120 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KIT	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (999 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (973 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	GNAO1	G protein subunit alpha o1. (354 aa)
	PRKCA	Protein kinase C alpha; Belongs to the protein kinase superfamily. (484 aa)
	PLCB1	Phosphoinositide phospholipase C. (658 aa)
	FZD4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
	FZD5	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (727 aa)
	POMC	Proopiomelanocortin. (223 aa)
	GSK3B	Glycogen synthase kinase 3 beta. (335 aa)
	ENSUAMP00000012266	CTNNB1_binding domain-containing protein. (162 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
	WNT9A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
	MAPK1	Mitogen-activated protein kinase. (364 aa)
	ERAS	ES cell expressed Ras. (219 aa)
	CALML6	Calmodulin like 6. (180 aa)
	ENSUAMP00000014629	Uncharacterized protein. (105 aa)
	WNT7B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	ENSUAMP00000015993	Uncharacterized protein. (98 aa)
	DVL1	Dishevelled segment polarity protein 1. (700 aa)
	EFCAB13	EF-hand calcium binding domain 13. (939 aa)
	TYR	Tyrosinase. (401 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	WNT10A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
	DVL2	Dishevelled segment polarity protein 2. (731 aa)
	ENSUAMP00000019174	CaMKII_AD domain-containing protein. (267 aa)
	ENSUAMP00000019181	Protein kinase domain-containing protein. (206 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
	CALML4	Calmodulin like 4. (153 aa)
	FZD6	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (657 aa)
	CAMK2B	Calcium/calmodulin dependent protein kinase II beta. (589 aa)
	PRKCG	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (714 aa)
	KRAS	KRAS proto-oncogene, GTPase. (188 aa)
	GNAQ	G protein subunit alpha q. (352 aa)
	GEM	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
	FZD9	Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (561 aa)
	CALM3	Calmodulin 3; Belongs to the calmodulin family. (149 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	ENSUAMP00000022172	Uncharacterized protein. (157 aa)
	ENSUAMP00000022336	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (163 aa)
	ENSUAMP00000022339	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (107 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	CREB3L3	cAMP responsive element binding protein 3 like 3. (457 aa)
	WNT8A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (344 aa)
	ENSUAMP00000025300	Non-specific serine/threonine protein kinase. (254 aa)
	ENSUAMP00000025311	Uncharacterized protein. (295 aa)
	ENSUAMP00000025726	annotation not available (113 aa)
	ENSUAMP00000026030	Uncharacterized protein. (236 aa)
	TCF7L2	Transcription factor 7 like 2. (524 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (343 aa)
	ENSUAMP00000026993	Uncharacterized protein. (118 aa)
	FZD10	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (595 aa)
	ADCY5	Adenylate cyclase 5. (940 aa)
	EDNRB	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (445 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
	ENSUAMP00000028178	Uncharacterized protein. (311 aa)
	ENSUAMP00000028179	CSD domain-containing protein. (89 aa)
	GNAS	GNAS complex locus. (994 aa)
	EFCAB3	EF-hand calcium binding domain 3. (436 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1136 aa)
	ENSUAMP00000029031	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
	KITLG	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (274 aa)
	MITF	Melanocyte inducing transcription factor. (525 aa)
	ENSUAMP00000030280	Protein kinase domain-containing protein. (206 aa)
	MAP2K1	Protein kinase domain-containing protein. (216 aa)
	EDN1	Endothelin 1. (202 aa)
	REM1	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (313 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (564 aa)
	CREBBP	CREB binding protein. (2333 aa)
	ENSUAMP00000030787	Uncharacterized protein. (84 aa)
	MAPK3	Mitogen-activated protein kinase. (354 aa)
	ENSUAMP00000031719	Uncharacterized protein. (627 aa)
	CREB3L4	cAMP responsive element binding protein 3 like 4. (247 aa)
	EP300	E1A binding protein p300. (2399 aa)
	ADCY4	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
	ENSUAMP00000032382	CaMKII_AD domain-containing protein. (189 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
	ENSUAMP00000032618	Uncharacterized protein. (68 aa)
	ENSUAMP00000032843	Uncharacterized protein. (186 aa)
	FZD7	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
