STRINGSTRING
ATF2 ATF2 ENSUAMP00000009789 ENSUAMP00000009789 CCNE1 CCNE1 WNT2 WNT2 ADCY3 ADCY3 ADCY2 ADCY2 CDK6 CDK6 GNAI3 GNAI3 ENSUAMP00000008027 ENSUAMP00000008027 WNT2B WNT2B TCF7 TCF7 ORAI1 ORAI1 ENSUAMP00000007617 ENSUAMP00000007617 CDKN1B CDKN1B ENSUAMP00000007288 ENSUAMP00000007288 DVL3 DVL3 AIP AIP RASD1 RASD1 RBBP5 RBBP5 ENSUAMP00000005950 ENSUAMP00000005950 ADCY9 ADCY9 ITPR3 ITPR3 CACNA1S CACNA1S ENSUAMP00000005012 ENSUAMP00000005012 SCARB1 SCARB1 ATF4 ATF4 CACNA1I CACNA1I PLCB2 PLCB2 ENSUAMP00000004542 ENSUAMP00000004542 E2F2 E2F2 STAR STAR ASH2L ASH2L KCNA10 KCNA10 KCNA2 KCNA2 KCNA3 KCNA3 ENSUAMP00000003880 ENSUAMP00000003880 WNT8B WNT8B WNT11 WNT11 ENSUAMP00000002341 ENSUAMP00000002341 FZD2 FZD2 WNT6 WNT6 ENSUAMP00000001524 ENSUAMP00000001524 ENSUAMP00000001392 ENSUAMP00000001392 AXIN2 AXIN2 CDKN2B CDKN2B ENSUAMP00000000622 ENSUAMP00000000622 GNA11 GNA11 ENSUAMP00000000176 ENSUAMP00000000176 APC APC GNAI2 GNAI2 TCF7L1 TCF7L1 FZD1 FZD1 ENSUAMP00000036162 ENSUAMP00000036162 WNT9B WNT9B WNT3 WNT3 ENSUAMP00000035777 ENSUAMP00000035777 WNT7A WNT7A ADCY6 ADCY6 WNT10B WNT10B WNT1 WNT1 KMT2D KMT2D CREB3 CREB3 ENSUAMP00000035193 ENSUAMP00000035193 ENSUAMP00000035192 ENSUAMP00000035192 CYP17A1 CYP17A1 CREB3L1 CREB3L1 ENSUAMP00000034960 ENSUAMP00000034960 ENSUAMP00000034830 ENSUAMP00000034830 E2F3 E2F3 E2F1 E2F1 PRKACB PRKACB ARSI ARSI FZD7 FZD7 ENSUAMP00000032909 ENSUAMP00000032909 ENSUAMP00000032843 ENSUAMP00000032843 ENSUAMP00000032699 ENSUAMP00000032699 ENSUAMP00000032618 ENSUAMP00000032618 CCND1 CCND1 ADCY7 ADCY7 ENSUAMP00000032382 ENSUAMP00000032382 ADCY4 ADCY4 CYP11A1 CYP11A1 CREB3L4 CREB3L4 USP8 USP8 MAPK3 MAPK3 KCNA1 KCNA1 ENSUAMP00000031131 ENSUAMP00000031131 MAP2K1 MAP2K1 ENSUAMP00000030280 ENSUAMP00000030280 CYP21A2 CYP21A2 CACNA1F CACNA1F ENSUAMP00000029031 ENSUAMP00000029031 PLCB4 PLCB4 CDKN1A CDKN1A GNAS GNAS ADCY1 ADCY1 ADCY5 ADCY5 FZD10 FZD10 CREB5 CREB5 WNT4 WNT4 TCF7L2 TCF7L2 ENSUAMP00000026030 ENSUAMP00000026030 CDKN2C CDKN2C WNT8A WNT8A ENSUAMP00000024746 ENSUAMP00000024746 FH FH BRAF BRAF CREB3L3 CREB3L3 WDR5B WDR5B CREB1 CREB1 KCNA5 KCNA5 KCNK2 KCNK2 WNT5A WNT5A ENSUAMP00000023102 ENSUAMP00000023102 ENSUAMP00000022968 ENSUAMP00000022968 ENSUAMP00000022339 ENSUAMP00000022339 ENSUAMP00000022336 ENSUAMP00000022336 ENSUAMP00000022172 ENSUAMP00000022172 FZD3 FZD3 WNT16 WNT16 NCEH1 NCEH1 KCNA4 KCNA4 CRHR2 CRHR2 FZD9 FZD9 ENSUAMP00000021070 ENSUAMP00000021070 GNAQ GNAQ ATF6B ATF6B AXIN1 AXIN1 CAMK2B CAMK2B FZD6 FZD6 LDLR LDLR PLCB3 PLCB3 ENSUAMP00000019181 ENSUAMP00000019181 ENSUAMP00000019174 ENSUAMP00000019174 ENSUAMP00000018707 ENSUAMP00000018707 DVL2 DVL2 APC2 APC2 ENSUAMP00000018470 ENSUAMP00000018470 WNT10A WNT10A RAP1A RAP1A CACNA1D CACNA1D ARMC5 ARMC5 ENSUAMP00000017524 ENSUAMP00000017524 CTNNB1 CTNNB1 CDK4 CDK4 CACNA1H CACNA1H DVL1 DVL1 MC2R MC2R WNT7B WNT7B ENSUAMP00000015348 ENSUAMP00000015348 MEN1 MEN1 AGTR1 AGTR1 RB1 RB1 ENSUAMP00000014629 ENSUAMP00000014629 SP1 SP1 MAPK1 MAPK1 ARNT ARNT WNT9A WNT9A WNT3A WNT3A CACNA1G CACNA1G ENSUAMP00000012266 ENSUAMP00000012266 GSK3B GSK3B POMC POMC PDE8A PDE8A ENSUAMP00000011731 ENSUAMP00000011731 FZD5 FZD5 FZD4 FZD4 RAP1B RAP1B PLCB1 PLCB1 WDR5 WDR5 CRH CRH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ENSUAMP00000009789Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (3862 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (370 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (973 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
GNAI3G protein subunit alpha i3. (295 aa)
ENSUAMP00000008027Uncharacterized protein. (123 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (299 aa)
TCF7Transcription factor 7. (443 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (305 aa)
ENSUAMP00000007617Protein kinase domain-containing protein. (271 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (200 aa)
ENSUAMP00000007288Ca_chan_IQ domain-containing protein. (832 aa)
DVL3Dishevelled segment polarity protein 3. (716 aa)
AIPPeptidylprolyl isomerase. (330 aa)
RASD1Ras related dexamethasone induced 1. (186 aa)
