STRINGSTRING
ITGA8 ITGA8 GNAS GNAS TNNC1 TNNC1 ADCY1 ADCY1 ADCY5 ADCY5 TNNT3 TNNT3 ENSUAMP00000026862 ENSUAMP00000026862 EMD EMD ATP2A1 ATP2A1 ENSUAMP00000026030 ENSUAMP00000026030 SLC8A2 SLC8A2 ENSUAMP00000025894 ENSUAMP00000025894 CACNG5 CACNG5 ENSUAMP00000022642 ENSUAMP00000022642 ENSUAMP00000022636 ENSUAMP00000022636 TNNT1 TNNT1 TNNI3 TNNI3 CACNA2D4 CACNA2D4 CACNG2 CACNG2 ENSUAMP00000021965 ENSUAMP00000021965 ENSUAMP00000021960 ENSUAMP00000021960 IGHM IGHM ACTG1 ACTG1 IGF1 IGF1 TGFB2 TGFB2 CACNA2D3 CACNA2D3 ITGA11 ITGA11 ACTA1 ACTA1 ITGA7 ITGA7 MYBPC3 MYBPC3 ENSUAMP00000018707 ENSUAMP00000018707 ITGA3 ITGA3 PLN PLN CACNA1D CACNA1D ENSUAMP00000017736 ENSUAMP00000017736 ATP2A3 ATP2A3 ENSUAMP00000017416 ENSUAMP00000017416 LMNA LMNA TGFB3 TGFB3 ENSUAMP00000016192 ENSUAMP00000016192 CACNG7 CACNG7 TNF TNF ENSUAMP00000015680 ENSUAMP00000015680 ENSUAMP00000015656 ENSUAMP00000015656 ENSUAMP00000015653 ENSUAMP00000015653 SGCG SGCG CACNB1 CACNB1 CACNG1 CACNG1 ENSUAMP00000013919 ENSUAMP00000013919 ATP2A2 ATP2A2 ENSUAMP00000012642 ENSUAMP00000012642 TGFB1 TGFB1 ENSUAMP00000012276 ENSUAMP00000012276 ENSUAMP00000010867 ENSUAMP00000010867 DAG1 DAG1 ENSUAMP00000007288 ENSUAMP00000007288 ENSUAMP00000007032 ENSUAMP00000007032 ITGA2B ITGA2B ENSUAMP00000006638 ENSUAMP00000006638 ENSUAMP00000006515 ENSUAMP00000006515 ENSUAMP00000005950 ENSUAMP00000005950 ADCY9 ADCY9 CACNA1S CACNA1S TNNT2 TNNT2 CACNB2 CACNB2 ENSUAMP00000004823 ENSUAMP00000004823 ACTC1 ACTC1 SLC8A1 SLC8A1 ITGB4 ITGB4 ENSUAMP00000003698 ENSUAMP00000003698 ITGB7 ITGB7 ITGA1 ITGA1 ENSUAMP00000001579 ENSUAMP00000001579 ITGB8 ITGB8 ENSUAMP00000001254 ENSUAMP00000001254 ENSUAMP00000000563 ENSUAMP00000000563 ITGB5 ITGB5 ADCY6 ADCY6 CACNB3 CACNB3 SGCA SGCA ITGA2 ITGA2 ITGA6 ITGA6 MYH8 MYH8 ENSUAMP00000033448 ENSUAMP00000033448 PRKACB PRKACB MYH1 MYH1 TPM2 TPM2 ENSUAMP00000032619 ENSUAMP00000032619 ENSUAMP00000032618 ENSUAMP00000032618 ADCY7 ADCY7 ENSUAMP00000032296 ENSUAMP00000032296 SGCB SGCB ADCY4 ADCY4 ENSUAMP00000031866 ENSUAMP00000031866 ENSUAMP00000031863 ENSUAMP00000031863 MYL2 MYL2 DES DES ENSUAMP00000030750 ENSUAMP00000030750 ITGAV ITGAV ENSUAMP00000029346 ENSUAMP00000029346 CACNA1F CACNA1F ITGB6 ITGB6 TPM1 TPM1 ITGA5 ITGA5 ITGA10 ITGA10 CACNG3 CACNG3 ADCY2 ADCY2 ADCY3 ADCY3 SLC8A3 SLC8A3 ITGB1 ITGB1 ENSUAMP00000010475 ENSUAMP00000010475 ENSUAMP00000010858 ENSUAMP00000010858
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (901 aa)
GNASGNAS complex locus. (994 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (158 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
ADCY5Adenylate cyclase 5. (940 aa)
TNNT3Troponin T3, fast skeletal type. (260 aa)
ENSUAMP00000026862Uncharacterized protein. (920 aa)
EMDEmerin. (260 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1060 aa)
ENSUAMP00000026030Uncharacterized protein. (236 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (902 aa)
ENSUAMP00000025894Integrin_alpha2 domain-containing protein. (435 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (275 aa)
ENSUAMP00000022642Uncharacterized protein. (552 aa)
ENSUAMP00000022636Uncharacterized protein. (644 aa)
TNNT1Troponin T1, slow skeletal type. (256 aa)
TNNI3Troponin I3, cardiac type. (211 aa)
CACNA2D4Calcium voltage-gated channel auxiliary subunit alpha2delta 4. (1067 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
ENSUAMP00000021965Uncharacterized protein. (81 aa)
ENSUAMP00000021960Uncharacterized protein; Belongs to the tropomyosin family. (248 aa)
IGHMImmunoglobulin heavy constant mu. (480 aa)
ACTG1Actin gamma 1. (375 aa)
IGF1Insulin like growth factor 1. (171 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (439 aa)
CACNA2D3Calcium voltage-gated channel auxiliary subunit alpha2delta 3. (633 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1220 aa)
ACTA1Actin alpha 1, skeletal muscle. (377 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1181 aa)
MYBPC3Myosin binding protein C, cardiac. (1245 aa)
ENSUAMP00000018707SERPIN domain-containing protein; Belongs to the serpin family. (416 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1051 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2160 aa)
ENSUAMP00000017736Cation_ATPase_N domain-containing protein. (54 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (982 aa)
