(105 nodes) Progesterone-mediated oocyte maturation network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSUAMP00000012092	Uncharacterized protein. (589 aa)
	BUB1	BUB1 mitotic checkpoint serine/threonine kinase. (1071 aa)
	ADCY5	Adenylate cyclase 5. (940 aa)
	CPEB3	Cytoplasmic polyadenylation element binding protein 3. (710 aa)
	ANAPC7	Anaphase promoting complex subunit 7. (586 aa)
	MAPK1	Mitogen-activated protein kinase. (364 aa)
	CCNA2	Cyclin A2; Belongs to the cyclin family. (425 aa)
	ENSUAMP00000014629	Uncharacterized protein. (105 aa)
	RPS6KA1	Ribosomal protein S6 kinase. (836 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1288 aa)
	MAPK12	Mitogen-activated protein kinase 12. (373 aa)
	MAPK11	Mitogen-activated protein kinase. (357 aa)
	ENSUAMP00000017435	Uncharacterized protein. (459 aa)
	ENSUAMP00000017692	Uncharacterized protein. (704 aa)
	CPEB4	Cytoplasmic polyadenylation element binding protein 4. (656 aa)
	ANAPC5	Anaphase promoting complex subunit 5. (727 aa)
	ENSUAMP00000018470	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (298 aa)
	CDC16	Cell division cycle 16. (624 aa)
	MAD2L1	Mitotic arrest deficient 2 like 1. (205 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
	ANAPC1	APC1_C domain-containing protein. (1191 aa)
	KRAS	KRAS proto-oncogene, GTPase. (188 aa)
	GEM	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
	IGF1	Insulin like growth factor 1. (171 aa)
	HSP90AB1	Heat shock protein 90 alpha family class B member 1. (728 aa)
	ENSUAMP00000021380	Uncharacterized protein. (424 aa)
	ENSUAMP00000021381	Protein kinase domain-containing protein. (363 aa)
	ENSUAMP00000021540	Uncharacterized protein. (311 aa)
	ENSUAMP00000021561	RING-type domain-containing protein. (84 aa)
	FZR1	Fizzy and cell division cycle 20 related 1. (493 aa)
	ENSUAMP00000022131	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (636 aa)
	ENSUAMP00000022172	Uncharacterized protein. (157 aa)
	MAPK10	Mitogen-activated protein kinase. (422 aa)
	ENSUAMP00000023307	Uncharacterized protein. (243 aa)
	CDC26	Cell division cycle 26. (85 aa)
	AURKA	Aurora kinase A; Belongs to the protein kinase superfamily. (405 aa)
	PKMYT1	Protein kinase, membrane associated tyrosine/threonine 1; Belongs to the protein kinase superfamily. (492 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (676 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	GNAI2	G protein subunit alpha i2. (436 aa)
	ANAPC13	Anaphase promoting complex subunit 13. (74 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
	AP5S1	Adaptor related protein complex 5 subunit sigma 1. (200 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
	MAPK9	Mitogen-activated protein kinase. (433 aa)
	ENSUAMP00000029737	Uncharacterized protein. (105 aa)
	RPS6KA3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
	REM1	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (313 aa)
	CDC25A	Cell division cycle 25A. (498 aa)
	ENSUAMP00000030741	Uncharacterized protein. (248 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (564 aa)
	ENSUAMP00000030787	Uncharacterized protein. (84 aa)
	ANAPC4	Anaphase promoting complex subunit 4. (659 aa)
	STK10	Serine/threonine kinase 10. (967 aa)
	ENSUAMP00000031131	Protein kinase domain-containing protein. (264 aa)
	MAPK3	Mitogen-activated protein kinase. (354 aa)
	ADCY4	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	MAPK13	Mitogen-activated protein kinase. (366 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
	ENSUAMP00000033175	Uncharacterized protein. (91 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (361 aa)
	ENSUAMP00000034116	Uncharacterized protein. (571 aa)
	MOS	MOS proto-oncogene, serine/threonine kinase; Belongs to the protein kinase superfamily. (349 aa)
	ENSUAMP00000035331	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (506 aa)
	CDC25B	Cell division cycle 25B. (559 aa)
	RRAD	RRAD, Ras related glycolysis inhibitor and calcium channel regulator. (373 aa)
	CCNB2	Cyclin B2; Belongs to the cyclin family. (397 aa)
	MAPK8	Mitogen-activated protein kinase. (456 aa)
	GNAI3	G protein subunit alpha i3. (295 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (973 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	ANAPC10	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
