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ATP1B4 ATP1B4 GCK GCK ATP1A1 ATP1A1 CACNA1S CACNA1S ITPR3 ITPR3 ADCY9 ADCY9 ENSUAMP00000005986 ENSUAMP00000005986 KCNMA1 KCNMA1 ENSUAMP00000007288 ENSUAMP00000007288 ENSUAMP00000007617 ENSUAMP00000007617 PRKCB PRKCB CCK CCK ADCY2 ADCY2 ADCY3 ADCY3 ATF2 ATF2 PRKCA PRKCA PLCB1 PLCB1 GLP1R GLP1R PCLO PCLO ADCYAP1R1 ADCYAP1R1 ENSUAMP00000012276 ENSUAMP00000012276 ENSUAMP00000013458 ENSUAMP00000013458 ATP1A2 ATP1A2 CACNA1D CACNA1D KCNN3 KCNN3 ENSUAMP00000019174 ENSUAMP00000019174 ENSUAMP00000019181 ENSUAMP00000019181 PLCB3 PLCB3 CAMK2B CAMK2B GCG GCG FAP FAP KCNMB1 KCNMB1 PRKCG PRKCG ATF6B ATF6B ADCYAP1 ADCYAP1 GNAQ GNAQ CCKAR CCKAR STX1A STX1A ENSUAMP00000023100 ENSUAMP00000023100 KCNN1 KCNN1 CREB1 CREB1 ATP1B3 ATP1B3 CREB3L3 CREB3L3 ENSUAMP00000025300 ENSUAMP00000025300 ENSUAMP00000025375 ENSUAMP00000025375 ATP1A4 ATP1A4 ENSUAMP00000026030 ENSUAMP00000026030 CREB5 CREB5 FFAR1 FFAR1 INS INS ENSUAMP00000027098 ENSUAMP00000027098 CHRM3 CHRM3 ADCY5 ADCY5 ADCY1 ADCY1 GNAS GNAS PLCB4 PLCB4 ENSUAMP00000028824 ENSUAMP00000028824 CACNA1F CACNA1F PDX1 PDX1 GIP GIP ENSUAMP00000030764 ENSUAMP00000030764 ATP1B1 ATP1B1 RAPGEF4 RAPGEF4 CREB3L4 CREB3L4 ADCY4 ADCY4 ENSUAMP00000032382 ENSUAMP00000032382 ATP1B2 ATP1B2 ENSUAMP00000000935 ENSUAMP00000000935 GPR119 GPR119 GNA11 GNA11 SLC2A1 SLC2A1 ENSUAMP00000000176 ENSUAMP00000000176 SNAP25 SNAP25 ADCY6 ADCY6 CREB3 CREB3 CREB3L1 CREB3L1 ENSUAMP00000034960 ENSUAMP00000034960 RAB3B RAB3B ENSUAMP00000034481 ENSUAMP00000034481 SLC2A2 SLC2A2 TNIK TNIK KCNN2 KCNN2 PRKACB PRKACB ARSI ARSI ENSUAMP00000032843 ENSUAMP00000032843 ENSUAMP00000032618 ENSUAMP00000032618 ADCY7 ADCY7 RAB3A RAB3A KCNJ11 KCNJ11 ENSUAMP00000036226 ENSUAMP00000036226 ENSUAMP00000003408 ENSUAMP00000003408 KCNN4 KCNN4 ENSUAMP00000003964 ENSUAMP00000003964 PLCB2 PLCB2 ATF4 ATF4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (348 aa)
GCKPhosphotransferase. (466 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1021 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1872 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2656 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1338 aa)
ENSUAMP00000005986V-SNARE coiled-coil homology domain-containing protein. (169 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1143 aa)
ENSUAMP00000007288Ca_chan_IQ domain-containing protein. (832 aa)
ENSUAMP00000007617Protein kinase domain-containing protein. (271 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (651 aa)
CCKCholecystokinin. (115 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (973 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
PRKCAProtein kinase C alpha; Belongs to the protein kinase superfamily. (484 aa)
PLCB1Phosphoinositide phospholipase C. (658 aa)
GLP1RGlucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (482 aa)
PCLOPiccolo presynaptic cytomatrix protein. (4502 aa)
ADCYAP1R1ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (440 aa)
ENSUAMP00000012276B30.2/SPRY domain-containing protein. (334 aa)
ENSUAMP00000013458KcnmB2_inactiv domain-containing protein. (235 aa)
ATP1A2ATPase Na+/K+ transporting subunit alpha 2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1127 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2160 aa)
KCNN3Potassium calcium-activated channel subfamily N member 3. (400 aa)
ENSUAMP00000019174CaMKII_AD domain-containing protein. (267 aa)
ENSUAMP00000019181Protein kinase domain-containing protein. (206 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (589 aa)
GCGGlucagon. (179 aa)
FAPFibroblast activation protein alpha; Belongs to the peptidase S9B family. (724 aa)