RBBP5RB binding protein 5, histone lysine methyltransferase complex subunit. (475 aa)
ENSUAMP00000005950SERPIN domain-containing protein; Belongs to the serpin family. (366 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1338 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2656 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1872 aa)
ENSUAMP00000005012Uncharacterized protein. (59 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (543 aa)
ATF4Activating transcription factor 4. (351 aa)
CACNA1ICalcium voltage-gated channel subunit alpha1 I. (2118 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1166 aa)
ENSUAMP00000004542Uncharacterized protein. (171 aa)
E2F2E2F transcription factor 2. (431 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
ASH2LASH2 like, histone lysine methyltransferase complex subunit. (628 aa)
KCNA10Potassium voltage-gated channel subfamily A member 10; Belongs to the potassium channel family. (511 aa)
KCNA2Potassium voltage-gated channel subfamily A member 2; Belongs to the potassium channel family. (499 aa)
KCNA3Potassium voltage-gated channel subfamily A member 3; Belongs to the potassium channel family. (532 aa)
ENSUAMP00000003880Uncharacterized protein. (91 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (332 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
ENSUAMP00000002341Uncharacterized protein. (957 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (563 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
ENSUAMP00000001524Uncharacterized protein. (75 aa)
ENSUAMP00000001392Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (545 aa)
AXIN2Axin 2. (843 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
ENSUAMP00000000622Uncharacterized protein. (151 aa)
GNA11G protein subunit alpha 11. (353 aa)
ENSUAMP00000000176Protein kinase domain-containing protein. (82 aa)
APCAPC regulator of WNT signaling pathway. (2832 aa)
GNAI2G protein subunit alpha i2. (436 aa)
TCF7L1Transcription factor 7 like 1. (597 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (534 aa)
ENSUAMP00000036162Protein kinase domain-containing protein. (462 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
ENSUAMP00000035777HMG box domain-containing protein. (191 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
KMT2DLysine methyltransferase 2D. (5333 aa)
CREB3cAMP responsive element binding protein 3. (352 aa)
ENSUAMP00000035193Uncharacterized protein. (279 aa)
ENSUAMP00000035192Uncharacterized protein. (82 aa)
CYP17A1Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family. (356 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
ENSUAMP00000034960C2H2-type domain-containing protein. (123 aa)
ENSUAMP00000034830Uncharacterized protein. (1872 aa)
E2F3E2F transcription factor 3. (469 aa)
E2F1E2F transcription factor 1. (400 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (361 aa)
ARSIArylsulfatase family member I. (573 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
ENSUAMP00000032909Uncharacterized protein. (592 aa)
ENSUAMP00000032843Uncharacterized protein. (186 aa)
ENSUAMP000000326993Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (373 aa)
ENSUAMP00000032618Uncharacterized protein. (68 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (294 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
ENSUAMP00000032382CaMKII_AD domain-containing protein. (189 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
CYP11A1Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (482 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (247 aa)
USP8Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1116 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
KCNA1Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa)
ENSUAMP00000031131Protein kinase domain-containing protein. (264 aa)
MAP2K1Protein kinase domain-containing protein. (216 aa)
ENSUAMP00000030280Protein kinase domain-containing protein. (206 aa)
CYP21A2Cytochrome P450 family 21 subfamily A member 2; Belongs to the cytochrome P450 family. (493 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1866 aa)