	ENSUAMP00000000641	Uncharacterized protein. (139 aa)
	PGR	Progesterone receptor. (634 aa)
	ENSUAMP00000001840	Uncharacterized protein. (586 aa)
	CCNB1	Cyclin B1; Belongs to the cyclin family. (425 aa)
	ENSUAMP00000002455	TPR_REGION domain-containing protein. (149 aa)
	ENSUAMP00000002462	Uncharacterized protein. (120 aa)
	CCNA1	Cyclin A1; Belongs to the cyclin family. (447 aa)
	ENSUAMP00000002888	Uncharacterized protein. (295 aa)
	ENSUAMP00000002920	Uncharacterized protein. (80 aa)
	ENSUAMP00000003375	Uncharacterized protein. (90 aa)
	ENSUAMP00000003880	Uncharacterized protein. (91 aa)
	CDK3	Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
	ENSUAMP00000005048	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (241 aa)
	KIF22	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (657 aa)
	TMEM82	Transmembrane protein 82. (344 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1338 aa)
	AURKB	Aurora kinase B; Belongs to the protein kinase superfamily. (344 aa)
	HSP90AA1	Heat shock protein 90 alpha family class A member 1. (733 aa)
	CDK1	Cyclin dependent kinase 1. (305 aa)
	MAD2L2	Mitotic arrest deficient 2 like 2. (211 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (728 aa)
	RPS6KA6	Non-specific serine/threonine protein kinase. (686 aa)
	SPDYA	Speedy/RINGO cell cycle regulator family member A. (311 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
	ANAPC2	Anaphase promoting complex subunit 2; Belongs to the cullin family. (893 aa)
	AKT1	Non-specific serine/threonine protein kinase. (572 aa)
	CDC27	Cell division cycle 27. (729 aa)
	RPS6KA2	Ribosomal protein S6 kinase. (753 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	AURKC	Aurora kinase C; Belongs to the protein kinase superfamily. (307 aa)
	ENSUAMP00000011956	Uncharacterized protein. (119 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSUAMP00000028025	ENSUAMP00000008551	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.564
ADCY1	ADCY3	ENSUAMP00000028025	ENSUAMP00000008710	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.931
ADCY1	ADCY4	ENSUAMP00000028025	ENSUAMP00000032005	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.559
ADCY1	ADCY5	ENSUAMP00000028025	ENSUAMP00000027941	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 5.	0.539
ADCY1	ADCY6	ENSUAMP00000028025	ENSUAMP00000035722	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.542
ADCY1	ADCY7	ENSUAMP00000028025	ENSUAMP00000032396	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.666
ADCY1	ADCY9	ENSUAMP00000028025	ENSUAMP00000005924	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.646
ADCY1	AKT1	ENSUAMP00000028025	ENSUAMP00000010674	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase.	0.841
ADCY1	AKT2	ENSUAMP00000028025	ENSUAMP00000037592	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.841
ADCY1	AKT3	ENSUAMP00000028025	ENSUAMP00000011671	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.882
ADCY1	ANAPC5	ENSUAMP00000028025	ENSUAMP00000018417	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Anaphase promoting complex subunit 5.	0.452
ADCY1	ANAPC7	ENSUAMP00000028025	ENSUAMP00000013583	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Anaphase promoting complex subunit 7.	0.524
ADCY1	ENSUAMP00000003375	ENSUAMP00000028025	ENSUAMP00000003375	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.452
ADCY1	ENSUAMP00000003880	ENSUAMP00000028025	ENSUAMP00000003880	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.807
ADCY1	ENSUAMP00000014629	ENSUAMP00000028025	ENSUAMP00000014629	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.807
ADCY1	ENSUAMP00000022172	ENSUAMP00000028025	ENSUAMP00000022172	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.807
ADCY1	GNAI2	ENSUAMP00000028025	ENSUAMP00000037424	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i2.	0.807
ADCY1	GNAI3	ENSUAMP00000028025	ENSUAMP00000008046	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i3.	0.807
ADCY1	PRKACB	ENSUAMP00000028025	ENSUAMP00000033341	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.947
ADCY2	ADCY1	ENSUAMP00000008551	ENSUAMP00000028025	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.564