STRINGSTRING
ENSUAMP00000028178 ENSUAMP00000028178 ENSUAMP00000028179 ENSUAMP00000028179 F3 F3 ENSUAMP00000028558 ENSUAMP00000028558 PLCB4 PLCB4 MAPK9 MAPK9 COL4A4 COL4A4 EDN1 EDN1 VEGFD VEGFD IL6 IL6 STAT5B STAT5B PLCD3 PLCD3 MAPK3 MAPK3 ENSUAMP00000031719 ENSUAMP00000031719 XK XK CYBB CYBB MAPK14 MAPK14 MAPK13 MAPK13 FN1 FN1 CCND1 CCND1 NOS3 NOS3 IL1B IL1B IL1A IL1A MMP2 MMP2 STAT1 STAT1 NOX1 NOX1 ENSUAMP00000035331 ENSUAMP00000035331 ENSUAMP00000035681 ENSUAMP00000035681 ENSUAMP00000036253 ENSUAMP00000036253 ENSUAMP00000036324 ENSUAMP00000036324 DIAPH1 DIAPH1 AKT2 AKT2 CCL2 CCL2 TGFB1 TGFB1 BAX BAX MAPK1 MAPK1 ERAS ERAS EGR1 EGR1 ENSUAMP00000000384 ENSUAMP00000000384 ENSUAMP00000001437 ENSUAMP00000001437 MFF MFF ENSUAMP00000002712 ENSUAMP00000002712 THBD THBD ENSUAMP00000002835 ENSUAMP00000002835 ENSUAMP00000003365 ENSUAMP00000003365 ENSUAMP00000003693 ENSUAMP00000003693 FOXO1 FOXO1 ENSUAMP00000004598 ENSUAMP00000004598 PLCB2 PLCB2 VCAM1 VCAM1 PLCD1 PLCD1 ENSUAMP00000005950 ENSUAMP00000005950 PIM1 PIM1 COL3A1 COL3A1 CDKN1B CDKN1B PRKCB PRKCB PLCG2 PLCG2 JAK2 JAK2 STAT3 STAT3 PRKCD PRKCD JUN JUN TGFBR2 TGFBR2 PIK3CA PIK3CA MAPK8 MAPK8 ENSUAMP00000009775 ENSUAMP00000009775 PLCG1 PLCG1 SERPINE1 SERPINE1 PIK3R1 PIK3R1 PRKCA PRKCA AKT1 AKT1 PLCB1 PLCB1 NFATC1 NFATC1 AKT3 AKT3 PLCE1 PLCE1 STAT5A STAT5A COL4A2 COL4A2 BCL2 BCL2 VEGFC VEGFC AGTR1 AGTR1 TNF TNF ENSUAMP00000015993 ENSUAMP00000015993 CDK4 CDK4 TGFB3 TGFB3 TGFBR1 TGFBR1 MAPK12 MAPK12 MAPK11 MAPK11 ENSUAMP00000017435 ENSUAMP00000017435 ENSUAMP00000017692 ENSUAMP00000017692 SMAD4 SMAD4 ENSUAMP00000018707 ENSUAMP00000018707 PLCB3 PLCB3 VEGFB VEGFB PIK3CD PIK3CD VEGFA VEGFA COL4A1 COL4A1 CXCL8 CXCL8 CASP3 CASP3 AGER AGER TGFB2 TGFB2 KRAS KRAS MMP20 MMP20 NFKB1 NFKB1 ENSUAMP00000022131 ENSUAMP00000022131 MAPK10 MAPK10 ENSUAMP00000023048 ENSUAMP00000023048 ENSUAMP00000023119 ENSUAMP00000023119 ENSUAMP00000025300 ENSUAMP00000025300 COL4A6 COL4A6 ENSUAMP00000026301 ENSUAMP00000026301 CDC42 CDC42 SMAD3 SMAD3 SMAD2 SMAD2 RELA RELA COL1A2 COL1A2 ENSUAMP00000026993 ENSUAMP00000026993 PLCD4 PLCD4 NOX3 NOX3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000028178Uncharacterized protein. (311 aa)
ENSUAMP00000028179CSD domain-containing protein. (89 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (288 aa)
ENSUAMP00000028558Uncharacterized protein. (222 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1136 aa)
MAPK9Mitogen-activated protein kinase. (433 aa)
COL4A4Collagen type IV alpha 4 chain. (1177 aa)
EDN1Endothelin 1. (202 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (329 aa)
IL6Interleukin 6. (212 aa)
STAT5BSignal transducer and activator of transcription. (784 aa)
PLCD3Phosphoinositide phospholipase C. (783 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
ENSUAMP00000031719Uncharacterized protein. (627 aa)
XKXK-related protein. (433 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
FN1Fibronectin 1. (2385 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (294 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1202 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (244 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
STAT1Signal transducer and activator of transcription. (824 aa)
NOX1NADPH oxidase 1. (594 aa)
ENSUAMP00000035331Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (506 aa)
ENSUAMP00000035681Protein kinase domain-containing protein. (217 aa)
ENSUAMP00000036253Protein kinase domain-containing protein. (66 aa)
ENSUAMP00000036324Uncharacterized protein. (189 aa)
DIAPH1Diaphanous related formin 1. (1266 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CCL2C-C motif chemokine. (101 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
BAXBCL2 associated X, apoptosis regulator. (205 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
