STRINGSTRING
ILK ILK CDH1 CDH1 ENSUAMP00000035331 ENSUAMP00000035331 ENSUAMP00000035777 ENSUAMP00000035777 ENSUAMP00000035901 ENSUAMP00000035901 GADD45A GADD45A ENSUAMP00000032923 ENSUAMP00000032923 ENSUAMP00000032909 ENSUAMP00000032909 SOS1 SOS1 CCND1 CCND1 ENSUAMP00000031719 ENSUAMP00000031719 MYC MYC MAPK3 MAPK3 ENSUAMP00000031057 ENSUAMP00000031057 ENSUAMP00000030787 ENSUAMP00000030787 RAF1 RAF1 MAP2K1 MAP2K1 ERAS ERAS MAPK1 MAPK1 BAX BAX GRB2 GRB2 ENSUAMP00000012266 ENSUAMP00000012266 FOXO3B FOXO3B FOXO3 FOXO3 GSK3B GSK3B AKT3 AKT3 ERBB2 ERBB2 ENSUAMP00000011147 ENSUAMP00000011147 AKT1 AKT1 PIK3R1 PIK3R1 POLK POLK ENSUAMP00000010013 ENSUAMP00000010013 ENSUAMP00000009491 ENSUAMP00000009491 PIK3CA PIK3CA TCF7 TCF7 ENSUAMP00000007208 ENSUAMP00000007208 DDB2 DDB2 ENSUAMP00000003693 ENSUAMP00000003693 ENSUAMP00000002344 ENSUAMP00000002344 ENSUAMP00000002339 ENSUAMP00000002339 EGF EGF ENSUAMP00000001492 ENSUAMP00000001492 AXIN2 AXIN2 TP53 TP53 BAK1 BAK1 APC APC ENSUAMP00000030280 ENSUAMP00000030280 ENSUAMP00000029031 ENSUAMP00000029031 CDKN1A CDKN1A ENSUAMP00000028179 ENSUAMP00000028179 ENSUAMP00000028178 ENSUAMP00000028178 ELK1 ELK1 ENSUAMP00000026993 ENSUAMP00000026993 TCF7L2 TCF7L2 ENSUAMP00000025705 ENSUAMP00000025705 ENSUAMP00000025109 ENSUAMP00000025109 BRAF BRAF CASP9 CASP9 ENSUAMP00000022131 ENSUAMP00000022131 SOS2 SOS2 ENSUAMP00000015993 ENSUAMP00000015993 ENSUAMP00000016187 ENSUAMP00000016187 ENSUAMP00000016387 ENSUAMP00000016387 PDPK1 PDPK1 GADD45B GADD45B CTNNB1 CTNNB1 ENSUAMP00000017435 ENSUAMP00000017435 ENSUAMP00000017692 ENSUAMP00000017692 ENSUAMP00000018321 ENSUAMP00000018321 APC2 APC2 BAD BAD PPP1R14B PPP1R14B PIK3CD PIK3CD AXIN1 AXIN1 GADD45G GADD45G KRAS KRAS ENSUAMP00000021380 ENSUAMP00000021380 ENSUAMP00000021381 ENSUAMP00000021381 ENSUAMP00000036162 ENSUAMP00000036162 ENSUAMP00000036324 ENSUAMP00000036324 TCF7L1 TCF7L1 MLH1 MLH1 AKT2 AKT2 ENSUAMP00000033613 ENSUAMP00000033613
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ILKIntegrin linked kinase. (503 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (881 aa)
ENSUAMP00000035331Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (506 aa)
ENSUAMP00000035777HMG box domain-containing protein. (191 aa)
ENSUAMP00000035901Uncharacterized protein. (79 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (150 aa)
ENSUAMP00000032923Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (387 aa)
ENSUAMP00000032909Uncharacterized protein. (592 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1232 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (294 aa)
ENSUAMP00000031719Uncharacterized protein. (627 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
ENSUAMP00000031057Uncharacterized protein. (169 aa)
ENSUAMP00000030787Uncharacterized protein. (84 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (564 aa)
MAP2K1Protein kinase domain-containing protein. (216 aa)
ERASES cell expressed Ras. (219 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
BAXBCL2 associated X, apoptosis regulator. (205 aa)
GRB2Growth factor receptor bound protein 2. (203 aa)
ENSUAMP00000012266CTNNB1_binding domain-containing protein. (162 aa)
FOXO3BForkhead box O3B. (244 aa)
FOXO3Forkhead box O3. (453 aa)
GSK3BGlycogen synthase kinase 3 beta. (335 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ERBB2Receptor protein-tyrosine kinase. (1261 aa)
ENSUAMP00000011147Ion_trans domain-containing protein. (118 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (676 aa)
POLKDNA polymerase kappa. (542 aa)
ENSUAMP00000010013Uncharacterized protein. (73 aa)
ENSUAMP00000009491C2 tensin-type domain-containing protein. (179 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TCF7Transcription factor 7. (443 aa)
ENSUAMP00000007208Uncharacterized protein. (81 aa)
DDB2Damage specific DNA binding protein 2. (421 aa)
ENSUAMP00000003693Uncharacterized protein. (166 aa)
ENSUAMP00000002344Uncharacterized protein. (257 aa)
ENSUAMP00000002339Uncharacterized protein. (108 aa)
EGFEpidermal growth factor. (979 aa)
ENSUAMP00000001492Uncharacterized protein. (66 aa)
AXIN2Axin 2. (843 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
APCAPC regulator of WNT signaling pathway. (2832 aa)
ENSUAMP00000030280Protein kinase domain-containing protein. (206 aa)
ENSUAMP00000029031Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
ENSUAMP00000028179CSD domain-containing protein. (89 aa)
ENSUAMP00000028178Uncharacterized protein. (311 aa)
ELK1ETS transcription factor ELK1. (435 aa)
ENSUAMP00000026993Uncharacterized protein. (118 aa)
TCF7L2Transcription factor 7 like 2. (524 aa)
ENSUAMP00000025705Uncharacterized protein. (84 aa)
ENSUAMP00000025109Uncharacterized protein. (168 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (728 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (467 aa)
ENSUAMP00000022131Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (636 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1306 aa)
ENSUAMP00000015993Uncharacterized protein. (98 aa)
ENSUAMP00000016187Uncharacterized protein. (81 aa)
ENSUAMP00000016387Uncharacterized protein. (118 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (531 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (182 aa)
CTNNB1Catenin beta 1. (781 aa)
ENSUAMP00000017435Uncharacterized protein. (459 aa)
ENSUAMP00000017692Uncharacterized protein. (704 aa)
ENSUAMP00000018321Uncharacterized protein. (509 aa)
APC2APC regulator of WNT signaling pathway 2. (2266 aa)
BADBCL2 associated agonist of cell death. (168 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (147 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
AXIN1Axin 1. (867 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (228 aa)
KRASKRAS proto-oncogene, GTPase. (188 aa)
ENSUAMP00000021380Uncharacterized protein. (424 aa)
ENSUAMP00000021381Protein kinase domain-containing protein. (363 aa)
ENSUAMP00000036162Protein kinase domain-containing protein. (462 aa)
ENSUAMP00000036324Uncharacterized protein. (189 aa)
TCF7L1Transcription factor 7 like 1. (597 aa)
MLH1MutL homolog 1. (758 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSUAMP00000033613Uncharacterized protein. (72 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
Server load: medium (52%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.