STRINGSTRING
CASP3 CASP3 RFXANK RFXANK ENSUAMP00000000176 ENSUAMP00000000176 IL10 IL10 ENSUAMP00000000439 ENSUAMP00000000439 CLEC4E CLEC4E ENSUAMP00000001254 ENSUAMP00000001254 ENSUAMP00000001501 ENSUAMP00000001501 HSPA9 HSPA9 RFXAP RFXAP ENSUAMP00000003525 ENSUAMP00000003525 IL10RA IL10RA ENSUAMP00000004604 ENSUAMP00000004604 NFYC NFYC ATP6V0D2 ATP6V0D2 ENSUAMP00000005976 ENSUAMP00000005976 MYD88 MYD88 TIRAP TIRAP ENSUAMP00000006398 ENSUAMP00000006398 ENSUAMP00000006595 ENSUAMP00000006595 ENSUAMP00000006641 ENSUAMP00000006641 CORO1B CORO1B ENSUAMP00000006735 ENSUAMP00000006735 ENSUAMP00000006865 ENSUAMP00000006865 ENSUAMP00000006872 ENSUAMP00000006872 ENSUAMP00000007032 ENSUAMP00000007032 LAMP1 LAMP1 ENSUAMP00000007617 ENSUAMP00000007617 CASP10 CASP10 CASP8 CASP8 JAK2 JAK2 PPP3CA PPP3CA NOS2 NOS2 KSR1 KSR1 CIITA CIITA CALML5 CALML5 LAMP2 LAMP2 RHOB RHOB ATP6V0A1 ATP6V0A1 CEBPG CEBPG MAPK8 MAPK8 ENSUAMP00000009398 ENSUAMP00000009398 PPP3CB PPP3CB ITGAM ITGAM CLEC4G CLEC4G ENSUAMP00000010475 ENSUAMP00000010475 ENSUAMP00000010491 ENSUAMP00000010491 AKT1 AKT1 CLEC7A CLEC7A ENSUAMP00000011223 ENSUAMP00000011223 IL12A IL12A JAK1 JAK1 ENSUAMP00000011530 ENSUAMP00000011530 ENSUAMP00000011531 ENSUAMP00000011531 AKT3 AKT3 CARD9 CARD9 BCL2 BCL2 ENSUAMP00000012405 ENSUAMP00000012405 TGFB1 TGFB1 HLA-DMA HLA-DMA ENSUAMP00000012503 ENSUAMP00000012503 CORO1A CORO1A CTSS CTSS BAX BAX SPHK2 SPHK2 BID BID ENSUAMP00000013482 ENSUAMP00000013482 MAPK1 MAPK1 CALML6 CALML6 IL12B IL12B ENSUAMP00000014737 ENSUAMP00000014737 TNF TNF EFCAB13 EFCAB13 ENSUAMP00000016311 ENSUAMP00000016311 ATP6V0C ATP6V0C CYP27B1 CYP27B1 ENSUAMP00000016547 ENSUAMP00000016547 HLA-DOB HLA-DOB TGFB3 TGFB3 MAPK12 MAPK12 MAPK11 MAPK11 HLA-DRA HLA-DRA RAB5B RAB5B IFNGR2 IFNGR2 ENSUAMP00000019086 ENSUAMP00000019086 MRC2 MRC2 ENSUAMP00000019174 ENSUAMP00000019174 ENSUAMP00000019181 ENSUAMP00000019181 BAD BAD PPP1R14B PPP1R14B ENSUAMP00000019310 ENSUAMP00000019310 TLR6 TLR6 TLR1 TLR1 CALML4 CALML4 CAMK2B CAMK2B TRADD TRADD ATP6V0A4 ATP6V0A4 ATP6V0D1 ATP6V0D1 AKT2 AKT2 IL10RB IL10RB ENSUAMP00000037283 ENSUAMP00000037283 ENSUAMP00000036524 ENSUAMP00000036524 RAB5A RAB5A RFX5 RFX5 CALM2 CALM2 ENSUAMP00000035427 ENSUAMP00000035427 HLA-DOA HLA-DOA VDR VDR IRAK4 IRAK4 ENSUAMP00000035001 ENSUAMP00000035001 IL23A IL23A ITGB2 ITGB2 ATP6V0B ATP6V0B ENSUAMP00000034569 ENSUAMP00000034569 NFYB NFYB STAT1 STAT1 RAB17 RAB17 FCER1G FCER1G ATP6V1H ATP6V1H CD74 CD74 IL1A IL1A IL1B IL1B ARSI ARSI TLR4 TLR4 PPP3CC PPP3CC ARHGEF12 ARHGEF12 PIK3C3 PIK3C3 ENSUAMP00000032382 ENSUAMP00000032382 IRAK2 IRAK2 MAPK13 MAPK13 MAPK14 MAPK14 SYK SYK ENSUAMP00000031906 ENSUAMP00000031906 EP300 EP300 ENSUAMP00000031800 ENSUAMP00000031800 MAPK3 MAPK3 C3 C3 CORO1C CORO1C ATP6V0A2 ATP6V0A2 IL6 IL6 ENSUAMP00000030787 ENSUAMP00000030787 CREBBP CREBBP RAF1 RAF1 ENSUAMP00000030678 ENSUAMP00000030678 TRAF6 TRAF6 ENSUAMP00000030153 ENSUAMP00000030153 LBP LBP SRC SRC CLEC4A CLEC4A SPHK1 SPHK1 TNFRSF1A TNFRSF1A ENSUAMP00000029199 ENSUAMP00000029199 PLA2R1 PLA2R1 C7orf31 C7orf31 CYCS CYCS CORO6 CORO6 MAPK9 MAPK9 EFCAB3 EFCAB3 ENSUAMP00000027770 ENSUAMP00000027770 FADD FADD CEBPB CEBPB IFITM10 IFITM10 ENSUAMP00000027063 ENSUAMP00000027063 LSP1 LSP1 ENSUAMP00000026919 ENSUAMP00000026919 RELA RELA ATP6AP1 ATP6AP1 ENSUAMP00000025726 ENSUAMP00000025726 APAF1 APAF1 ENSUAMP00000025311 ENSUAMP00000025311 ANKRA2 ANKRA2 TCIRG1 TCIRG1 IRAK1 IRAK1 BCL10 BCL10 MRC1 MRC1 RAB7A RAB7A CREB1 CREB1 ENSUAMP00000023976 ENSUAMP00000023976 IL18 IL18 RIPK2 RIPK2 MAPK10 MAPK10 CASP9 CASP9 IFNGR1 IFNGR1 TLR2 TLR2 ENSUAMP00000021954 ENSUAMP00000021954 IGHM IGHM CALM3 CALM3 NFKB1 NFKB1 TGFB2 TGFB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CASP3Caspase 3; Belongs to the peptidase C14A family. (266 aa)
