STRINGSTRING
PSMB2 PSMB2 TBPL1 TBPL1 RORA RORA ENSUAMP00000024291 ENSUAMP00000024291 ULK2 ULK2 ENSUAMP00000023390 ENSUAMP00000023390 ENSUAMP00000023294 ENSUAMP00000023294 PUM1 PUM1 TWNK TWNK ENSUAMP00000023102 ENSUAMP00000023102 PSMA4 PSMA4 MAPK10 MAPK10 RBPJL RBPJL ENSUAMP00000022131 ENSUAMP00000022131 ENSUAMP00000022022 ENSUAMP00000022022 ULK1 ULK1 GRIN2A GRIN2A RB1CC1 RB1CC1 RBPJ RBPJ GNAQ GNAQ VDAC3 VDAC3 PRKCG PRKCG ENSUAMP00000019817 ENSUAMP00000019817 ENSUAMP00000019816 ENSUAMP00000019816 PSMD3 PSMD3 ENSUAMP00000019493 ENSUAMP00000019493 PIK3CD PIK3CD MTOR MTOR PLCB3 PLCB3 SLC25A5 SLC25A5 KCNC3 KCNC3 ATXN10 ATXN10 SPTBN2 SPTBN2 RYR1 RYR1 ENSUAMP00000017736 ENSUAMP00000017736 ATP2A3 ATP2A3 ENSUAMP00000017692 ENSUAMP00000017692 PSMD8 PSMD8 ATG101 ATG101 ENSUAMP00000017435 ENSUAMP00000017435 PSMD13 PSMD13 BECN1 BECN1 ENSUAMP00000016311 ENSUAMP00000016311 ENSUAMP00000015788 ENSUAMP00000015788 SLC25A4 SLC25A4 ENSUAMP00000015620 ENSUAMP00000015620 ENSUAMP00000015381 ENSUAMP00000015381 ATG2A ATG2A ENSUAMP00000014933 ENSUAMP00000014933 GRIA3 GRIA3 ENSUAMP00000013707 ENSUAMP00000013707 SP1 SP1 CIC CIC ATP2A2 ATP2A2 RELN RELN ENSUAMP00000012220 ENSUAMP00000012220 ENSUAMP00000011731 ENSUAMP00000011731 TRPC3 TRPC3 AKT3 AKT3 WIPI2 WIPI2 ENSUAMP00000010738 ENSUAMP00000010738 PLCB1 PLCB1 AKT1 AKT1 PSMD9 PSMD9 PRKCA PRKCA PIK3R1 PIK3R1 PUM2 PUM2 PSMB5 PSMB5 PSMD7 PSMD7 MAPK8 MAPK8 PSMA3 PSMA3 PIK3CA PIK3CA ERN1 ERN1 PSMC5 PSMC5 ENSUAMP00000008157 ENSUAMP00000008157 ENSUAMP00000008156 ENSUAMP00000008156 BEAN1 BEAN1 ENSUAMP00000007793 ENSUAMP00000007793 VDAC1 VDAC1 PRKCB PRKCB ENSUAMP00000007671 ENSUAMP00000007671 MCU MCU BECN2 BECN2 MAP3K5 MAP3K5 NOP56 NOP56 GRIN3B GRIN3B PSMB3 PSMB3 PSMB6 PSMB6 PSMC3 PSMC3 ENSUAMP00000005735 ENSUAMP00000005735 ITPR3 ITPR3 PLCB2 PLCB2 ENSUAMP00000004531 ENSUAMP00000004531 ATXN1 ATXN1 TBP TBP PSMB1 PSMB1 ENSUAMP00000003509 ENSUAMP00000003509 ENSUAMP00000003372 ENSUAMP00000003372 PSMD11 PSMD11 ENSUAMP00000002341 ENSUAMP00000002341 PSMD2 PSMD2 PSMD1 PSMD1 TRAF2 TRAF2 PSMC4 PSMC4 ENSUAMP00000001579 ENSUAMP00000001579 ATXN2L ATXN2L ATG14 ATG14 TBPL2 TBPL2 ENSUAMP00000000802 ENSUAMP00000000802 ENSUAMP00000000721 ENSUAMP00000000721 ENSUAMP00000000292 ENSUAMP00000000292 FGF14 FGF14 AKT2 AKT2 PPIF PPIF ENSUAMP00000037175 ENSUAMP00000037175 ENSUAMP00000037110 ENSUAMP00000037110 PSMD12 PSMD12 KCNC1 KCNC1 MYOD1 MYOD1 ENSUAMP00000036637 ENSUAMP00000036637 SLC1A6 SLC1A6 ENSUAMP00000036524 ENSUAMP00000036524 OPA1 OPA1 PSMD4 PSMD4 NRBF2 NRBF2 ENSUAMP00000035331 ENSUAMP00000035331 ENSUAMP00000035186 ENSUAMP00000035186 AMBRA1 AMBRA1 ENSUAMP00000035001 ENSUAMP00000035001 ENSUAMP00000034850 ENSUAMP00000034850 ENSUAMP00000034830 ENSUAMP00000034830 ATG13 ATG13 GTF2B GTF2B PSMA2 PSMA2 GRIN2B GRIN2B WIPI1 WIPI1 PSMB7 PSMB7 PSMA7 PSMA7 ATXN2 ATXN2 PIK3C3 PIK3C3 PSMA6 PSMA6 PSMC6 PSMC6 ENSUAMP00000029591 ENSUAMP00000029591 C7orf31 C7orf31 CYCS CYCS MAPK9 MAPK9 PLCB4 PLCB4 AFG3L2 AFG3L2 GRIN1 GRIN1 GRIA1 GRIA1 GRIN3A GRIN3A KAT5 KAT5 ATXN1L ATXN1L ATP2A1 ATP2A1 SLC25A31 SLC25A31 ENSUAMP00000026056 ENSUAMP00000026056 VLDLR VLDLR ATG2B ATG2B PSMA1 PSMA1 PDYN PDYN ENSUAMP00000025300 ENSUAMP00000025300 PSMC2 PSMC2 PSMB4 PSMB4 ENSUAMP00000024890 ENSUAMP00000024890
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMB2Proteasome subunit beta. (167 aa)
TBPL1TATA-box binding protein like 1. (186 aa)
RORARAR related orphan receptor A. (522 aa)
ENSUAMP00000024291Uncharacterized protein. (76 aa)
ULK2Unc-51 like autophagy activating kinase 2. (654 aa)
ENSUAMP00000023390Uncharacterized protein. (286 aa)
ENSUAMP00000023294Uncharacterized protein. (67 aa)
PUM1PUM-HD domain-containing protein. (1082 aa)
TWNKTwinkle mtDNA helicase. (684 aa)
ENSUAMP00000023102Uncharacterized protein. (1102 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
MAPK10Mitogen-activated protein kinase. (422 aa)
RBPJLRecombination signal binding protein for immunoglobulin kappa J region like. (537 aa)
