STRINGSTRING
ENSUAMP00000003880 ENSUAMP00000003880 IL10RA IL10RA E2F2 E2F2 ENSUAMP00000004602 ENSUAMP00000004602 PLCB2 PLCB2 ATF4 ATF4 PTK2B PTK2B GNB5 GNB5 ENSUAMP00000005465 ENSUAMP00000005465 ENSUAMP00000005552 ENSUAMP00000005552 CCL5 CCL5 ITPR3 ITPR3 ADCY9 ADCY9 ENSUAMP00000005976 ENSUAMP00000005976 ENSUAMP00000006240 ENSUAMP00000006240 ENSUAMP00000006289 ENSUAMP00000006289 ENSUAMP00000006641 ENSUAMP00000006641 RPS6KB2 RPS6KB2 ENSUAMP00000006735 ENSUAMP00000006735 CGAS CGAS GNG4 GNG4 PRKCB PRKCB CASP8 CASP8 GNAI3 GNAI3 PPP3CA PPP3CA NFATC4 NFATC4 CRKL CRKL ARHGEF1 ARHGEF1 CDK6 CDK6 ADCY2 ADCY2 CALML5 CALML5 RHOB RHOB ADCY3 ADCY3 STAT3 STAT3 ENSUAMP00000008826 ENSUAMP00000008826 GNB4 GNB4 PIK3CA PIK3CA ENSUAMP00000009584 ENSUAMP00000009584 ENSUAMP00000010013 ENSUAMP00000010013 PTGER4 PTGER4 ATF2 ATF2 GNAO1 GNAO1 ENSUAMP00000010227 ENSUAMP00000010227 PPP3CB PPP3CB PIK3R1 PIK3R1 PRKCA PRKCA AKT1 AKT1 PLCB1 PLCB1 ENSUAMP00000011111 ENSUAMP00000011111 NFATC1 NFATC1 JAK1 JAK1 ENSUAMP00000011530 ENSUAMP00000011530 ENSUAMP00000011531 ENSUAMP00000011531 AKT3 AKT3 ENSUAMP00000011731 ENSUAMP00000011731 ENSUAMP00000012032 ENSUAMP00000012032 ENSUAMP00000012035 ENSUAMP00000012035 ENSUAMP00000012037 ENSUAMP00000012037 GSK3B GSK3B CCL2 CCL2 ENSUAMP00000012405 ENSUAMP00000012405 CALR CALR GRB2 GRB2 ENSUAMP00000012729 ENSUAMP00000012729 BAX BAX BID BID ENSUAMP00000013482 ENSUAMP00000013482 GNG2 GNG2 MAPK1 MAPK1 ERAS ERAS SP1 SP1 CCR1 CCR1 CALML6 CALML6 IKBKG IKBKG ENSUAMP00000014629 ENSUAMP00000014629 ENSUAMP00000014949 ENSUAMP00000014949 RB1 RB1 SOS2 SOS2 TNF TNF GNG13 GNG13 ENSUAMP00000015993 ENSUAMP00000015993 ENSUAMP00000016192 ENSUAMP00000016192 ENSUAMP00000016311 ENSUAMP00000016311 ENSUAMP00000016352 ENSUAMP00000016352 CDK4 CDK4 GNG7 GNG7 CRK CRK MAPK12 MAPK12 CTNNB1 CTNNB1 MAPK11 MAPK11 ENSUAMP00000017283 ENSUAMP00000017283 CXCL12 CXCL12 ENSUAMP00000017400 ENSUAMP00000017400 ENSUAMP00000017435 ENSUAMP00000017435 TAP1 TAP1 ENSUAMP00000017692 ENSUAMP00000017692 PTGER2 PTGER2 IL6R IL6R ENSUAMP00000018082 ENSUAMP00000018082 ENSUAMP00000018363 ENSUAMP00000018363 TBK1 TBK1 PDGFRA PDGFRA ROCK1 ROCK1 PDIA3 PDIA3 PLCB3 PLCB3 ENSUAMP00000019310 ENSUAMP00000019310 MTOR MTOR PTGS2 PTGS2 PIK3CD PIK3CD RIPK1 RIPK1 CALML4 CALML4 TRADD TRADD ENSUAMP00000020061 ENSUAMP00000020061 VEGFA VEGFA GNGT2 GNGT2 PRKCG PRKCG ATF6B ATF6B CASP3 CASP3 IKBKB IKBKB CXCL8 CXCL8 NFATC3 NFATC3 ENSUAMP00000020433 ENSUAMP00000020433 ENSUAMP00000026424 ENSUAMP00000026424 ENSUAMP00000026337 ENSUAMP00000026337 ENSUAMP00000026030 ENSUAMP00000026030 ENSUAMP00000025726 ENSUAMP00000025726 ENSUAMP00000025608 ENSUAMP00000025608 ENSUAMP00000025311 ENSUAMP00000025311 ENSUAMP00000025300 ENSUAMP00000025300 ENSUAMP00000025177 ENSUAMP00000025177 CREB3L3 CREB3L3 ROCK2 ROCK2 CREB1 CREB1 MDM2 MDM2 B2M B2M ENSUAMP00000023632 ENSUAMP00000023632 ENSUAMP00000023102 ENSUAMP00000023102 ENSUAMP00000022738 ENSUAMP00000022738 CASP9 CASP9 RPS6KB1 RPS6KB1 BCAR1 BCAR1 ENSUAMP00000022172 ENSUAMP00000022172 ENSUAMP00000022131 ENSUAMP00000022131 ENSUAMP00000021954 ENSUAMP00000021954 CX3CL1 CX3CL1 GNG8 GNG8 CALM3 CALM3 NFKB1 NFKB1 GNAQ GNAQ KRAS KRAS CREB5 CREB5 RELA RELA MAP2K6 MAP2K6 ENSUAMP00000026993 ENSUAMP00000026993 ENSUAMP00000027431 ENSUAMP00000027431 FADD FADD ELK1 ELK1 ADCY5 ADCY5 ADCY1 ADCY1 ENSUAMP00000028178 ENSUAMP00000028178 ENSUAMP00000028179 ENSUAMP00000028179 GNAS GNAS CDKN1A CDKN1A PLCB4 PLCB4 ENSUAMP00000028781 ENSUAMP00000028781 ENSUAMP00000029031 ENSUAMP00000029031 CYCS CYCS C7orf31 C7orf31 TNFRSF1A TNFRSF1A PTGER3 PTGER3 SRC SRC