STRINGSTRING
JUN JUN AKT2 AKT2 PCYT1A PCYT1A ENSUAMP00000036324 ENSUAMP00000036324 ENSUAMP00000036162 ENSUAMP00000036162 PIP5K1A PIP5K1A RHEBL1 RHEBL1 ENSUAMP00000035555 ENSUAMP00000035555 ENSUAMP00000035331 ENSUAMP00000035331 DGKZ DGKZ HIF1A HIF1A PDGFC PDGFC ENSUAMP00000032909 ENSUAMP00000032909 SOS1 SOS1 TSC1 TSC1 ENSUAMP00000032419 ENSUAMP00000032419 DGKB DGKB PDGFRB PDGFRB CHPT1 CHPT1 RAC3 RAC3 SLC44A4 SLC44A4 TSC2 TSC2 ENSUAMP00000031719 ENSUAMP00000031719 MAPK3 MAPK3 RAC2 RAC2 ENSUAMP00000030787 ENSUAMP00000030787 RAF1 RAF1 RAC1 RAC1 EIF4EBP1 EIF4EBP1 SLC44A3 SLC44A3 MAP2K1 MAP2K1 ENSUAMP00000030280 ENSUAMP00000030280 ENSUAMP00000030088 ENSUAMP00000030088 PLPP1 PLPP1 DGKH DGKH PLA2G4E PLA2G4E ENSUAMP00000029031 ENSUAMP00000029031 MAPK9 MAPK9 JMJD7 JMJD7 ENSUAMP00000028672 ENSUAMP00000028672 WAS WAS ENSUAMP00000028179 ENSUAMP00000028179 ENSUAMP00000028178 ENSUAMP00000028178 WASF1 WASF1 ENSUAMP00000026993 ENSUAMP00000026993 DGKI DGKI PCYT1B PCYT1B PLA2G4D PLA2G4D PLA2G4F PLA2G4F ENSUAMP00000025300 ENSUAMP00000025300 CHKA CHKA ENSUAMP00000024111 ENSUAMP00000024111 LYPLA1 LYPLA1 SLC44A2 SLC44A2 SLC22A1 SLC22A1 SLC22A2 SLC22A2 MAPK10 MAPK10 RPS6KB1 RPS6KB1 ENSUAMP00000022227 ENSUAMP00000022227 ENSUAMP00000022131 ENSUAMP00000022131 PIP5K1C PIP5K1C DGKD DGKD GPCPD1 GPCPD1 KRAS KRAS PRKCG PRKCG PLPP2 PLPP2 PIK3CD PIK3CD ENSUAMP00000019350 ENSUAMP00000019350 SLC22A4 SLC22A4 MTOR MTOR PDGFRA PDGFRA DGKA DGKA ENSUAMP00000017692 ENSUAMP00000017692 ENSUAMP00000017435 ENSUAMP00000017435 ENSUAMP00000016793 ENSUAMP00000016793 PDGFD PDGFD PDPK1 PDPK1 ENSUAMP00000015993 ENSUAMP00000015993 SOS2 SOS2 SLC22A5 SLC22A5 SP1 SP1 ERAS ERAS MAPK1 MAPK1 SLC44A5 SLC44A5 GRB2 GRB2 PLA2G4A PLA2G4A AKT3 AKT3 ENSUAMP00000011319 ENSUAMP00000011319 AKT1 AKT1 PRKCA PRKCA PIK3R1 PIK3R1 ENSUAMP00000010308 ENSUAMP00000010308 PLCG1 PLCG1 ENSUAMP00000010104 ENSUAMP00000010104 ENSUAMP00000010013 ENSUAMP00000010013 MAPK8 MAPK8 PIK3CA PIK3CA PDGFA PDGFA DGKE DGKE PRKCB PRKCB SLC22A3 SLC22A3 RPS6KB2 RPS6KB2 SLC5A7 SLC5A7 PLD2 PLD2 PDGFB PDGFB ENSUAMP00000003693 ENSUAMP00000003693 RHEB RHEB CHKB CHKB DGKQ DGKQ EGF EGF DGKG DGKG WASF2 WASF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PCYT1APhosphate cytidylyltransferase 1, choline, alpha. (367 aa)
ENSUAMP00000036324Uncharacterized protein. (189 aa)
ENSUAMP00000036162Protein kinase domain-containing protein. (462 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (549 aa)
RHEBL1RHEB like 1. (183 aa)
ENSUAMP00000035555WH2 domain-containing protein. (207 aa)
ENSUAMP00000035331Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (506 aa)
DGKZDiacylglycerol kinase. (946 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (823 aa)
PDGFCPlatelet derived growth factor C. (218 aa)
ENSUAMP00000032909Uncharacterized protein. (592 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1232 aa)
TSC1TSC complex subunit 1. (1168 aa)
ENSUAMP00000032419DAGKa domain-containing protein. (191 aa)
DGKBDiacylglycerol kinase beta. (432 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1100 aa)
CHPT1Choline phosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (399 aa)
RAC3Rac family small GTPase 3. (202 aa)
SLC44A4Solute carrier family 44 member 4; Belongs to the CTL (choline transporter-like) family. (709 aa)
TSC2TSC complex subunit 2. (1614 aa)
ENSUAMP00000031719Uncharacterized protein. (627 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
RAC2Rac family small GTPase 2. (192 aa)
ENSUAMP00000030787Uncharacterized protein. (84 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (564 aa)
RAC1Rac family small GTPase 1. (229 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
SLC44A3Solute carrier family 44 member 3; Belongs to the CTL (choline transporter-like) family. (572 aa)
MAP2K1Protein kinase domain-containing protein. (216 aa)
ENSUAMP00000030280Protein kinase domain-containing protein. (206 aa)
ENSUAMP00000030088DAGKa domain-containing protein. (90 aa)
PLPP1Phospholipid phosphatase 1. (286 aa)
DGKHDiacylglycerol kinase. (1191 aa)
