STRINGSTRING
IL10 IL10 ENSUAMP00000001083 ENSUAMP00000001083 ENSUAMP00000001103 ENSUAMP00000001103 ENSUAMP00000001114 ENSUAMP00000001114 ENSUAMP00000001144 ENSUAMP00000001144 ENSUAMP00000001168 ENSUAMP00000001168 ENSUAMP00000001254 ENSUAMP00000001254 ENSUAMP00000001437 ENSUAMP00000001437 ENSUAMP00000001451 ENSUAMP00000001451 ENSUAMP00000001460 ENSUAMP00000001460 HBQ1 HBQ1 ENSUAMP00000002525 ENSUAMP00000002525 ENSUAMP00000002526 ENSUAMP00000002526 HBM HBM ENSUAMP00000002533 ENSUAMP00000002533 ENSUAMP00000002712 ENSUAMP00000002712 ENSUAMP00000002835 ENSUAMP00000002835 ENSUAMP00000003378 ENSUAMP00000003378 ENSUAMP00000004579 ENSUAMP00000004579 ENSUAMP00000004598 ENSUAMP00000004598 PLCB2 PLCB2 VCAM1 VCAM1 F2RL1 F2RL1 MYD88 MYD88 ENSUAMP00000007032 ENSUAMP00000007032 PRKCB PRKCB ENSUAMP00000010117 ENSUAMP00000010117 ENSUAMP00000010475 ENSUAMP00000010475 PRKCA PRKCA PLCB1 PLCB1 IL12A IL12A ENSUAMP00000013982 ENSUAMP00000013982 IDO1 IDO1 IL12B IL12B NGB NGB TNF TNF THOP1 THOP1 CYGB CYGB ENSUAMP00000017764 ENSUAMP00000017764 ENSUAMP00000018082 ENSUAMP00000018082 PLCB3 PLCB3 LAMA4 LAMA4 ENSUAMP00000019938 ENSUAMP00000019938 PRKCG PRKCG GNAQ GNAQ ENSUAMP00000021688 ENSUAMP00000021688 MB MB IGHM IGHM ENSUAMP00000022738 ENSUAMP00000022738 ENSUAMP00000023119 ENSUAMP00000023119 IL18 IL18 NPPA NPPA ENSUAMP00000025300 ENSUAMP00000025300 APOA1 APOA1 ENSUAMP00000026182 ENSUAMP00000026182 ENSUAMP00000026301 ENSUAMP00000026301 ENSUAMP00000026353 ENSUAMP00000026353 ENSUAMP00000026919 ENSUAMP00000026919 PLCB4 PLCB4 IL6 IL6 IL1B IL1B ENSUAMP00000033421 ENSUAMP00000033421
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL10Interleukin 10. (178 aa)
ENSUAMP00000001083GLOBIN domain-containing protein; Belongs to the globin family. (147 aa)
ENSUAMP00000001103GLOBIN domain-containing protein; Belongs to the globin family. (147 aa)
ENSUAMP00000001114GLOBIN domain-containing protein; Belongs to the globin family. (147 aa)
ENSUAMP00000001144annotation not available (92 aa)
ENSUAMP00000001168GLOBIN domain-containing protein; Belongs to the globin family. (185 aa)
ENSUAMP00000001254Uncharacterized protein. (96 aa)
ENSUAMP00000001437Uncharacterized protein. (607 aa)
ENSUAMP00000001451Uncharacterized protein. (368 aa)
ENSUAMP00000001460Uncharacterized protein. (65 aa)
HBQ1Hemoglobin subunit theta 1; Belongs to the globin family. (161 aa)
ENSUAMP00000002525GLOBIN domain-containing protein; Belongs to the globin family. (142 aa)
ENSUAMP00000002526GLOBIN domain-containing protein; Belongs to the globin family. (153 aa)
HBMHemoglobin subunit mu; Belongs to the globin family. (143 aa)
ENSUAMP00000002533GLOBIN domain-containing protein; Belongs to the globin family. (142 aa)
ENSUAMP00000002712Uncharacterized protein. (561 aa)
ENSUAMP00000002835ICAM_N domain-containing protein. (149 aa)
ENSUAMP00000003378Uncharacterized protein. (332 aa)
ENSUAMP00000004579Abhydrolase_3 domain-containing protein. (224 aa)
ENSUAMP00000004598Uncharacterized protein. (299 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1166 aa)
VCAM1Vascular cell adhesion molecule 1. (702 aa)
F2RL1F2R like trypsin receptor 1. (397 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
ENSUAMP00000007032Uncharacterized protein. (505 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (651 aa)
ENSUAMP00000010117Uncharacterized protein. (108 aa)
ENSUAMP00000010475IGv domain-containing protein. (144 aa)
PRKCAProtein kinase C alpha; Belongs to the protein kinase superfamily. (484 aa)
PLCB1Phosphoinositide phospholipase C. (658 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
ENSUAMP00000013982Uncharacterized protein. (305 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (386 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
NGBNeuroglobin; Belongs to the globin family. (151 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (230 aa)
THOP1Thimet oligopeptidase 1. (666 aa)
CYGBCytoglobin; Belongs to the globin family. (190 aa)
ENSUAMP00000017764Uncharacterized protein. (365 aa)
ENSUAMP00000018082Uncharacterized protein. (249 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
LAMA4Laminin subunit alpha 4. (1784 aa)
ENSUAMP00000019938Uncharacterized protein. (193 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (714 aa)
GNAQG protein subunit alpha q. (352 aa)
ENSUAMP00000021688Uncharacterized protein. (297 aa)
MBMyoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (148 aa)
IGHMImmunoglobulin heavy constant mu. (480 aa)
ENSUAMP00000022738Uncharacterized protein. (126 aa)
ENSUAMP00000023119Uncharacterized protein. (607 aa)
IL18Interleukin 18. (167 aa)
NPPANatriuretic peptide A. (182 aa)
ENSUAMP00000025300Non-specific serine/threonine protein kinase. (254 aa)
APOA1Apolipoprotein A1. (266 aa)
ENSUAMP00000026182Abhydrolase_3 domain-containing protein. (237 aa)
ENSUAMP00000026301Ig-like domain-containing protein. (331 aa)
ENSUAMP00000026353Haptoglobin; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. (346 aa)
ENSUAMP00000026919TIR domain-containing protein. (1033 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1136 aa)
IL6Interleukin 6. (212 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
ENSUAMP00000033421GLOBIN domain-containing protein; Belongs to the globin family. (135 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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