STRINGSTRING
WNT9B WNT9B SHC1 SHC1 GALK2 GALK2 ENSUAMP00000017692 ENSUAMP00000017692 TERT TERT ENSUAMP00000017435 ENSUAMP00000017435 CTNNB1 CTNNB1 TGFBR1 TGFBR1 TGFB3 TGFB3 GADD45B GADD45B ENSUAMP00000016387 ENSUAMP00000016387 ENSUAMP00000016187 ENSUAMP00000016187 DVL1 DVL1 ENSUAMP00000015993 ENSUAMP00000015993 WNT7B WNT7B SOS2 SOS2 FGF7 FGF7 RB1 RB1 ERAS ERAS MAPK1 MAPK1 BAX BAX RARB RARB FGF21 FGF21 GRB2 GRB2 TGFB1 TGFB1 WNT9A WNT9A WNT3A WNT3A ENSUAMP00000012266 ENSUAMP00000012266 GSK3B GSK3B BCL2 BCL2 AKT3 AKT3 FZD5 FZD5 ERBB2 ERBB2 FZD4 FZD4 AKT1 AKT1 PIK3R1 PIK3R1 FZD3 FZD3 ENSUAMP00000022131 ENSUAMP00000022131 ENSUAMP00000022336 ENSUAMP00000022336 ENSUAMP00000022339 ENSUAMP00000022339 RPS6KB1 RPS6KB1 FGFR2 FGFR2 WNT5A WNT5A ENSUAMP00000023691 ENSUAMP00000023691 ENSUAMP00000024255 ENSUAMP00000024255 ENSUAMP00000024259 ENSUAMP00000024259 BRAF BRAF WNT8A WNT8A ENSUAMP00000025109 ENSUAMP00000025109 CSNK1A1 CSNK1A1 FGF22 FGF22 LRP5 LRP5 ENSUAMP00000025705 ENSUAMP00000025705 TCF7L2 TCF7L2 WNT4 WNT4 SMAD3 SMAD3 SMAD2 SMAD2 RXRA RXRA ENSUAMP00000026993 ENSUAMP00000026993 FZD10 FZD10 ENSUAMP00000027844 ENSUAMP00000027844 ENSUAMP00000027845 ENSUAMP00000027845 ENSUAMP00000028178 ENSUAMP00000028178 ENSUAMP00000028179 ENSUAMP00000028179 CDKN1A CDKN1A ENSUAMP00000029031 ENSUAMP00000029031 ENSUAMP00000029322 ENSUAMP00000029322 FGF1 FGF1 CDX2 CDX2 ENSUAMP00000030280 ENSUAMP00000030280 MAP2K1 MAP2K1 GAB1 GAB1 FGF18 FGF18 RAF1 RAF1 ENSUAMP00000030787 ENSUAMP00000030787 ENSUAMP00000031057 ENSUAMP00000031057 ENSUAMP00000031131 ENSUAMP00000031131 MAPK3 MAPK3 MYC MYC ENSUAMP00000031719 ENSUAMP00000031719 JUP JUP CCND1 CCND1 FGF19 FGF19 FGF4 FGF4 FGF3 FGF3 REG4 REG4 SOS1 SOS1 ENSUAMP00000032909 ENSUAMP00000032909 FZD7 FZD7 ENSUAMP00000033613 ENSUAMP00000033613 CDH1 CDH1 E2F1 E2F1 E2F3 E2F3 ENSUAMP00000035331 ENSUAMP00000035331 RXRB RXRB WNT1 WNT1 WNT10B WNT10B WNT7A WNT7A ENSUAMP00000035777 ENSUAMP00000035777 ENSUAMP00000035901 ENSUAMP00000035901 GADD45A GADD45A WNT3 WNT3 ENSUAMP00000036162 ENSUAMP00000036162 ENSUAMP00000036324 ENSUAMP00000036324 FZD1 FZD1 TCF7L1 TCF7L1 MLH1 MLH1 FRAT2 FRAT2 AKT2 AKT2 POLK POLK ENSUAMP00000010013 ENSUAMP00000010013 WNT2 WNT2 MET MET PIK3CA PIK3CA TGFBR2 TGFBR2 CCNE1 CCNE1 FGF20 FGF20 FGF10 FGF10 FGF5 FGF5 WNT2B WNT2B TCF7 TCF7 CDKN1B CDKN1B ENSUAMP00000007208 ENSUAMP00000007208 FGF6 FGF6 FGF23 FGF23 DVL3 DVL3 RPS6KB2 RPS6KB2 FGF9 FGF9 E2F2 E2F2 DDB2 DDB2 ENSUAMP00000003693 ENSUAMP00000003693 WNT8B WNT8B FGF17 FGF17 WNT11 WNT11 ENSUAMP00000002344 ENSUAMP00000002344 ENSUAMP00000002339 ENSUAMP00000002339 FZD2 FZD2 LRP6 LRP6 CEP152 CEP152 EGF EGF WNT6 WNT6 ENSUAMP00000001524 ENSUAMP00000001524 ENSUAMP00000001492 ENSUAMP00000001492 ENSUAMP00000001392 ENSUAMP00000001392 AXIN2 AXIN2 TP53 TP53 FGF16 FGF16 ENSUAMP00000000785 ENSUAMP00000000785 CDKN2B CDKN2B ENSUAMP00000000622 ENSUAMP00000000622 BAK1 BAK1 APC APC SMAD4 SMAD4 ENSUAMP00000018470 ENSUAMP00000018470 APC2 APC2 DVL2 DVL2 MTOR MTOR PIK3CD PIK3CD FZD6 FZD6 AXIN1 AXIN1 ENSUAMP00000020574 ENSUAMP00000020574 GADD45G GADD45G TGFB2 TGFB2 KRAS KRAS CDH17 CDH17 FZD9 FZD9 ENSUAMP00000021380 ENSUAMP00000021380 ENSUAMP00000021381 ENSUAMP00000021381 WNT16 WNT16 ENSUAMP00000018321 ENSUAMP00000018321 WNT10A WNT10A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
SHC1SHC adaptor protein 1. (474 aa)
GALK2Galactokinase 2. (460 aa)
ENSUAMP00000017692Uncharacterized protein. (704 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1117 aa)
ENSUAMP00000017435Uncharacterized protein. (459 aa)
CTNNB1Catenin beta 1. (781 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (182 aa)
ENSUAMP00000016387Uncharacterized protein. (118 aa)
