STRINGSTRING
ENSUAMP00000001398 ENSUAMP00000001398 AKT2 AKT2 NQO1 NQO1 CHUK CHUK BMPR2 BMPR2 TRPV4 TRPV4 ENSUAMP00000036430 ENSUAMP00000036430 ENSUAMP00000036336 ENSUAMP00000036336 ENSUAMP00000036314 ENSUAMP00000036314 ENSUAMP00000036253 ENSUAMP00000036253 BMPR1A BMPR1A SQSTM1 SQSTM1 CALM2 CALM2 ENSUAMP00000035331 ENSUAMP00000035331 PECAM1 PECAM1 NOX1 NOX1 ENSUAMP00000034866 ENSUAMP00000034866 ENSUAMP00000034862 ENSUAMP00000034862 MMP2 MMP2 ENSUAMP00000033470 ENSUAMP00000033470 MAP2K4 MAP2K4 ENSUAMP00000033175 ENSUAMP00000033175 ENSUAMP00000033138 ENSUAMP00000033138 IL1A IL1A IL1B IL1B ENSUAMP00000032917 ENSUAMP00000032917 PRKAA1 PRKAA1 BMPR1B BMPR1B NOS3 NOS3 PLAT PLAT ENSUAMP00000032511 ENSUAMP00000032511 ENSUAMP00000032358 ENSUAMP00000032358 MAPK13 MAPK13 MAPK14 MAPK14 RAC3 RAC3 MAP3K7 MAP3K7 CAV3 CAV3 RAC2 RAC2 PTK2 PTK2 ENSUAMP00000030750 ENSUAMP00000030750 RAC1 RAC1 ENSUAMP00000030620 ENSUAMP00000030620 ITGAV ITGAV EDN1 EDN1 ENSUAMP00000030465 ENSUAMP00000030465 SRC SRC MEF2C MEF2C MGST2 MGST2 TNFRSF1A TNFRSF1A PIAS4 PIAS4 BMP4 BMP4 MAPK9 MAPK9 MMP9 MMP9 MAP2K7 MAP2K7 MAP2K6 MAP2K6 RELA RELA ENSUAMP00000026301 ENSUAMP00000026301 ENSUAMP00000025819 ENSUAMP00000025819 ENSUAMP00000025782 ENSUAMP00000025782 ENSUAMP00000025726 ENSUAMP00000025726 ENSUAMP00000025311 ENSUAMP00000025311 HSP90AA1 HSP90AA1 KEAP1 KEAP1 ENSUAMP00000023518 ENSUAMP00000023518 MEF2A MEF2A ENSUAMP00000023384 ENSUAMP00000023384 KDR KDR ENSUAMP00000023119 ENSUAMP00000023119 ENSUAMP00000023048 ENSUAMP00000023048 MAPK10 MAPK10 ENSUAMP00000022734 ENSUAMP00000022734 SDC4 SDC4 TXN2 TXN2 NCF2 NCF2 ENSUAMP00000022131 ENSUAMP00000022131 ENSUAMP00000021933 ENSUAMP00000021933 CALM3 CALM3 ENSUAMP00000021540 ENSUAMP00000021540 ACTG1 ACTG1 NFKB1 NFKB1 HSP90AB1 HSP90AB1 MMP20 MMP20 IKBKB IKBKB VEGFA VEGFA ARHGEF2 ARHGEF2 HMOX1 HMOX1 CALML4 CALML4 PIK3CD PIK3CD NOXA1 NOXA1 ENSUAMP00000017692 ENSUAMP00000017692 ENSUAMP00000017435 ENSUAMP00000017435 MAPK11 MAPK11 CTNNB1 CTNNB1 MGST3 MGST3 MAPK12 MAPK12 ENSUAMP00000016793 ENSUAMP00000016793 ENSUAMP00000016192 ENSUAMP00000016192 TNF TNF PRKAA2 PRKAA2 ACVR2A ACVR2A ENSUAMP00000014949 ENSUAMP00000014949 ENSUAMP00000014440 ENSUAMP00000014440 IKBKG IKBKG CALML6 CALML6 ENSUAMP00000013435 ENSUAMP00000013435 ENSUAMP00000013433 ENSUAMP00000013433 GSTT4 GSTT4 ENSUAMP00000013425 ENSUAMP00000013425 ENSUAMP00000013421 ENSUAMP00000013421 ENSUAMP00000012486 ENSUAMP00000012486 ENSUAMP00000012405 ENSUAMP00000012405 ENSUAMP00000012385 ENSUAMP00000012385 CCL2 CCL2 ENSUAMP00000012071 ENSUAMP00000012071 ENSUAMP00000011956 ENSUAMP00000011956 BCL2 BCL2 AKT3 AKT3 ENSUAMP00000011487 ENSUAMP00000011487 AKT1 AKT1 PIK3R1 PIK3R1 NCF1 NCF1 SDC1 SDC1 MAPK8 MAPK8 PIK3CA PIK3CA GSTA4 GSTA4 ENSUAMP00000009044 ENSUAMP00000009044 ENSUAMP00000009042 ENSUAMP00000009042 ENSUAMP00000009040 ENSUAMP00000009040 JUN JUN PDGFA PDGFA RHOB RHOB CALML5 CALML5 CAV1 CAV1 CAV2 CAV2 NFE2L2 NFE2L2 ENSUAMP00000008117 ENSUAMP00000008117 CDH5 CDH5 MAP3K5 MAP3K5 NPPC NPPC ACVR2B ACVR2B ITGA2B ITGA2B GPC1 GPC1 ENSUAMP00000006430 ENSUAMP00000006430 ENSUAMP00000006241 ENSUAMP00000006241 ENSUAMP00000005976 ENSUAMP00000005976 ENSUAMP00000005458 ENSUAMP00000005458 VCAM1 VCAM1 PDGFB PDGFB ENSUAMP00000004598 ENSUAMP00000004598 ENSUAMP00000004109 ENSUAMP00000004109 GSTM3 GSTM3 ACVR1 ACVR1 ENSUAMP00000003787 ENSUAMP00000003787 SDC2 SDC2 ENSUAMP00000002835 ENSUAMP00000002835 THBD THBD ENSUAMP00000002712 ENSUAMP00000002712 GSTO1 GSTO1 GSTO2 GSTO2 ENSUAMP00000002330 ENSUAMP00000002330 ENSUAMP00000001920 ENSUAMP00000001920 CTSV CTSV ENSUAMP00000001757 ENSUAMP00000001757 ENSUAMP00000001690 ENSUAMP00000001690 ENSUAMP00000001437 ENSUAMP00000001437 IL1R1 IL1R1 TP53 TP53 ENSUAMP00000000765 ENSUAMP00000000765 ENSUAMP00000000641 ENSUAMP00000000641
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000001398Uncharacterized protein. (73 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
NQO1NAD(P)H quinone dehydrogenase 1. (261 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (857 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (861 aa)
ENSUAMP00000036430Uncharacterized protein; Belongs to the peptidase C1 family. (372 aa)
ENSUAMP00000036336Inhibitor_I29 domain-containing protein. (93 aa)