RFXANKRegulatory factor X associated ankyrin containing protein. (260 aa)
ENSUAMP00000000176Protein kinase domain-containing protein. (82 aa)
IL10Interleukin 10. (178 aa)
ENSUAMP00000000439Uncharacterized protein. (456 aa)
CLEC4EC-type lectin domain family 4 member E. (154 aa)
ENSUAMP00000001254Uncharacterized protein. (96 aa)
ENSUAMP00000001501Uncharacterized protein. (470 aa)
HSPA9Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family. (678 aa)
RFXAPRegulatory factor X associated protein. (282 aa)
ENSUAMP00000003525Ig-like domain-containing protein; Belongs to the MHC class II family. (205 aa)
IL10RAInterleukin 10 receptor subunit alpha. (575 aa)
ENSUAMP00000004604Uncharacterized protein. (54 aa)
NFYCNuclear transcription factor Y subunit gamma. (335 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
ENSUAMP00000005976Uncharacterized protein. (94 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
TIRAPTIR domain containing adaptor protein. (224 aa)
ENSUAMP00000006398annotation not available (356 aa)
ENSUAMP00000006595Ig-like domain-containing protein; Belongs to the MHC class II family. (202 aa)
ENSUAMP00000006641Uncharacterized protein. (184 aa)
CORO1BCoronin; Belongs to the WD repeat coronin family. (655 aa)
ENSUAMP00000006735Uncharacterized protein. (185 aa)
ENSUAMP00000006865MHC_II_beta domain-containing protein. (274 aa)
ENSUAMP00000006872MHC_II_beta domain-containing protein. (218 aa)
ENSUAMP00000007032Uncharacterized protein. (505 aa)
LAMP1Lysosomal associated membrane protein 1. (414 aa)
ENSUAMP00000007617Protein kinase domain-containing protein. (271 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (481 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (395 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
PPP3CASerine/threonine-protein phosphatase. (317 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1064 aa)
KSR1Kinase suppressor of ras 1. (872 aa)
CIITAClass II major histocompatibility complex transactivator. (1063 aa)
CALML5Calmodulin like 5. (156 aa)
LAMP2Lysosomal associated membrane protein 2. (411 aa)
RHOBRas homolog family member B. (172 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (838 aa)
CEBPGCCAAT enhancer binding protein gamma. (147 aa)
MAPK8Mitogen-activated protein kinase. (456 aa)
ENSUAMP00000009398VWFA domain-containing protein; Belongs to the integrin alpha chain family. (1150 aa)
PPP3CBSerine/threonine-protein phosphatase. (479 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1208 aa)
CLEC4GC-type lectin domain family 4 member G. (254 aa)
ENSUAMP00000010475IGv domain-containing protein. (144 aa)
ENSUAMP00000010491Uncharacterized protein; Belongs to the TCP-1 chaperonin family. (153 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
CLEC7AC-type lectin domain containing 7A. (237 aa)
ENSUAMP00000011223Uncharacterized protein. (224 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
JAK1Tyrosine-protein kinase. (1152 aa)
ENSUAMP00000011530Uncharacterized protein. (197 aa)
ENSUAMP00000011531Uncharacterized protein. (172 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CARD9Caspase recruitment domain family member 9. (566 aa)
