STRINGSTRING
PRKAG3 PRKAG3 LEPR LEPR PPARGC1A PPARGC1A RELA RELA RXRA RXRA ENSUAMP00000026668 ENSUAMP00000026668 ENSUAMP00000026643 ENSUAMP00000026643 PCK1 PCK1 ENSUAMP00000025004 ENSUAMP00000025004 ENSUAMP00000024714 ENSUAMP00000024714 SLC2A1 SLC2A1 ENSUAMP00000000674 ENSUAMP00000000674 ENSUAMP00000001197 ENSUAMP00000001197 ENSUAMP00000001167 ENSUAMP00000001167 ACSBG2 ACSBG2 ENSUAMP00000001879 ENSUAMP00000001879 TRAF2 TRAF2 CPT1B CPT1B ENSUAMP00000002904 ENSUAMP00000002904 IRS4 IRS4 ENSUAMP00000003542 ENSUAMP00000003542 ENSUAMP00000003966 ENSUAMP00000003966 PRKCQ PRKCQ ENSUAMP00000006800 ENSUAMP00000006800 ENSUAMP00000007256 ENSUAMP00000007256 JAK2 JAK2 ENSUAMP00000008512 ENSUAMP00000008512 STAT3 STAT3 CPT1C CPT1C MAPK8 MAPK8 ENSUAMP00000009785 ENSUAMP00000009785 PTPN11 PTPN11 NPY NPY AKT1 AKT1 PPARA PPARA AKT3 AKT3 POMC POMC ACACB ACACB NFKBIB NFKBIB IKBKG IKBKG IRS2 IRS2 PRKAA2 PRKAA2 TNF TNF ENSUAMP00000016357 ENSUAMP00000016357 ACSL1 ACSL1 ADIPOR1 ADIPOR1 ENSUAMP00000022818 ENSUAMP00000022818 ACSBG1 ACSBG1 MAPK10 MAPK10 ADIPOR2 ADIPOR2 LEP LEP ACSL3 ACSL3 NFKB1 NFKB1 NFKBIE NFKBIE IKBKB IKBKB ADIPOQ ADIPOQ AGRP AGRP TRADD TRADD MTOR MTOR ENSUAMP00000018915 ENSUAMP00000018915 SLC2A4 SLC2A4 ENSUAMP00000017349 ENSUAMP00000017349 ENSUAMP00000017347 ENSUAMP00000017347 ENSUAMP00000016622 ENSUAMP00000016622 ENSUAMP00000016618 ENSUAMP00000016618 G6PC G6PC AKT2 AKT2 ENSUAMP00000037274 ENSUAMP00000037274 CHUK CHUK ACSL4 ACSL4 ENSUAMP00000035755 ENSUAMP00000035755 PRKAG1 PRKAG1 RXRB RXRB TNFRSF1B TNFRSF1B PRKAA1 PRKAA1 CPT1A CPT1A ENSUAMP00000032511 ENSUAMP00000032511 PCK2 PCK2 SOCS3 SOCS3 NFKBIA NFKBIA IRS1 IRS1 TNFRSF1A TNFRSF1A MAPK9 MAPK9 PRKAB2 PRKAB2 ENSUAMP00000027845 ENSUAMP00000027845 ENSUAMP00000027844 ENSUAMP00000027844
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (491 aa)
LEPRLeptin receptor. (1166 aa)
PPARGC1APPARG coactivator 1 alpha. (761 aa)
RELARELA proto-oncogene, NF-kB subunit. (508 aa)
RXRARetinoid X receptor alpha. (469 aa)
ENSUAMP00000026668Uncharacterized protein. (112 aa)
ENSUAMP00000026643Uncharacterized protein. (232 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
ENSUAMP00000025004Uncharacterized protein; Belongs to the CD36 family. (96 aa)
ENSUAMP00000024714annotation not available (356 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
ENSUAMP00000000674Uncharacterized protein. (258 aa)
ENSUAMP00000001197Uncharacterized protein. (228 aa)
ENSUAMP00000001167AMP-binding domain-containing protein. (493 aa)
ACSBG2Acyl-CoA synthetase bubblegum family member 2. (660 aa)
ENSUAMP00000001879Protein kinase domain-containing protein. (335 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
CPT1BCarnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
ENSUAMP00000002904Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (356 aa)
IRS4Insulin receptor substrate 4. (1256 aa)
ENSUAMP00000003542annotation not available (356 aa)
ENSUAMP00000003966MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (503 aa)
PRKCQProtein kinase C theta. (526 aa)
ENSUAMP00000006800Uncharacterized protein. (97 aa)
ENSUAMP00000007256Uncharacterized protein. (73 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
ENSUAMP00000008512Biotin carboxylation domain-containing protein. (206 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
CPT1CCarnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (803 aa)
MAPK8Mitogen-activated protein kinase. (456 aa)
ENSUAMP00000009785Uncharacterized protein; Belongs to the CD36 family. (215 aa)
PTPN11Protein tyrosine phosphatase non-receptor type 11. (552 aa)
NPYNeuropeptide Y. (90 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
PPARAPeroxisome proliferator activated receptor alpha. (503 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
POMCProopiomelanocortin. (223 aa)
ACACBAcetyl-CoA carboxylase beta. (2045 aa)
NFKBIBNFKB inhibitor beta. (354 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (442 aa)
IRS2Insulin receptor substrate 2. (1089 aa)
PRKAA2Non-specific serine/threonine protein kinase. (525 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (230 aa)
ENSUAMP00000016357Uncharacterized protein. (330 aa)
ACSL1Acyl-CoA synthetase long chain family member 1. (436 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
ENSUAMP00000022818Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
ACSBG1Acyl-CoA synthetase bubblegum family member 1. (703 aa)
MAPK10Mitogen-activated protein kinase. (422 aa)
ADIPOR2Adiponectin receptor 2. (386 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (157 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (659 aa)
NFKB1Nuclear factor kappa B subunit 1. (972 aa)
NFKBIENFKB inhibitor epsilon. (362 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (703 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
AGRPAgouti related neuropeptide. (131 aa)
TRADDTNFRSF1A associated via death domain. (314 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2523 aa)
ENSUAMP00000018915AMP-binding domain-containing protein. (730 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
ENSUAMP00000017349Uncharacterized protein. (125 aa)
ENSUAMP00000017347Uncharacterized protein. (64 aa)
ENSUAMP00000016622Uncharacterized protein. (246 aa)
ENSUAMP00000016618Protein kinase domain-containing protein. (317 aa)
G6PCGlucose-6-phosphatase catalytic subunit. (223 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSUAMP00000037274Uncharacterized protein. (439 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (515 aa)
ENSUAMP00000035755Protein kinase domain-containing protein. (105 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (330 aa)
RXRBRetinoid X receptor beta. (532 aa)
TNFRSF1BTNF receptor superfamily member 1B. (460 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
ENSUAMP00000032511Protein kinase domain-containing protein. (132 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
IRS1Insulin receptor substrate 1. (1237 aa)
TNFRSF1ATNF receptor superfamily member 1A. (502 aa)
MAPK9Mitogen-activated protein kinase. (433 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (286 aa)
ENSUAMP00000027845Uncharacterized protein. (347 aa)
ENSUAMP00000027844Nuc_recep-AF1 domain-containing protein. (202 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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