STRINGSTRING
TCF7L1 TCF7L1 BAK1 BAK1 TP53 TP53 PPARG PPARG ENSUAMP00000003693 ENSUAMP00000003693 DDB2 DDB2 TFG TFG CCDC6 CCDC6 TCF7 TCF7 ENSUAMP00000009856 ENSUAMP00000009856 POLK POLK ENSUAMP00000011146 ENSUAMP00000011146 ENSUAMP00000012266 ENSUAMP00000012266 BAX BAX MAPK1 MAPK1 ERAS ERAS ENSUAMP00000015993 ENSUAMP00000015993 GADD45B GADD45B CTNNB1 CTNNB1 NTRK1 NTRK1 GADD45G GADD45G KRAS KRAS BRAF BRAF PAX8 PAX8 TCF7L2 TCF7L2 RXRA RXRA ENSUAMP00000026993 ENSUAMP00000026993 ENSUAMP00000027844 ENSUAMP00000027844 ENSUAMP00000027845 ENSUAMP00000027845 ENSUAMP00000028178 ENSUAMP00000028178 ENSUAMP00000028179 ENSUAMP00000028179 CDKN1A CDKN1A ENSUAMP00000029031 ENSUAMP00000029031 ENSUAMP00000030280 ENSUAMP00000030280 MAP2K1 MAP2K1 RET RET MAPK3 MAPK3 MYC MYC ENSUAMP00000031719 ENSUAMP00000031719 ENSUAMP00000031863 ENSUAMP00000031863 ENSUAMP00000031866 ENSUAMP00000031866 CCND1 CCND1 CDH1 CDH1 RXRB RXRB ENSUAMP00000035777 ENSUAMP00000035777 GADD45A GADD45A ENSUAMP00000036324 ENSUAMP00000036324
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TCF7L1Transcription factor 7 like 1. (597 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
ENSUAMP00000003693Uncharacterized protein. (166 aa)
DDB2Damage specific DNA binding protein 2. (421 aa)
TFGTrafficking from ER to golgi regulator. (401 aa)
CCDC6Coiled-coil domain containing 6. (476 aa)
TCF7Transcription factor 7. (443 aa)
ENSUAMP00000009856Uncharacterized protein. (79 aa)
POLKDNA polymerase kappa. (542 aa)
ENSUAMP00000011146ARA70 domain-containing protein. (110 aa)
ENSUAMP00000012266CTNNB1_binding domain-containing protein. (162 aa)
BAXBCL2 associated X, apoptosis regulator. (205 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
ERASES cell expressed Ras. (219 aa)
ENSUAMP00000015993Uncharacterized protein. (98 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (182 aa)
CTNNB1Catenin beta 1. (781 aa)
NTRK1Tyrosine-protein kinase receptor. (787 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (228 aa)
KRASKRAS proto-oncogene, GTPase. (188 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (728 aa)
PAX8Paired box 8. (458 aa)
TCF7L2Transcription factor 7 like 2. (524 aa)
RXRARetinoid X receptor alpha. (469 aa)
ENSUAMP00000026993Uncharacterized protein. (118 aa)
ENSUAMP00000027844Nuc_recep-AF1 domain-containing protein. (202 aa)
ENSUAMP00000027845Uncharacterized protein. (347 aa)
ENSUAMP00000028178Uncharacterized protein. (311 aa)
ENSUAMP00000028179CSD domain-containing protein. (89 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
ENSUAMP00000029031Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
ENSUAMP00000030280Protein kinase domain-containing protein. (206 aa)
MAP2K1Protein kinase domain-containing protein. (216 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1121 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
ENSUAMP00000031719Uncharacterized protein. (627 aa)
ENSUAMP00000031863Uncharacterized protein; Belongs to the tropomyosin family. (248 aa)
ENSUAMP00000031866Uncharacterized protein. (135 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (294 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (881 aa)
RXRBRetinoid X receptor beta. (532 aa)
ENSUAMP00000035777HMG box domain-containing protein. (191 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (150 aa)
ENSUAMP00000036324Uncharacterized protein. (189 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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