STRINGSTRING
TP53 TP53 RPS6KB1 RPS6KB1 ENSUAMP00000022131 ENSUAMP00000022131 ENSUAMP00000021381 ENSUAMP00000021381 ENSUAMP00000021380 ENSUAMP00000021380 KRAS KRAS TGFB2 TGFB2 GADD45G GADD45G CASP3 CASP3 AXIN1 AXIN1 PIK3CD PIK3CD MTOR MTOR PPP1R14B PPP1R14B BAD BAD APC2 APC2 SMAD4 SMAD4 MSH2 MSH2 MSH6 MSH6 ENSUAMP00000017692 ENSUAMP00000017692 ENSUAMP00000017435 ENSUAMP00000017435 CTNNB1 CTNNB1 TGFBR1 TGFBR1 ENSUAMP00000016793 ENSUAMP00000016793 TGFB3 TGFB3 GADD45B GADD45B ENSUAMP00000016311 ENSUAMP00000016311 ENSUAMP00000016279 ENSUAMP00000016279 EREG EREG AREG AREG ENSUAMP00000015993 ENSUAMP00000015993 SOS2 SOS2 ERAS ERAS MAPK1 MAPK1 BAX BAX RALB RALB GRB2 GRB2 TGFB1 TGFB1 ENSUAMP00000012405 ENSUAMP00000012405 ENSUAMP00000012266 ENSUAMP00000012266 GSK3B GSK3B BCL2 BCL2 AKT3 AKT3 AKT1 AKT1 PIK3R1 PIK3R1 ENSUAMP00000010308 ENSUAMP00000010308 POLK POLK ENSUAMP00000010013 ENSUAMP00000010013 MAPK8 MAPK8 PIK3CA PIK3CA TGFBR2 TGFBR2 JUN JUN RHOB RHOB TCF7 TCF7 ENSUAMP00000007328 ENSUAMP00000007328 RPS6KB2 RPS6KB2 ENSUAMP00000005976 ENSUAMP00000005976 DDB2 DDB2 ENSUAMP00000003693 ENSUAMP00000003693 EGF EGF AXIN2 AXIN2 ENSUAMP00000001020 ENSUAMP00000001020 CASP9 CASP9 BAK1 BAK1 APC APC AKT2 AKT2 MLH1 MLH1 TCF7L1 TCF7L1 ENSUAMP00000036324 ENSUAMP00000036324 PMAIP1 PMAIP1 ENSUAMP00000036162 ENSUAMP00000036162 APPL1 APPL1 GADD45A GADD45A ENSUAMP00000035777 ENSUAMP00000035777 ENSUAMP00000035331 ENSUAMP00000035331 ENSUAMP00000035027 ENSUAMP00000035027 ENSUAMP00000032909 ENSUAMP00000032909 SOS1 SOS1 CCND1 CCND1 RAC3 RAC3 ENSUAMP00000031719 ENSUAMP00000031719 MYC MYC MAPK3 MAPK3 RAC2 RAC2 RALA RALA ENSUAMP00000030787 ENSUAMP00000030787 RAF1 RAF1 RAC1 RAC1 MAP2K1 MAP2K1 ENSUAMP00000030280 ENSUAMP00000030280 BCL2L11 BCL2L11 C7orf31 C7orf31 CYCS CYCS ENSUAMP00000029031 ENSUAMP00000029031 MAPK9 MAPK9 CDKN1A CDKN1A ENSUAMP00000028179 ENSUAMP00000028179 ENSUAMP00000028178 ENSUAMP00000028178 BIRC5 BIRC5 ENSUAMP00000026993 ENSUAMP00000026993 SMAD2 SMAD2 SMAD3 SMAD3 TCF7L2 TCF7L2 BRAF BRAF MAPK10 MAPK10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (524 aa)
ENSUAMP00000022131Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (636 aa)
ENSUAMP00000021381Protein kinase domain-containing protein. (363 aa)
ENSUAMP00000021380Uncharacterized protein. (424 aa)
KRASKRAS proto-oncogene, GTPase. (188 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (439 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (228 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (266 aa)
AXIN1Axin 1. (867 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2523 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (147 aa)
BADBCL2 associated agonist of cell death. (168 aa)
APC2APC regulator of WNT signaling pathway 2. (2266 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1260 aa)
ENSUAMP00000017692Uncharacterized protein. (704 aa)
ENSUAMP00000017435Uncharacterized protein. (459 aa)
CTNNB1Catenin beta 1. (781 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
ENSUAMP00000016793BZIP domain-containing protein. (179 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (182 aa)
ENSUAMP00000016311Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (98 aa)
ENSUAMP00000016279Uncharacterized protein. (85 aa)
EREGEpiregulin. (175 aa)
AREGAmphiregulin. (257 aa)
ENSUAMP00000015993Uncharacterized protein. (98 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1306 aa)
ERASES cell expressed Ras. (219 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