ENSUAMP00000022131Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (636 aa)
ENSUAMP00000022022Uncharacterized protein. (107 aa)
ULK1Unc-51 like autophagy activating kinase 1. (974 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1427 aa)
RB1CC1RB1 inducible coiled-coil 1. (1273 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (408 aa)
GNAQG protein subunit alpha q. (352 aa)
VDAC3Voltage dependent anion channel 3. (279 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (714 aa)
ENSUAMP00000019817Uncharacterized protein. (107 aa)
ENSUAMP00000019816Uncharacterized protein; Belongs to the heparin-binding growth factors family. (113 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (536 aa)
ENSUAMP00000019493Uncharacterized protein. (519 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2523 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
SLC25A5Solute carrier family 25 member 5; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
KCNC3Potassium voltage-gated channel subfamily C member 3; Belongs to the potassium channel family. (672 aa)
ATXN10Ataxin 10. (308 aa)
SPTBN2Spectrin beta chain; Belongs to the spectrin family. (2171 aa)
RYR1Ryanodine receptor 1. (3775 aa)
ENSUAMP00000017736Cation_ATPase_N domain-containing protein. (54 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (982 aa)
ENSUAMP00000017692Uncharacterized protein. (704 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (351 aa)
ATG101Autophagy related 101. (218 aa)
ENSUAMP00000017435Uncharacterized protein. (459 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (376 aa)
BECN1Beclin 1. (448 aa)
ENSUAMP00000016311Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (98 aa)
ENSUAMP00000015788BZIP domain-containing protein. (359 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (361 aa)
ENSUAMP00000015620Uncharacterized protein. (577 aa)
ENSUAMP00000015381ANF_receptor domain-containing protein. (158 aa)
ATG2AAutophagy related 2A. (1940 aa)
ENSUAMP00000014933Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (286 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (601 aa)
ENSUAMP00000013707Uncharacterized protein. (382 aa)
SP1Sp1 transcription factor. (780 aa)
CICCapicua transcriptional repressor. (2470 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
RELNReelin. (3263 aa)
ENSUAMP00000012220ATPase_AAA_core domain-containing protein. (174 aa)
ENSUAMP00000011731Ion_trans domain-containing protein. (408 aa)
TRPC3Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (907 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
WIPI2WD repeat domain, phosphoinositide interacting 2. (436 aa)
ENSUAMP00000010738Uncharacterized protein. (181 aa)
PLCB1Phosphoinositide phospholipase C. (658 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
PSMD9PDZ domain-containing protein. (309 aa)
PRKCAProtein kinase C alpha; Belongs to the protein kinase superfamily. (484 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (676 aa)
PUM2Pumilio RNA binding family member 2. (851 aa)
PSMB5Proteasome subunit beta. (263 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (322 aa)
MAPK8Mitogen-activated protein kinase. (456 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (978 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
ENSUAMP00000008157Oxysterol-binding protein; Belongs to the OSBP family. (761 aa)
ENSUAMP00000008156Uncharacterized protein. (93 aa)
BEAN1Brain expressed associated with NEDD4 1. (260 aa)
ENSUAMP00000007793Uncharacterized protein. (171 aa)
VDAC1Voltage dependent anion channel 1. (283 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (651 aa)
ENSUAMP00000007671Uncharacterized protein. (161 aa)
MCUMitochondrial calcium uniporter. (343 aa)
BECN2Beclin 2. (433 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1212 aa)
NOP56NOP56 ribonucleoprotein. (650 aa)
GRIN3BGlutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1001 aa)