ENSUAMP00000030280 ENSUAMP00000030280 MAP2K1 MAP2K1 ITGAV ITGAV NFKBIA NFKBIA EIF4EBP1 EIF4EBP1 RAC1 RAC1 RAF1 RAF1 ENSUAMP00000030787 ENSUAMP00000030787 IL6 IL6 PTK2 PTK2 RAC2 RAC2 GNB1 GNB1 MAPK3 MAPK3 MYC MYC ENSUAMP00000031719 ENSUAMP00000031719 RUFY4 RUFY4 ENSUAMP00000031758 ENSUAMP00000031758 CXCR4 CXCR4 CREB3L4 CREB3L4 TSC2 TSC2 ADCY4 ADCY4 RAC3 RAC3 MAPK14 MAPK14 MAPK13 MAPK13 ADCY7 ADCY7 TSC1 TSC1 ENSUAMP00000032511 ENSUAMP00000032511 CCND1 CCND1 ARHGEF12 ARHGEF12 PPP3CC PPP3CC ENSUAMP00000032618 ENSUAMP00000032618 ENSUAMP00000032843 ENSUAMP00000032843 SOS1 SOS1 ENSUAMP00000032909 ENSUAMP00000032909 IL1B IL1B LPXN LPXN ENSUAMP00000033199 ENSUAMP00000033199 PRKACB PRKACB GNG3 GNG3 E2F1 E2F1 E2F3 E2F3 PXN PXN ENSUAMP00000034830 ENSUAMP00000034830 ENSUAMP00000034960 ENSUAMP00000034960 CREB3L1 CREB3L1 STING1 STING1 ENSUAMP00000035331 ENSUAMP00000035331 CREB3 CREB3 GNB3 GNB3 TAPBP TAPBP CALM2 CALM2 RHEBL1 RHEBL1 ADCY6 ADCY6 GNG12 GNG12 ENSUAMP00000036029 ENSUAMP00000036029 ENSUAMP00000036043 ENSUAMP00000036043 ENSUAMP00000036162 ENSUAMP00000036162 ENSUAMP00000036324 ENSUAMP00000036324 ENSUAMP00000036887 ENSUAMP00000036887 CHUK CHUK GNAI2 GNAI2 IL10RB IL10RB AKT2 AKT2 GNA12 GNA12 GNB2 GNB2 GNA11 GNA11 BAK1 BAK1 CCR5 CCR5 TP53 TP53 ENSUAMP00000000976 ENSUAMP00000000976 GNGT1 GNGT1 GNG11 GNG11 IL1R1 IL1R1 ENSUAMP00000001479 ENSUAMP00000001479 TRAF2 TRAF2 ENSUAMP00000002341 ENSUAMP00000002341 RHEB RHEB ENSUAMP00000003693 ENSUAMP00000003693 CCR3 CCR3 ENSUAMP00000003818 ENSUAMP00000003818
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000003880Uncharacterized protein. (91 aa)
IL10RAInterleukin 10 receptor subunit alpha. (575 aa)
E2F2E2F transcription factor 2. (431 aa)
ENSUAMP00000004602DH domain-containing protein. (325 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1166 aa)
ATF4Activating transcription factor 4. (351 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (969 aa)
GNB5G protein subunit beta 5. (264 aa)
ENSUAMP00000005465Ig-like domain-containing protein; Belongs to the MHC class I family. (431 aa)
ENSUAMP00000005552SCY domain-containing protein. (93 aa)
CCL5C-C motif chemokine. (116 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2656 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1338 aa)
ENSUAMP00000005976Uncharacterized protein. (94 aa)
ENSUAMP00000006240Ig-like domain-containing protein; Belongs to the MHC class I family. (359 aa)
ENSUAMP00000006289Uncharacterized protein. (158 aa)
ENSUAMP00000006641Uncharacterized protein. (184 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
ENSUAMP00000006735Uncharacterized protein. (185 aa)
CGASCyclic GMP-AMP synthase. (406 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (651 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (395 aa)
GNAI3G protein subunit alpha i3. (295 aa)
PPP3CASerine/threonine-protein phosphatase. (317 aa)
NFATC4Nuclear factor of activated T cells 4. (911 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (975 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
CALML5Calmodulin like 5. (156 aa)
RHOBRas homolog family member B. (172 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (973 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
ENSUAMP00000008826IRF tryptophan pentad repeat domain-containing protein. (421 aa)
GNB4G protein subunit beta 4. (331 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ENSUAMP00000009584Ig-like domain-containing protein; Belongs to the MHC class I family. (336 aa)
ENSUAMP00000010013Uncharacterized protein. (73 aa)