ENSUAMP00000016187Uncharacterized protein. (81 aa)
DVL1Dishevelled segment polarity protein 1. (700 aa)
ENSUAMP00000015993Uncharacterized protein. (98 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1306 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
RB1RB transcriptional corepressor 1. (870 aa)
ERASES cell expressed Ras. (219 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
BAXBCL2 associated X, apoptosis regulator. (205 aa)
RARBRetinoic acid receptor beta. (336 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
GRB2Growth factor receptor bound protein 2. (203 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
ENSUAMP00000012266CTNNB1_binding domain-containing protein. (162 aa)
GSK3BGlycogen synthase kinase 3 beta. (335 aa)
BCL2BCL2 apoptosis regulator. (205 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (727 aa)
ERBB2Receptor protein-tyrosine kinase. (1261 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (676 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
ENSUAMP00000022131Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (636 aa)
ENSUAMP00000022336Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (163 aa)
ENSUAMP00000022339Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (107 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (524 aa)
FGFR2Fibroblast growth factor receptor 2. (661 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ENSUAMP00000023691Uncharacterized protein. (268 aa)
ENSUAMP00000024255C-type lectin domain-containing protein. (175 aa)
ENSUAMP00000024259C-type lectin domain-containing protein. (175 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (728 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (344 aa)
ENSUAMP00000025109Uncharacterized protein. (168 aa)
CSNK1A1Casein kinase 1 alpha 1; Belongs to the protein kinase superfamily. (365 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (171 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
ENSUAMP00000025705Uncharacterized protein. (84 aa)
TCF7L2Transcription factor 7 like 2. (524 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (343 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
RXRARetinoid X receptor alpha. (469 aa)
ENSUAMP00000026993Uncharacterized protein. (118 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (595 aa)
ENSUAMP00000027844Nuc_recep-AF1 domain-containing protein. (202 aa)
ENSUAMP00000027845Uncharacterized protein. (347 aa)
ENSUAMP00000028178Uncharacterized protein. (311 aa)
ENSUAMP00000028179CSD domain-containing protein. (89 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
ENSUAMP00000029031Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
ENSUAMP00000029322Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
CDX2Caudal type homeobox 2. (312 aa)
ENSUAMP00000030280Protein kinase domain-containing protein. (206 aa)
MAP2K1Protein kinase domain-containing protein. (216 aa)
GAB1GRB2 associated binding protein 1. (721 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (564 aa)
ENSUAMP00000030787Uncharacterized protein. (84 aa)
ENSUAMP00000031057Uncharacterized protein. (169 aa)
ENSUAMP00000031131Protein kinase domain-containing protein. (264 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
ENSUAMP00000031719Uncharacterized protein. (627 aa)
JUPJunction plakoglobin. (744 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (294 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (197 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (226 aa)
REG4Regenerating family member 4. (158 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1232 aa)
ENSUAMP00000032909Uncharacterized protein. (592 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
