STRINGSTRING
E2F2 E2F2 DDB2 DDB2 ENSUAMP00000003693 ENSUAMP00000003693 FGF17 FGF17 AKT2 AKT2 ENSUAMP00000036324 ENSUAMP00000036324 ENSUAMP00000036162 ENSUAMP00000036162 GADD45A GADD45A TP53 TP53 FGF16 FGF16 BAK1 BAK1 ENSUAMP00000035331 ENSUAMP00000035331 E2F3 E2F3 E2F1 E2F1 CDH1 CDH1 PDGFC PDGFC ENSUAMP00000032923 ENSUAMP00000032923 ENSUAMP00000032909 ENSUAMP00000032909 FGF3 FGF3 FGF4 FGF4 FGF19 FGF19 CCND1 CCND1 PDGFRB PDGFRB ENSUAMP00000031719 ENSUAMP00000031719 MAPK3 MAPK3 ENSUAMP00000030787 ENSUAMP00000030787 RAF1 RAF1 FGF18 FGF18 MAP2K1 MAP2K1 ENSUAMP00000030280 ENSUAMP00000030280 MITF MITF FGF1 FGF1 ENSUAMP00000029322 ENSUAMP00000029322 ENSUAMP00000029031 ENSUAMP00000029031 CDKN1A CDKN1A ENSUAMP00000028179 ENSUAMP00000028179 ENSUAMP00000028178 ENSUAMP00000028178 ENSUAMP00000027431 ENSUAMP00000027431 ENSUAMP00000026993 ENSUAMP00000026993 FGFR1 FGFR1 FGF22 FGF22 BRAF BRAF MDM2 MDM2 ENSUAMP00000023691 ENSUAMP00000023691 ENSUAMP00000022131 ENSUAMP00000022131 ENSUAMP00000021381 ENSUAMP00000021381 ENSUAMP00000021380 ENSUAMP00000021380 EGF EGF IGF1 IGF1 KRAS KRAS GADD45G GADD45G PIK3CD PIK3CD PPP1R14B PPP1R14B BAD BAD PDGFRA PDGFRA GALK2 GALK2 ENSUAMP00000017692 ENSUAMP00000017692 ENSUAMP00000017435 ENSUAMP00000017435 ENSUAMP00000017364 ENSUAMP00000017364 PDGFD PDGFD GADD45B GADD45B CDK4 CDK4 ENSUAMP00000015993 ENSUAMP00000015993 FGF7 FGF7 IGF1R IGF1R RB1 RB1 ERAS ERAS MAPK1 MAPK1 BAX BAX FGF21 FGF21 AKT3 AKT3 ENSUAMP00000011147 ENSUAMP00000011147 AKT1 AKT1 PIK3R1 PIK3R1 POLK POLK ENSUAMP00000009491 ENSUAMP00000009491 MET MET PIK3CA PIK3CA PDGFA PDGFA CDK6 CDK6 FGF20 FGF20 FGF10 FGF10 FGF5 FGF5 FGF6 FGF6 FGF23 FGF23 PDGFB PDGFB FGF9 FGF9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
E2F2E2F transcription factor 2. (431 aa)
DDB2Damage specific DNA binding protein 2. (421 aa)
ENSUAMP00000003693Uncharacterized protein. (166 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSUAMP00000036324Uncharacterized protein. (189 aa)
ENSUAMP00000036162Protein kinase domain-containing protein. (462 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (150 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (198 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
ENSUAMP00000035331Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (506 aa)
E2F3E2F transcription factor 3. (469 aa)
E2F1E2F transcription factor 1. (400 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (881 aa)
PDGFCPlatelet derived growth factor C. (218 aa)
ENSUAMP00000032923Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (387 aa)
ENSUAMP00000032909Uncharacterized protein. (592 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (226 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (197 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (294 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1100 aa)
ENSUAMP00000031719Uncharacterized protein. (627 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
ENSUAMP00000030787Uncharacterized protein. (84 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (564 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
MAP2K1Protein kinase domain-containing protein. (216 aa)
ENSUAMP00000030280Protein kinase domain-containing protein. (206 aa)
MITFMelanocyte inducing transcription factor. (525 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
ENSUAMP00000029322Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
ENSUAMP00000029031Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
ENSUAMP00000028179CSD domain-containing protein. (89 aa)
ENSUAMP00000028178Uncharacterized protein. (311 aa)
ENSUAMP00000027431Uncharacterized protein. (74 aa)
ENSUAMP00000026993Uncharacterized protein. (118 aa)
FGFR1Fibroblast growth factor receptor. (848 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (171 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (728 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (495 aa)
ENSUAMP00000023691Uncharacterized protein. (268 aa)
ENSUAMP00000022131Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (636 aa)
ENSUAMP00000021381Protein kinase domain-containing protein. (363 aa)
ENSUAMP00000021380Uncharacterized protein. (424 aa)
EGFEpidermal growth factor. (979 aa)
IGF1Insulin like growth factor 1. (171 aa)
KRASKRAS proto-oncogene, GTPase. (188 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (228 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (147 aa)
BADBCL2 associated agonist of cell death. (168 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
GALK2Galactokinase 2. (460 aa)
ENSUAMP00000017692Uncharacterized protein. (704 aa)
ENSUAMP00000017435Uncharacterized protein. (459 aa)
ENSUAMP00000017364Uncharacterized protein. (53 aa)
PDGFDPlatelet derived growth factor D. (368 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (182 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (340 aa)
ENSUAMP00000015993Uncharacterized protein. (98 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
IGF1RTyrosine-protein kinase receptor. (1288 aa)
RB1RB transcriptional corepressor 1. (870 aa)
ERASES cell expressed Ras. (219 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
BAXBCL2 associated X, apoptosis regulator. (205 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ENSUAMP00000011147Ion_trans domain-containing protein. (118 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (676 aa)
POLKDNA polymerase kappa. (542 aa)
ENSUAMP00000009491C2 tensin-type domain-containing protein. (179 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1399 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (248 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (270 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.