PTGER4Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (489 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
GNAO1G protein subunit alpha o1. (354 aa)
ENSUAMP00000010227Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
PPP3CBSerine/threonine-protein phosphatase. (479 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (676 aa)
PRKCAProtein kinase C alpha; Belongs to the protein kinase superfamily. (484 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
PLCB1Phosphoinositide phospholipase C. (658 aa)
ENSUAMP00000011111DH domain-containing protein. (317 aa)
NFATC1Nuclear factor of activated T cells 1. (931 aa)
JAK1Tyrosine-protein kinase. (1152 aa)
ENSUAMP00000011530Uncharacterized protein. (197 aa)
ENSUAMP00000011531Uncharacterized protein. (172 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ENSUAMP00000011731Ion_trans domain-containing protein. (408 aa)
ENSUAMP00000012032C-C motif chemokine. (93 aa)
ENSUAMP00000012035C-C motif chemokine. (93 aa)
ENSUAMP00000012037C-C motif chemokine. (92 aa)
GSK3BGlycogen synthase kinase 3 beta. (335 aa)
CCL2C-C motif chemokine. (101 aa)
ENSUAMP00000012405Uncharacterized protein. (110 aa)
CALRCalreticulin. (417 aa)
GRB2Growth factor receptor bound protein 2. (203 aa)
ENSUAMP00000012729RHD domain-containing protein. (481 aa)
BAXBCL2 associated X, apoptosis regulator. (205 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (196 aa)
ENSUAMP00000013482Uncharacterized protein. (91 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (105 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
ERASES cell expressed Ras. (219 aa)
SP1Sp1 transcription factor. (780 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
CALML6Calmodulin like 6. (180 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (442 aa)
ENSUAMP00000014629Uncharacterized protein. (105 aa)
ENSUAMP00000014949FERM domain-containing protein. (121 aa)
RB1RB transcriptional corepressor 1. (870 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1306 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (230 aa)
GNG13G protein subunit gamma 13. (67 aa)
ENSUAMP00000015993Uncharacterized protein. (98 aa)
ENSUAMP00000016192Integrin beta; Belongs to the integrin beta chain family. (786 aa)
ENSUAMP00000016311Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (98 aa)
ENSUAMP00000016352Ig-like domain-containing protein; Belongs to the MHC class I family. (358 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (340 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CRKCRK proto-oncogene, adaptor protein. (204 aa)
MAPK12Mitogen-activated protein kinase 12. (373 aa)
CTNNB1Catenin beta 1. (781 aa)
MAPK11Mitogen-activated protein kinase. (357 aa)
ENSUAMP00000017283Uncharacterized protein. (60 aa)
CXCL12SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. (109 aa)
ENSUAMP00000017400Uncharacterized protein. (703 aa)
ENSUAMP00000017435Uncharacterized protein. (459 aa)
TAP1Transporter 1, ATP binding cassette subfamily B member. (750 aa)
ENSUAMP00000017692Uncharacterized protein. (704 aa)
PTGER2Prostaglandin E receptor 2; Belongs to the G-protein coupled receptor 1 family. (347 aa)
IL6RInterleukin 6 receptor. (496 aa)
ENSUAMP00000018082Uncharacterized protein. (249 aa)
ENSUAMP00000018363Uncharacterized protein. (1484 aa)
TBK1TANK binding kinase 1. (709 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1365 aa)
PDIA3Protein disulfide-isomerase. (460 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
