003358	SER_THR_PHOSPHATASE domain-containing protein. (106 aa)
	ENSUAMP00000003355	Uncharacterized protein. (76 aa)
	ENSUAMP00000002638	Uncharacterized protein. (76 aa)
	ENSUAMP00000002341	Uncharacterized protein. (957 aa)
	ASIC2	Acid sensing ion channel subunit 2; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (318 aa)
	IL1R1	Interleukin 1 receptor type 1. (584 aa)
	ENSUAMP00000000176	Protein kinase domain-containing protein. (82 aa)
	HTR2B	5-hydroxytryptamine receptor 2B. (480 aa)
	TRPV3	Transient receptor potential cation channel subfamily V member 3; Belongs to the transient receptor (TC 1.A.4) family. (791 aa)
	TRPV1	Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (851 aa)
	TRPM8	LSDAT_euk domain-containing protein. (646 aa)
	ENSUAMP00000036797	Ion_trans domain-containing protein. (308 aa)
	TRPV4	Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (861 aa)
	ENSUAMP00000035755	Protein kinase domain-containing protein. (105 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
	ENSUAMP00000035681	Protein kinase domain-containing protein. (217 aa)
	CALM2	Calmodulin 2; Belongs to the calmodulin family. (163 aa)
	ENSUAMP00000035568	Uncharacterized protein. (99 aa)
	ENSUAMP00000035331	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (506 aa)
	CYP2W1	Cytochrome P450 family 2 subfamily W member 1; Belongs to the cytochrome P450 family. (501 aa)
	ENSUAMP00000034830	Uncharacterized protein. (1872 aa)
	ENSUAMP00000034639	Uncharacterized protein. (463 aa)
	ENSUAMP00000034638	Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa)
	ENSUAMP00000034394	Uncharacterized protein; Belongs to the cytochrome P450 family. (506 aa)
	CYP4B1	Cytochrome P450 family 4 subfamily B member 1; Belongs to the cytochrome P450 family. (493 aa)
	ENSUAMP00000033863	Uncharacterized protein; Belongs to the cytochrome P450 family. (496 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (361 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
	ARSI	Arylsulfatase family member I. (573 aa)
	ENSUAMP00000032618	Uncharacterized protein. (68 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
	ENSUAMP00000032382	CaMKII_AD domain-containing protein. (189 aa)
	MAPK13	Mitogen-activated protein kinase. (366 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	ADCY4	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
	NGF	Nerve growth factor; Belongs to the NGF-beta family. (240 aa)
	ASIC4	Acid sensing ion channel subunit family member 4; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (574 aa)
	ENSUAMP00000030353	C2 domain-containing protein. (165 aa)
	SRC	Tyrosine-protein kinase. (557 aa)
	ASIC3	Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (532 aa)
	PLA2G4E	Phospholipase A2. (822 aa)
	MAPK9	Mitogen-activated protein kinase. (433 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1136 aa)
	JMJD7	Jumonji domain containing 7. (303 aa)
	ENSUAMP00000028672	Phospholipase A2. (765 aa)
	GNAS	GNAS complex locus. (994 aa)
	ASIC5	Acid sensing ion channel subunit family member 5; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (505 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
	ENSUAMP00000028019	Uncharacterized protein. (163 aa)
	ADCY5	Adenylate cyclase 5. (940 aa)
	ALOX12	Arachidonate 12-lipoxygenase, 12S type. (666 aa)
	HRH1	Histamine receptor H1; Belongs to the G-protein coupled receptor 1 family. (487 aa)
	MAP2K6	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
	ENSUAMP00000026182	Abhydrolase_3 domain-containing protein. (237 aa)
	ENSUAMP00000026030	Uncharacterized protein. (236 aa)
	PLA2G4D	Phospholipase A2. (776 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSUAMP00000028025	ENSUAMP00000008551	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.564
ADCY1	ADCY3	ENSUAMP00000028025	ENSUAMP00000008710	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.931
ADCY1	ADCY4	ENSUAMP00000028025	ENSUAMP00000032005	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.559
ADCY1	ADCY5	ENSUAMP00000028025	ENSUAMP00000027941	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 5.	0.539
ADCY1	ADCY6	ENSUAMP00000028025	ENSUAMP00000035722	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.542
ADCY1	ADCY7	ENSUAMP00000028025	ENSUAMP00000032396	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.666
ADCY1	ADCY9	ENSUAMP00000028025	ENSUAMP00000005924	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.646
ADCY1	CALM2	ENSUAMP00000028025	ENSUAMP00000035625	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 2; Belongs to the calmodulin family.	0.848
ADCY1	CALM3	ENSUAMP00000028025	ENSUAMP00000021541	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 3; Belongs to the calmodulin family.	0.848
ADCY1	CALML4	ENSUAMP00000028025	ENSUAMP00000019475	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 4.	0.930
ADCY1	CALML5	ENSUAMP00000028025	ENSUAMP00000008609	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 5.	0.956
ADCY1	CALML6	ENSUAMP00000028025	ENSUAMP00000013788	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 6.	0.957
ADCY1	CAMK2B	ENSUAMP00000028025	ENSUAMP00000019832	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase II beta.	0.851
ADCY1	ENSUAMP00000000176	ENSUAMP00000028025	ENSUAMP00000000176	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase domain-containing protein.	0.875
ADCY1	ENSUAMP00000007617	ENSUAMP00000028025	ENSUAMP00000007617	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase domain-containing protein.	0.875
ADCY1	ENSUAMP00000019174	ENSUAMP00000028025	ENSUAMP00000019174	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	CaMKII_AD domain-containing protein.	0.843
ADCY1	ENSUAMP00000019181	ENSUAMP00000028025	ENSUAMP00000019181	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase domain-containing protein.	0.843
ADCY1	ENSUAMP00000025300	ENSUAMP00000028025	ENSUAMP00000025300	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase.	0.875
ADCY1	ENSUAMP00000025311	ENSUAMP00000028025	ENSUAMP00000025311	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.844
ADCY1	ENSUAMP00000025726	ENSUAMP00000028025	ENSUAMP00000025726	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	annotation not available	0.848