PLA2G4EPhospholipase A2. (822 aa)
ENSUAMP00000029031Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
MAPK9Mitogen-activated protein kinase. (433 aa)
JMJD7Jumonji domain containing 7. (303 aa)
ENSUAMP00000028672Phospholipase A2. (765 aa)
WASWASP actin nucleation promoting factor. (503 aa)
ENSUAMP00000028179CSD domain-containing protein. (89 aa)
ENSUAMP00000028178Uncharacterized protein. (311 aa)
WASF1WASP family member 1. (530 aa)
ENSUAMP00000026993Uncharacterized protein. (118 aa)
DGKIDiacylglycerol kinase. (1052 aa)
PCYT1BPhosphate cytidylyltransferase 1, choline, beta. (369 aa)
PLA2G4DPhospholipase A2. (776 aa)
PLA2G4FPhospholipase A2. (837 aa)
ENSUAMP00000025300Non-specific serine/threonine protein kinase. (254 aa)
CHKACholine kinase alpha. (388 aa)
ENSUAMP00000024111PIPK domain-containing protein. (248 aa)
LYPLA1Lysophospholipase 1. (230 aa)
SLC44A2Solute carrier family 44 member 2; Belongs to the CTL (choline transporter-like) family. (684 aa)
SLC22A1Solute carrier family 22 member 1. (554 aa)
SLC22A2Solute carrier family 22 member 2. (554 aa)
MAPK10Mitogen-activated protein kinase. (422 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (524 aa)
ENSUAMP00000022227Uncharacterized protein. (64 aa)
ENSUAMP00000022131Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (636 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (624 aa)
DGKDDiacylglycerol kinase. (1166 aa)
GPCPD1Glycerophosphocholine phosphodiesterase 1. (429 aa)
KRASKRAS proto-oncogene, GTPase. (188 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (714 aa)
PLPP2Phospholipid phosphatase 2. (288 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
ENSUAMP00000019350Uncharacterized protein. (137 aa)
SLC22A4Solute carrier family 22 member 4. (553 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2523 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
DGKADiacylglycerol kinase. (734 aa)
ENSUAMP00000017692Uncharacterized protein. (704 aa)
ENSUAMP00000017435Uncharacterized protein. (459 aa)
ENSUAMP00000016793BZIP domain-containing protein. (179 aa)
PDGFDPlatelet derived growth factor D. (368 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (531 aa)
ENSUAMP00000015993Uncharacterized protein. (98 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1306 aa)
SLC22A5Solute carrier family 22 member 5. (501 aa)
SP1Sp1 transcription factor. (780 aa)
ERASES cell expressed Ras. (219 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
SLC44A5Solute carrier family 44 member 5; Belongs to the CTL (choline transporter-like) family. (699 aa)
GRB2Growth factor receptor bound protein 2. (203 aa)
PLA2G4APhospholipase A2. (756 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ENSUAMP00000011319Uncharacterized protein. (66 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
PRKCAProtein kinase C alpha; Belongs to the protein kinase superfamily. (484 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (676 aa)
ENSUAMP00000010308Uncharacterized protein. (854 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1256 aa)
ENSUAMP00000010104acidPPc domain-containing protein. (312 aa)
ENSUAMP00000010013Uncharacterized protein. (73 aa)
MAPK8Mitogen-activated protein kinase. (456 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (248 aa)
DGKEDiacylglycerol kinase. (572 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (651 aa)
SLC22A3Solute carrier family 22 member 3. (404 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
SLC5A7Solute carrier family 5 member 7; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (579 aa)
PLD2Phospholipase. (1025 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
ENSUAMP00000003693Uncharacterized protein. (166 aa)
RHEBRas homolog, mTORC1 binding. (179 aa)
CHKBCholine kinase beta. (395 aa)
DGKQDiacylglycerol kinase. (950 aa)
EGFEpidermal growth factor. (979 aa)
DGKGDiacylglycerol kinase. (790 aa)
WASF2WASP family member 2. (461 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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