ENSUAMP00000019310Uncharacterized protein. (182 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2523 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (550 aa)
CALML4Calmodulin like 4. (153 aa)
TRADDTNFRSF1A associated via death domain. (314 aa)
ENSUAMP00000020061Ig-like domain-containing protein; Belongs to the MHC class I family. (332 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (516 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (714 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (266 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (703 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
NFATC3Nuclear factor of activated T cells 3. (1079 aa)
ENSUAMP00000020433Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
ENSUAMP00000026424Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
ENSUAMP00000026337Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
ENSUAMP00000026030Uncharacterized protein. (236 aa)
ENSUAMP00000025726annotation not available (113 aa)
ENSUAMP00000025608IRF-3 domain-containing protein. (295 aa)
ENSUAMP00000025311Uncharacterized protein. (295 aa)
ENSUAMP00000025300Non-specific serine/threonine protein kinase. (254 aa)
ENSUAMP00000025177Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (457 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1384 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (495 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa)
ENSUAMP00000023632Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ENSUAMP00000023102Uncharacterized protein. (1102 aa)
ENSUAMP00000022738Uncharacterized protein. (126 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (467 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (524 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (867 aa)
ENSUAMP00000022172Uncharacterized protein. (157 aa)
ENSUAMP00000022131Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (636 aa)
ENSUAMP00000021954Uncharacterized protein. (209 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (392 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (149 aa)
NFKB1Nuclear factor kappa B subunit 1. (972 aa)
GNAQG protein subunit alpha q. (352 aa)
KRASKRAS proto-oncogene, GTPase. (188 aa)
CREB5cAMP responsive element binding protein 5. (327 aa)
RELARELA proto-oncogene, NF-kB subunit. (508 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
ENSUAMP00000026993Uncharacterized protein. (118 aa)
ENSUAMP00000027431Uncharacterized protein. (74 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (220 aa)
ELK1ETS transcription factor ELK1. (435 aa)
ADCY5Adenylate cyclase 5. (940 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
ENSUAMP00000028178Uncharacterized protein. (311 aa)
ENSUAMP00000028179CSD domain-containing protein. (89 aa)
GNASGNAS complex locus. (994 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1136 aa)
ENSUAMP00000028781G protein gamma domain-containing protein. (61 aa)
ENSUAMP00000029031Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
CYCSCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
C7orf31Chromosome 7 open reading frame 31. (575 aa)
TNFRSF1ATNF receptor superfamily member 1A. (502 aa)
PTGER3Prostaglandin E receptor 3. (387 aa)
SRCTyrosine-protein kinase. (557 aa)
ENSUAMP00000030280Protein kinase domain-containing protein. (206 aa)
MAP2K1Protein kinase domain-containing protein. (216 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
RAC1Rac family small GTPase 1. (229 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (564 aa)
ENSUAMP00000030787Uncharacterized protein. (84 aa)
IL6Interleukin 6. (212 aa)
