STRINGSTRING
ENSUAMP00000011731 ENSUAMP00000011731 ENSUAMP00000000176 ENSUAMP00000000176 GNA11 GNA11 ATP1B2 ATP1B2 ENSUAMP00000002341 ENSUAMP00000002341 STAR STAR ENSUAMP00000004542 ENSUAMP00000004542 PLCB2 PLCB2 CACNA1I CACNA1I ATF4 ATF4 SCARB1 SCARB1 ATP1B4 ATP1B4 ATP1A1 ATP1A1 CACNA1S CACNA1S ITPR3 ITPR3 ADCY9 ADCY9 ENSUAMP00000005950 ENSUAMP00000005950 ENSUAMP00000007288 ENSUAMP00000007288 ATP2B4 ATP2B4 ENSUAMP00000007617 ENSUAMP00000007617 ORAI1 ORAI1 PRKCB PRKCB ENSUAMP00000008027 ENSUAMP00000008027 ADCY2 ADCY2 CALML5 CALML5 ADCY3 ADCY3 ATP2B1 ATP2B1 PRKD1 PRKD1 ENSUAMP00000009775 ENSUAMP00000009775 ATF2 ATF2 PRKCA PRKCA PLCB1 PLCB1 POMC POMC CACNA1G CACNA1G LIPE LIPE CALML6 CALML6 CAMK1 CAMK1 AGTR1 AGTR1 NR4A2 NR4A2 MC2R MC2R CACNA1H CACNA1H ATP1A2 ATP1A2 ATF1 ATF1 ENSUAMP00000017524 ENSUAMP00000017524 CACNA1D CACNA1D ENSUAMP00000018707 ENSUAMP00000018707 KCNJ5 KCNJ5 PRKD3 PRKD3 ENSUAMP00000019174 ENSUAMP00000019174 ENSUAMP00000019181 ENSUAMP00000019181 PLCB3 PLCB3 CALML4 CALML4 LDLR LDLR CAMK2B CAMK2B PRKCG PRKCG ENSUAMP00000020485 ENSUAMP00000020485 ATF6B ATF6B GNAQ GNAQ CAMK1G CAMK1G CALM3 CALM3 PRKD2 PRKD2 KCNK9 KCNK9 ENSUAMP00000023102 ENSUAMP00000023102 ENSUAMP00000023165 ENSUAMP00000023165 DAGLA DAGLA CREB1 CREB1 ATP1B3 ATP1B3 CREB3L3 CREB3L3 NPPA NPPA ENSUAMP00000025300 ENSUAMP00000025300 ENSUAMP00000025311 ENSUAMP00000025311 ATP1A4 ATP1A4 ENSUAMP00000025726 ENSUAMP00000025726 ENSUAMP00000026030 ENSUAMP00000026030 CREB5 CREB5 ADCY5 ADCY5 ADCY1 ADCY1 GNAS GNAS PLCB4 PLCB4 CACNA1F CACNA1F CYP21A2 CYP21A2 DAGLB DAGLB ENSUAMP00000030764 ENSUAMP00000030764 ATP1B1 ATP1B1 CREB3L4 CREB3L4 CYP11A1 CYP11A1 ADCY4 ADCY4 ATP2B2 ATP2B2 ENSUAMP00000032382 ENSUAMP00000032382 ADCY7 ADCY7 ENSUAMP00000032618 ENSUAMP00000032618 ENSUAMP00000032699 ENSUAMP00000032699 ENSUAMP00000032843 ENSUAMP00000032843 ARSI ARSI PRKACB PRKACB ENSUAMP00000034830 ENSUAMP00000034830 ENSUAMP00000034960 ENSUAMP00000034960 CREB3L1 CREB3L1 CREB3 CREB3 CALM2 CALM2 ENSUAMP00000035681 ENSUAMP00000035681 ADCY6 ADCY6 PDE2A PDE2A ATP2B3 ATP2B3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000011731Ion_trans domain-containing protein. (408 aa)
ENSUAMP00000000176Protein kinase domain-containing protein. (82 aa)
GNA11G protein subunit alpha 11. (353 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
ENSUAMP00000002341Uncharacterized protein. (957 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
ENSUAMP00000004542Uncharacterized protein. (171 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1166 aa)
CACNA1ICalcium voltage-gated channel subunit alpha1 I. (2118 aa)
ATF4Activating transcription factor 4. (351 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (543 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (348 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1021 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1872 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2656 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1338 aa)
ENSUAMP00000005950SERPIN domain-containing protein; Belongs to the serpin family. (366 aa)
ENSUAMP00000007288Ca_chan_IQ domain-containing protein. (832 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1260 aa)
ENSUAMP00000007617Protein kinase domain-containing protein. (271 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (305 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (651 aa)
ENSUAMP00000008027Uncharacterized protein. (123 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
CALML5Calmodulin like 5. (156 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (973 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1214 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (848 aa)
ENSUAMP00000009775C2 domain-containing protein. (151 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
PRKCAProtein kinase C alpha; Belongs to the protein kinase superfamily. (484 aa)
PLCB1Phosphoinositide phospholipase C. (658 aa)
POMCProopiomelanocortin. (223 aa)
