STRINGSTRING
ENSUAMP00000035925 ENSUAMP00000035925 ENSUAMP00000035427 ENSUAMP00000035427 HLA-DOA HLA-DOA IL1A IL1A IL1B IL1B ENSUAMP00000031906 ENSUAMP00000031906 ENSUAMP00000029879 ENSUAMP00000029879 IL2 IL2 ENSUAMP00000029280 ENSUAMP00000029280 CD28 CD28 INS INS ENSUAMP00000023925 ENSUAMP00000023925 ENSUAMP00000022738 ENSUAMP00000022738 PRF1 PRF1 ENSUAMP00000020826 ENSUAMP00000020826 ENSUAMP00000020061 ENSUAMP00000020061 ENSUAMP00000000911 ENSUAMP00000000911 ENSUAMP00000000976 ENSUAMP00000000976 ENSUAMP00000002874 ENSUAMP00000002874 ENSUAMP00000003162 ENSUAMP00000003162 ENSUAMP00000003263 ENSUAMP00000003263 ENSUAMP00000003525 ENSUAMP00000003525 ENSUAMP00000005465 ENSUAMP00000005465 GAD1 GAD1 ENSUAMP00000005697 ENSUAMP00000005697 ENSUAMP00000006240 ENSUAMP00000006240 ENSUAMP00000006865 ENSUAMP00000006865 ENSUAMP00000006872 ENSUAMP00000006872 GZMB GZMB ENSUAMP00000006971 ENSUAMP00000006971 ENSUAMP00000009584 ENSUAMP00000009584 ENSUAMP00000010491 ENSUAMP00000010491 PTPRN PTPRN ENSUAMP00000011129 ENSUAMP00000011129 ENSUAMP00000011260 ENSUAMP00000011260 IL12A IL12A ENSUAMP00000011928 ENSUAMP00000011928 CD80 CD80 HLA-DMA HLA-DMA ENSUAMP00000012503 ENSUAMP00000012503 IL12B IL12B ENSUAMP00000014588 ENSUAMP00000014588 ENSUAMP00000014590 ENSUAMP00000014590 ENSUAMP00000014720 ENSUAMP00000014720 TRBV16 TRBV16 ENSUAMP00000014831 ENSUAMP00000014831 TNF TNF LTA LTA ENSUAMP00000015817 ENSUAMP00000015817 ENSUAMP00000015819 ENSUAMP00000015819 TRBV28 TRBV28 ENSUAMP00000016042 ENSUAMP00000016042 HLA-DRA HLA-DRA ENSUAMP00000018082 ENSUAMP00000018082 HLA-DOB HLA-DOB ENSUAMP00000016547 ENSUAMP00000016547 CPE CPE ENSUAMP00000016352 ENSUAMP00000016352 ENSUAMP00000037283 ENSUAMP00000037283 ICA1L ICA1L ENSUAMP00000036887 ENSUAMP00000036887 ENSUAMP00000036043 ENSUAMP00000036043 ENSUAMP00000036029 ENSUAMP00000036029
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000035925Ig-like domain-containing protein. (236 aa)
ENSUAMP00000035427Ig-like domain-containing protein; Belongs to the MHC class II family. (241 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (283 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (244 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
ENSUAMP00000031906Uncharacterized protein. (55 aa)
ENSUAMP00000029879AH domain-containing protein. (301 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
ENSUAMP00000029280DUF1968 domain-containing protein. (198 aa)
CD28CD28 molecule. (216 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
ENSUAMP00000023925Ig-like domain-containing protein. (180 aa)
ENSUAMP00000022738Uncharacterized protein. (126 aa)
PRF1Perforin 1. (555 aa)
ENSUAMP00000020826Ig-like domain-containing protein. (196 aa)
ENSUAMP00000020061Ig-like domain-containing protein; Belongs to the MHC class I family. (332 aa)
ENSUAMP00000000911Uncharacterized protein. (111 aa)
ENSUAMP00000000976Ig-like domain-containing protein; Belongs to the MHC class I family. (481 aa)
ENSUAMP00000002874Ig-like domain-containing protein. (122 aa)
ENSUAMP00000003162Ig-like domain-containing protein. (206 aa)
ENSUAMP00000003263Ig-like domain-containing protein. (160 aa)
ENSUAMP00000003525Ig-like domain-containing protein; Belongs to the MHC class II family. (205 aa)
ENSUAMP00000005465Ig-like domain-containing protein; Belongs to the MHC class I family. (431 aa)
GAD1Glutamate decarboxylase 1. (594 aa)
ENSUAMP00000005697Uncharacterized protein. (93 aa)
ENSUAMP00000006240Ig-like domain-containing protein; Belongs to the MHC class I family. (359 aa)
ENSUAMP00000006865MHC_II_beta domain-containing protein. (274 aa)
ENSUAMP00000006872MHC_II_beta domain-containing protein. (218 aa)
GZMBGranzyme B; Belongs to the peptidase S1 family. (260 aa)
ENSUAMP00000006971Peptidase S1 domain-containing protein. (238 aa)
ENSUAMP00000009584Ig-like domain-containing protein; Belongs to the MHC class I family. (336 aa)
ENSUAMP00000010491Uncharacterized protein; Belongs to the TCP-1 chaperonin family. (153 aa)
PTPRNProtein tyrosine phosphatase receptor type N. (979 aa)
ENSUAMP00000011129RESP18 domain-containing protein. (172 aa)
ENSUAMP00000011260DUF1968 domain-containing protein. (153 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
ENSUAMP00000011928AH domain-containing protein. (101 aa)
CD80CD80 molecule. (283 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (261 aa)
ENSUAMP00000012503Ig-like domain-containing protein. (263 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
ENSUAMP00000014588IGv domain-containing protein. (107 aa)
ENSUAMP00000014590Ig-like domain-containing protein. (148 aa)
ENSUAMP00000014720Ig-like domain-containing protein. (177 aa)
TRBV16T cell receptor beta variable 16 (gene/pseudogene). (127 aa)
ENSUAMP00000014831Uncharacterized protein. (351 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (230 aa)
LTALymphotoxin alpha; Belongs to the tumor necrosis factor family. (204 aa)
ENSUAMP00000015817Ig-like domain-containing protein. (126 aa)
ENSUAMP00000015819Ig-like domain-containing protein. (141 aa)
TRBV28T cell receptor beta variable 28. (113 aa)
ENSUAMP00000016042Ig-like domain-containing protein. (387 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
ENSUAMP00000018082Uncharacterized protein. (249 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (261 aa)
ENSUAMP00000016547MHC_II_beta domain-containing protein. (275 aa)
CPECarboxypeptidase E. (338 aa)
ENSUAMP00000016352Ig-like domain-containing protein; Belongs to the MHC class I family. (358 aa)
ENSUAMP00000037283Ig-like domain-containing protein. (145 aa)
ICA1LIslet cell autoantigen 1 like. (426 aa)
ENSUAMP00000036887Ig-like domain-containing protein. (179 aa)
ENSUAMP00000036043MHC_I-like_Ag-recog domain-containing protein. (150 aa)
ENSUAMP00000036029Ig-like domain-containing protein; Belongs to the MHC class I family. (359 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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