ENSUAMP00000017416Uncharacterized protein. (1272 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (671 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ENSUAMP00000016192Integrin beta; Belongs to the integrin beta chain family. (786 aa)
CACNG7Calcium voltage-gated channel auxiliary subunit gamma 7. (408 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (230 aa)
ENSUAMP00000015680Uncharacterized protein. (92 aa)
ENSUAMP00000015656Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (300 aa)
ENSUAMP00000015653Uncharacterized protein. (172 aa)
SGCGSarcoglycan gamma. (182 aa)
CACNB1Calcium voltage-gated channel auxiliary subunit beta 1. (646 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (224 aa)
ENSUAMP00000013919Uncharacterized protein. (497 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
ENSUAMP00000012642Integrin_alpha2 domain-containing protein. (261 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ENSUAMP00000012276B30.2/SPRY domain-containing protein. (334 aa)
ENSUAMP00000010867Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (207 aa)
DAG1Dystroglycan 1. (892 aa)
ENSUAMP00000007288Ca_chan_IQ domain-containing protein. (832 aa)
ENSUAMP00000007032Uncharacterized protein. (505 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1032 aa)
ENSUAMP00000006638ZZ-type domain-containing protein. (342 aa)
ENSUAMP00000006515Uncharacterized protein. (190 aa)
ENSUAMP00000005950SERPIN domain-containing protein; Belongs to the serpin family. (366 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1338 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1872 aa)
TNNT2Troponin T2, cardiac type. (215 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (618 aa)
ENSUAMP00000004823SH3 domain-containing protein. (506 aa)
ACTC1Actin alpha cardiac muscle 1. (381 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (619 aa)
ITGB4Integrin subunit beta 4. (1096 aa)
ENSUAMP00000003698Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (164 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (847 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1143 aa)
ENSUAMP00000001579Cation_ATPase_N domain-containing protein. (75 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (767 aa)
ENSUAMP00000001254Uncharacterized protein. (96 aa)
ENSUAMP00000000563Uncharacterized protein. (1604 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (621 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (484 aa)
SGCASarcoglycan alpha. (386 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1121 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1091 aa)
MYH8Myosin heavy chain 8; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1941 aa)
ENSUAMP00000033448Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1911 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (361 aa)
MYH1Myosin heavy chain 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
TPM2Tropomyosin 2; Belongs to the tropomyosin family. (284 aa)
ENSUAMP00000032619Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
ENSUAMP00000032618Uncharacterized protein. (68 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
ENSUAMP00000032296Uncharacterized protein. (1042 aa)
SGCBSarcoglycan beta. (219 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ENSUAMP00000031866Uncharacterized protein. (135 aa)
ENSUAMP00000031863Uncharacterized protein; Belongs to the tropomyosin family. (248 aa)
MYL2Myosin light chain 2. (192 aa)
DESDesmin; Belongs to the intermediate filament family. (516 aa)
ENSUAMP00000030750Uncharacterized protein. (160 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa)
ENSUAMP00000029346Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (703 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1866 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
TPM1Tropomyosin 1; Belongs to the tropomyosin family. (284 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1067 aa)
ITGA10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1130 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (973 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (771 aa)
ENSUAMP00000010475IGv domain-containing protein. (144 aa)
ENSUAMP00000010858Myosin_tail_1 domain-containing protein. (890 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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