KCNMB1Potassium calcium-activated channel subfamily M regulatory beta subunit 1. (191 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (714 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (176 aa)
GNAQG protein subunit alpha q. (352 aa)
CCKARCholecystokinin A receptor; Belongs to the G-protein coupled receptor 1 family. (428 aa)
STX1ASyntaxin 1A; Belongs to the syntaxin family. (289 aa)
ENSUAMP00000023100PDZ domain-containing protein. (451 aa)
KCNN1Potassium calcium-activated channel subfamily N member 1. (542 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (280 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (457 aa)
ENSUAMP00000025300Non-specific serine/threonine protein kinase. (254 aa)
ENSUAMP00000025375Uncharacterized protein. (354 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1011 aa)
ENSUAMP00000026030Uncharacterized protein. (236 aa)
CREB5cAMP responsive element binding protein 5. (327 aa)
FFAR1Free fatty acid receptor 1. (280 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
ENSUAMP00000027098Uncharacterized protein. (74 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
ADCY5Adenylate cyclase 5. (940 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
GNASGNAS complex locus. (994 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1136 aa)
ENSUAMP00000028824LSDAT_euk domain-containing protein. (181 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1866 aa)
PDX1Pancreatic and duodenal homeobox 1. (282 aa)
GIPGastric inhibitory polypeptide. (176 aa)
ENSUAMP00000030764Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1123 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1019 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (247 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ENSUAMP00000032382CaMKII_AD domain-containing protein. (189 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
ENSUAMP00000000935CaMBD domain-containing protein. (170 aa)
GPR119G protein-coupled receptor 119; Belongs to the G-protein coupled receptor 1 family. (335 aa)
GNA11G protein subunit alpha 11. (353 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
ENSUAMP00000000176Protein kinase domain-containing protein. (82 aa)
SNAP25Synaptosomal-associated protein; Belongs to the SNAP-25 family. (143 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
CREB3cAMP responsive element binding protein 3. (352 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
ENSUAMP00000034960C2H2-type domain-containing protein. (123 aa)
RAB3BRAB3B, member RAS oncogene family. (219 aa)
ENSUAMP00000034481C2 domain-containing protein. (220 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (531 aa)
TNIKTRAF2 and NCK interacting kinase. (1273 aa)
KCNN2Potassium calcium-activated channel subfamily N member 2. (604 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (361 aa)
ARSIArylsulfatase family member I. (573 aa)
ENSUAMP00000032843Uncharacterized protein. (186 aa)
ENSUAMP00000032618Uncharacterized protein. (68 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
RAB3ARAB3A, member RAS oncogene family. (230 aa)
KCNJ11Potassium voltage-gated channel subfamily J member 11. (390 aa)
ENSUAMP00000036226Uncharacterized protein. (886 aa)
ENSUAMP00000003408Uncharacterized protein. (64 aa)
KCNN4Potassium calcium-activated channel subfamily N member 4. (308 aa)
ENSUAMP00000003964FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (59 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1166 aa)
ATF4Activating transcription factor 4. (351 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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