STRINGSTRING
RELA RELA ENSUAMP00000026993 ENSUAMP00000026993 INS INS ENSUAMP00000027431 ENSUAMP00000027431 ENSUAMP00000028178 ENSUAMP00000028178 ENSUAMP00000028179 ENSUAMP00000028179 CDKN1A CDKN1A MMP9 MMP9 ENSUAMP00000029031 ENSUAMP00000029031 ENSUAMP00000030280 ENSUAMP00000030280 MAP2K1 MAP2K1 NFKBIA NFKBIA RAF1 RAF1 CREBBP CREBBP ENSUAMP00000030787 ENSUAMP00000030787 ENSUAMP00000031131 ENSUAMP00000031131 MAPK3 MAPK3 NKX2-3 NKX2-3 ENSUAMP00000031719 ENSUAMP00000031719 CREB3L4 CREB3L4 EP300 EP300 PDGFRB PDGFRB ENSUAMP00000032511 ENSUAMP00000032511 PLAT PLAT CCND1 CCND1 ENSUAMP00000032843 ENSUAMP00000032843 SOS1 SOS1 ENSUAMP00000032909 ENSUAMP00000032909 ENSUAMP00000032923 ENSUAMP00000032923 ENSUAMP00000033175 ENSUAMP00000033175 PDGFC PDGFC E2F1 E2F1 E2F3 E2F3 ENSUAMP00000034960 ENSUAMP00000034960 CREB3L1 CREB3L1 TMPRSS2 TMPRSS2 ENSUAMP00000035331 ENSUAMP00000035331 CREB3 CREB3 ENSUAMP00000035777 ENSUAMP00000035777 ENSUAMP00000036162 ENSUAMP00000036162 ENSUAMP00000036324 ENSUAMP00000036324 TCF7L1 TCF7L1 CHUK CHUK AKT2 AKT2 E2F2 E2F2 ATF4 ATF4 PDGFB PDGFB ENSUAMP00000004918 ENSUAMP00000004918 ENSUAMP00000006241 ENSUAMP00000006241 ENSUAMP00000006430 ENSUAMP00000006430 CDKN1B CDKN1B TCF7 TCF7 CCNE1 CCNE1 PDGFA PDGFA MMP12 MMP12 ENSUAMP00000000641 ENSUAMP00000000641 ETV5 ETV5 TP53 TP53 ENSUAMP00000001020 ENSUAMP00000001020 ENSUAMP00000001524 ENSUAMP00000001524 EGF EGF ZEB1 ZEB1 ENSUAMP00000003693 ENSUAMP00000003693 ENSUAMP00000003787 ENSUAMP00000003787 PIK3CA PIK3CA FOXO1 FOXO1 ENSUAMP00000009491 ENSUAMP00000009491 ENSUAMP00000010013 ENSUAMP00000010013 PIK3R1 PIK3R1 AKT1 AKT1 ENSUAMP00000011147 ENSUAMP00000011147 ENSUAMP00000011487 ENSUAMP00000011487 ERBB2 ERBB2 AKT3 AKT3 BCL2 BCL2 ENSUAMP00000011956 ENSUAMP00000011956 ENSUAMP00000012071 ENSUAMP00000012071 GSK3B GSK3B ENSUAMP00000012266 ENSUAMP00000012266 GRB2 GRB2 AR AR MAPK1 MAPK1 ERAS ERAS IKBKG IKBKG SRD5A2 SRD5A2 RB1 RB1 IGF1R IGF1R ENSUAMP00000015441 ENSUAMP00000015441 SOS2 SOS2 ENSUAMP00000015993 ENSUAMP00000015993 PDPK1 PDPK1 PDGFD PDGFD INSRR INSRR CTNNB1 CTNNB1 ENSUAMP00000017364 ENSUAMP00000017364 ENSUAMP00000017435 ENSUAMP00000017435 ENSUAMP00000017692 ENSUAMP00000017692 ENSUAMP00000018470 ENSUAMP00000018470 PDGFRA PDGFRA PLAU PLAU BAD BAD PPP1R14B PPP1R14B MTOR MTOR PIK3CD PIK3CD IKBKB IKBKB KRAS KRAS SPINT1 SPINT1 IGF1 IGF1 HSP90AB1 HSP90AB1 ENSUAMP00000021380 ENSUAMP00000021380 ENSUAMP00000021381 ENSUAMP00000021381 NFKB1 NFKB1 ENSUAMP00000021540 ENSUAMP00000021540 ENSUAMP00000022131 ENSUAMP00000022131 MMP3 MMP3 FGFR2 FGFR2 CASP9 CASP9 MDM2 MDM2 HSP90AA1 HSP90AA1 CREB1 CREB1 CREB3L3 CREB3L3 BRAF BRAF FGFR1 FGFR1 TCF7L2 TCF7L2 CREB5 CREB5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RELARELA proto-oncogene, NF-kB subunit. (508 aa)
ENSUAMP00000026993Uncharacterized protein. (118 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
ENSUAMP00000027431Uncharacterized protein. (74 aa)
ENSUAMP00000028178Uncharacterized protein. (311 aa)
ENSUAMP00000028179CSD domain-containing protein. (89 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
MMP9Matrix metallopeptidase 9. (704 aa)
ENSUAMP00000029031Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
ENSUAMP00000030280Protein kinase domain-containing protein. (206 aa)
MAP2K1Protein kinase domain-containing protein. (216 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (564 aa)
CREBBPCREB binding protein. (2333 aa)
ENSUAMP00000030787Uncharacterized protein. (84 aa)
ENSUAMP00000031131Protein kinase domain-containing protein. (264 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
NKX2-3NK2 homeobox 3. (318 aa)
ENSUAMP00000031719Uncharacterized protein. (627 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (247 aa)
EP300E1A binding protein p300. (2399 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1100 aa)
ENSUAMP00000032511Protein kinase domain-containing protein. (132 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (563 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (294 aa)
ENSUAMP00000032843Uncharacterized protein. (186 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1232 aa)
ENSUAMP00000032909Uncharacterized protein. (592 aa)
ENSUAMP00000032923Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (387 aa)
ENSUAMP00000033175Uncharacterized protein. (91 aa)
PDGFCPlatelet derived growth factor C. (218 aa)
E2F1E2F transcription factor 1. (400 aa)
E2F3E2F transcription factor 3. (469 aa)
ENSUAMP00000034960C2H2-type domain-containing protein. (123 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
TMPRSS2Transmembrane serine protease 2; Belongs to the peptidase S1 family. (492 aa)
ENSUAMP00000035331Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (506 aa)
