STRINGSTRING
GAST GAST ENSUAMP00000000176 ENSUAMP00000000176 SLC26A7 SLC26A7 ATP1B2 ATP1B2 ENSUAMP00000002341 ENSUAMP00000002341 ENSUAMP00000003880 ENSUAMP00000003880 OTUD6B OTUD6B PLCB2 PLCB2 ATP1B4 ATP1B4 ATP1A1 ATP1A1 ITPR3 ITPR3 ADCY9 ADCY9 SLC9A4 SLC9A4 ATP4B ATP4B ENSUAMP00000007617 ENSUAMP00000007617 KCNQ1 KCNQ1 PRKCB PRKCB GNAI3 GNAI3 ADCY2 ADCY2 CALML5 CALML5 ADCY3 ADCY3 SSTR2 SSTR2 CFTR CFTR PRKCA PRKCA PLCB1 PLCB1 MYLK3 MYLK3 ENSUAMP00000011731 ENSUAMP00000011731 CA2 CA2 CALML6 CALML6 SST SST ENSUAMP00000014629 ENSUAMP00000014629 KCNJ10 KCNJ10 HRH2 HRH2 ATP1A2 ATP1A2 KCNJ1 KCNJ1 ENSUAMP00000019174 ENSUAMP00000019174 ENSUAMP00000019181 ENSUAMP00000019181 PLCB3 PLCB3 CALML4 CALML4 OTUD6A OTUD6A CAMK2B CAMK2B PRKCG PRKCG GNAQ GNAQ ENSUAMP00000020898 ENSUAMP00000020898 ACTG1 ACTG1 CALM3 CALM3 ENSUAMP00000022172 ENSUAMP00000022172 ENSUAMP00000023102 ENSUAMP00000023102 KCNJ15 KCNJ15 KCNK2 KCNK2 ATP1B3 ATP1B3 ENSUAMP00000025300 ENSUAMP00000025300 ENSUAMP00000025311 ENSUAMP00000025311 ATP1A4 ATP1A4 ENSUAMP00000025726 ENSUAMP00000025726 ENSUAMP00000026030 ENSUAMP00000026030 ATP4A ATP4A CHRM3 CHRM3 ADCY5 ADCY5 ADCY1 ADCY1 SLC9A1 SLC9A1 GNAS GNAS MYLK MYLK PLCB4 PLCB4 EZR EZR SLC4A2 SLC4A2 MYLK2 MYLK2 ENSUAMP00000030750 ENSUAMP00000030750 ENSUAMP00000030764 ENSUAMP00000030764 ATP1B1 ATP1B1 CCKBR CCKBR ADCY4 ADCY4 ENSUAMP00000032382 ENSUAMP00000032382 ADCY7 ADCY7 ENSUAMP00000032618 ENSUAMP00000032618 KCNJ2 KCNJ2 KCNJ16 KCNJ16 ARSI ARSI PRKACB PRKACB ENSUAMP00000034022 ENSUAMP00000034022 ENSUAMP00000034830 ENSUAMP00000034830 CALM2 CALM2 ADCY6 ADCY6 GNAI2 GNAI2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GASTGastrin. (104 aa)
ENSUAMP00000000176Protein kinase domain-containing protein. (82 aa)
SLC26A7Anion exchange transporter. (656 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
ENSUAMP00000002341Uncharacterized protein. (957 aa)
ENSUAMP00000003880Uncharacterized protein. (91 aa)
OTUD6BOTU domain containing 6B. (324 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1166 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (348 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1021 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2656 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1338 aa)
SLC9A4Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (776 aa)
ATP4BSodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (294 aa)
ENSUAMP00000007617Protein kinase domain-containing protein. (271 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (672 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (651 aa)
GNAI3G protein subunit alpha i3. (295 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
CALML5Calmodulin like 5. (156 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (973 aa)
SSTR2Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1475 aa)
PRKCAProtein kinase C alpha; Belongs to the protein kinase superfamily. (484 aa)
PLCB1Phosphoinositide phospholipase C. (658 aa)
MYLK3Myosin light chain kinase 3. (791 aa)
ENSUAMP00000011731Ion_trans domain-containing protein. (408 aa)
CA2Carbonic anhydrase 2; Belongs to the alpha-carbonic anhydrase family. (251 aa)
CALML6Calmodulin like 6. (180 aa)
SSTSomatostatin. (116 aa)
ENSUAMP00000014629Uncharacterized protein. (105 aa)
KCNJ10Potassium voltage-gated channel subfamily J member 10. (379 aa)
HRH2Histamine receptor H2; Belongs to the G-protein coupled receptor 1 family. (359 aa)
ATP1A2ATPase Na+/K+ transporting subunit alpha 2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1127 aa)
KCNJ1Potassium voltage-gated channel subfamily J member 1. (372 aa)
ENSUAMP00000019174CaMKII_AD domain-containing protein. (267 aa)
ENSUAMP00000019181Protein kinase domain-containing protein. (206 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
CALML4Calmodulin like 4. (153 aa)
OTUD6AOTU deubiquitinase 6A. (300 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (589 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (714 aa)
GNAQG protein subunit alpha q. (352 aa)
ENSUAMP00000020898Ion_trans_2 domain-containing protein. (228 aa)
ACTG1Actin gamma 1. (375 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (149 aa)
ENSUAMP00000022172Uncharacterized protein. (157 aa)
ENSUAMP00000023102Uncharacterized protein. (1102 aa)
KCNJ15Potassium voltage-gated channel subfamily J member 15. (375 aa)
KCNK2Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (385 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (280 aa)
ENSUAMP00000025300Non-specific serine/threonine protein kinase. (254 aa)
ENSUAMP00000025311Uncharacterized protein. (295 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1011 aa)
ENSUAMP00000025726annotation not available (113 aa)
ENSUAMP00000026030Uncharacterized protein. (236 aa)
ATP4ASodium/potassium-transporting ATPase subunit alpha. (1050 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
ADCY5Adenylate cyclase 5. (940 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (816 aa)
GNASGNAS complex locus. (994 aa)
MYLKMyosin light chain kinase. (1485 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1136 aa)
EZREzrin. (586 aa)
SLC4A2Anion exchange protein. (1237 aa)
MYLK2Myosin light chain kinase 2. (615 aa)
ENSUAMP00000030750Uncharacterized protein. (160 aa)
ENSUAMP00000030764Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1123 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
CCKBRCholecystokinin B receptor; Belongs to the G-protein coupled receptor 1 family. (444 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ENSUAMP00000032382CaMKII_AD domain-containing protein. (189 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
ENSUAMP00000032618Uncharacterized protein. (68 aa)
KCNJ2Potassium voltage-gated channel subfamily J member 2. (427 aa)
KCNJ16Potassium voltage-gated channel subfamily J member 16. (418 aa)
ARSIArylsulfatase family member I. (573 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (361 aa)
ENSUAMP00000034022Uncharacterized protein. (97 aa)
ENSUAMP00000034830Uncharacterized protein. (1872 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (163 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
GNAI2G protein subunit alpha i2. (436 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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