121 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MMP13	Matrix metallopeptidase 13. (484 aa)
	ENSUAMP00000034830	Uncharacterized protein. (1872 aa)
	PTH1R	Parathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (594 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (361 aa)
	ENSUAMP00000032909	Uncharacterized protein. (592 aa)
	ENSUAMP00000032843	Uncharacterized protein. (186 aa)
	ENSUAMP00000032618	Uncharacterized protein. (68 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
	ADCY4	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
	CREB3L4	cAMP responsive element binding protein 3 like 4. (247 aa)
	MAPK3	Mitogen-activated protein kinase. (354 aa)
	PDE4D	Phosphodiesterase. (585 aa)
	HBEGF	Heparin binding EGF like growth factor. (208 aa)
	SLC9A3R1	Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (366 aa)
	ENSUAMP00000030787	Uncharacterized protein. (84 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (564 aa)
	SLC34A1	Solute carrier family 34 member 1. (582 aa)
	ENSUAMP00000030381	Uncharacterized protein. (67 aa)
	PTHLH	Parathyroid hormone like hormone. (175 aa)
	MEF2C	Myocyte enhancer factor 2C. (483 aa)
	MMP14	Matrix metallopeptidase 14. (582 aa)
	GATA3	GATA binding protein 3. (444 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1136 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (164 aa)
	GNAS	GNAS complex locus. (994 aa)
	ENSUAMP00000028126	NAC-A/B domain-containing protein. (219 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
	ADCY5	Adenylate cyclase 5. (940 aa)
	PTH	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
	ENSUAMP00000027845	Uncharacterized protein. (347 aa)
	ENSUAMP00000027844	Nuc_recep-AF1 domain-containing protein. (202 aa)
	SLC34A3	Solute carrier family 34 member 3. (602 aa)
	ENSUAMP00000027729	Uncharacterized protein. (72 aa)
	PDE4B	Phosphodiesterase. (682 aa)
	RXRA	Retinoid X receptor alpha. (469 aa)
	CREB5	cAMP responsive element binding protein 5. (327 aa)
	ENSUAMP00000026030	Uncharacterized protein. (236 aa)
	FGFR1	Fibroblast growth factor receptor. (848 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
	ENSUAMP00000025300	Non-specific serine/threonine protein kinase. (254 aa)
	ARR3	Arrestin 3. (380 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (728 aa)
	CREB3L3	cAMP responsive element binding protein 3 like 3. (457 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	PDE4A	Phosphodiesterase 4A; Belongs to the cyclic nucleotide phosphodiesterase family. (872 aa)
	ARRB1	Arrestin beta 1. (380 aa)
	MEF2A	Myocyte enhancer factor 2A. (466 aa)
	ENSUAMP00000023102	Uncharacterized protein. (1102 aa)
	SOST	Sclerostin. (213 aa)
	ENSUAMP00000022227	Uncharacterized protein. (64 aa)
	ENSUAMP00000022172	Uncharacterized protein. (157 aa)
	MMP17	Matrix metallopeptidase 17. (592 aa)
	MMP15	Matrix metallopeptidase 15. (640 aa)
	ENSUAMP00000021381	Protein kinase domain-containing protein. (363 aa)
	ENSUAMP00000021380	Uncharacterized protein. (424 aa)
	CYP24A1	Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family. (516 aa)
	GNAQ	G protein subunit alpha q. (352 aa)
	ATF6B	Activating transcription factor 6 beta. (708 aa)
	PRKCG	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (714 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
	ENSUAMP00000018363	Uncharacterized protein. (1484 aa)
	ENSUAMP00000017364	Uncharacterized protein. (53 aa)
	BGLAP	Osteocalcin; Binds strongly to apatite and calcium. (93 aa)
	MEF2D	Myocyte enhancer factor 2D. (515 aa)
	ENSUAMP00000016793	BZIP domain-containing protein. (179 aa)
	CYP27B1	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
	TRPV5	Transient receptor potential cation channel subfamily V member 5; Belongs to the transient receptor (TC 1.A.4) family. (732 aa)
	ENSUAMP00000015785	NAC-A/B domain-containing protein. (126 aa)
	NR4A2	Nuclear receptor subfamily 4 group A member 2. (598 aa)
	ENSUAMP00000014629	Uncharacterized protein. (105 aa)
	SP1	Sp1 transcription factor. (780 aa)
	MAPK1	Mitogen-activated protein kinase. (364 aa)
	ENSUAMP00000012405	Uncharacterized protein. (110 aa)
	BCL2	BCL2 apoptosis regulator. (205 aa)
	ENSUAMP00000011731	Ion_trans domain-containing protein. (408 aa)
	ENSUAMP00000011111	DH domain-containing protein. (317 aa)
	ENSUAMP00000010849	PDE4_UCR domain-containing protein. (136 aa)
	MAFB	MAF bZIP transcription factor B. (323 aa)
	PLCB1	Phosphoinositide phospholipase C. (658 aa)
	PRKCA	Protein kinase C alpha; Belongs to the protein kinase superfamily. (484 aa)
