(89 nodes) Chronic myeloid leukemia network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSUAMP00000003693	Uncharacterized protein. (166 aa)
	DDB2	Damage specific DNA binding protein 2. (421 aa)
	E2F2	E2F transcription factor 2. (431 aa)
	CDKN1B	Cyclin dependent kinase inhibitor 1B. (200 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (303 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	ABL1	Tyrosine-protein kinase. (1138 aa)
	MECOM	MDS1 and EVI1 complex locus. (1120 aa)
	ENSUAMP00000010013	Uncharacterized protein. (73 aa)
	POLK	DNA polymerase kappa. (542 aa)
	PTPN11	Protein tyrosine phosphatase non-receptor type 11. (552 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (676 aa)
	AKT1	Non-specific serine/threonine protein kinase. (572 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	GRB2	Growth factor receptor bound protein 2. (203 aa)
	BCR	BCR activator of RhoGEF and GTPase. (1100 aa)
	BAX	BCL2 associated X, apoptosis regulator. (205 aa)
	MAPK1	Mitogen-activated protein kinase. (364 aa)
	ERAS	ES cell expressed Ras. (219 aa)
	STAT5A	Signal transducer and activator of transcription. (797 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (442 aa)
	RB1	RB transcriptional corepressor 1. (870 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1306 aa)
	ENSUAMP00000015993	Uncharacterized protein. (98 aa)
	CDK4	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (340 aa)
	GADD45B	Growth arrest and DNA damage inducible beta. (182 aa)
	CRK	CRK proto-oncogene, adaptor protein. (204 aa)
	ENSUAMP00000021380	Uncharacterized protein. (424 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
	ENSUAMP00000036324	Uncharacterized protein. (189 aa)
	GADD45A	Growth arrest and DNA damage inducible alpha. (150 aa)
	ENSUAMP00000035331	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (506 aa)
	E2F3	E2F transcription factor 3. (469 aa)
	E2F1	E2F transcription factor 1. (400 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1232 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (294 aa)
	ENSUAMP00000032511	Protein kinase domain-containing protein. (132 aa)
	ENSUAMP00000030280	Protein kinase domain-containing protein. (206 aa)
	MAP2K1	Protein kinase domain-containing protein. (216 aa)
	NFKBIA	NFKB inhibitor alpha. (314 aa)
	BCL2L1	BCL2 like 1. (233 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (564 aa)
	ENSUAMP00000030787	Uncharacterized protein. (84 aa)
	STAT5B	Signal transducer and activator of transcription. (784 aa)
	ENSUAMP00000031719	Uncharacterized protein. (627 aa)
	MAPK3	Mitogen-activated protein kinase. (354 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
	ENSUAMP00000028178	Uncharacterized protein. (311 aa)
	ENSUAMP00000028179	CSD domain-containing protein. (89 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (164 aa)
	ENSUAMP00000029031	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
	ENSUAMP00000021381	Protein kinase domain-containing protein. (363 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (972 aa)
	RUNX1	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (444 aa)
	ENSUAMP00000022131	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (636 aa)
	ENSUAMP00000022818	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
	MDM2	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (495 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
	ENSUAMP00000017435	Uncharacterized protein. (459 aa)
	ENSUAMP00000017692	Uncharacterized protein. (704 aa)
	CBL	Cbl proto-oncogene. (796 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (479 aa)
	SHC1	SHC adaptor protein 1. (474 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	BAD	BCL2 associated agonist of cell death. (168 aa)
	PPP1R14B	Protein phosphatase 1 regulatory inhibitor subunit 14B. (147 aa)
	CTBP1	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (421 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
	ENSUAMP00000020051	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (445 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (703 aa)
	GADD45G	Growth arrest and DNA damage inducible gamma. (228 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (439 aa)
	KRAS	KRAS proto-oncogene, GTPase. (188 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (728 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (508 aa)
	ENSUAMP00000026993	Uncharacterized protein. (118 aa)
	ENSUAMP00000027431	Uncharacterized protein. (74 aa)
	BAK1	BCL2 antagonist/killer 1. (211 aa)
	ENSUAMP00000000785	SH2 domain-containing protein. (91 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (446 aa)
	GAB2	GRB2 associated binding protein 2. (665 aa)
	CEP152	Centrosomal protein 152. (1716 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	BCR	ENSUAMP00000009706	ENSUAMP00000012844	Tyrosine-protein kinase.	BCR activator of RhoGEF and GTPase.	0.980
ABL1	CBL	ENSUAMP00000009706	ENSUAMP00000017866	Tyrosine-protein kinase.	Cbl proto-oncogene.	0.990
ABL1	CCND1	ENSUAMP00000009706	ENSUAMP00000032516	Tyrosine-protein kinase.	Cyclin D1; Belongs to the cyclin family.	0.415
ABL1	CDK4	ENSUAMP00000009706	ENSUAMP00000016521	Tyrosine-protein kinase.	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.	0.410
ABL1	CDKN1A	ENSUAMP00000009706	ENSUAMP00000028410	Tyrosine-protein kinase.	Cyclin dependent kinase inhibitor 1A.	0.533
ABL1	CDKN1B	ENSUAMP00000009706	ENSUAMP00000007606	Tyrosine-protein kinase.	Cyclin dependent kinase inhibitor 1B.	0.415
ABL1	CRK	ENSUAMP00000009706	ENSUAMP00000016663	Tyrosine-protein kinase.	CRK proto-oncogene, adaptor protein.	0.996
ABL1	CRKL	ENSUAMP00000009706	ENSUAMP00000008326	Tyrosine-protein kinase.	CRK like proto-oncogene, adaptor protein.	0.991
ABL1	ENSUAMP00000000785	ENSUAMP00000009706	ENSUAMP00000000785	Tyrosine-protein kinase.	SH2 domain-containing protein.	0.958
ABL1	ENSUAMP00000027431	ENSUAMP00000009706	ENSUAMP00000027431	Tyrosine-protein kinase.	Uncharacterized protein.	0.409
ABL1	GRB2	ENSUAMP00000009706	ENSUAMP00000012687	Tyrosine-protein kinase.	Growth factor receptor bound protein 2.	0.989
ABL1	MAPK1	ENSUAMP00000009706	ENSUAMP00000013584	Tyrosine-protein kinase.	Mitogen-activated protein kinase.	0.466
ABL1	MAPK3	ENSUAMP00000009706	ENSUAMP00000031536	Tyrosine-protein kinase.	Mitogen-activated protein kinase.	0.466
ABL1	MDM2	ENSUAMP00000009706	ENSUAMP00000023763	Tyrosine-protein kinase.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.409
ABL1	PIK3R1	ENSUAMP00000009706	ENSUAMP00000010522	Tyrosine-protein kinase.	Phosphoinositide-3-kinase regulatory subunit 1.	0.583
ABL1	RB1	ENSUAMP00000009706	ENSUAMP00000014989	Tyrosine-protein kinase.	RB transcriptional corepressor 1.	0.972
ABL1	RUNX1	ENSUAMP00000009706	ENSUAMP00000021322	Tyrosine-protein kinase.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.430
ABL1	SHC1	ENSUAMP00000009706	ENSUAMP00000018062	Tyrosine-protein kinase.	SHC adaptor protein 1.	0.958
ABL1	STAT5A	ENSUAMP00000009706	ENSUAMP00000013947	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.955
ABL1	STAT5B	ENSUAMP00000009706	ENSUAMP00000031354	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.955