STRINGSTRING
ADRB2 ADRB2 GUCY1A1 GUCY1A1 ADRA1A ADRA1A ATP1B2 ATP1B2 ENSUAMP00000002341 ENSUAMP00000002341 RYR3 RYR3 ENSUAMP00000003408 ENSUAMP00000003408 KCNN4 KCNN4 ENSUAMP00000003964 ENSUAMP00000003964 PLCB2 PLCB2 ATP1B4 ATP1B4 ATP1A1 ATP1A1 ITPR3 ITPR3 ADCY9 ADCY9 ENSUAMP00000005986 ENSUAMP00000005986 CD163 CD163 AQP5 AQP5 LPO LPO KCNMA1 KCNMA1 ATP2B4 ATP2B4 ENSUAMP00000007690 ENSUAMP00000007690 PRKCB PRKCB ADCY2 ADCY2 CALML5 CALML5 ADCY3 ADCY3 ATP2B1 ATP2B1 PRKCA PRKCA PLCB1 PLCB1 ENSUAMP00000037285 ENSUAMP00000037285 ENSUAMP00000011731 ENSUAMP00000011731 ENSUAMP00000013358 ENSUAMP00000013358 CALML6 CALML6 TRPV6 TRPV6 ATP1A2 ATP1A2 BST1 BST1 PLCB3 PLCB3 CALML4 CALML4 ENSUAMP00000019744 ENSUAMP00000019744 ADRA1B ADRA1B PRKCG PRKCG ENSUAMP00000020550 ENSUAMP00000020550 GNAQ GNAQ CALM3 CALM3 ENSUAMP00000023102 ENSUAMP00000023102 ENSUAMP00000023255 ENSUAMP00000023255 ATP1B3 ATP1B3 ENSUAMP00000024809 ENSUAMP00000024809 BEST2 BEST2 ENSUAMP00000025300 ENSUAMP00000025300 ENSUAMP00000025311 ENSUAMP00000025311 ATP1A4 ATP1A4 ENSUAMP00000025726 ENSUAMP00000025726 ENSUAMP00000026030 ENSUAMP00000026030 ENSUAMP00000027612 ENSUAMP00000027612 CHRM3 CHRM3 ADCY5 ADCY5 ADCY1 ADCY1 GUCY1B1 GUCY1B1 SLC9A1 SLC9A1 GNAS GNAS PLCB4 PLCB4 SLC4A2 SLC4A2 ATP2B3 ATP2B3 ENSUAMP00000029679 ENSUAMP00000029679 LYZ LYZ ENSUAMP00000030764 ENSUAMP00000030764 ENSUAMP00000030894 ENSUAMP00000030894 ATP1B1 ATP1B1 ADCY4 ADCY4 ATP2B2 ATP2B2 ADCY7 ADCY7 ENSUAMP00000032618 ENSUAMP00000032618 PRKACB PRKACB PRKG2 PRKG2 NOS1 NOS1 FBXO21 FBXO21 ENSUAMP00000034686 ENSUAMP00000034686 ENSUAMP00000034830 ENSUAMP00000034830 CALM2 CALM2 ENSUAMP00000035715 ENSUAMP00000035715 ADCY6 ADCY6 ADRA1D ADRA1D LYZL6 LYZL6 ENSUAMP00000036122 ENSUAMP00000036122
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADRB2Adrenoceptor beta 2. (418 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (681 aa)
ADRA1AAdrenoceptor alpha 1A. (319 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
ENSUAMP00000002341Uncharacterized protein. (957 aa)
RYR3Ryanodine receptor 3. (4856 aa)
ENSUAMP00000003408Uncharacterized protein. (64 aa)
KCNN4Potassium calcium-activated channel subfamily N member 4. (308 aa)
ENSUAMP00000003964FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (59 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1166 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (348 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1021 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2656 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1338 aa)
ENSUAMP00000005986V-SNARE coiled-coil homology domain-containing protein. (169 aa)
CD163CD163 molecule. (1096 aa)
AQP5Aquaporin 5; Belongs to the MIP/aquaporin (TC 1.A.8) family. (265 aa)
LPOLactoperoxidase. (699 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1143 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1260 aa)
ENSUAMP00000007690Uncharacterized protein. (259 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (651 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
CALML5Calmodulin like 5. (156 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (973 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1214 aa)
PRKCAProtein kinase C alpha; Belongs to the protein kinase superfamily. (484 aa)
PLCB1Phosphoinositide phospholipase C. (658 aa)
ENSUAMP00000037285Uncharacterized protein. (609 aa)
ENSUAMP00000011731Ion_trans domain-containing protein. (408 aa)
ENSUAMP00000013358Uncharacterized protein. (1774 aa)
CALML6Calmodulin like 6. (180 aa)
TRPV6Transient receptor potential cation channel subfamily V member 6; Belongs to the transient receptor (TC 1.A.4) family. (764 aa)
ATP1A2ATPase Na+/K+ transporting subunit alpha 2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1127 aa)
BST1Bone marrow stromal cell antigen 1. (312 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
CALML4Calmodulin like 4. (153 aa)
ENSUAMP00000019744SLC12 domain-containing protein. (300 aa)
ADRA1BAdrenoceptor alpha 1B. (311 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (714 aa)
ENSUAMP00000020550Uncharacterized protein. (503 aa)
GNAQG protein subunit alpha q. (352 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (149 aa)
ENSUAMP00000023102Uncharacterized protein. (1102 aa)
ENSUAMP00000023255Uncharacterized protein. (1022 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (280 aa)
ENSUAMP00000024809Uncharacterized protein. (1236 aa)
BEST2Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (487 aa)
ENSUAMP00000025300Non-specific serine/threonine protein kinase. (254 aa)
ENSUAMP00000025311Uncharacterized protein. (295 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1011 aa)
ENSUAMP00000025726annotation not available (113 aa)
ENSUAMP00000026030Uncharacterized protein. (236 aa)
ENSUAMP00000027612Uncharacterized protein; Belongs to the glycosyl hydrolase 22 family. (146 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
ADCY5Adenylate cyclase 5. (940 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (540 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (816 aa)
GNASGNAS complex locus. (994 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1136 aa)
SLC4A2Anion exchange protein. (1237 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1254 aa)
ENSUAMP00000029679Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (673 aa)
LYZLysozyme; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Belongs to the glycosyl hydrolase 22 family. (168 aa)
ENSUAMP00000030764Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1123 aa)
ENSUAMP00000030894Uncharacterized protein. (1028 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1250 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
ENSUAMP00000032618Uncharacterized protein. (68 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (361 aa)
PRKG2cGMP-dependent protein kinase. (711 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1095 aa)
FBXO21F-box protein 21. (456 aa)
ENSUAMP00000034686SRCR domain-containing protein. (171 aa)
ENSUAMP00000034830Uncharacterized protein. (1872 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (163 aa)
ENSUAMP00000035715Uncharacterized protein; Belongs to the glycosyl hydrolase 22 family. (148 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
ADRA1DAdrenoceptor alpha 1D. (510 aa)
LYZL6Lysozyme like 6; Belongs to the glycosyl hydrolase 22 family. (148 aa)
ENSUAMP00000036122Uncharacterized protein. (967 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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