ENSUAMP00000036314Protein kinase domain-containing protein. (321 aa)
ENSUAMP00000036253Protein kinase domain-containing protein. (66 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SQSTM1Sequestosome 1. (491 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (163 aa)
ENSUAMP00000035331Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (506 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (707 aa)
NOX1NADPH oxidase 1. (594 aa)
ENSUAMP00000034866Ubiquitin-like domain-containing protein. (139 aa)
ENSUAMP00000034862PSI domain-containing protein. (187 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
ENSUAMP00000033470Ubiquitin-like domain-containing protein. (101 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (416 aa)
ENSUAMP00000033175Uncharacterized protein. (91 aa)
ENSUAMP00000033138Uncharacterized protein. (153 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (244 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
ENSUAMP00000032917Uncharacterized protein. (117 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1202 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (563 aa)
ENSUAMP00000032511Protein kinase domain-containing protein. (132 aa)
ENSUAMP00000032358Thioredoxin domain-containing protein. (104 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
RAC3Rac family small GTPase 3. (202 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
RAC2Rac family small GTPase 2. (192 aa)
PTK2Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (976 aa)
ENSUAMP00000030750Uncharacterized protein. (160 aa)
RAC1Rac family small GTPase 1. (229 aa)
ENSUAMP00000030620Rad60-SLD domain-containing protein. (51 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa)
EDN1Endothelin 1. (202 aa)
ENSUAMP00000030465Rad60-SLD domain-containing protein. (51 aa)
SRCTyrosine-protein kinase. (557 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
MGST2Microsomal glutathione S-transferase 2. (146 aa)
TNFRSF1ATNF receptor superfamily member 1A. (502 aa)
PIAS4Protein inhibitor of activated STAT 4. (505 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
MAPK9Mitogen-activated protein kinase. (433 aa)
MMP9Matrix metallopeptidase 9. (704 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
RELARELA proto-oncogene, NF-kB subunit. (508 aa)
ENSUAMP00000026301Ig-like domain-containing protein. (331 aa)
ENSUAMP00000025819Thioredoxin domain-containing protein. (103 aa)
ENSUAMP00000025782Uncharacterized protein. (257 aa)
ENSUAMP00000025726annotation not available (113 aa)
ENSUAMP00000025311Uncharacterized protein. (295 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (733 aa)
KEAP1Kelch like ECH associated protein 1. (624 aa)
ENSUAMP00000023518Small ubiquitin-related modifier. (101 aa)
MEF2AMyocyte enhancer factor 2A. (466 aa)
ENSUAMP00000023384Rad60-SLD domain-containing protein. (67 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1282 aa)
ENSUAMP00000023119Uncharacterized protein. (607 aa)
ENSUAMP00000023048PB1 domain-containing protein. (123 aa)
MAPK10Mitogen-activated protein kinase. (422 aa)
ENSUAMP00000022734Uncharacterized protein; Belongs to the peptidase C1 family. (323 aa)
SDC4Syndecan 4. (201 aa)
TXN2Thioredoxin 2. (163 aa)
NCF2Neutrophil cytosolic factor 2. (517 aa)
ENSUAMP00000022131Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (636 aa)
ENSUAMP00000021933Uncharacterized protein. (105 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (149 aa)
ENSUAMP00000021540Uncharacterized protein. (311 aa)
ACTG1Actin gamma 1. (375 aa)
NFKB1Nuclear factor kappa B subunit 1. (972 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (728 aa)
MMP20Matrix metallopeptidase 20. (483 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (703 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (516 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1188 aa)
HMOX1Heme oxygenase 1. (288 aa)
CALML4Calmodulin like 4. (153 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
NOXA1NADPH oxidase activator 1. (467 aa)
ENSUAMP00000017692Uncharacterized protein. (704 aa)
ENSUAMP00000017435Uncharacterized protein. (459 aa)
MAPK11Mitogen-activated protein kinase. (357 aa)
CTNNB1Catenin beta 1. (781 aa)
MGST3Microsomal glutathione S-transferase 3. (152 aa)
