STRINGSTRING
PLCB4 PLCB4 ENSUAMP00000000176 ENSUAMP00000000176 GNA11 GNA11 ATP1B2 ATP1B2 DAGLA DAGLA ENSUAMP00000023165 ENSUAMP00000023165 ENSUAMP00000023102 ENSUAMP00000023102 KCNK9 KCNK9 PRKD2 PRKD2 CALM3 CALM3 CAMK1G CAMK1G GNAQ GNAQ ATF6B ATF6B ENSUAMP00000020485 ENSUAMP00000020485 PRKCG PRKCG CAMK2B CAMK2B LDLR LDLR CALML4 CALML4 PLCB3 PLCB3 ENSUAMP00000019181 ENSUAMP00000019181 ENSUAMP00000019174 ENSUAMP00000019174 PRKD3 PRKD3 ATP1B3 ATP1B3 KCNJ5 KCNJ5 ENSUAMP00000018707 ENSUAMP00000018707 CACNA1D CACNA1D ENSUAMP00000017524 ENSUAMP00000017524 ATF1 ATF1 ATP1A2 ATP1A2 CACNA1H CACNA1H MC2R MC2R NR4A2 NR4A2 AGTR1 AGTR1 CAMK1 CAMK1 CALML6 CALML6 LIPE LIPE CACNA1G CACNA1G POMC POMC ENSUAMP00000011731 ENSUAMP00000011731 PLCB1 PLCB1 PRKCA PRKCA ATF2 ATF2 ENSUAMP00000009775 ENSUAMP00000009775 PRKD1 PRKD1 ATP2B1 ATP2B1 ADCY3 ADCY3 CALML5 CALML5 ADCY2 ADCY2 ENSUAMP00000008027 ENSUAMP00000008027 PRKCB PRKCB ORAI1 ORAI1 ENSUAMP00000007617 ENSUAMP00000007617 ATP2B4 ATP2B4 ENSUAMP00000007288 ENSUAMP00000007288 ENSUAMP00000005950 ENSUAMP00000005950 ADCY9 ADCY9 ITPR3 ITPR3 CACNA1S CACNA1S ATP1A1 ATP1A1 ATP1B4 ATP1B4 SCARB1 SCARB1 ATF4 ATF4 CACNA1I CACNA1I PLCB2 PLCB2 ENSUAMP00000004542 ENSUAMP00000004542 STAR STAR ENSUAMP00000002341 ENSUAMP00000002341 ENSUAMP00000035681 ENSUAMP00000035681 CALM2 CALM2 CREB3 CREB3 CREB3L1 CREB3L1 ENSUAMP00000034960 ENSUAMP00000034960 ENSUAMP00000034830 ENSUAMP00000034830 PRKACB PRKACB ARSI ARSI ENSUAMP00000032843 ENSUAMP00000032843 ENSUAMP00000032699 ENSUAMP00000032699 ENSUAMP00000032618 ENSUAMP00000032618 ADCY7 ADCY7 ENSUAMP00000032382 ENSUAMP00000032382 ATP2B2 ATP2B2 ADCY4 ADCY4 CYP11A1 CYP11A1 CREB3L4 CREB3L4 ATP1B1 ATP1B1 ENSUAMP00000030764 ENSUAMP00000030764 DAGLB DAGLB CYP21A2 CYP21A2 CACNA1F CACNA1F GNAS GNAS ADCY1 ADCY1 ADCY5 ADCY5 CREB5 CREB5 ENSUAMP00000026030 ENSUAMP00000026030 ENSUAMP00000025726 ENSUAMP00000025726 ATP1A4 ATP1A4 ENSUAMP00000025311 ENSUAMP00000025311 ENSUAMP00000025300 ENSUAMP00000025300 NPPA NPPA CREB3L3 CREB3L3 CREB1 CREB1 ADCY6 ADCY6 PDE2A PDE2A ATP2B3 ATP2B3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1136 aa)
ENSUAMP00000000176Protein kinase domain-containing protein. (82 aa)
GNA11G protein subunit alpha 11. (353 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
DAGLADiacylglycerol lipase alpha. (1038 aa)
ENSUAMP00000023165Protein kinase domain-containing protein. (270 aa)
ENSUAMP00000023102Uncharacterized protein. (1102 aa)
KCNK9Potassium channel subfamily K member. (374 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (840 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (149 aa)
CAMK1GCalcium/calmodulin dependent protein kinase IG; Belongs to the protein kinase superfamily. (476 aa)
GNAQG protein subunit alpha q. (352 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
ENSUAMP00000020485Protein kinase domain-containing protein. (108 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (714 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (589 aa)
LDLRLow density lipoprotein receptor. (856 aa)
CALML4Calmodulin like 4. (153 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
ENSUAMP00000019181Protein kinase domain-containing protein. (206 aa)
ENSUAMP00000019174CaMKII_AD domain-containing protein. (267 aa)
PRKD3Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (876 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (280 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
ENSUAMP00000018707SERPIN domain-containing protein; Belongs to the serpin family. (416 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2160 aa)
ENSUAMP00000017524Uncharacterized protein. (542 aa)
ATF1Activating transcription factor 1. (270 aa)
ATP1A2ATPase Na+/K+ transporting subunit alpha 2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1127 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2205 aa)
MC2RMelanocortin 2 receptor. (297 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (370 aa)
CALML6Calmodulin like 6. (180 aa)