ENSUAMP00000033613Uncharacterized protein. (72 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (881 aa)
E2F1E2F transcription factor 1. (400 aa)
E2F3E2F transcription factor 3. (469 aa)
ENSUAMP00000035331Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (506 aa)
RXRBRetinoid X receptor beta. (532 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
ENSUAMP00000035777HMG box domain-containing protein. (191 aa)
ENSUAMP00000035901Uncharacterized protein. (79 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (150 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
ENSUAMP00000036162Protein kinase domain-containing protein. (462 aa)
ENSUAMP00000036324Uncharacterized protein. (189 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (534 aa)
TCF7L1Transcription factor 7 like 1. (597 aa)
MLH1MutL homolog 1. (758 aa)
FRAT2FRAT regulator of WNT signaling pathway 2. (221 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
POLKDNA polymerase kappa. (542 aa)
ENSUAMP00000010013Uncharacterized protein. (73 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1399 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (370 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (270 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (299 aa)
TCF7Transcription factor 7. (443 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (200 aa)
ENSUAMP00000007208Uncharacterized protein. (81 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
DVL3Dishevelled segment polarity protein 3. (716 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
E2F2E2F transcription factor 2. (431 aa)
DDB2Damage specific DNA binding protein 2. (421 aa)
ENSUAMP00000003693Uncharacterized protein. (166 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (332 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
ENSUAMP00000002344Uncharacterized protein. (257 aa)
ENSUAMP00000002339Uncharacterized protein. (108 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (563 aa)
LRP6LDL receptor related protein 6. (1431 aa)
CEP152Centrosomal protein 152. (1716 aa)
EGFEpidermal growth factor. (979 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
ENSUAMP00000001524Uncharacterized protein. (75 aa)
ENSUAMP00000001492Uncharacterized protein. (66 aa)
ENSUAMP00000001392Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (545 aa)
AXIN2Axin 2. (843 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (198 aa)
ENSUAMP00000000785SH2 domain-containing protein. (91 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
ENSUAMP00000000622Uncharacterized protein. (151 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
APCAPC regulator of WNT signaling pathway. (2832 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ENSUAMP00000018470Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (298 aa)
APC2APC regulator of WNT signaling pathway 2. (2266 aa)
DVL2Dishevelled segment polarity protein 2. (731 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2523 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (657 aa)
AXIN1Axin 1. (867 aa)
ENSUAMP00000020574VWFD domain-containing protein. (247 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (228 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (439 aa)
KRASKRAS proto-oncogene, GTPase. (188 aa)
CDH17Cadherin 17. (810 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (561 aa)
ENSUAMP00000021380Uncharacterized protein. (424 aa)
ENSUAMP00000021381Protein kinase domain-containing protein. (363 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
ENSUAMP00000018321Uncharacterized protein. (509 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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