STRINGSTRING
ENSUAMP00000005578 ENSUAMP00000005578 CD28 CD28 ENSUAMP00000024274 ENSUAMP00000024274 ENSUAMP00000023925 ENSUAMP00000023925 ENSUAMP00000022738 ENSUAMP00000022738 IGHM IGHM PRF1 PRF1 ENSUAMP00000020826 ENSUAMP00000020826 ENSUAMP00000020061 ENSUAMP00000020061 IL5 IL5 ENSUAMP00000019310 ENSUAMP00000019310 HLA-DRA HLA-DRA ENSUAMP00000018082 ENSUAMP00000018082 CD40LG CD40LG HLA-DOB HLA-DOB ENSUAMP00000016547 ENSUAMP00000016547 ENSUAMP00000016352 ENSUAMP00000016352 ENSUAMP00000016042 ENSUAMP00000016042 TRBV28 TRBV28 ENSUAMP00000015819 ENSUAMP00000015819 ENSUAMP00000015817 ENSUAMP00000015817 TSHB TSHB CD40 CD40 TRBV16 TRBV16 ENSUAMP00000014720 ENSUAMP00000014720 ENSUAMP00000014590 ENSUAMP00000014590 ENSUAMP00000014588 ENSUAMP00000014588 ENSUAMP00000012503 ENSUAMP00000012503 HLA-DMA HLA-DMA CD80 CD80 ENSUAMP00000011531 ENSUAMP00000011531 ENSUAMP00000011530 ENSUAMP00000011530 ENSUAMP00000011260 ENSUAMP00000011260 ENSUAMP00000010475 ENSUAMP00000010475 ENSUAMP00000009584 ENSUAMP00000009584 ENSUAMP00000007032 ENSUAMP00000007032 ENSUAMP00000006971 ENSUAMP00000006971 GZMB GZMB ENSUAMP00000006872 ENSUAMP00000006872 ENSUAMP00000006865 ENSUAMP00000006865 ENSUAMP00000006735 ENSUAMP00000006735 ENSUAMP00000006641 ENSUAMP00000006641 ENSUAMP00000006240 ENSUAMP00000006240 CTLA4 CTLA4 ENSUAMP00000005465 ENSUAMP00000005465 ENSUAMP00000003525 ENSUAMP00000003525 ENSUAMP00000003263 ENSUAMP00000003263 ENSUAMP00000003162 ENSUAMP00000003162 ENSUAMP00000002874 ENSUAMP00000002874 ENSUAMP00000001254 ENSUAMP00000001254 ENSUAMP00000000976 ENSUAMP00000000976 IL10 IL10 ENSUAMP00000037283 ENSUAMP00000037283 ENSUAMP00000036887 ENSUAMP00000036887 CGA CGA ENSUAMP00000036043 ENSUAMP00000036043 ENSUAMP00000036029 ENSUAMP00000036029 ENSUAMP00000035925 ENSUAMP00000035925 ENSUAMP00000035427 ENSUAMP00000035427 HLA-DOA HLA-DOA TPO TPO TSHR TSHR IL2 IL2 ENSUAMP00000029280 ENSUAMP00000029280
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000005578Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (132 aa)
CD28CD28 molecule. (216 aa)
ENSUAMP00000024274COesterase domain-containing protein. (355 aa)
ENSUAMP00000023925Ig-like domain-containing protein. (180 aa)
ENSUAMP00000022738Uncharacterized protein. (126 aa)
IGHMImmunoglobulin heavy constant mu. (480 aa)
PRF1Perforin 1. (555 aa)
ENSUAMP00000020826Ig-like domain-containing protein. (196 aa)
ENSUAMP00000020061Ig-like domain-containing protein; Belongs to the MHC class I family. (332 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (131 aa)
ENSUAMP00000019310Uncharacterized protein. (182 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
ENSUAMP00000018082Uncharacterized protein. (249 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (249 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (261 aa)
ENSUAMP00000016547MHC_II_beta domain-containing protein. (275 aa)
ENSUAMP00000016352Ig-like domain-containing protein; Belongs to the MHC class I family. (358 aa)
ENSUAMP00000016042Ig-like domain-containing protein. (387 aa)
TRBV28T cell receptor beta variable 28. (113 aa)
ENSUAMP00000015819Ig-like domain-containing protein. (141 aa)
ENSUAMP00000015817Ig-like domain-containing protein. (126 aa)
TSHBThyroid stimulating hormone subunit beta. (138 aa)
CD40CD40 molecule. (265 aa)
TRBV16T cell receptor beta variable 16 (gene/pseudogene). (127 aa)
ENSUAMP00000014720Ig-like domain-containing protein. (177 aa)
ENSUAMP00000014590Ig-like domain-containing protein. (148 aa)
ENSUAMP00000014588IGv domain-containing protein. (107 aa)
ENSUAMP00000012503Ig-like domain-containing protein. (263 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (261 aa)
CD80CD80 molecule. (283 aa)
ENSUAMP00000011531Uncharacterized protein. (172 aa)
ENSUAMP00000011530Uncharacterized protein. (197 aa)
ENSUAMP00000011260DUF1968 domain-containing protein. (153 aa)
ENSUAMP00000010475IGv domain-containing protein. (144 aa)
ENSUAMP00000009584Ig-like domain-containing protein; Belongs to the MHC class I family. (336 aa)
ENSUAMP00000007032Uncharacterized protein. (505 aa)
ENSUAMP00000006971Peptidase S1 domain-containing protein. (238 aa)
GZMBGranzyme B; Belongs to the peptidase S1 family. (260 aa)
ENSUAMP00000006872MHC_II_beta domain-containing protein. (218 aa)
ENSUAMP00000006865MHC_II_beta domain-containing protein. (274 aa)
ENSUAMP00000006735Uncharacterized protein. (185 aa)
ENSUAMP00000006641Uncharacterized protein. (184 aa)
ENSUAMP00000006240Ig-like domain-containing protein; Belongs to the MHC class I family. (359 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (223 aa)
ENSUAMP00000005465Ig-like domain-containing protein; Belongs to the MHC class I family. (431 aa)
ENSUAMP00000003525Ig-like domain-containing protein; Belongs to the MHC class II family. (205 aa)
ENSUAMP00000003263Ig-like domain-containing protein. (160 aa)
ENSUAMP00000003162Ig-like domain-containing protein. (206 aa)
ENSUAMP00000002874Ig-like domain-containing protein. (122 aa)
ENSUAMP00000001254Uncharacterized protein. (96 aa)
ENSUAMP00000000976Ig-like domain-containing protein; Belongs to the MHC class I family. (481 aa)
IL10Interleukin 10. (178 aa)
ENSUAMP00000037283Ig-like domain-containing protein. (145 aa)
ENSUAMP00000036887Ig-like domain-containing protein. (179 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
ENSUAMP00000036043MHC_I-like_Ag-recog domain-containing protein. (150 aa)
ENSUAMP00000036029Ig-like domain-containing protein; Belongs to the MHC class I family. (359 aa)
ENSUAMP00000035925Ig-like domain-containing protein. (236 aa)
ENSUAMP00000035427Ig-like domain-containing protein; Belongs to the MHC class II family. (241 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (283 aa)
TPOThyroid peroxidase. (1068 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (764 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
ENSUAMP00000029280DUF1968 domain-containing protein. (198 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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