LIPELipase E, hormone sensitive type. (805 aa)
CACNA1GCalcium voltage-gated channel subunit alpha1 G. (2369 aa)
POMCProopiomelanocortin. (223 aa)
ENSUAMP00000011731Ion_trans domain-containing protein. (408 aa)
PLCB1Phosphoinositide phospholipase C. (658 aa)
PRKCAProtein kinase C alpha; Belongs to the protein kinase superfamily. (484 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ENSUAMP00000009775C2 domain-containing protein. (151 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (848 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1214 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (973 aa)
CALML5Calmodulin like 5. (156 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
ENSUAMP00000008027Uncharacterized protein. (123 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (651 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (305 aa)
ENSUAMP00000007617Protein kinase domain-containing protein. (271 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1260 aa)
ENSUAMP00000007288Ca_chan_IQ domain-containing protein. (832 aa)
ENSUAMP00000005950SERPIN domain-containing protein; Belongs to the serpin family. (366 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1338 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2656 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1872 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1021 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (348 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (543 aa)
ATF4Activating transcription factor 4. (351 aa)
CACNA1ICalcium voltage-gated channel subunit alpha1 I. (2118 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1166 aa)
ENSUAMP00000004542Uncharacterized protein. (171 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
ENSUAMP00000002341Uncharacterized protein. (957 aa)
ENSUAMP00000035681Protein kinase domain-containing protein. (217 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (163 aa)
CREB3cAMP responsive element binding protein 3. (352 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
ENSUAMP00000034960C2H2-type domain-containing protein. (123 aa)
ENSUAMP00000034830Uncharacterized protein. (1872 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (361 aa)
ARSIArylsulfatase family member I. (573 aa)
ENSUAMP00000032843Uncharacterized protein. (186 aa)
ENSUAMP000000326993Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (373 aa)
ENSUAMP00000032618Uncharacterized protein. (68 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
ENSUAMP00000032382CaMKII_AD domain-containing protein. (189 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1250 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
CYP11A1Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (482 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (247 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
ENSUAMP00000030764Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1123 aa)
DAGLBDiacylglycerol lipase beta. (671 aa)
CYP21A2Cytochrome P450 family 21 subfamily A member 2; Belongs to the cytochrome P450 family. (493 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1866 aa)
GNASGNAS complex locus. (994 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
ADCY5Adenylate cyclase 5. (940 aa)
CREB5cAMP responsive element binding protein 5. (327 aa)
ENSUAMP00000026030Uncharacterized protein. (236 aa)
ENSUAMP00000025726annotation not available (113 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1011 aa)
ENSUAMP00000025311Uncharacterized protein. (295 aa)
ENSUAMP00000025300Non-specific serine/threonine protein kinase. (254 aa)
NPPANatriuretic peptide A. (182 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (457 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
PDE2APhosphodiesterase. (975 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1254 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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