STRINGSTRING
PLCB1 PLCB1 RAP1B RAP1B ENSUAMP00000011731 ENSUAMP00000011731 CA2 CA2 ENSUAMP00000012276 ENSUAMP00000012276 ENSUAMP00000012405 ENSUAMP00000012405 PLA2G3 PLA2G3 PLA2G2E PLA2G2E ATP2A2 ATP2A2 TRPC1 TRPC1 RAB27B RAB27B PLA2G5 PLA2G5 PLA2G2D PLA2G2D PLA2G2F PLA2G2F PLA2G2C PLA2G2C CLCA2 CLCA2 CPA3 CPA3 CPB1 CPB1 CLCA1 CLCA1 CLCA4 CLCA4 ENSUAMP00000015057 ENSUAMP00000015057 PNLIP PNLIP PNLIPRP1 PNLIPRP1 PNLIPRP2 PNLIPRP2 ENSUAMP00000015967 ENSUAMP00000015967 ATP1A2 ATP1A2 BST1 BST1 ATP2A3 ATP2A3 ENSUAMP00000017736 ENSUAMP00000017736 RAP1A RAP1A PLCB3 PLCB3 ENSUAMP00000019744 ENSUAMP00000019744 PRKCG PRKCG GNAQ GNAQ CCKAR CCKAR CPB2 CPB2 ENSUAMP00000022405 ENSUAMP00000022405 ENSUAMP00000022425 ENSUAMP00000022425 ENSUAMP00000022426 ENSUAMP00000022426 PRSS37 PRSS37 ENSUAMP00000023102 ENSUAMP00000023102 ENSUAMP00000023927 ENSUAMP00000023927 ENSUAMP00000023928 ENSUAMP00000023928 ATP1B3 ATP1B3 PLA2G1B PLA2G1B ENSUAMP00000025300 ENSUAMP00000025300 CTRC CTRC ATP1A4 ATP1A4 RAB27A RAB27A ENSUAMP00000026030 ENSUAMP00000026030 ATP2A1 ATP2A1 ENSUAMP00000026363 ENSUAMP00000026363 CTRL CTRL CHRM3 CHRM3 ADCY5 ADCY5 ADCY1 ADCY1 SLC9A1 SLC9A1 GNAS GNAS ENSUAMP00000028700 ENSUAMP00000028700 PLCB4 PLCB4 SLC4A2 SLC4A2 ENSUAMP00000030764 ENSUAMP00000030764 ATP1B1 ATP1B1 ADCY4 ADCY4 CEL CEL PLA2G12A PLA2G12A ATP2B2 ATP2B2 ADCY7 ADCY7 ENSUAMP00000032503 ENSUAMP00000032503 ENSUAMP00000032618 ENSUAMP00000032618 SLC26A3 SLC26A3 CELA1 CELA1 CPA2 CPA2 CPA4 CPA4 CPA1 CPA1 ENSUAMP00000034830 ENSUAMP00000034830 RAB11A RAB11A ENSUAMP00000035616 ENSUAMP00000035616 ENSUAMP00000035617 ENSUAMP00000035617 ADCY6 ADCY6 ENSUAMP00000036122 ENSUAMP00000036122 ATP2B3 ATP2B3 ATP1B2 ATP1B2 ENSUAMP00000001579 ENSUAMP00000001579 ENSUAMP00000001987 ENSUAMP00000001987 ENSUAMP00000002341 ENSUAMP00000002341 ENSUAMP00000003964 ENSUAMP00000003964 PLCB2 PLCB2 ATP1B4 ATP1B4 ATP1A1 ATP1A1 ITPR3 ITPR3 ADCY9 ADCY9 ENSUAMP00000005976 ENSUAMP00000005976 KCNMA1 KCNMA1 SCTR SCTR ATP2B4 ATP2B4 PLA2G12B PLA2G12B ENSUAMP00000007477 ENSUAMP00000007477 KCNQ1 KCNQ1 PRKCB PRKCB ENSUAMP00000007730 ENSUAMP00000007730 CCK CCK OVCH2 OVCH2 ADCY2 ADCY2 RHOB RHOB ADCY3 ADCY3 ATP2B1 ATP2B1 CFTR CFTR PLA2G10 PLA2G10 PRKCA PRKCA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLCB1Phosphoinositide phospholipase C. (658 aa)
RAP1BRAP1B, member of RAS oncogene family. (184 aa)
ENSUAMP00000011731Ion_trans domain-containing protein. (408 aa)
CA2Carbonic anhydrase 2; Belongs to the alpha-carbonic anhydrase family. (251 aa)
ENSUAMP00000012276B30.2/SPRY domain-containing protein. (334 aa)
ENSUAMP00000012405Uncharacterized protein. (110 aa)
PLA2G3Phospholipase A2 group III. (508 aa)
PLA2G2EPhospholipase A(2). (142 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (794 aa)
RAB27BRAB27B, member RAS oncogene family. (154 aa)
PLA2G5Phospholipase A(2). (137 aa)
PLA2G2DPhospholipase A(2). (159 aa)
PLA2G2FPhospholipase A(2). (199 aa)
PLA2G2CPhospholipase A(2). (144 aa)
CLCA2Chloride channel accessory 2. (943 aa)
CPA3Carboxypeptidase A3. (407 aa)
CPB1Carboxypeptidase B1. (417 aa)
CLCA1Chloride channel accessory 1. (913 aa)
CLCA4Chloride channel accessory 4. (922 aa)
ENSUAMP00000015057VWFA domain-containing protein. (905 aa)
PNLIPTriacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (465 aa)
PNLIPRP1Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (467 aa)
PNLIPRP2Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (469 aa)
ENSUAMP00000015967Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (258 aa)
ATP1A2ATPase Na+/K+ transporting subunit alpha 2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1127 aa)
BST1Bone marrow stromal cell antigen 1. (312 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (982 aa)
ENSUAMP00000017736Cation_ATPase_N domain-containing protein. (54 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
ENSUAMP00000019744SLC12 domain-containing protein. (300 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (714 aa)
GNAQG protein subunit alpha q. (352 aa)
CCKARCholecystokinin A receptor; Belongs to the G-protein coupled receptor 1 family. (428 aa)
CPB2Carboxypeptidase B2. (423 aa)
ENSUAMP00000022405Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (247 aa)