ERASES cell expressed Ras. (219 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
ENSUAMP00000000384NAD_binding_6 domain-containing protein. (147 aa)
ENSUAMP00000001437Uncharacterized protein. (607 aa)
MFFMitochondrial fission factor. (291 aa)
ENSUAMP00000002712Uncharacterized protein. (561 aa)
THBDThrombomodulin. (579 aa)
ENSUAMP00000002835ICAM_N domain-containing protein. (149 aa)
ENSUAMP00000003365Collagen IV NC1 domain-containing protein. (654 aa)
ENSUAMP00000003693Uncharacterized protein. (166 aa)
FOXO1Forkhead box O1. (660 aa)
ENSUAMP00000004598Uncharacterized protein. (299 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1166 aa)
VCAM1Vascular cell adhesion molecule 1. (702 aa)
PLCD1Phosphoinositide phospholipase C. (777 aa)
ENSUAMP00000005950SERPIN domain-containing protein; Belongs to the serpin family. (366 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (392 aa)
COL3A1Collagen type III alpha 1 chain. (997 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (200 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (651 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1252 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAPK8Mitogen-activated protein kinase. (456 aa)
ENSUAMP00000009775C2 domain-containing protein. (151 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1256 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (676 aa)
PRKCAProtein kinase C alpha; Belongs to the protein kinase superfamily. (484 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
PLCB1Phosphoinositide phospholipase C. (658 aa)
NFATC1Nuclear factor of activated T cells 1. (931 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PLCE1Phosphoinositide phospholipase C. (1942 aa)
STAT5ASignal transducer and activator of transcription. (797 aa)
COL4A2Collagen type IV alpha 2 chain. (1617 aa)
BCL2BCL2 apoptosis regulator. (205 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (391 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (230 aa)
ENSUAMP00000015993Uncharacterized protein. (98 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (340 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
MAPK12Mitogen-activated protein kinase 12. (373 aa)
MAPK11Mitogen-activated protein kinase. (357 aa)
ENSUAMP00000017435Uncharacterized protein. (459 aa)
ENSUAMP00000017692Uncharacterized protein. (704 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ENSUAMP00000018707SERPIN domain-containing protein; Belongs to the serpin family. (416 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (191 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (516 aa)
COL4A1Collagen type IV alpha 1 chain. (1573 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (266 aa)
AGERAdvanced glycosylation end-product specific receptor. (410 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (439 aa)
KRASKRAS proto-oncogene, GTPase. (188 aa)
MMP20Matrix metallopeptidase 20. (483 aa)
NFKB1Nuclear factor kappa B subunit 1. (972 aa)
ENSUAMP00000022131Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (636 aa)
MAPK10Mitogen-activated protein kinase. (422 aa)
ENSUAMP00000023048PB1 domain-containing protein. (123 aa)
ENSUAMP00000023119Uncharacterized protein. (607 aa)
ENSUAMP00000025300Non-specific serine/threonine protein kinase. (254 aa)
COL4A6Collagen type IV alpha 6 chain. (1544 aa)
ENSUAMP00000026301Ig-like domain-containing protein. (331 aa)
CDC42Cell division cycle 42. (191 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
RELARELA proto-oncogene, NF-kB subunit. (508 aa)
COL1A2Collagen type I alpha 2 chain. (1243 aa)
ENSUAMP00000026993Uncharacterized protein. (118 aa)
PLCD4Phosphoinositide phospholipase C. (799 aa)
NOX3NADPH oxidase 3. (567 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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