CREB3cAMP responsive element binding protein 3. (352 aa)
ENSUAMP00000035777HMG box domain-containing protein. (191 aa)
ENSUAMP00000036162Protein kinase domain-containing protein. (462 aa)
ENSUAMP00000036324Uncharacterized protein. (189 aa)
TCF7L1Transcription factor 7 like 1. (597 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
E2F2E2F transcription factor 2. (431 aa)
ATF4Activating transcription factor 4. (351 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
ENSUAMP00000004918Homeobox domain-containing protein. (230 aa)
ENSUAMP00000006241GST N-terminal domain-containing protein. (60 aa)
ENSUAMP00000006430Uncharacterized protein; Belongs to the GST superfamily. (226 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (200 aa)
TCF7Transcription factor 7. (443 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (370 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (248 aa)
MMP12Matrix metallopeptidase 12. (495 aa)
ENSUAMP00000000641Uncharacterized protein. (139 aa)
ETV5ETS variant 5. (510 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
ENSUAMP00000001020Uncharacterized protein. (147 aa)
ENSUAMP00000001524Uncharacterized protein. (75 aa)
EGFEpidermal growth factor. (979 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1017 aa)
ENSUAMP00000003693Uncharacterized protein. (166 aa)
ENSUAMP00000003787Uncharacterized protein. (209 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FOXO1Forkhead box O1. (660 aa)
ENSUAMP00000009491C2 tensin-type domain-containing protein. (179 aa)
ENSUAMP00000010013Uncharacterized protein. (73 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (676 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
ENSUAMP00000011147Ion_trans domain-containing protein. (118 aa)
ENSUAMP00000011487HATPase_c domain-containing protein. (333 aa)
ERBB2Receptor protein-tyrosine kinase. (1261 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
BCL2BCL2 apoptosis regulator. (205 aa)
ENSUAMP00000011956Uncharacterized protein. (119 aa)
ENSUAMP00000012071GST N-terminal domain-containing protein. (193 aa)
GSK3BGlycogen synthase kinase 3 beta. (335 aa)
ENSUAMP00000012266CTNNB1_binding domain-containing protein. (162 aa)
GRB2Growth factor receptor bound protein 2. (203 aa)
ARAndrogen receptor. (905 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
ERASES cell expressed Ras. (219 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (442 aa)
SRD5A23-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (254 aa)
RB1RB transcriptional corepressor 1. (870 aa)
IGF1RTyrosine-protein kinase receptor. (1288 aa)
ENSUAMP00000015441Uncharacterized protein. (236 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1306 aa)
ENSUAMP00000015993Uncharacterized protein. (98 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (531 aa)
PDGFDPlatelet derived growth factor D. (368 aa)
INSRRTyrosine-protein kinase receptor. (1318 aa)
CTNNB1Catenin beta 1. (781 aa)
ENSUAMP00000017364Uncharacterized protein. (53 aa)
ENSUAMP00000017435Uncharacterized protein. (459 aa)
ENSUAMP00000017692Uncharacterized protein. (704 aa)
ENSUAMP00000018470Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (298 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
PLAUPlasminogen activator, urokinase; Belongs to the peptidase S1 family. (432 aa)
BADBCL2 associated agonist of cell death. (168 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (147 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2523 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (703 aa)
KRASKRAS proto-oncogene, GTPase. (188 aa)
SPINT1Serine peptidase inhibitor, Kunitz type 1. (510 aa)
IGF1Insulin like growth factor 1. (171 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (728 aa)
ENSUAMP00000021380Uncharacterized protein. (424 aa)
ENSUAMP00000021381Protein kinase domain-containing protein. (363 aa)
NFKB1Nuclear factor kappa B subunit 1. (972 aa)
ENSUAMP00000021540Uncharacterized protein. (311 aa)
ENSUAMP00000022131Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (636 aa)
MMP3ZnMc domain-containing protein. (477 aa)
FGFR2Fibroblast growth factor receptor 2. (661 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (467 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (495 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (733 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (457 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (728 aa)
FGFR1Fibroblast growth factor receptor. (848 aa)
TCF7L2Transcription factor 7 like 2. (524 aa)
CREB5cAMP responsive element binding protein 5. (327 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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