ENSUAMP00000022425Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (254 aa)
ENSUAMP00000022426Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (243 aa)
PRSS37Serine protease 37. (236 aa)
ENSUAMP00000023102Uncharacterized protein. (1102 aa)
ENSUAMP00000023927Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (203 aa)
ENSUAMP00000023928Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (246 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (280 aa)
PLA2G1BPhospholipase A(2). (119 aa)
ENSUAMP00000025300Non-specific serine/threonine protein kinase. (254 aa)
CTRCChymotrypsin C; Belongs to the peptidase S1 family. (278 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1011 aa)
RAB27ARAB27A, member RAS oncogene family. (221 aa)
ENSUAMP00000026030Uncharacterized protein. (236 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1060 aa)
ENSUAMP00000026363Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (271 aa)
CTRLChymotrypsin like; Belongs to the peptidase S1 family. (264 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
ADCY5Adenylate cyclase 5. (940 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (816 aa)
GNASGNAS complex locus. (994 aa)
ENSUAMP00000028700Uncharacterized protein. (117 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1136 aa)
SLC4A2Anion exchange protein. (1237 aa)
ENSUAMP00000030764Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1123 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
CELCarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (599 aa)
PLA2G12APhospholipase A2 group XIIA. (190 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1250 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
ENSUAMP00000032503Uncharacterized protein. (753 aa)
ENSUAMP00000032618Uncharacterized protein. (68 aa)
SLC26A3Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (691 aa)
CELA1Chymotrypsin like elastase 1; Belongs to the peptidase S1 family. (258 aa)
CPA2Carboxypeptidase A2. (419 aa)
CPA4Carboxypeptidase A4. (424 aa)
CPA1Carboxypeptidase A1. (426 aa)
ENSUAMP00000034830Uncharacterized protein. (1872 aa)
RAB11ARAB11A, member RAS oncogene family. (210 aa)
ENSUAMP00000035616Uncharacterized protein. (219 aa)
ENSUAMP00000035617Uncharacterized protein. (164 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
ENSUAMP00000036122Uncharacterized protein. (967 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1254 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
ENSUAMP00000001579Cation_ATPase_N domain-containing protein. (75 aa)
ENSUAMP00000001987Peptidase S1 domain-containing protein. (155 aa)
ENSUAMP00000002341Uncharacterized protein. (957 aa)
ENSUAMP00000003964FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (59 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1166 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (348 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1021 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2656 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1338 aa)
ENSUAMP00000005976Uncharacterized protein. (94 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1143 aa)
SCTRSecretin receptor; Belongs to the G-protein coupled receptor 2 family. (451 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1260 aa)
PLA2G12BPhospholipase A2 group XIIB. (117 aa)
ENSUAMP00000007477Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (253 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (672 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (651 aa)
ENSUAMP00000007730Uncharacterized protein. (206 aa)
CCKCholecystokinin. (115 aa)
OVCH2Ovochymase 2 (gene/pseudogene); Belongs to the peptidase S1 family. (579 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
RHOBRas homolog family member B. (172 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (973 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1214 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1475 aa)
PLA2G10Phospholipase A(2). (157 aa)
PRKCAProtein kinase C alpha; Belongs to the protein kinase superfamily. (484 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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