BAXBCL2 associated X, apoptosis regulator. (205 aa)
RALBRAS like proto-oncogene B. (206 aa)
GRB2Growth factor receptor bound protein 2. (203 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ENSUAMP00000012405Uncharacterized protein. (110 aa)
ENSUAMP00000012266CTNNB1_binding domain-containing protein. (162 aa)
GSK3BGlycogen synthase kinase 3 beta. (335 aa)
BCL2BCL2 apoptosis regulator. (205 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (676 aa)
ENSUAMP00000010308Uncharacterized protein. (854 aa)
POLKDNA polymerase kappa. (542 aa)
ENSUAMP00000010013Uncharacterized protein. (73 aa)
MAPK8Mitogen-activated protein kinase. (456 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
RHOBRas homolog family member B. (172 aa)
TCF7Transcription factor 7. (443 aa)
ENSUAMP00000007328DNA_MISMATCH_REPAIR_2 domain-containing protein. (366 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
ENSUAMP00000005976Uncharacterized protein. (94 aa)
DDB2Damage specific DNA binding protein 2. (421 aa)
ENSUAMP00000003693Uncharacterized protein. (166 aa)
EGFEpidermal growth factor. (979 aa)
AXIN2Axin 2. (843 aa)
ENSUAMP00000001020Uncharacterized protein. (147 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (467 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
APCAPC regulator of WNT signaling pathway. (2832 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MLH1MutL homolog 1. (758 aa)
TCF7L1Transcription factor 7 like 1. (597 aa)
ENSUAMP00000036324Uncharacterized protein. (189 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
ENSUAMP00000036162Protein kinase domain-containing protein. (462 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (665 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (150 aa)
ENSUAMP00000035777HMG box domain-containing protein. (191 aa)
ENSUAMP00000035331Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (506 aa)
ENSUAMP00000035027Uncharacterized protein. (146 aa)
ENSUAMP00000032909Uncharacterized protein. (592 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1232 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (294 aa)
RAC3Rac family small GTPase 3. (202 aa)
ENSUAMP00000031719Uncharacterized protein. (627 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
RAC2Rac family small GTPase 2. (192 aa)
RALARAS like proto-oncogene A. (206 aa)
ENSUAMP00000030787Uncharacterized protein. (84 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (564 aa)
RAC1Rac family small GTPase 1. (229 aa)
MAP2K1Protein kinase domain-containing protein. (216 aa)
ENSUAMP00000030280Protein kinase domain-containing protein. (206 aa)
BCL2L11BCL2 like 11. (140 aa)
C7orf31Chromosome 7 open reading frame 31. (575 aa)
CYCSCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ENSUAMP00000029031Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
MAPK9Mitogen-activated protein kinase. (433 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
ENSUAMP00000028179CSD domain-containing protein. (89 aa)
ENSUAMP00000028178Uncharacterized protein. (311 aa)
BIRC5Baculoviral IAP repeat containing 5. (142 aa)
ENSUAMP00000026993Uncharacterized protein. (118 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
TCF7L2Transcription factor 7 like 2. (524 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (728 aa)
MAPK10Mitogen-activated protein kinase. (422 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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