MAPK12Mitogen-activated protein kinase 12. (373 aa)
ENSUAMP00000016793BZIP domain-containing protein. (179 aa)
ENSUAMP00000016192Integrin beta; Belongs to the integrin beta chain family. (786 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (230 aa)
PRKAA2Non-specific serine/threonine protein kinase. (525 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
ENSUAMP00000014949FERM domain-containing protein. (121 aa)
ENSUAMP00000014440Protein kinase domain-containing protein. (251 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (442 aa)
CALML6Calmodulin like 6. (180 aa)
ENSUAMP00000013435Uncharacterized protein; Belongs to the GST superfamily. (244 aa)
ENSUAMP00000013433Uncharacterized protein; Belongs to the GST superfamily. (242 aa)
GSTT4Glutathione S-transferase theta 4; Belongs to the GST superfamily. (241 aa)
ENSUAMP00000013425Uncharacterized protein; Belongs to the GST superfamily. (240 aa)
ENSUAMP00000013421Uncharacterized protein. (240 aa)
ENSUAMP00000012486Uncharacterized protein. (314 aa)
ENSUAMP00000012405Uncharacterized protein. (110 aa)
ENSUAMP00000012385Rad60-SLD domain-containing protein. (63 aa)
CCL2C-C motif chemokine. (101 aa)
ENSUAMP00000012071GST N-terminal domain-containing protein. (193 aa)
ENSUAMP00000011956Uncharacterized protein. (119 aa)
BCL2BCL2 apoptosis regulator. (205 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ENSUAMP00000011487HATPase_c domain-containing protein. (333 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (676 aa)
NCF1Neutrophil cytosolic factor 1. (396 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (301 aa)
MAPK8Mitogen-activated protein kinase. (456 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GSTA4Glutathione S-transferase alpha 4; Belongs to the GST superfamily. (223 aa)
ENSUAMP00000009044Uncharacterized protein; Belongs to the GST superfamily. (222 aa)
ENSUAMP00000009042Uncharacterized protein. (158 aa)
ENSUAMP00000009040GST N-terminal domain-containing protein. (150 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (248 aa)
RHOBRas homolog family member B. (172 aa)
CALML5Calmodulin like 5. (156 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (606 aa)
ENSUAMP00000008117Uncharacterized protein. (230 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (783 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1212 aa)
NPPCNatriuretic peptide C. (126 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (527 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1032 aa)
GPC1Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (556 aa)
ENSUAMP00000006430Uncharacterized protein; Belongs to the GST superfamily. (226 aa)
ENSUAMP00000006241GST N-terminal domain-containing protein. (60 aa)
ENSUAMP00000005976Uncharacterized protein. (94 aa)
ENSUAMP00000005458Uncharacterized protein. (51 aa)
VCAM1Vascular cell adhesion molecule 1. (702 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
ENSUAMP00000004598Uncharacterized protein. (299 aa)
ENSUAMP00000004109Uncharacterized protein; Belongs to the GST superfamily. (256 aa)
GSTM3Glutathione S-transferase. (226 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ENSUAMP00000003787Uncharacterized protein. (209 aa)
SDC2Syndecan 2. (187 aa)
ENSUAMP00000002835ICAM_N domain-containing protein. (149 aa)
THBDThrombomodulin. (579 aa)
ENSUAMP00000002712Uncharacterized protein. (561 aa)
GSTO1Glutathione S-transferase omega 1; Belongs to the GST superfamily. (278 aa)
GSTO2Glutathione S-transferase omega 2; Belongs to the GST superfamily. (244 aa)
ENSUAMP00000002330Uncharacterized protein. (50 aa)
ENSUAMP00000001920Uncharacterized protein. (229 aa)
CTSVCathepsin V; Belongs to the peptidase C1 family. (324 aa)
ENSUAMP00000001757Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (151 aa)
ENSUAMP00000001690Thioredoxin; Belongs to the thioredoxin family. (105 aa)
ENSUAMP00000001437Uncharacterized protein. (607 aa)
IL1R1Interleukin 1 receptor type 1. (584 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
ENSUAMP00000000765Uncharacterized protein. (121 aa)
ENSUAMP00000000641Uncharacterized protein. (139 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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