(81 nodes) Thyroid hormone synthesis network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ASGR1	Asialoglycoprotein receptor 1. (284 aa)
	IYD	Iodotyrosine deiodinase. (289 aa)
	SERPINA7	Serpin family A member 7; Belongs to the serpin family. (414 aa)
	GPX8	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
	CGA	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
	CREB3	cAMP responsive element binding protein 3. (352 aa)
	CREB3L1	cAMP responsive element binding protein 3 like 1. (520 aa)
	ENSUAMP00000034960	C2H2-type domain-containing protein. (123 aa)
	ENSUAMP00000034830	Uncharacterized protein. (1872 aa)
	TPO	Thyroid peroxidase. (1068 aa)
	ENSUAMP00000034340	Uncharacterized protein. (1128 aa)
	ENSUAMP00000033373	STAS domain-containing protein. (230 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (361 aa)
	ENSUAMP00000032843	Uncharacterized protein. (186 aa)
	ENSUAMP00000032618	Uncharacterized protein. (68 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
	DUOX2	Dual oxidase 2. (1531 aa)
	DUOXA2	Dual oxidase maturation factor 2. (320 aa)
	DUOX1	Dual oxidase 1. (1539 aa)
	ADCY4	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
	CREB3L4	cAMP responsive element binding protein 3 like 4. (247 aa)
	ATP1B1	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
	ENSUAMP00000030764	Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1123 aa)
	GPX3	Glutathione peroxidase 3. (218 aa)
	TSHR	Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (764 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1136 aa)
	GNAS	GNAS complex locus. (994 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
	ADCY5	Adenylate cyclase 5. (940 aa)
	CLEC10A	C-type lectin domain containing 10A. (381 aa)
	GSR	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (519 aa)
	CREB5	cAMP responsive element binding protein 5. (327 aa)
	ENSUAMP00000026030	Uncharacterized protein. (236 aa)
	ATP1A4	Sodium/potassium-transporting ATPase subunit alpha. (1011 aa)
	PAX8	Paired box 8. (458 aa)
	ENSUAMP00000025300	Non-specific serine/threonine protein kinase. (254 aa)
	LRP2	LDL receptor related protein 2. (4684 aa)
	CREB3L3	cAMP responsive element binding protein 3 like 3. (457 aa)
	ENSUAMP00000024274	COesterase domain-containing protein. (355 aa)
	ATP1B3	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (280 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	SLC5A5	Solute carrier family 5 member 5; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (642 aa)
	ENSUAMP00000023102	Uncharacterized protein. (1102 aa)
	GNAQ	G protein subunit alpha q. (352 aa)
	ATF6B	Activating transcription factor 6 beta. (708 aa)
	PRKCG	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (714 aa)
	SERPINA9	Serpin family A member 9; Belongs to the serpin family. (418 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
	PDIA4	Protein disulfide-isomerase A4. (645 aa)
	ASGR2	Asialoglycoprotein receptor 2. (305 aa)
	HSPA5	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
	ATP1A2	ATPase Na+/K+ transporting subunit alpha 2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1127 aa)
	GPX6	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (219 aa)
	TSHB	Thyroid stimulating hormone subunit beta. (138 aa)
	CANX	Calnexin. (589 aa)
	ENSUAMP00000015463	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (221 aa)
	GPX1	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (145 aa)
	ENSUAMP00000011731	Ion_trans domain-containing protein. (408 aa)
	ENSUAMP00000011487	HATPase_c domain-containing protein. (333 aa)
	PLCB1	Phosphoinositide phospholipase C. (658 aa)
	PRKCA	Protein kinase C alpha; Belongs to the protein kinase superfamily. (484 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (973 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
	ALB	Albumin. (609 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (651 aa)
	ENSUAMP00000006845	Sulfate_transp domain-containing protein. (515 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1338 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2656 aa)
	ATP1A1	Sodium/potassium-transporting ATPase subunit alpha. (1021 aa)
	ATP1B4	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (348 aa)
	ATF4	Activating transcription factor 4. (351 aa)
	GPX2	Glutathione peroxidase 2. (175 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1166 aa)
	ENSUAMP00000003984	SANT domain-containing protein. (684 aa)
	ENSUAMP00000003964	FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (59 aa)
	GPX7	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
	TTR	Transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. (158 aa)
	ENSUAMP00000002341	Uncharacterized protein. (957 aa)
	ATP1B2	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSUAMP00000028025	ENSUAMP00000008551	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.564
ADCY1	ADCY3	ENSUAMP00000028025	ENSUAMP00000008710	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.931
ADCY1	ADCY4	ENSUAMP00000028025	ENSUAMP00000032005	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.559
ADCY1	ADCY5	ENSUAMP00000028025	ENSUAMP00000027941	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 5.	0.539
ADCY1	ADCY6	ENSUAMP00000028025	ENSUAMP00000035722	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.542
ADCY1	ADCY7	ENSUAMP00000028025	ENSUAMP00000032396	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.666
ADCY1	ADCY9	ENSUAMP00000028025	ENSUAMP00000005924	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.646
ADCY1	ENSUAMP00000025300	ENSUAMP00000028025	ENSUAMP00000025300	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase.	0.875
ADCY1	ENSUAMP00000026030	ENSUAMP00000028025	ENSUAMP00000026030	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.929
ADCY1	ENSUAMP00000032618	ENSUAMP00000028025	ENSUAMP00000032618	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.910
ADCY1	GNAS	ENSUAMP00000028025	ENSUAMP00000028340	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNAS complex locus.	0.910
ADCY1	PRKACB	ENSUAMP00000028025	ENSUAMP00000033341	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.947
ADCY1	PRKCA	ENSUAMP00000028025	ENSUAMP00000010550	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C alpha; Belongs to the protein kinase superfamily.	0.875
ADCY1	PRKCB	ENSUAMP00000028025	ENSUAMP00000007701	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.925
ADCY1	PRKCG	ENSUAMP00000028025	ENSUAMP00000020346	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.918
ADCY2	ADCY1	ENSUAMP00000008551	ENSUAMP00000028025	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.564
ADCY2	ADCY4	ENSUAMP00000008551	ENSUAMP00000032005	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.538
ADCY2	ADCY5	ENSUAMP00000008551	ENSUAMP00000027941	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 5.	0.991
ADCY2	ADCY6	ENSUAMP00000008551	ENSUAMP00000035722	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.861
ADCY2	ADCY7	ENSUAMP00000008551	ENSUAMP00000032396	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.540