(61 nodes) Cholesterol metabolism network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LPL	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (476 aa)
	VAPA	VAMP associated protein A. (294 aa)
	ENSUAMP00000000802	Uncharacterized protein. (67 aa)
	MYLIP	Myosin regulatory light chain interacting protein. (264 aa)
	ENSUAMP00000002066	MSP domain-containing protein. (70 aa)
	NPC2	NPC intracellular cholesterol transporter 2. (149 aa)
	ENSUAMP00000003226	Uncharacterized protein. (73 aa)
	STAR	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (543 aa)
	ENSUAMP00000005012	Uncharacterized protein. (59 aa)
	APOC2	Apolipoprotein C2. (100 aa)
	ENSUAMP00000006463	Uncharacterized protein. (89 aa)
	ANGPTL4	Angiopoietin like 4. (239 aa)
	VDAC1	Voltage dependent anion channel 1. (283 aa)
	LIPC	Lipase C, hepatic type. (498 aa)
	TSPO	Translocator protein. (169 aa)
	ENSUAMP00000009785	Uncharacterized protein; Belongs to the CD36 family. (215 aa)
	LIPG	Lipase G, endothelial type. (494 aa)
	ENSUAMP00000011110	ABC transporter domain-containing protein. (652 aa)
	STARD3	StAR related lipid transfer domain containing 3. (445 aa)
	PLTP	Phospholipid transfer protein. (496 aa)
	NPC1	NPC intracellular cholesterol transporter 1. (1278 aa)
	ANGPTL8	Angiopoietin like 8. (198 aa)
	LDLR	Low density lipoprotein receptor. (856 aa)
	VDAC3	Voltage dependent anion channel 3. (279 aa)
	SOAT2	Sterol O-acyltransferase 2; Belongs to the membrane-bound acyltransferase family. (370 aa)
	NCEH1	Neutral cholesterol ester hydrolase 1. (402 aa)
	APOH	Apolipoprotein H. (345 aa)
	BSND	Barttin CLCNK type accessory beta subunit. (318 aa)
	ENSUAMP00000023012	Uncharacterized protein. (149 aa)
	OSBPL8	Oxysterol binding protein like 8. (534 aa)
	ENSUAMP00000023301	Uncharacterized protein. (133 aa)
	ENSUAMP00000023390	Uncharacterized protein. (286 aa)
	ENSUAMP00000024187	Uncharacterized protein. (155 aa)
	ENSUAMP00000024197	ABC transporter domain-containing protein. (288 aa)
	SOAT1	O-acyltransferase. (513 aa)
	LRP2	LDL receptor related protein 2. (4684 aa)
	ABCB11	ATP binding cassette subfamily B member 11. (1319 aa)
	ENSUAMP00000025004	Uncharacterized protein; Belongs to the CD36 family. (96 aa)
	APOA1	Apolipoprotein A1. (266 aa)
	APOC3	Apolipoprotein C3. (100 aa)
	APOA4	Apolipoprotein A4. (382 aa)
	VAPB	VAMP associated protein B and C. (172 aa)
	LRPAP1	LDL receptor related protein associated protein 1. (367 aa)
	LCAT	Lecithin-cholesterol acyltransferase. (440 aa)
	LRP1	LDL receptor related protein 1. (4548 aa)
	ENSUAMP00000027762	Uncharacterized protein. (188 aa)
	CYP27A1	Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family. (441 aa)
	SORT1	Sortilin. (829 aa)
	ANGPTL3	Angiopoietin like 3. (425 aa)
	ABCG5	ATP binding cassette subfamily G member 5. (652 aa)
	ABCG8	ATP binding cassette subfamily G member 8. (672 aa)
	ENSUAMP00000030569	Uncharacterized protein. (137 aa)
	APOE	Apolipoprotein E. (323 aa)
	APOB	Apolipoprotein B. (4436 aa)
	NR1I3	Nuclear receptor subfamily 1 group I member 3. (356 aa)
	ENSUAMP00000033437	Uncharacterized protein. (181 aa)
