STRINGSTRING
ENSUAMP00000011731 ENSUAMP00000011731 ATF2 ATF2 ADCY3 ADCY3 ADCY2 ADCY2 ENSUAMP00000008027 ENSUAMP00000008027 ORAI1 ORAI1 ENSUAMP00000007288 ENSUAMP00000007288 ENSUAMP00000005950 ENSUAMP00000005950 ADCY9 ADCY9 ITPR3 ITPR3 CACNA1S CACNA1S ENSUAMP00000005012 ENSUAMP00000005012 SCARB1 SCARB1 ATF4 ATF4 CACNA1I CACNA1I PLCB2 PLCB2 ENSUAMP00000004542 ENSUAMP00000004542 STAR STAR KCNA10 KCNA10 KCNA2 KCNA2 KCNA3 KCNA3 ENSUAMP00000002341 ENSUAMP00000002341 GNA11 GNA11 ADCY6 ADCY6 CREB3 CREB3 CYP17A1 CYP17A1 CREB3L1 CREB3L1 ENSUAMP00000034960 ENSUAMP00000034960 ENSUAMP00000034830 ENSUAMP00000034830 PRKACB PRKACB ENSUAMP00000032843 ENSUAMP00000032843 ENSUAMP00000032699 ENSUAMP00000032699 ENSUAMP00000032618 ENSUAMP00000032618 ADCY7 ADCY7 ADCY4 ADCY4 CYP11A1 CYP11A1 CREB3L4 CREB3L4 KCNA1 KCNA1 NR0B1 NR0B1 CYP21A2 CYP21A2 CACNA1F CACNA1F PLCB4 PLCB4 GNAS GNAS ADCY1 ADCY1 ADCY5 ADCY5 CREB5 CREB5 ENSUAMP00000026030 ENSUAMP00000026030 ENSUAMP00000024746 ENSUAMP00000024746 CREB3L3 CREB3L3 CREB1 CREB1 KCNA5 KCNA5 KCNK2 KCNK2 ENSUAMP00000023102 ENSUAMP00000023102 NCEH1 NCEH1 KCNA4 KCNA4 GNAQ GNAQ ATF6B ATF6B LDLR LDLR PLCB3 PLCB3 ENSUAMP00000018707 ENSUAMP00000018707 CACNA1D CACNA1D ENSUAMP00000017524 ENSUAMP00000017524 CACNA1H CACNA1H MC2R MC2R ENSUAMP00000015348 ENSUAMP00000015348 AGTR1 AGTR1 SP1 SP1 CACNA1G CACNA1G POMC POMC PDE8A PDE8A PLCB1 PLCB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000011731Ion_trans domain-containing protein. (408 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (973 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
ENSUAMP00000008027Uncharacterized protein. (123 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (305 aa)
ENSUAMP00000007288Ca_chan_IQ domain-containing protein. (832 aa)
ENSUAMP00000005950SERPIN domain-containing protein; Belongs to the serpin family. (366 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1338 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2656 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1872 aa)
ENSUAMP00000005012Uncharacterized protein. (59 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (543 aa)
ATF4Activating transcription factor 4. (351 aa)
CACNA1ICalcium voltage-gated channel subunit alpha1 I. (2118 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1166 aa)
ENSUAMP00000004542Uncharacterized protein. (171 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
KCNA10Potassium voltage-gated channel subfamily A member 10; Belongs to the potassium channel family. (511 aa)
KCNA2Potassium voltage-gated channel subfamily A member 2; Belongs to the potassium channel family. (499 aa)
KCNA3Potassium voltage-gated channel subfamily A member 3; Belongs to the potassium channel family. (532 aa)
ENSUAMP00000002341Uncharacterized protein. (957 aa)
GNA11G protein subunit alpha 11. (353 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
CREB3cAMP responsive element binding protein 3. (352 aa)
CYP17A1Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family. (356 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
ENSUAMP00000034960C2H2-type domain-containing protein. (123 aa)
ENSUAMP00000034830Uncharacterized protein. (1872 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (361 aa)
ENSUAMP00000032843Uncharacterized protein. (186 aa)
ENSUAMP000000326993Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (373 aa)
ENSUAMP00000032618Uncharacterized protein. (68 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
CYP11A1Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (482 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (247 aa)
KCNA1Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1. (471 aa)
CYP21A2Cytochrome P450 family 21 subfamily A member 2; Belongs to the cytochrome P450 family. (493 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1866 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1136 aa)
GNASGNAS complex locus. (994 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
ADCY5Adenylate cyclase 5. (940 aa)
CREB5cAMP responsive element binding protein 5. (327 aa)
ENSUAMP00000026030Uncharacterized protein. (236 aa)
ENSUAMP00000024746PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family. (350 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (457 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (603 aa)
KCNK2Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (385 aa)
ENSUAMP00000023102Uncharacterized protein. (1102 aa)
NCEH1Neutral cholesterol ester hydrolase 1. (402 aa)
KCNA4Potassium voltage-gated channel subfamily A member 4; Belongs to the potassium channel family. (652 aa)
GNAQG protein subunit alpha q. (352 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
LDLRLow density lipoprotein receptor. (856 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
ENSUAMP00000018707SERPIN domain-containing protein; Belongs to the serpin family. (416 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2160 aa)
ENSUAMP00000017524Uncharacterized protein. (542 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2205 aa)
MC2RMelanocortin 2 receptor. (297 aa)
ENSUAMP00000015348Uncharacterized protein. (236 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
SP1Sp1 transcription factor. (780 aa)
CACNA1GCalcium voltage-gated channel subunit alpha1 G. (2369 aa)
POMCProopiomelanocortin. (223 aa)
PDE8APhosphodiesterase. (779 aa)
PLCB1Phosphoinositide phospholipase C. (658 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.