PTK2Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (976 aa)
RAC2Rac family small GTPase 2. (192 aa)
GNB1G protein subunit beta 1. (224 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
ENSUAMP00000031719Uncharacterized protein. (627 aa)
RUFY4RUN and FYVE domain containing 4. (558 aa)
ENSUAMP00000031758G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (366 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (247 aa)
TSC2TSC complex subunit 2. (1614 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
RAC3Rac family small GTPase 3. (202 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
TSC1TSC complex subunit 1. (1168 aa)
ENSUAMP00000032511Protein kinase domain-containing protein. (132 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (294 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1439 aa)
PPP3CCSerine/threonine-protein phosphatase. (449 aa)
ENSUAMP00000032618Uncharacterized protein. (68 aa)
ENSUAMP00000032843Uncharacterized protein. (186 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1232 aa)
ENSUAMP00000032909Uncharacterized protein. (592 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
LPXNLeupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (379 aa)
ENSUAMP00000033199RHD domain-containing protein. (458 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (361 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
E2F1E2F transcription factor 1. (400 aa)
E2F3E2F transcription factor 3. (469 aa)
PXNUncharacterized protein. (1082 aa)
ENSUAMP00000034830Uncharacterized protein. (1872 aa)
ENSUAMP00000034960C2H2-type domain-containing protein. (123 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
STING1Transmembrane protein 173. (392 aa)
ENSUAMP00000035331Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (506 aa)
CREB3cAMP responsive element binding protein 3. (352 aa)
GNB3G protein subunit beta 3. (339 aa)
TAPBPTAP binding protein. (448 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (163 aa)
RHEBL1RHEB like 1. (183 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
ENSUAMP00000036029Ig-like domain-containing protein; Belongs to the MHC class I family. (359 aa)
ENSUAMP00000036043MHC_I-like_Ag-recog domain-containing protein. (150 aa)
ENSUAMP00000036162Protein kinase domain-containing protein. (462 aa)
ENSUAMP00000036324Uncharacterized protein. (189 aa)
ENSUAMP00000036887Ig-like domain-containing protein. (179 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
GNAI2G protein subunit alpha i2. (436 aa)
IL10RBInterleukin 10 receptor subunit beta. (375 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
GNA12G protein subunit alpha 12. (350 aa)
GNB2G protein subunit beta 2. (340 aa)
GNA11G protein subunit alpha 11. (353 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
CCR5C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family. (352 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
ENSUAMP00000000976Ig-like domain-containing protein; Belongs to the MHC class I family. (481 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
IL1R1Interleukin 1 receptor type 1. (584 aa)
ENSUAMP00000001479Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (121 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
ENSUAMP00000002341Uncharacterized protein. (957 aa)
RHEBRas homolog, mTORC1 binding. (179 aa)
ENSUAMP00000003693Uncharacterized protein. (166 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (359 aa)
ENSUAMP00000003818Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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