	LDLRAP1	Low density lipoprotein receptor adaptor protein 1. (309 aa)
	ENSUAMP00000034850	Uncharacterized protein. (294 aa)
	TSPO2	Translocator protein 2. (174 aa)
	OSBPL5	Oxysterol-binding protein; Belongs to the OSBP family. (904 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCB11	ABCG5	ENSUAMP00000024712	ENSUAMP00000029838	ATP binding cassette subfamily B member 11.	ATP binding cassette subfamily G member 5.	0.567
ABCB11	ABCG8	ENSUAMP00000024712	ENSUAMP00000029841	ATP binding cassette subfamily B member 11.	ATP binding cassette subfamily G member 8.	0.541
ABCB11	NR1I3	ENSUAMP00000024712	ENSUAMP00000033432	ATP binding cassette subfamily B member 11.	Nuclear receptor subfamily 1 group I member 3.	0.461
ABCB11	SCARB1	ENSUAMP00000024712	ENSUAMP00000004952	ATP binding cassette subfamily B member 11.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.463
ABCG5	ABCB11	ENSUAMP00000029838	ENSUAMP00000024712	ATP binding cassette subfamily G member 5.	ATP binding cassette subfamily B member 11.	0.567
ABCG5	ABCG8	ENSUAMP00000029838	ENSUAMP00000029841	ATP binding cassette subfamily G member 5.	ATP binding cassette subfamily G member 8.	0.999
ABCG5	APOB	ENSUAMP00000029838	ENSUAMP00000032840	ATP binding cassette subfamily G member 5.	Apolipoprotein B.	0.554
ABCG5	APOC3	ENSUAMP00000029838	ENSUAMP00000025575	ATP binding cassette subfamily G member 5.	Apolipoprotein C3.	0.441
ABCG5	APOE	ENSUAMP00000029838	ENSUAMP00000030573	ATP binding cassette subfamily G member 5.	Apolipoprotein E.	0.489
ABCG5	CYP27A1	ENSUAMP00000029838	ENSUAMP00000027763	ATP binding cassette subfamily G member 5.	Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family.	0.476
ABCG5	ENSUAMP00000027762	ENSUAMP00000029838	ENSUAMP00000027762	ATP binding cassette subfamily G member 5.	Uncharacterized protein.	0.476
ABCG5	PLTP	ENSUAMP00000029838	ENSUAMP00000012827	ATP binding cassette subfamily G member 5.	Phospholipid transfer protein.	0.402
ABCG5	SCARB1	ENSUAMP00000029838	ENSUAMP00000004952	ATP binding cassette subfamily G member 5.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.578
ABCG5	SOAT2	ENSUAMP00000029838	ENSUAMP00000021650	ATP binding cassette subfamily G member 5.	Sterol O-acyltransferase 2; Belongs to the membrane-bound acyltransferase family.	0.427
ABCG8	ABCB11	ENSUAMP00000029841	ENSUAMP00000024712	ATP binding cassette subfamily G member 8.	ATP binding cassette subfamily B member 11.	0.541
ABCG8	ABCG5	ENSUAMP00000029841	ENSUAMP00000029838	ATP binding cassette subfamily G member 8.	ATP binding cassette subfamily G member 5.	0.999
ABCG8	APOB	ENSUAMP00000029841	ENSUAMP00000032840	ATP binding cassette subfamily G member 8.	Apolipoprotein B.	0.672
ABCG8	APOE	ENSUAMP00000029841	ENSUAMP00000030573	ATP binding cassette subfamily G member 8.	Apolipoprotein E.	0.439
ABCG8	CYP27A1	ENSUAMP00000029841	ENSUAMP00000027763	ATP binding cassette subfamily G member 8.	Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family.	0.479
ABCG8	ENSUAMP00000027762	ENSUAMP00000029841	ENSUAMP00000027762	ATP binding cassette subfamily G member 8.	Uncharacterized protein.	0.479