STRINGSTRING
CRKL CRKL PAK1 PAK1 ENSUAMP00000006566 ENSUAMP00000006566 RAPGEF1 RAPGEF1 SLC2A1 SLC2A1 ENSUAMP00000001020 ENSUAMP00000001020 ENSUAMP00000001042 ENSUAMP00000001042 PAK4 PAK4 ENSUAMP00000003693 ENSUAMP00000003693 PAK6 PAK6 PDGFB PDGFB AKT2 AKT2 ENSUAMP00000037224 ENSUAMP00000037224 ENSUAMP00000036324 ENSUAMP00000036324 ENSUAMP00000035331 ENSUAMP00000035331 ENSUAMP00000035193 ENSUAMP00000035193 ENSUAMP00000035192 ENSUAMP00000035192 TFE3 TFE3 HIF1A HIF1A ENSUAMP00000034334 ENSUAMP00000034334 SOS1 SOS1 ARNT2 ARNT2 EP300 EP300 ENSUAMP00000031719 ENSUAMP00000031719 MAPK3 MAPK3 RBX1 RBX1 ENSUAMP00000030787 ENSUAMP00000030787 CREBBP CREBBP RAF1 RAF1 GAB1 GAB1 MAP2K1 MAP2K1 ENSUAMP00000030280 ENSUAMP00000030280 CUL2 CUL2 ENSUAMP00000029031 ENSUAMP00000029031 ENSUAMP00000028558 ENSUAMP00000028558 CDKN1A CDKN1A ENSUAMP00000028179 ENSUAMP00000028179 ENSUAMP00000028178 ENSUAMP00000028178 EGLN3 EGLN3 ENSUAMP00000026993 ENSUAMP00000026993 PAK5 PAK5 CDC42 CDC42 ELOC ELOC FH FH BRAF BRAF PAK2 PAK2 ENSUAMP00000023691 ENSUAMP00000023691 ENSUAMP00000023057 ENSUAMP00000023057 ENSUAMP00000022818 ENSUAMP00000022818 ENSUAMP00000022131 ENSUAMP00000022131 ENSUAMP00000021701 ENSUAMP00000021701 ENSUAMP00000021381 ENSUAMP00000021381 ENSUAMP00000021380 ENSUAMP00000021380 KRAS KRAS TGFB2 TGFB2 VEGFA VEGFA PIK3CD PIK3CD PPP1R14B PPP1R14B BAD BAD ETS1 ETS1 RAP1A RAP1A ENSUAMP00000017692 ENSUAMP00000017692 ENSUAMP00000017435 ENSUAMP00000017435 ENSUAMP00000017404 ENSUAMP00000017404 PRCC PRCC TGFB3 TGFB3 CRK CRK ENSUAMP00000015993 ENSUAMP00000015993 SOS2 SOS2 ERAS ERAS MAPK1 MAPK1 ARNT ARNT GRB2 GRB2 TGFB1 TGFB1 AKT3 AKT3 PAK3 PAK3 RAP1B RAP1B AKT1 AKT1 PIK3R1 PIK3R1 EPAS1 EPAS1 PTPN11 PTPN11 ENSUAMP00000010013 ENSUAMP00000010013 ENSUAMP00000009508 ENSUAMP00000009508 MET MET PIK3CA PIK3CA JUN JUN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
ENSUAMP00000006566UDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1234 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
ENSUAMP00000001020Uncharacterized protein. (147 aa)
ENSUAMP00000001042Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (112 aa)
PAK4Non-specific serine/threonine protein kinase. (488 aa)
ENSUAMP00000003693Uncharacterized protein. (166 aa)
PAK6P21 (RAC1) activated kinase 6. (684 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSUAMP00000037224Fe2OG dioxygenase domain-containing protein. (126 aa)
ENSUAMP00000036324Uncharacterized protein. (189 aa)
ENSUAMP00000035331Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (506 aa)
ENSUAMP00000035193Uncharacterized protein. (279 aa)
ENSUAMP00000035192Uncharacterized protein. (82 aa)
TFE3Transcription factor binding to IGHM enhancer 3. (565 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (823 aa)
ENSUAMP00000034334Uncharacterized protein. (94 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1232 aa)
ARNT2Aryl hydrocarbon receptor nuclear translocator 2. (706 aa)
EP300E1A binding protein p300. (2399 aa)
ENSUAMP00000031719Uncharacterized protein. (627 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
RBX1Ring-box 1. (108 aa)
ENSUAMP00000030787Uncharacterized protein. (84 aa)
CREBBPCREB binding protein. (2333 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (564 aa)
GAB1GRB2 associated binding protein 1. (721 aa)
MAP2K1Protein kinase domain-containing protein. (216 aa)
ENSUAMP00000030280Protein kinase domain-containing protein. (206 aa)
CUL2Cullin 2; Belongs to the cullin family. (745 aa)
ENSUAMP00000029031Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
ENSUAMP00000028558Uncharacterized protein. (222 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
ENSUAMP00000028179CSD domain-containing protein. (89 aa)
ENSUAMP00000028178Uncharacterized protein. (311 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (239 aa)
ENSUAMP00000026993Uncharacterized protein. (118 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
CDC42Cell division cycle 42. (191 aa)
ELOCElongin C; Belongs to the SKP1 family. (112 aa)
FHFumarate hydratase. (493 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (728 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
ENSUAMP00000023691Uncharacterized protein. (268 aa)
ENSUAMP00000023057Ubiquitin-like domain-containing protein. (126 aa)
ENSUAMP00000022818Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
ENSUAMP00000022131Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (636 aa)
ENSUAMP00000021701Fe2OG dioxygenase domain-containing protein. (233 aa)
ENSUAMP00000021381Protein kinase domain-containing protein. (363 aa)
ENSUAMP00000021380Uncharacterized protein. (424 aa)
KRASKRAS proto-oncogene, GTPase. (188 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (439 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (516 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (147 aa)
BADBCL2 associated agonist of cell death. (168 aa)
ETS1ETS proto-oncogene 1, transcription factor. (531 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
ENSUAMP00000017692Uncharacterized protein. (704 aa)
ENSUAMP00000017435Uncharacterized protein. (459 aa)
ENSUAMP00000017404Fe2OG dioxygenase domain-containing protein. (125 aa)
PRCCProline rich mitotic checkpoint control factor. (491 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
CRKCRK proto-oncogene, adaptor protein. (204 aa)
ENSUAMP00000015993Uncharacterized protein. (98 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1306 aa)
ERASES cell expressed Ras. (219 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (481 aa)
GRB2Growth factor receptor bound protein 2. (203 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PAK3P21 (RAC1) activated kinase 3. (547 aa)
RAP1BRAP1B, member of RAS oncogene family. (184 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (676 aa)
EPAS1Endothelial PAS domain protein 1. (863 aa)
PTPN11Protein tyrosine phosphatase non-receptor type 11. (552 aa)
ENSUAMP00000010013Uncharacterized protein. (73 aa)
ENSUAMP00000009508Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (111 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1399 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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