	SLC34A2	Solute carrier family 34 member 2. (693 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
	GCM2	Glial cells missing transcription factor 2. (506 aa)
	MMP24	Matrix metallopeptidase 24. (614 aa)
	MMP25	Matrix metallopeptidase 25. (564 aa)
	GCM1	Glial cells missing transcription factor 1. (435 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (973 aa)
	RHOB	Ras homolog family member B. (172 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
	ARHGEF1	Rho guanine nucleotide exchange factor 1. (975 aa)
	GNAI3	G protein subunit alpha i3. (295 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (651 aa)
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (242 aa)
	FGF23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
	ENSUAMP00000006289	Uncharacterized protein. (158 aa)
	ARRB2	Arrestin beta 2. (405 aa)
	PLD2	Phospholipase. (1025 aa)
	ENSUAMP00000005976	Uncharacterized protein. (94 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1338 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2656 aa)
	ATF4	Activating transcription factor 4. (351 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1166 aa)
	ENSUAMP00000004602	DH domain-containing protein. (325 aa)
	ENSUAMP00000003880	Uncharacterized protein. (91 aa)
	ENSUAMP00000002341	Uncharacterized protein. (957 aa)
	LRP6	LDL receptor related protein 6. (1431 aa)
	KL	Klotho; Belongs to the glycosyl hydrolase 1 family. (705 aa)
	GNA11	G protein subunit alpha 11. (353 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
	GNA12	G protein subunit alpha 12. (350 aa)
	GNAI2	G protein subunit alpha i2. (436 aa)
	MMP16	Matrix metallopeptidase 16. (607 aa)
	ENSUAMP00000036162	Protein kinase domain-containing protein. (462 aa)
	ENSUAMP00000036154	Phosphodiesterase. (696 aa)
	CASR	Calcium sensing receptor. (1079 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
	RXRB	Retinoid X receptor beta. (532 aa)
	CREB3	cAMP responsive element binding protein 3. (352 aa)
	VDR	Vitamin D receptor. (427 aa)
	CREB3L1	cAMP responsive element binding protein 3 like 1. (520 aa)
	ENSUAMP00000034960	C2H2-type domain-containing protein. (123 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSUAMP00000028025	ENSUAMP00000008551	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.564
ADCY1	ADCY3	ENSUAMP00000028025	ENSUAMP00000008710	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.931
ADCY1	ADCY4	ENSUAMP00000028025	ENSUAMP00000032005	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.559
ADCY1	ADCY5	ENSUAMP00000028025	ENSUAMP00000027941	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 5.	0.539
ADCY1	ADCY6	ENSUAMP00000028025	ENSUAMP00000035722	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.542
ADCY1	ADCY7	ENSUAMP00000028025	ENSUAMP00000032396	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.666
ADCY1	ADCY9	ENSUAMP00000028025	ENSUAMP00000005924	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.646
ADCY1	ENSUAMP00000003880	ENSUAMP00000028025	ENSUAMP00000003880	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.807
ADCY1	ENSUAMP00000010849	ENSUAMP00000028025	ENSUAMP00000010849	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	PDE4_UCR domain-containing protein.	0.897
ADCY1	ENSUAMP00000014629	ENSUAMP00000028025	ENSUAMP00000014629	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.807
ADCY1	ENSUAMP00000022172	ENSUAMP00000028025	ENSUAMP00000022172	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.807
ADCY1	ENSUAMP00000025300	ENSUAMP00000028025	ENSUAMP00000025300	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase.	0.875
ADCY1	ENSUAMP00000026030	ENSUAMP00000028025	ENSUAMP00000026030	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.929
ADCY1	ENSUAMP00000032618	ENSUAMP00000028025	ENSUAMP00000032618	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.910
ADCY1	ENSUAMP00000036154	ENSUAMP00000028025	ENSUAMP00000036154	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.922
ADCY1	GNAI2	ENSUAMP00000028025	ENSUAMP00000037424	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i2.	0.807
ADCY1	GNAI3	ENSUAMP00000028025	ENSUAMP00000008046	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i3.	0.807
ADCY1	GNAS	ENSUAMP00000028025	ENSUAMP00000028340	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNAS complex locus.	0.910
ADCY1	PDE4A	ENSUAMP00000028025	ENSUAMP00000023831	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase 4A; Belongs to the cyclic nucleotide phosphodiesterase family.	0.922
ADCY1	PDE4B	ENSUAMP00000028025	ENSUAMP00000027685	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.926