STRINGSTRING
GADD45G GADD45G KRAS KRAS CAMK1G CAMK1G IGF1 IGF1 ENSUAMP00000021380 ENSUAMP00000021380 ENSUAMP00000021381 ENSUAMP00000021381 CALM3 CALM3 ENSUAMP00000022131 ENSUAMP00000022131 ENSUAMP00000023165 ENSUAMP00000023165 MDM2 MDM2 BRAF BRAF ENSUAMP00000025300 ENSUAMP00000025300 ENSUAMP00000025311 ENSUAMP00000025311 ENSUAMP00000025726 ENSUAMP00000025726 ENSUAMP00000026993 ENSUAMP00000026993 ENSUAMP00000027431 ENSUAMP00000027431 ENSUAMP00000028178 ENSUAMP00000028178 ENSUAMP00000028179 ENSUAMP00000028179 CDKN1A CDKN1A ENSUAMP00000029031 ENSUAMP00000029031 ENSUAMP00000030280 ENSUAMP00000030280 MAP2K1 MAP2K1 RAF1 RAF1 ENSUAMP00000030787 ENSUAMP00000030787 MAPK3 MAPK3 ENSUAMP00000031719 ENSUAMP00000031719 PDGFRB PDGFRB ENSUAMP00000032382 ENSUAMP00000032382 CCND1 CCND1 SOS1 SOS1 ENSUAMP00000032909 ENSUAMP00000032909 ENSUAMP00000032923 ENSUAMP00000032923 ARSI ARSI E2F1 E2F1 E2F3 E2F3 ENSUAMP00000035331 ENSUAMP00000035331 CALM2 CALM2 GADD45A GADD45A ENSUAMP00000036162 ENSUAMP00000036162 ENSUAMP00000036324 ENSUAMP00000036324 AKT2 AKT2 BAX BAX GRB2 GRB2 AKT3 AKT3 CALML4 CALML4 ENSUAMP00000011147 ENSUAMP00000011147 AKT1 AKT1 PRKCA PRKCA PIK3R1 PIK3R1 POLK POLK PLCG1 PLCG1 ENSUAMP00000010013 ENSUAMP00000010013 ENSUAMP00000009491 ENSUAMP00000009491 PIK3CA PIK3CA PDGFA PDGFA CALML5 CALML5 CDK6 CDK6 PLCG2 PLCG2 PRKCB PRKCB ENSUAMP00000007617 ENSUAMP00000007617 PDGFB PDGFB E2F2 E2F2 DDB2 DDB2 ENSUAMP00000003693 ENSUAMP00000003693 CEP152 CEP152 EGF EGF ENSUAMP00000001020 ENSUAMP00000001020 TP53 TP53 ENSUAMP00000000785 ENSUAMP00000000785 BAK1 BAK1 ENSUAMP00000000176 ENSUAMP00000000176 PIK3CD PIK3CD MTOR MTOR ENSUAMP00000019181 ENSUAMP00000019181 ENSUAMP00000019174 ENSUAMP00000019174 PDGFRA PDGFRA SHC1 SHC1 ENSUAMP00000017692 ENSUAMP00000017692 ENSUAMP00000017435 ENSUAMP00000017435 GADD45B GADD45B CDK4 CDK4 ENSUAMP00000015993 ENSUAMP00000015993 SOS2 SOS2 IGF1R IGF1R RB1 RB1 CAMK1 CAMK1 CALML6 CALML6 ERAS ERAS MAPK1 MAPK1 CAMK2B CAMK2B PRKCG PRKCG ENSUAMP00000020485 ENSUAMP00000020485
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GADD45GGrowth arrest and DNA damage inducible gamma. (228 aa)
KRASKRAS proto-oncogene, GTPase. (188 aa)
CAMK1GCalcium/calmodulin dependent protein kinase IG; Belongs to the protein kinase superfamily. (476 aa)
IGF1Insulin like growth factor 1. (171 aa)
ENSUAMP00000021380Uncharacterized protein. (424 aa)
ENSUAMP00000021381Protein kinase domain-containing protein. (363 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (149 aa)
ENSUAMP00000022131Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (636 aa)
ENSUAMP00000023165Protein kinase domain-containing protein. (270 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (495 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (728 aa)
ENSUAMP00000025300Non-specific serine/threonine protein kinase. (254 aa)
ENSUAMP00000025311Uncharacterized protein. (295 aa)
ENSUAMP00000025726annotation not available (113 aa)
ENSUAMP00000026993Uncharacterized protein. (118 aa)
ENSUAMP00000027431Uncharacterized protein. (74 aa)
ENSUAMP00000028178Uncharacterized protein. (311 aa)
ENSUAMP00000028179CSD domain-containing protein. (89 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
ENSUAMP00000029031Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
ENSUAMP00000030280Protein kinase domain-containing protein. (206 aa)
MAP2K1Protein kinase domain-containing protein. (216 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (564 aa)
ENSUAMP00000030787Uncharacterized protein. (84 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