PSMB3Proteasome subunit beta. (202 aa)
PSMB6Proteasome subunit beta. (219 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (439 aa)
ENSUAMP00000005735PROTEASOME_ALPHA_1 domain-containing protein. (80 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2656 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1166 aa)
ENSUAMP00000004531AAA domain-containing protein; Belongs to the AAA ATPase family. (421 aa)
ATXN1Ataxin 1. (794 aa)
TBPTATA-box binding protein. (324 aa)
PSMB1Proteasome subunit beta. (241 aa)
ENSUAMP00000003509LAG1_DNAbind domain-containing protein. (58 aa)
ENSUAMP00000003372Uncharacterized protein. (157 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (418 aa)
ENSUAMP00000002341Uncharacterized protein. (957 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (683 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (400 aa)
ENSUAMP00000001579Cation_ATPase_N domain-containing protein. (75 aa)
ATXN2LAtaxin 2 like. (1046 aa)
ATG14Autophagy related 14. (492 aa)
TBPL2TATA-box binding protein like 2. (344 aa)
ENSUAMP00000000802Uncharacterized protein. (67 aa)
ENSUAMP00000000721Uncharacterized protein. (284 aa)
ENSUAMP00000000292PCI domain-containing protein. (389 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (247 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (210 aa)
ENSUAMP00000037175MPN domain-containing protein. (156 aa)
ENSUAMP00000037110Josephin domain-containing protein. (358 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
KCNC1Potassium voltage-gated channel subfamily C member 1; Belongs to the potassium channel family. (479 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
ENSUAMP00000036637PCI domain-containing protein. (405 aa)
SLC1A6Amino acid transporter. (564 aa)
ENSUAMP00000036524Uncharacterized protein. (347 aa)
OPA1OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1015 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (344 aa)
NRBF2Nuclear receptor binding factor 2. (244 aa)
ENSUAMP00000035331Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (506 aa)
ENSUAMP00000035186ANF_receptor domain-containing protein. (305 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1182 aa)
ENSUAMP00000035001Uncharacterized protein. (321 aa)
ENSUAMP00000034850Uncharacterized protein. (294 aa)
ENSUAMP00000034830Uncharacterized protein. (1872 aa)
ATG13Autophagy related 13. (550 aa)
GTF2BGeneral transcription factor IIB. (316 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (443 aa)
PSMB7Proteasome subunit beta. (277 aa)
PSMA7Proteasome endopeptidase complex. (248 aa)
ATXN2Ataxin 2. (1143 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (746 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa)
ENSUAMP00000029591Uncharacterized protein. (70 aa)
C7orf31Chromosome 7 open reading frame 31. (575 aa)
CYCSCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
MAPK9Mitogen-activated protein kinase. (433 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1136 aa)
AFG3L2AFG3 like matrix AAA peptidase subunit 2. (806 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (814 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (906 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (1103 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
ATXN1LAtaxin 1 like. (688 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1060 aa)
SLC25A31Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (323 aa)
ENSUAMP00000026056MitMem_reg domain-containing protein. (95 aa)
VLDLRVery low density lipoprotein receptor. (892 aa)
ATG2BAutophagy related 2B. (1440 aa)
PSMA1Proteasome subunit alpha type. (269 aa)
PDYNProdynorphin. (258 aa)
ENSUAMP00000025300Non-specific serine/threonine protein kinase. (254 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
ENSUAMP00000024890Uncharacterized protein. (134 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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