ENSUAMP00000029031Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1136 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
GNASGNAS complex locus. (994 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
ADCY5Adenylate cyclase 5. (940 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (595 aa)
CREB5cAMP responsive element binding protein 5. (327 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (343 aa)
TCF7L2Transcription factor 7 like 2. (524 aa)
ENSUAMP00000026030Uncharacterized protein. (236 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (344 aa)
ENSUAMP00000024746PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family. (350 aa)
FHFumarate hydratase. (493 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (728 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (457 aa)
WDR5BWD repeat domain 5B. (330 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (603 aa)
KCNK2Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (385 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ENSUAMP00000023102Uncharacterized protein. (1102 aa)
ENSUAMP00000022968Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (422 aa)
ENSUAMP00000022339Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (107 aa)
ENSUAMP00000022336Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (163 aa)
ENSUAMP00000022172Uncharacterized protein. (157 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
NCEH1Neutral cholesterol ester hydrolase 1. (402 aa)
KCNA4Potassium voltage-gated channel subfamily A member 4; Belongs to the potassium channel family. (652 aa)
CRHR2Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. (418 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (561 aa)
ENSUAMP00000021070Uncharacterized protein. (833 aa)
GNAQG protein subunit alpha q. (352 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
AXIN1Axin 1. (867 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (589 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (657 aa)
LDLRLow density lipoprotein receptor. (856 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
ENSUAMP00000019181Protein kinase domain-containing protein. (206 aa)
ENSUAMP00000019174CaMKII_AD domain-containing protein. (267 aa)
ENSUAMP00000018707SERPIN domain-containing protein; Belongs to the serpin family. (416 aa)
DVL2Dishevelled segment polarity protein 2. (731 aa)
APC2APC regulator of WNT signaling pathway 2. (2266 aa)
ENSUAMP00000018470Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (298 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2160 aa)
ARMC5Armadillo repeat containing 5. (943 aa)
ENSUAMP00000017524Uncharacterized protein. (542 aa)
CTNNB1Catenin beta 1. (781 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (340 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2205 aa)
DVL1Dishevelled segment polarity protein 1. (700 aa)
MC2RMelanocortin 2 receptor. (297 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
ENSUAMP00000015348Uncharacterized protein. (236 aa)
MEN1Menin 1. (610 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
RB1RB transcriptional corepressor 1. (870 aa)
ENSUAMP00000014629Uncharacterized protein. (105 aa)
SP1Sp1 transcription factor. (780 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (481 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
CACNA1GCalcium voltage-gated channel subunit alpha1 G. (2369 aa)
ENSUAMP00000012266CTNNB1_binding domain-containing protein. (162 aa)
GSK3BGlycogen synthase kinase 3 beta. (335 aa)
POMCProopiomelanocortin. (223 aa)
PDE8APhosphodiesterase. (779 aa)
ENSUAMP00000011731Ion_trans domain-containing protein. (408 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (727 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
RAP1BRAP1B, member of RAS oncogene family. (184 aa)
PLCB1Phosphoinositide phospholipase C. (658 aa)
WDR5WD repeat domain 5. (378 aa)
CRHCorticotropin releasing hormone. (196 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
Server load: low (10%) [HD]