BCL2BCL2 apoptosis regulator. (205 aa)
ENSUAMP00000012405Uncharacterized protein. (110 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (261 aa)
ENSUAMP00000012503Ig-like domain-containing protein. (263 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
CTSSCathepsin S; Belongs to the peptidase C1 family. (313 aa)
BAXBCL2 associated X, apoptosis regulator. (205 aa)
SPHK2Sphingosine kinase 2. (662 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (196 aa)
ENSUAMP00000013482Uncharacterized protein. (91 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
CALML6Calmodulin like 6. (180 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
ENSUAMP00000014737Uncharacterized protein. (242 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (230 aa)
EFCAB13EF-hand calcium binding domain 13. (939 aa)
ENSUAMP00000016311Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (98 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
ENSUAMP00000016547MHC_II_beta domain-containing protein. (275 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (261 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
MAPK12Mitogen-activated protein kinase 12. (373 aa)
MAPK11Mitogen-activated protein kinase. (357 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
RAB5BRAB5B, member RAS oncogene family. (215 aa)
IFNGR2Interferon gamma receptor 2. (343 aa)
ENSUAMP00000019086Uncharacterized protein. (361 aa)
MRC2Mannose receptor C type 2. (1045 aa)
ENSUAMP00000019174CaMKII_AD domain-containing protein. (267 aa)
ENSUAMP00000019181Protein kinase domain-containing protein. (206 aa)
BADBCL2 associated agonist of cell death. (168 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (147 aa)
ENSUAMP00000019310Uncharacterized protein. (182 aa)
TLR6Toll like receptor 6; Belongs to the Toll-like receptor family. (778 aa)
TLR1Toll like receptor 1; Belongs to the Toll-like receptor family. (802 aa)
CALML4Calmodulin like 4. (153 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (589 aa)
TRADDTNFRSF1A associated via death domain. (314 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (840 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
IL10RBInterleukin 10 receptor subunit beta. (375 aa)
ENSUAMP00000037283Ig-like domain-containing protein. (145 aa)
ENSUAMP00000036524Uncharacterized protein. (347 aa)
RAB5ARAB5A, member RAS oncogene family. (229 aa)
RFX5Regulatory factor X5. (532 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (163 aa)
ENSUAMP00000035427Ig-like domain-containing protein; Belongs to the MHC class II family. (241 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (283 aa)
VDRVitamin D receptor. (427 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (477 aa)
ENSUAMP00000035001Uncharacterized protein. (321 aa)
IL23AInterleukin 23 subunit alpha. (190 aa)
ITGB2Integrin beta. (815 aa)
ATP6V0BATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (205 aa)
ENSUAMP00000034569Uncharacterized protein. (250 aa)
NFYBNuclear transcription factor Y subunit beta. (216 aa)
STAT1Signal transducer and activator of transcription. (824 aa)
RAB17RAB17, member RAS oncogene family. (275 aa)
FCER1GFc fragment of IgE receptor Ig. (80 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
CD74CD74 molecule. (279 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (244 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