ENSUAMP00000031719Uncharacterized protein. (627 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1100 aa)
ENSUAMP00000032382CaMKII_AD domain-containing protein. (189 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (294 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1232 aa)
ENSUAMP00000032909Uncharacterized protein. (592 aa)
ENSUAMP00000032923Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (387 aa)
ARSIArylsulfatase family member I. (573 aa)
E2F1E2F transcription factor 1. (400 aa)
E2F3E2F transcription factor 3. (469 aa)
ENSUAMP00000035331Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (506 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (163 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (150 aa)
ENSUAMP00000036162Protein kinase domain-containing protein. (462 aa)
ENSUAMP00000036324Uncharacterized protein. (189 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
BAXBCL2 associated X, apoptosis regulator. (205 aa)
GRB2Growth factor receptor bound protein 2. (203 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CALML4Calmodulin like 4. (153 aa)
ENSUAMP00000011147Ion_trans domain-containing protein. (118 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
PRKCAProtein kinase C alpha; Belongs to the protein kinase superfamily. (484 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (676 aa)
POLKDNA polymerase kappa. (542 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1256 aa)
ENSUAMP00000010013Uncharacterized protein. (73 aa)
ENSUAMP00000009491C2 tensin-type domain-containing protein. (179 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (248 aa)
CALML5Calmodulin like 5. (156 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1252 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (651 aa)
ENSUAMP00000007617Protein kinase domain-containing protein. (271 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
E2F2E2F transcription factor 2. (431 aa)
DDB2Damage specific DNA binding protein 2. (421 aa)
ENSUAMP00000003693Uncharacterized protein. (166 aa)
CEP152Centrosomal protein 152. (1716 aa)
EGFEpidermal growth factor. (979 aa)
ENSUAMP00000001020Uncharacterized protein. (147 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
ENSUAMP00000000785SH2 domain-containing protein. (91 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
ENSUAMP00000000176Protein kinase domain-containing protein. (82 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2523 aa)
ENSUAMP00000019181Protein kinase domain-containing protein. (206 aa)
ENSUAMP00000019174CaMKII_AD domain-containing protein. (267 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
SHC1SHC adaptor protein 1. (474 aa)
ENSUAMP00000017692Uncharacterized protein. (704 aa)
ENSUAMP00000017435Uncharacterized protein. (459 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (182 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (340 aa)
ENSUAMP00000015993Uncharacterized protein. (98 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1306 aa)
IGF1RTyrosine-protein kinase receptor. (1288 aa)
RB1RB transcriptional corepressor 1. (870 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (370 aa)
CALML6Calmodulin like 6. (180 aa)
ERASES cell expressed Ras. (219 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (589 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (714 aa)
ENSUAMP00000020485Protein kinase domain-containing protein. (108 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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