CACNA1GCalcium voltage-gated channel subunit alpha1 G. (2369 aa)
LIPELipase E, hormone sensitive type. (805 aa)
CALML6Calmodulin like 6. (180 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (370 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
MC2RMelanocortin 2 receptor. (297 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2205 aa)
ATP1A2ATPase Na+/K+ transporting subunit alpha 2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1127 aa)
ATF1Activating transcription factor 1. (270 aa)
ENSUAMP00000017524Uncharacterized protein. (542 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2160 aa)
ENSUAMP00000018707SERPIN domain-containing protein; Belongs to the serpin family. (416 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
PRKD3Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (876 aa)
ENSUAMP00000019174CaMKII_AD domain-containing protein. (267 aa)
ENSUAMP00000019181Protein kinase domain-containing protein. (206 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
CALML4Calmodulin like 4. (153 aa)
LDLRLow density lipoprotein receptor. (856 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (589 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (714 aa)
ENSUAMP00000020485Protein kinase domain-containing protein. (108 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
GNAQG protein subunit alpha q. (352 aa)
CAMK1GCalcium/calmodulin dependent protein kinase IG; Belongs to the protein kinase superfamily. (476 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (149 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (840 aa)
KCNK9Potassium channel subfamily K member. (374 aa)
ENSUAMP00000023102Uncharacterized protein. (1102 aa)
ENSUAMP00000023165Protein kinase domain-containing protein. (270 aa)
DAGLADiacylglycerol lipase alpha. (1038 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (280 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (457 aa)
NPPANatriuretic peptide A. (182 aa)
ENSUAMP00000025300Non-specific serine/threonine protein kinase. (254 aa)
ENSUAMP00000025311Uncharacterized protein. (295 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1011 aa)
ENSUAMP00000025726annotation not available (113 aa)
ENSUAMP00000026030Uncharacterized protein. (236 aa)
CREB5cAMP responsive element binding protein 5. (327 aa)
ADCY5Adenylate cyclase 5. (940 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
GNASGNAS complex locus. (994 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1136 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1866 aa)
CYP21A2Cytochrome P450 family 21 subfamily A member 2; Belongs to the cytochrome P450 family. (493 aa)
DAGLBDiacylglycerol lipase beta. (671 aa)
ENSUAMP00000030764Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1123 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (247 aa)
CYP11A1Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (482 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1250 aa)
ENSUAMP00000032382CaMKII_AD domain-containing protein. (189 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
ENSUAMP00000032618Uncharacterized protein. (68 aa)
ENSUAMP000000326993Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (373 aa)
ENSUAMP00000032843Uncharacterized protein. (186 aa)
ARSIArylsulfatase family member I. (573 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (361 aa)
ENSUAMP00000034830Uncharacterized protein. (1872 aa)
ENSUAMP00000034960C2H2-type domain-containing protein. (123 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
CREB3cAMP responsive element binding protein 3. (352 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (163 aa)
ENSUAMP00000035681Protein kinase domain-containing protein. (217 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
PDE2APhosphodiesterase. (975 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1254 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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