(53 nodes) Vasopressin-regulated water reabsorption network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RAB11A	RAB11A, member RAS oncogene family. (210 aa)
	DYNC1I1	Dynein cytoplasmic 1 intermediate chain 1. (590 aa)
	ARHGDIB	Rho GDP dissociation inhibitor beta. (200 aa)
	ENSUAMP00000001906	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (270 aa)
	DYNC1LI2	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (492 aa)
	ENSUAMP00000004347	Uncharacterized protein. (80 aa)
	ENSUAMP00000004604	Uncharacterized protein. (54 aa)
	DCTN5	Dynactin subunit 5. (167 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1338 aa)
	ENSUAMP00000005986	V-SNARE coiled-coil homology domain-containing protein. (169 aa)
	ENSUAMP00000007730	Uncharacterized protein. (206 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (973 aa)
	AVP	Arginine vasopressin; Belongs to the vasopressin/oxytocin family. (149 aa)
	STX4	Syntaxin 4; Belongs to the syntaxin family. (297 aa)
	DYNLL2	Dynein light chain. (89 aa)
	AVPR2	Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (370 aa)
	ENSUAMP00000012243	Dynein light chain. (89 aa)
	ENSUAMP00000016706	Uncharacterized protein. (520 aa)
	AQP10	Aquaporin 10; Belongs to the MIP/aquaporin (TC 1.A.8) family. (301 aa)
	ENSUAMP00000018174	Uncharacterized protein. (156 aa)
	RAB5B	RAB5B, member RAS oncogene family. (215 aa)
	DYNLL1	Dynein light chain. (89 aa)
	ARHGDIG	Rho GDP dissociation inhibitor gamma. (220 aa)
	ARHGDIA	Rho GDP dissociation inhibitor alpha. (214 aa)
	DYNC1I2	Dynein cytoplasmic 1 intermediate chain 2. (650 aa)
	DYNC1H1	Dynein cytoplasmic 1 heavy chain 1. (4647 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	CREB3L3	cAMP responsive element binding protein 3 like 3. (457 aa)
	ENSUAMP00000026030	Uncharacterized protein. (236 aa)
	AQP4	Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (323 aa)
	CREB5	cAMP responsive element binding protein 5. (327 aa)
	ENSUAMP00000028111	CAP-Gly domain-containing protein. (1261 aa)
	GNAS	GNAS complex locus. (994 aa)
	DYNC2LI1	Dynein cytoplasmic 2 light intermediate chain 1. (333 aa)
	ENSUAMP00000031800	Uncharacterized protein. (216 aa)
	CREB3L4	cAMP responsive element binding protein 3 like 4. (247 aa)
	ENSUAMP00000032618	Uncharacterized protein. (68 aa)
	ENSUAMP00000032843	Uncharacterized protein. (186 aa)
	ENSUAMP00000032974	Uncharacterized protein. (190 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (361 aa)
	AQP3	Aquaporin 3 (Gill blood group); Belongs to the MIP/aquaporin (TC 1.A.8) family. (292 aa)
	DCTN2	Dynactin subunit 2. (422 aa)
	RAB17	RAB17, member RAS oncogene family. (275 aa)
	ENSUAMP00000034960	C2H2-type domain-containing protein. (123 aa)
	CREB3L1	cAMP responsive element binding protein 3 like 1. (520 aa)
	CREB3	cAMP responsive element binding protein 3. (352 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
	ENSUAMP00000035948	CDC48_N domain-containing protein. (137 aa)
	ENSUAMP00000035951	Uncharacterized protein. (98 aa)
	RAB5A	RAB5A, member RAS oncogene family. (229 aa)
	DYNC1LI1	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (524 aa)
	ENSUAMP00000037191	Uncharacterized protein. (121 aa)
	ENSUAMP00000021593	Uncharacterized protein. (76 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY3	ADCY6	ENSUAMP00000008710	ENSUAMP00000035722	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.947
ADCY3	ADCY9	ENSUAMP00000008710	ENSUAMP00000005924	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.954
ADCY3	ENSUAMP00000026030	ENSUAMP00000008710	ENSUAMP00000026030	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.943
ADCY3	ENSUAMP00000032618	ENSUAMP00000008710	ENSUAMP00000032618	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.920
ADCY3	GNAS	ENSUAMP00000008710	ENSUAMP00000028340	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNAS complex locus.	0.920
ADCY3	PRKACB	ENSUAMP00000008710	ENSUAMP00000033341	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.959
ADCY6	ADCY3	ENSUAMP00000035722	ENSUAMP00000008710	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.947
ADCY6	ADCY9	ENSUAMP00000035722	ENSUAMP00000005924	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.956
ADCY6	ENSUAMP00000026030	ENSUAMP00000035722	ENSUAMP00000026030	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.942
ADCY6	ENSUAMP00000032618	ENSUAMP00000035722	ENSUAMP00000032618	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.937
ADCY6	GNAS	ENSUAMP00000035722	ENSUAMP00000028340	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNAS complex locus.	0.937
ADCY6	PRKACB	ENSUAMP00000035722	ENSUAMP00000033341	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.963
ADCY9	ADCY3	ENSUAMP00000005924	ENSUAMP00000008710	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.954
ADCY9	ADCY6	ENSUAMP00000005924	ENSUAMP00000035722	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.956
ADCY9	ENSUAMP00000026030	ENSUAMP00000005924	ENSUAMP00000026030	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.947
ADCY9	ENSUAMP00000032618	ENSUAMP00000005924	ENSUAMP00000032618	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.997
ADCY9	GNAS	ENSUAMP00000005924	ENSUAMP00000028340	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	GNAS complex locus.	0.997
ADCY9	PRKACB	ENSUAMP00000005924	ENSUAMP00000033341	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.969
AQP10	AQP3	ENSUAMP00000017836	ENSUAMP00000033671	Aquaporin 10; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin 3 (Gill blood group); Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.459
AQP10	AQP4	ENSUAMP00000017836	ENSUAMP00000026179	Aquaporin 10; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.830