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GABRA2 GABRA2 PDE4D PDE4D GNB1 GNB1 ADCY4 ADCY4 ADCY7 ADCY7 ENSUAMP00000032618 ENSUAMP00000032618 PDE10A PDE10A PRKACB PRKACB GNG3 GNG3 PDE1A PDE1A ENSUAMP00000034716 ENSUAMP00000034716 GNB3 GNB3 GNAI2 GNAI2 PDE2A PDE2A ENSUAMP00000036154 ENSUAMP00000036154 GABRA3 GABRA3 GNB2 GNB2 ENSUAMP00000000513 ENSUAMP00000000513 PDE7A PDE7A ENSUAMP00000000883 ENSUAMP00000000883 GNGT1 GNGT1 GNG11 GNG11 ENSUAMP00000001479 ENSUAMP00000001479 ENSUAMP00000002251 ENSUAMP00000002251 ENSUAMP00000002311 ENSUAMP00000002311 ENSUAMP00000003186 ENSUAMP00000003186 ENSUAMP00000003460 ENSUAMP00000003460 GABRR3 GABRR3 ENSUAMP00000003880 ENSUAMP00000003880 GABRG3 GABRG3 OPRM1 OPRM1 GNB5 GNB5 GABRQ GABRQ ADCY9 ADCY9 ARRB2 ARRB2 GRK2 GRK2 GNG4 GNG4 KCNJ3 KCNJ3 ENSUAMP00000007406 ENSUAMP00000007406 ADORA1 ADORA1 PRKCB PRKCB GNAI3 GNAI3 ADCY2 ADCY2 ADCY3 ADCY3 GNB4 GNB4 ENSUAMP00000009534 ENSUAMP00000009534 GABRA1 GABRA1 ENSUAMP00000009960 ENSUAMP00000009960 ENSUAMP00000009965 ENSUAMP00000009965 GNAO1 GNAO1 ENSUAMP00000010227 ENSUAMP00000010227 PRKCA PRKCA ENSUAMP00000010849 ENSUAMP00000010849 GRK3 GRK3 GRK5 GRK5 PDE8A PDE8A PDE1B PDE1B SLC32A1 SLC32A1 GABBR1 GABBR1 ENSUAMP00000012611 ENSUAMP00000012611 ENSUAMP00000013490 ENSUAMP00000013490 GNG2 GNG2 ENSUAMP00000013843 ENSUAMP00000013843 ENSUAMP00000014016 ENSUAMP00000014016 ENSUAMP00000014629 ENSUAMP00000014629 KCNJ9 KCNJ9 DRD1 DRD1 GABRA5 GABRA5 GABRG2 GABRG2 GNG13 GNG13 GABRE GABRE GNG7 GNG7 ENSUAMP00000017181 ENSUAMP00000017181 ENSUAMP00000003818 ENSUAMP00000003818 KCNJ5 KCNJ5 GNG12 GNG12 GABRB2 GABRB2 ENSUAMP00000019493 ENSUAMP00000019493 GNGT2 GNGT2 PRKCG PRKCG ENSUAMP00000020433 ENSUAMP00000020433 ENSUAMP00000020705 ENSUAMP00000020705 GABRR2 GABRR2 GABRR1 GABRR1 ADCY6 ADCY6 PDE3A PDE3A ENSUAMP00000021520 ENSUAMP00000021520 GNG8 GNG8 ENSUAMP00000022172 ENSUAMP00000022172 GABRD GABRD ARRB1 ARRB1 ENSUAMP00000023632 ENSUAMP00000023632 PDE4A PDE4A ENSUAMP00000024746 ENSUAMP00000024746 ARR3 ARR3 ENSUAMP00000025177 ENSUAMP00000025177 ENSUAMP00000025300 ENSUAMP00000025300 ENSUAMP00000026030 ENSUAMP00000026030 ENSUAMP00000026337 ENSUAMP00000026337 ENSUAMP00000026424 ENSUAMP00000026424 PDE4B PDE4B ADCY5 ADCY5 GABRA4 GABRA4 ADCY1 ADCY1 GNAS GNAS ENSUAMP00000028781 ENSUAMP00000028781 ENSUAMP00000030381 ENSUAMP00000030381 GRK6 GRK6 GABRG1 GABRG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GABRA2Gamma-aminobutyric acid type A receptor alpha2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (511 aa)
PDE4DPhosphodiesterase. (585 aa)
GNB1G protein subunit beta 1. (224 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
ENSUAMP00000032618Uncharacterized protein. (68 aa)
PDE10APhosphodiesterase. (525 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (361 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PDE1APhosphodiesterase. (518 aa)
ENSUAMP00000034716Uncharacterized protein. (118 aa)
GNB3G protein subunit beta 3. (339 aa)
GNAI2G protein subunit alpha i2. (436 aa)
PDE2APhosphodiesterase. (975 aa)
ENSUAMP00000036154Phosphodiesterase. (696 aa)
GABRA3Gamma-aminobutyric acid type A receptor alpha3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (454 aa)
GNB2G protein subunit beta 2. (340 aa)
ENSUAMP00000000513G_PROTEIN_RECEP_F3_4 domain-containing protein. (287 aa)
PDE7APhosphodiesterase. (457 aa)
ENSUAMP00000000883Neur_chan_LBD domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (198 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
ENSUAMP00000001479Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (121 aa)
ENSUAMP00000002251Uncharacterized protein. (450 aa)
ENSUAMP00000002311Uncharacterized protein. (114 aa)
ENSUAMP00000003186Uncharacterized protein. (52 aa)
ENSUAMP00000003460Uncharacterized protein. (281 aa)
GABRR3Gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene); Belongs to the ligand-gated ion channel (TC 1.A.9) family. (430 aa)
ENSUAMP00000003880Uncharacterized protein. (91 aa)
GABRG3Gamma-aminobutyric acid type A receptor gamma3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (259 aa)
OPRM1Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (450 aa)
GNB5G protein subunit beta 5. (264 aa)
GABRQGamma-aminobutyric acid type A receptor theta subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (645 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1338 aa)
ARRB2Arrestin beta 2. (405 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (647 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (308 aa)
