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ABCB11 ABCB11 ENSUAMP00000003964 ENSUAMP00000003964 SLC25A40 SLC25A40 ENSUAMP00000002620 ENSUAMP00000002620 ATP1B2 ATP1B2 ENSUAMP00000000355 ENSUAMP00000000355 SLC2A1 SLC2A1 ENSUAMP00000004668 ENSUAMP00000004668 SCARB1 SCARB1 ATP1B4 ATP1B4 ENSUAMP00000005012 ENSUAMP00000005012 ATP1A1 ATP1A1 ADCY9 ADCY9 SLC22A7 SLC22A7 SCTR SCTR ADCY2 ADCY2 ADCY3 ADCY3 CFTR CFTR SLCO1A2 SLCO1A2 ENSUAMP00000011462 ENSUAMP00000011462 ABCC3 ABCC3 UGT1A1 UGT1A1 CA2 CA2 HMGCR HMGCR SLC25A39 SLC25A39 ENSUAMP00000014595 ENSUAMP00000014595 AQP9 AQP9 ATP1A2 ATP1A2 SLC10A1 SLC10A1 LDLR LDLR SLC9A5 SLC9A5 ABCB1 ABCB1 SLC10A2 SLC10A2 ENSUAMP00000021363 ENSUAMP00000021363 ENSUAMP00000021515 ENSUAMP00000021515 SLC51B SLC51B ENSUAMP00000021744 ENSUAMP00000021744 SLC22A8 SLC22A8 SLC22A6 SLC22A6 NCEH1 NCEH1 SLC5A4 SLC5A4 SLC5A1 SLC5A1 AQP8 AQP8 ENSUAMP00000024133 ENSUAMP00000024133 ATP1B3 ATP1B3 ABCC4 ABCC4 ATP1A4 ATP1A4 ENSUAMP00000026030 ENSUAMP00000026030 AQP4 AQP4 RXRA RXRA BAAT BAAT ENSUAMP00000027111 ENSUAMP00000027111 ADCY5 ADCY5 ADCY1 ADCY1 ENSUAMP00000028114 ENSUAMP00000028114 SLC4A5 SLC4A5 SLC9A1 SLC9A1 GNAS GNAS ENSUAMP00000028700 ENSUAMP00000028700 SLC9A3 SLC9A3 SLC4A2 SLC4A2 ENSUAMP00000029557 ENSUAMP00000029557 ABCG5 ABCG5 ABCG8 ABCG8 ENSUAMP00000030764 ENSUAMP00000030764 ATP1B1 ATP1B1 ABCC2 ABCC2 ADCY4 ADCY4 ADCY7 ADCY7 ENSUAMP00000032618 ENSUAMP00000032618 ENSUAMP00000032777 ENSUAMP00000032777 PRKACB PRKACB NR0B2 NR0B2 ADCY6 ADCY6 NR1H4 NR1H4 SLC51A SLC51A EPHX1 EPHX1 ENSUAMP00000004665 ENSUAMP00000004665
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABCB11ATP binding cassette subfamily B member 11. (1319 aa)
ENSUAMP00000003964FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (59 aa)
SLC25A40Solute carrier family 25 member 40; Belongs to the mitochondrial carrier (TC 2.A.29) family. (338 aa)
ENSUAMP00000002620ABC transmembrane type-1 domain-containing protein. (183 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
ENSUAMP00000000355Uncharacterized protein. (58 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
ENSUAMP00000004668Uncharacterized protein. (95 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (543 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (348 aa)
ENSUAMP00000005012Uncharacterized protein. (59 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1021 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1338 aa)
SLC22A7Solute carrier family 22 member 7. (545 aa)
SCTRSecretin receptor; Belongs to the G-protein coupled receptor 2 family. (451 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (973 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1475 aa)
SLCO1A2Solute carrier organic anion transporter family member. (407 aa)
ENSUAMP00000011462Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
ABCC3ATP binding cassette subfamily C member 3. (1680 aa)
UGT1A1UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (533 aa)
CA2Carbonic anhydrase 2; Belongs to the alpha-carbonic anhydrase family. (251 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (897 aa)
SLC25A39Solute carrier family 25 member 39; Belongs to the mitochondrial carrier (TC 2.A.29) family. (359 aa)
ENSUAMP00000014595UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (527 aa)
AQP9Aquaporin 9; Belongs to the MIP/aquaporin (TC 1.A.8) family. (275 aa)
ATP1A2ATPase Na+/K+ transporting subunit alpha 2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1127 aa)
SLC10A1Solute carrier family 10 member 1. (349 aa)
LDLRLow density lipoprotein receptor. (856 aa)
SLC9A5Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (901 aa)
ABCB1ATP binding cassette subfamily B member 1. (1178 aa)
SLC10A2Solute carrier family 10 member 2. (346 aa)
ENSUAMP00000021363DUF4205 domain-containing protein. (489 aa)
ENSUAMP00000021515Solute carrier organic anion transporter family member. (689 aa)
SLC51BSolute carrier family 51 beta subunit. (133 aa)
ENSUAMP00000021744Uncharacterized protein. (353 aa)
SLC22A8Solute carrier family 22 member 8. (543 aa)
SLC22A6Solute carrier family 22 member 6. (550 aa)
NCEH1Neutral cholesterol ester hydrolase 1. (402 aa)
SLC5A4Solute carrier family 5 member 4; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (502 aa)
SLC5A1Solute carrier family 5 member 1; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (627 aa)
AQP8Aquaporin 8; Belongs to the MIP/aquaporin (TC 1.A.8) family. (251 aa)
ENSUAMP00000024133Uncharacterized protein. (470 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (280 aa)
ABCC4ATP binding cassette subfamily C member 4. (942 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1011 aa)
ENSUAMP00000026030Uncharacterized protein. (236 aa)
AQP4Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (323 aa)
RXRARetinoid X receptor alpha. (469 aa)
BAATBile acid-CoA:amino acid N-acyltransferase. (421 aa)
ENSUAMP00000027111Uncharacterized protein. (418 aa)
ADCY5Adenylate cyclase 5. (940 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
ENSUAMP00000028114Uncharacterized protein. (153 aa)
SLC4A5Anion exchange protein. (948 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (816 aa)
GNASGNAS complex locus. (994 aa)
ENSUAMP00000028700Uncharacterized protein. (117 aa)
SLC9A3Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (908 aa)
SLC4A2Anion exchange protein. (1237 aa)
ENSUAMP00000029557ABC transporter domain-containing protein. (649 aa)
ABCG5ATP binding cassette subfamily G member 5. (652 aa)
ABCG8ATP binding cassette subfamily G member 8. (672 aa)
ENSUAMP00000030764Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1123 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
ABCC2ATP binding cassette subfamily C member 2. (1541 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
ENSUAMP00000032618Uncharacterized protein. (68 aa)
ENSUAMP00000032777Uncharacterized protein. (323 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (361 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (301 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (482 aa)
SLC51ASolute carrier family 51 alpha subunit. (341 aa)
EPHX1Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. (444 aa)
ENSUAMP00000004665AMP-binding domain-containing protein. (629 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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