ARSIArylsulfatase family member I. (573 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
PPP3CCSerine/threonine-protein phosphatase. (449 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1439 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (746 aa)
ENSUAMP00000032382CaMKII_AD domain-containing protein. (189 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (621 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
SYKSpleen associated tyrosine kinase. (638 aa)
ENSUAMP00000031906Uncharacterized protein. (55 aa)
EP300E1A binding protein p300. (2399 aa)
ENSUAMP00000031800Uncharacterized protein. (216 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
C3Complement C3. (1667 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (474 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (832 aa)
IL6Interleukin 6. (212 aa)
ENSUAMP00000030787Uncharacterized protein. (84 aa)
CREBBPCREB binding protein. (2333 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (564 aa)
ENSUAMP00000030678Uncharacterized protein. (169 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
ENSUAMP00000030153BPI2 domain-containing protein. (268 aa)
LBPLipopolysaccharide binding protein. (406 aa)
SRCTyrosine-protein kinase. (557 aa)
CLEC4AC-type lectin domain family 4 member A. (250 aa)
SPHK1Sphingosine kinase 1. (387 aa)
TNFRSF1ATNF receptor superfamily member 1A. (502 aa)
ENSUAMP00000029199Uncharacterized protein. (351 aa)
PLA2R1Phospholipase A2 receptor 1. (1559 aa)
C7orf31Chromosome 7 open reading frame 31. (575 aa)
CYCSCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CORO6Coronin; Belongs to the WD repeat coronin family. (471 aa)
MAPK9Mitogen-activated protein kinase. (433 aa)
EFCAB3EF-hand calcium binding domain 3. (436 aa)
ENSUAMP00000027770C-type lectin domain-containing protein. (246 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (220 aa)
CEBPBCCAAT/enhancer-binding protein. (346 aa)
IFITM10Interferon induced transmembrane protein 10. (225 aa)
ENSUAMP00000027063Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (410 aa)
LSP1Lymphocyte specific protein 1. (361 aa)
ENSUAMP00000026919TIR domain-containing protein. (1033 aa)
RELARELA proto-oncogene, NF-kB subunit. (508 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (464 aa)
ENSUAMP00000025726annotation not available (113 aa)
APAF1Apoptotic peptidase activating factor 1. (948 aa)
ENSUAMP00000025311Uncharacterized protein. (295 aa)
ANKRA2Ankyrin repeat family A member 2. (320 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (828 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (664 aa)
BCL10BCL10 immune signaling adaptor. (234 aa)
MRC1Mannose receptor C-type 1. (1453 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
ENSUAMP00000023976Uncharacterized protein. (158 aa)
IL18Interleukin 18. (167 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (536 aa)
MAPK10Mitogen-activated protein kinase. (422 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (467 aa)
IFNGR1Interferon gamma receptor 1. (505 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (787 aa)
ENSUAMP00000021954Uncharacterized protein. (209 aa)
IGHMImmunoglobulin heavy constant mu. (480 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (149 aa)
NFKB1Nuclear factor kappa B subunit 1. (972 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (439 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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