ENSUAMP00000007406PDEase domain-containing protein. (173 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (651 aa)
GNAI3G protein subunit alpha i3. (295 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (973 aa)
GNB4G protein subunit beta 4. (331 aa)
ENSUAMP00000009534G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (236 aa)
GABRA1Gamma-aminobutyric acid type A receptor alpha1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (471 aa)
ENSUAMP00000009960Neur_chan_memb domain-containing protein. (224 aa)
ENSUAMP00000009965Neur_chan_LBD domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (182 aa)
GNAO1G protein subunit alpha o1. (354 aa)
ENSUAMP00000010227Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
PRKCAProtein kinase C alpha; Belongs to the protein kinase superfamily. (484 aa)
ENSUAMP00000010849PDE4_UCR domain-containing protein. (136 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (649 aa)
GRK5G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (590 aa)
PDE8APhosphodiesterase. (779 aa)
PDE1BPhosphodiesterase. (535 aa)
SLC32A1Solute carrier family 32 member 1. (526 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (844 aa)
ENSUAMP00000012611Sushi domain-containing protein. (238 aa)
ENSUAMP00000013490Neur_chan_memb domain-containing protein. (195 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (105 aa)
ENSUAMP00000013843Neur_chan_memb domain-containing protein. (224 aa)
ENSUAMP00000014016Uncharacterized protein. (77 aa)
ENSUAMP00000014629Uncharacterized protein. (105 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (392 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
GABRA5Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (261 aa)
GABRG2Gamma-aminobutyric acid type A receptor gamma2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (377 aa)
GNG13G protein subunit gamma 13. (67 aa)
GABREGamma-aminobutyric acid type A receptor epsilon subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (491 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ENSUAMP00000017181Uncharacterized protein. (462 aa)
ENSUAMP00000003818Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GABRB2Gamma-aminobutyric acid type A receptor beta2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (474 aa)
ENSUAMP00000019493Uncharacterized protein. (519 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (714 aa)
ENSUAMP00000020433Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
ENSUAMP00000020705G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (233 aa)
GABRR2Gamma-aminobutyric acid type A receptor rho2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (473 aa)
GABRR1Gamma-aminobutyric acid type A receptor rho1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (448 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
PDE3APhosphodiesterase. (777 aa)
ENSUAMP00000021520Uncharacterized protein. (210 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
ENSUAMP00000022172Uncharacterized protein. (157 aa)
GABRDGamma-aminobutyric acid type A receptor delta subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (428 aa)
ARRB1Arrestin beta 1. (380 aa)
ENSUAMP00000023632Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PDE4APhosphodiesterase 4A; Belongs to the cyclic nucleotide phosphodiesterase family. (872 aa)
ENSUAMP00000024746PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family. (350 aa)
ARR3Arrestin 3. (380 aa)
ENSUAMP00000025177Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
ENSUAMP00000025300Non-specific serine/threonine protein kinase. (254 aa)
ENSUAMP00000026030Uncharacterized protein. (236 aa)
ENSUAMP00000026337Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
ENSUAMP00000026424Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
PDE4BPhosphodiesterase. (682 aa)
ADCY5Adenylate cyclase 5. (940 aa)
GABRA4Gamma-aminobutyric acid type A receptor alpha4 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (576 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
GNASGNAS complex locus. (994 aa)
ENSUAMP00000028781G protein gamma domain-containing protein. (61 aa)
ENSUAMP00000030381Uncharacterized protein. (67 aa)
GRK6G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (550 aa)
GABRG1Gamma-aminobutyric acid type A receptor gamma1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (465 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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