	ARSI	Arylsulfatase family member I. (573 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (361 aa)
	CREB3L1	cAMP responsive element binding protein 3 like 1. (520 aa)
	CREB3	cAMP responsive element binding protein 3. (352 aa)
	CALM2	Calmodulin 2; Belongs to the calmodulin family. (163 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	WNT10B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	ENSUAMP00000035777	HMG box domain-containing protein. (191 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
	ENSUAMP00000036324	Uncharacterized protein. (189 aa)
	FZD1	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (534 aa)
	TCF7L1	Transcription factor 7 like 1. (597 aa)
	GNAI2	G protein subunit alpha i2. (436 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
	ASIP	Agouti signaling protein. (132 aa)
	GNAI3	G protein subunit alpha i3. (295 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (299 aa)
	TCF7	Transcription factor 7. (443 aa)
	RRAD	RRAD, Ras related glycolysis inhibitor and calcium channel regulator. (373 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (651 aa)
	TYRP1	Tyrosinase related protein 1. (537 aa)
	ENSUAMP00000007617	Protein kinase domain-containing protein. (271 aa)
	DVL3	Dishevelled segment polarity protein 3. (716 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1338 aa)
	CALML5	Calmodulin like 5. (156 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1166 aa)
	ENSUAMP00000003880	Uncharacterized protein. (91 aa)
	DCT	Dopachrome tautomerase. (400 aa)
	ENSUAMP00000003693	Uncharacterized protein. (166 aa)
	WNT8B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (332 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	FZD2	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (563 aa)
	WNT6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
	ENSUAMP00000001392	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (545 aa)
	ENSUAMP00000000176	Protein kinase domain-containing protein. (82 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSUAMP00000028025	ENSUAMP00000008551	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.564
ADCY1	ADCY3	ENSUAMP00000028025	ENSUAMP00000008710	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.931
ADCY1	ADCY4	ENSUAMP00000028025	ENSUAMP00000032005	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.559
ADCY1	ADCY5	ENSUAMP00000028025	ENSUAMP00000027941	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 5.	0.539
ADCY1	ADCY6	ENSUAMP00000028025	ENSUAMP00000035722	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.542
ADCY1	ADCY7	ENSUAMP00000028025	ENSUAMP00000032396	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.666
ADCY1	ADCY9	ENSUAMP00000028025	ENSUAMP00000005924	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.646
ADCY1	CALM2	ENSUAMP00000028025	ENSUAMP00000035625	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 2; Belongs to the calmodulin family.	0.848
ADCY1	CALM3	ENSUAMP00000028025	ENSUAMP00000021541	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 3; Belongs to the calmodulin family.	0.848
ADCY1	CALML4	ENSUAMP00000028025	ENSUAMP00000019475	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 4.	0.930
ADCY1	CALML5	ENSUAMP00000028025	ENSUAMP00000008609	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 5.	0.956
ADCY1	CALML6	ENSUAMP00000028025	ENSUAMP00000013788	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 6.	0.957
ADCY1	CAMK2B	ENSUAMP00000028025	ENSUAMP00000019832	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase II beta.	0.851
ADCY1	ENSUAMP00000000176	ENSUAMP00000028025	ENSUAMP00000000176	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase domain-containing protein.	0.875
ADCY1	ENSUAMP00000003880	ENSUAMP00000028025	ENSUAMP00000003880	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.807
ADCY1	ENSUAMP00000007617	ENSUAMP00000028025	ENSUAMP00000007617	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase domain-containing protein.	0.875
ADCY1	ENSUAMP00000014629	ENSUAMP00000028025	ENSUAMP00000014629	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.807
ADCY1	ENSUAMP00000019174	ENSUAMP00000028025	ENSUAMP00000019174	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	CaMKII_AD domain-containing protein.	0.843
ADCY1	ENSUAMP00000019181	ENSUAMP00000028025	ENSUAMP00000019181	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase domain-containing protein.	0.843
ADCY1	ENSUAMP00000022172	ENSUAMP00000028025	ENSUAMP00000022172	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.807